Phyllis Frosst, Ph.D.

Acting Branch Chief and Senior Science Policy Analyst
Policy and Program Analysis Branch

Frosst P. Prognosis for personalized medicine. What Matters, McKinsey Publishing. 2009. [Full Text]

Frosst P. Doing the Things that Interest You. ASBMB Today, 2:22-23. 2008. [Full Text ]

Frosst P, Wattendorf DJ. At-home genetic tests. Am Fam Physician, 73(3):540-1. 2006. [PubMed]

Hsu C, Boysen M, Gritton LD, Frosst PD, Nemerow GR, Von Seggern DJ. In vitro dendritic cell infection by pseudotyped adenoviral vectors does not correlate with their in vivo immunogenicity. Virology, 332(1):1-7. 2005. [PubMed]

Frosst, P., Guan, T., Subauste C., Hahn, K. and Gerace, L. Tpr is contained within the nuclear basket of the pore complex and has a role in nuclear protein export. J Cell Biol, 156(4):617-30. 2002. [PubMed]

Tran P., Hiou-Tim F., Frosst P., Lussier-Cacan S., Bagley P., Selhub J., Bottiglieri T., Rozen R. The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr. Mol Genet Metab, 76(4):297. 2002. [PubMed]

Goyette, P., Pai, A., Milos, R., Frosst, P., Tran, P., Chen, Z., Chan, M. and Rozen R. Gene structure of human and mouse methylenetetrahydrofolate reductase. Mamm. Genome, 9(8):652-6. 1998. [PubMed]

Christensen, B., Frosst, P., Lussier-Cacan, S., Selhub, J., Goyette, P., Rosenblatt, D.S., Genest Jr., J., Rozen, R. Correlation of a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol, 17(3):569-73. 1997. [PubMed]

Frosst, P., Zhang, Z., Rozen, R. Assignment of murine methylenetetrahydrofolate reductase (MTHFR) to distal chromosome 4. Mamm Genome, 7(11):864-5. 1996. [PubMed]

Ma, J., Stampfer, M.J., Hennekens, C.H., Frosst, P., Selhub, J., Horsford, J., Malinow, M.R., Willett, W.C., Rozen, R. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in U.S. physicians. Circulation, 94(10):2410-6. 1996. [PubMed]

Kluijtmans, L.A.J., ven den Heuvel, L.P., Boers, G.H.J., Frosst, P., Stevens E.M.B., van Oost, B.A., den Heijer M., Trijbels, F.J.M., Rozen, R., Blom, H.J. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am. J. Hum. Genet, 58:35-41. 1996. [PubMed]

van der Put, N., Steegers-Theunissen, R., Frosst, P., Trijbels, F., Eskes, T., van den Heuvel, L., Marimann, E., den Heyer, M., Rozen, R., Blom, H. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet, 346: 1070-1071. 1995. [PubMed]

Frosst, P., Blom H.J., Milos R., Goyette, P., Sheppard, C.A., Matthews, R., Boers, G.H.J., Heijer, M.D., Kluijtmans, L.A.J., van den Heuvel, L.P., Rozen, R. Identification of a candidate risk factor for cardiovascular disease: A common mutation at the methylenetetrahydrofolate reductase locus. Nature Genetics 10(1):111-113. 1995. [PubMed]

Goyette, P., Frosst, P., Rosenblatt, D.S., Rozen, R. (1995) Seven novel mutations at the methylenetetrahydrofolate reductase (MTHFR) locus with genotype-phenotype correlations in severe MTHFR deficiency. Am. J. Hum. Genet, 56:1052-1059. 1995. [PubMed]

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Last Reviewed: September 15, 2009