Stacie Loftus, Ph.D.

Associate Investigator, Genetic Disease Research Branch

Selected Publications

Loftus S.K., Chen Y., Gooden G., Ryan J.F., Birznieks G., Hilliard M., Baxevanis A.D., Bittner M., Meltzer P., Trent J., Pavan W.J. Informatic selection of a neural crest-melanocyte cDNA set for microarray analysis. Proc Natl Acad Sci U S A, 96:9277-9280. 1999. [PubMed]

Loftus S.K., Larson D.M., Watkins-Chow D., Church D.M., and Pavan W.J. Generation of RCAS vectors useful for functional genomic analyses. DNA Res, 8(5):221-6. 2001. [PubMed]

Loftus S.K., Erikcson R.P., Walkely S.U., Bryant M.A., Incao A., Heidenreich R.A. and Pavan W.J. Rescue of neurodegeneration in Niemann Pick-C mice by a prion-promoter-driven Npc1 cDNA transgene. Hum Mol Genet, 11: 3107-3144. 2002. [PubMed]

Loftus S.K., Larson D.M., Baxter L.L., Antonellis A., Chen Y., Wu X., Bittner M, Hammer JA and Pavan WJ. Mutation of the melanosomal protein RAB38 in chocolate mice. Proc Natl Acad Sci U S A, 99:4471-4476. 2002. [PubMed]

Rao C., Foernzler D., Loftus S.K., Liu S., McPherson J.D., Jungers K.A., Apte S.S., Pavan W.J., Beier D.R.. A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development, 30(19):4665-72. 2003. [PubMed]

Hou, L., Loftus, S. K., Incao, A., Chen, A., Pavan, W.J. Complementation of melanocyte development in SOX10 mutant neural crest using lineage-directed gene transfer. Dev Dyn, 229: 54-62. 2004. [PubMed]

Loftus, S. K., Cannons, J. L., Incao, A., Pak, E., Chen, A., Zerfas, P. M., Bryant, M. A., Biesecker, L. G., Schwartzberg, P. L., Pavan, W. J. Acinar Cell Apoptosis in Serpini2-DeficientMice Models Pancreatic Insufficiency. PLoS Genet, 1(3):e38. 2005. [PubMed]

Hakami, R. M., Hou, L., Baxter, L., Loftus S. K. , Southard-Smith, M. Incao, A., Cheng, J. and Pavan W. P. Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage. Mech Dev, 123:124-34. 2006. [PubMed]

Matera, I., Watkins-Chow, D. E., Loftus, S.K., Hou, L., Incao, A., Silver, D. L., Rivas, C., Elliott, E. C,. Baxter, L. L., Pavan, W.J. A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet, 17: 2118-31. 2008. [PubMed]

Buac K, Watkins-Chow DE, Loftus SK, Larson DM, Incao A, Gibney G, Pavan WJ. A Sox10 expression screen identifies an amino acid essential for Erbb3 function. PLoS Genet, 4(9). 2008. [PubMed]

Antonellis A, Huynh JL, Lee-Lin SQ, Vinton RM, Renaud G, Loftus SK, Elliot G, Wolfsberg TG, Green ED, McCallion AS, Pavan WJ. Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. PLoS Genet, 4(9). 2008. [PubMed]

Loftus SK, Antonellis A, Matera I, Renaud G, Baxter LL, Reid D, Wolfsberg TG, Chen Y, Wang C; NISC Comparative Sequencing Program, Prasad MK, Bessling SL, McCallion AS, Green ED, Bennett DC, Pavan WJ. Gpnmb is a Melanoblast-Expressed, MITF-Dependent Gene. Pigment Cell Melanoma Res, 22(1):99-110. 2009. [PubMed]

Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian BC, Pavan WJ, Samuels Y. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res, 22:435-444. 2009. [PubMed]

Loftus SK, Baxter LL, Buac K, Watkins-Chow DE, Larson DM, Pavan WJ. Comparison of melanoblast expression patterns identifies distinct classes of genes. Pigment Cell Melanoma Res, 22:611-622. 2009. [PubMed]

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Last Reviewed: June 25, 2013