Yingzi Yang, Ph.D.

Senior Investigator, Genetic Disease Research Branch
Head, Developmental Genetics Section

Selected Publications

Yang Y and Niswander L. Interaction between the signaling molecules WNT and SHH during vertebrate limb development: the role of dorsal ectoderm signals in anteroposterior patterning. Cell, 80:939-947. 1995. [PubMed]

Yang Y, Drossopoulou G, Chuang P-T, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A and Tickle C. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development, 124(21):4393-4404. 1997. [PubMed]

Yang Y, Guillot P, Boyd Y, Lyon M.F., and McMahon A.P. Evidence that preaxial polydactyly in Double Foot mutant is due to ectopic Indian Hedgehog signaling. Development, 125(16):3123-3132. 1998. [PubMed]

Long F, Zhang XM, Karp S, Yang Y, and McMahon AP. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development, 128:5099-5108. 2001. [PubMed]

Yang Y, Topol L, Lee H, Wu J. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development, 130 (5): 1003-15. 2003. [PubMed]

Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent ?-catenin degradation. J Cell Biol, 162(5):899-908. 2003. [PubMed]

Guo X., Day T.F., Jiang X., Garrett-Beal L., Topol L., Yang Y. Wnt/?-catenin signaling is sufficient and necessary for synovial joint formation. Genes & development, 18(19). 2004. [PubMed]

Day T, Guo X, Garrett-Beal L, Yang Y. Wnt/b-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell, 8(5): 739-750. 2005. [PubMed]

Mak KK, Chen MH, Day TF, Chuang PT and Yang Y. Wnt/ß-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development, 133(18): 3695-707. 2006. [PubMed]

Mak KK, Bi Y, Wan C, Chuang PT, Clemens T, Young M and Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell, 14(5):674-88. 2008. [PubMed]

Mak KK, Kronenberg HM, Chuang P-T, Meckem S and Yang Y. Indian Hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development, 135(11):1947-56. 2008. [PubMed]

Tzchori I, Day TF, Carolan PJ, Zhao Y, Wassif CA, Li L, Lewandoski M, Gorivodsky M, Love PE, Porter FD, Westphal H, Yang Y. LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development, 136(8):1375-85. 2009. [PubMed]

Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, Chen Y, Park O, Chang J, Simpson RM, Wang CY, Gao B, Jiang J, Yang Y. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A, 2010, 107(4):1431-6. 2010. [PubMed]

Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, and Yang Y. Planar cell polarity breaks the bilateral symmetry by controlling ciliary positioning. Nature, 466(7304):378-82. 2010. [PubMed]

Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y. Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2. Dev Cell, 20(2):163-76. 2011. [PubMed]

Regard JB, Palmer D, Celi FS, Guettier  J-M, Chen M, Cherman N, Kuznetsov SA, Bhattacharyya N, Jurgen Wess, Coughlin SR, Weinstein LS, Collins MT, Robey PG, and Yang Y. Wnt/ß-catenin signaling is differentially regulated by G? proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci USA, 108(50):20101-6. 2011. [PubMed]

Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore  EM Kaplan FS. Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med, 19(11):1505-12. 2013. [PubMed]

Andre P, Wang Q, Wang N, Gao B, Schilit A, Halford MM, Stacker SA, Zhang X, Yang Y. The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem, 287(53):44518-25. 2013. [PubMed]

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Last Updated: June 10, 2014