|
11/20/09 |
Paterson October 29, 2009 Diabetes A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both HbA1c and glucose
|
|
1,304 diabetics |
531 diabetics, up to 37,436 non-diabetics |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix and Illumina [2,518,578] (imputed) |
N |
|
11/18/09 |
Johansson October 22, 2009 Obesity Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene
|
Body mass index |
Up to 3,925 European individuals |
NR |
1p36.33 4q34.3 2q36.1 3q28 19p13.3 19q13.3 3p14.1 5q35.3 9p22.3 11q14.1 |
NR NR NR NR NR NR NR NR NR NR |
rs3934834-G rs2383393-G rs824931-G rs1152846-G rs3803915-C rs1878047-G rs1024889-G rs12517906-G rs1927702-G rs1458095-G |
0.80 0.63 0.35 0.77 0.89 0.37 0.28 0.85 0.42 0.90 |
6 x 10-7 (females + males) 2 x 10-6 (males) 3 x 10-6 (females + males) 3 x 10-6 (females +males) 5 x 10-6 (females + males) 5 x 10-6 (females + males) 6 x 10-6 (males) 6 x 10-6 (females) 6 x 10-6 (females) 7 x 10-6 (females) |
.11 [NR] kg increase .1 [NR] kg increase .07 [NR] kg increase .09 [NR] kg decrease .13 [NR] kg decrease .06 [NR] kg decrease .12 [NR] kg increase .16 [NR] kg decrease .08 [NR] kg increase .19 [NR] kg increase |
Illumina [318,237] |
N |
|
11/18/09 |
"
|
Weight |
Up to 3,925 European individuals |
NR |
5q35.3 18q11.2 17q24.1 10q22.2 12p11.21 13q12.12 3q28 10q22.1 9p13.3 |
MGAT1 NR NR NR NR NR NR NR NR |
rs12517906-G rs1840440-G rs7209395-G rs7919006-G rs10844154-C rs2765086-G rs1152846-G rs1816002-G rs10972341-G |
0.85 0.61 0.23 0.95 0.54 0.94 0.77 0.46 0.60 |
7 x 10-8 (females) 3 x 10-7 (females) 3 x 10-6 (females + males) 4 x 10-6 (females) 4 x 10-6 (females) 6 x 10-6 (females) 6 x 10-6 (females + males) 8 x 10-6 (females) 9 x 10-6 (males) |
2.96 [NR] kg decrease 2.16 [NR] kg increase 1.75 [NR] kg increase 4 [NR] kg decrease 1.87 [NR] kg increase 3.86 [NR] kg decrease 1.7 [NR] kg decrease 2.08 [NR] kg increase 2.32 [NR] kg increase |
Illumina [318,237] |
N |
|
11/12/09 |
Kim October 19, 2009 Neurobiol Dis Common CYP7A1 Promoter Polymorphism Associated With Risk of Neuromyelitis Optica
|
Neuromyelitis optica |
53 Korean cases, 240 Korean controls |
40 Korean cases |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [288,025] |
N |
|
11/09/09 |
Han October 18, 2009 Nat Genet Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
|
Systemic lupus erythematosus |
1,047 Chinese Han cases, 1,205 Chinese Han controls |
3,152 Chinese Han cases, 7,050 Chinese Han controls |
2q32.3 1q25.1 11q24.3 8p23.1 7p12.2 7q32.1 6q23.3 11q23.3 22q11.21 2p22.3 6p21.32 6q21 10q11.22 12q24.32 5q33.1 7q11.23 16p11.2 16p11.2 |
STAT4 TNFSF4 ETS1 BLK IKZF1 IRF5 TNFAIP3 NR HIC2, UBE2L3 RASGRP3 HLA-DRB1 PRDM1, ATG5 LRRC18, WDFY4 SLC15A4 TNIP1 NR NR NR |
rs7574865-A rs2205960-A rs6590330-A rs7812879-G rs4917014-A rs4728142-A rs2230926-C rs4639966-G rs131654-A rs13385731-A rs9271100-? rs548234-G rs1913517-A rs1385374-A rs10036748-A rs1167796-G rs7197475-A rs7186852-A |
0.33 0.27 0.34 0.76 0.68 0.13 0.04 0.30 0.48 0.85 NR 0.26 0.29 0.20 0.76 0.71 0.08 0.08 |
5 x 10-42 3 x 10-32 2 x 10-25 2 x 10-24 3 x 10-23 8 x 10-19 1 x 10-17 1 x 10-16 1 x 10-16 1 x 10-15 1 x 10-12 5 x 10-12 7 x 10-12 2 x 10-11 2 x 10-9 2 x 10-8 3 x 10-8 3 x 10-7 |
1.51 [1.43-1.61] 1.46 [1.37-1.56] 1.37 [1.29-1.45) 1.45 [1.35-1.56] 1.39 [1.30-1.47] 1.43 [1.32-1.54] 1.72 [1.52-1.94] 1.29 [1.22-1.37] 1.28 [1.20-1.35] 1.43 [1.32-1.56] 1.9 [1.59-2.27] 1.25 [1.17-1.33] 1.24 [1.17-1.32] 1.26 [1.18-1.35] 1.23 [1.15-1.33] 1.2 [1.12-1.28] 1.31 [1.20-1.46] 1.29 [1.17-1.42] |
Illumina [493,955] |
N |
|
11/09/09 |
Landi October 15, 2009 Am J Hum Genet A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma
|
Lung adenocarcinoma |
5,739 European descent cases, 5,848 European descent controls |
7,561 European descent cases, 13,818 European descent controls |
15q25.1 6p21.33 5p15.33 5p15.33 6p22.1 |
CHRNA3, CHRNA5 BAT3, APOM TERT CLPTM1L TRNAA-UGC |
rs1051730-T rs3117582-C rs2736100-G rs31489-C rs4324798-A |
0.35 0.10 0.50 0.59 0.09 |
2 x 10-51 5 x 10-12 2 x10-10 2 x 10-10 2 x 10-8 |
1.31 [1.27-1.36] 1.22 [1.15-1.29] 1.12 [1.08-1.16] 1.12 [1.09-1.16] 1.16 [1.09-1.24] |
Illumina [515,922] |
N |
|
11/05/09 |
Benyamin October 11, 2009 Nat Genet Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
|
Serum markers of iron status |
4,818 Australian siblings |
3,470 Dutch individuals |
22q12.3 6p22.1 22q12.3 6p22.1 |
TMPRSS6 HFE TMPRSS6 HFE |
rs855791-T rs1800562-A rs855791-T rs1800562-A |
0.42 0.08 0.42 0.08 |
1 x 10-10 (MCV) 2 x 10-8 (MCV) 5 x 10-7 (Hgb) 5 x 10-7 (Hgb) |
.13 [0.09-0.17] SD decrease .22 [0.14-0.30] SD increase .1 [0.06-0.14] SD decrease .2 [0.12-0.28] SD increase |
Illumina & Perlegen [427,037] |
N |
|
11/05/09 |
Chambers October 11, 2009 Nat Genet Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
|
Hemoglobin levels |
6,316 Europeans, 9,685 Indian Asians |
5,187 Europeans, 6,721 Indian Asians |
22q12.3 6p22.1 |
TMPRSS6 HFE |
rs855791-A rs198846-A |
0.53 NR |
2 x 10-13 1 x 10-8 |
.13 [0.09-0.17] g/dl decrease NR |
Affymetrix, Illumina & Perlegen [NR] |
N |
|
11/03/09 |
Ganesh October 11, 2009 Nat Genet Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
|
Hematocrit |
24,167 European ancestry individuals |
9,456 European ancestry individuals |
6q23.3 2p21 7q36.1 10q21.3 22q12.3 12q24.12 7q22.1 6p22.1 |
HBS1L, MYB PRKCE PRKAG2 HK1 TMPRSS6 SH2B3, ATXN2 TFR2 HFE |
rs9483788-C rs10168349-C rs10224002-G rs16926246-T rs2413450-T rs11065987-G rs7385804-C rs1800562-A |
NR NR NR NR NR NR NR NR |
3 x 10-15 4 x 10-15 6 x 10-15 1 x 10-13 2 x 10-13 1 x 10-12 4 x 10-10 2 x 10-9 |
.22 [0.16-0.28] % increase .19 [0.14-0.23] % increase .2 [0.15-0.25] % increase .33 [0.24-0.42] % increase .17 [0.13-0.22] % decrease .17 [0.12-0.22] % decrease .15 [0.10-0.20] % decrease .31 [0.21-0.41] % increase |
Affymetrix & Illumina [~2.5 million](imputed) |
N |
|
11/03/09 |
"
|
Hemoglobin |
24,167 European ancestry individuals |
9,456 European ancestry individuals |
22q12.3 6p22.1 7q36.1 2p21 12q24.12 10q21.3 20q13.2 |
TMPRSS6 HFE PRKAG2 PRKCE TRAFD1 HK1 TSHZ2 |
rs855791-A rs1800562-A rs10224002-G rs10495928-G rs11065987-A rs16926246-T rs6013509-A |
NR NR NR NR NR NR NR |
3 x 10-25 6 x 10-19 3 x 10-15 7 x 10-13 1 x 10-11 2 x 10-11 1 x 10-10 |
.09 [0.07-0.11] g/dl decrease .16 [0.13-0.20] g/dl increase .07 [0.05-0.09] g/dl increase .06 [0.05-0.08] g/dl increase .06 [0.04-0.08] g/dl increase .11 [0.08-0.14] g/dl increase .06 [0.05-0.08] g/dl decrease |
Affymetrix & Illumina [~2.5 million](imputed) |
N |
|
11/03/09 |
"
|
Mean corpuscular hemoglobin |
24,167 European ancestry individuals |
9,456 European ancestry individuals |
6q23.3 6p22.2 22q12.3 6p21.1 6q24.1 9p24.1 3q29 19p13.13 16p13.3 |
HBS1L, MYB SLC17A3 TMPRSS6 CCND3, BYSL CITED2 RCL1 TFRC GCDH ITFG3 |
rs7776054-G rs1408272-G rs2413450-T rs9349205-A rs628751-C rs10758658-A rs11915082-A rs11085824-G rs1122794-A |
NR NR NR NR NR NR NR NR NR |
7 x 10-69 4 x 10-39 9 x 10-34 8 x 10-20 1 x 10-17 2 x 10-14 8 x 10-13 1 x 10-11 3 x 10-10 |
.01 [0.009-0.0111] pg decrease .02 [0.01-0.02] pg decrease .01 [0.0005-0.007] pg decrease .01 [0.004-0.006] pg decrease 0 [0.003-0.005] pg decrease 0 [0.004-0.006] pg decrease 0 [0.003-0.005] pg increase 0 [0.003-0.005] pg decrease 0 [0.003-0.006] pg increase |
Affymetrix & Illumina [~2.5 million](imputed) |
N |
|
11/03/09 |
"
|
Mean corpuscular volume |
24,167 European ancestry individuals |
9,456 European ancestry individuals |
6q23.3 6p22.1 22q12.3 6p21.1 6q24.1 9p24.1 22q13.33 4q12 2p16.1 3q29 7p12.2 16p13.3 19p13.13 7q22.1 10q11.21 6q21 14q23.3 |
HBS1L, MYB HFE TMPRSS6 CCND3, BYSL CITED2 RCL1 ECGF1 KIT BCL11A TFRC IKZF1 ITFG3 RTBDN TFR2 MARCH8 CD164 FNTB |
rs4895441-G rs1800562-A rs2413450-T rs9349205-A rs643381-A rs10758658-A rs131794-A rs172629-G rs2540917-C rs9859260-C rs12718597-A rs7189020-T rs7255045-A rs7786877-G rs11239550-G rs9374080-C rs4466998-A |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
7 x 10-86 1 x 10-46 3 x 10-41 1 x 10-31 5 x 10-25 3 x 10-20 1 x 10-15 1 x 10-15 1 x 10-14 8 x 10-14 5 x 10-13 2 x 10-12 2 x 10-12 3 x 10-11 1 x 10-10 4 x 10-10 5 x 10-8 |
.01 [0.007-0.009] fl decrease .01 [0.010-0.014] fl increase .01 [0.004-0.006] fl decrease .01 [0.004-0.006] fl decrease 0 [0.003-0.005] fl decrease 0 [0.003-0.005] fl decrease 0 [0.003-0.005] fl decrease 0 [0.003-0.006] fl decrease 0 [0.002-0.004] fl decrease 0 [0.002-0.004] fl increase 0 [0.002-0.004] fl increase 0 [0.002-0.004] fl decrease 0 [0.002-0.004] fl decrease 0 [0.002-0.004] fl increase 0 [0.002-0.003] fl decrease 0 [0.002-0.003] fl decrease 0 [0.001-0.003] fl increase |
Affymetrix & Illumina [~2.5 million](imputed) |
N |
|
11/03/09 |
"
|
Other erythrocyte phenotypes |
24,167 European ancestry individuals |
9,456 European ancestry individuals |
6q23.3 6q23.3 1q23.1 7q22.1 |
HBS1L, MYB HBS1L, MYB SPTA1 EPO |
rs9483788-G rs9373124-C rs857721-A rs2075671-A |
NR NR NR NR |
1 x 10-47 (RBC) 7 x 10-14 (MCHC) 1 x 10-10 (MCHC) 1 x 10-9 (RBC) |
0 [0.012-0.016] 1 M cells/mm^3 increase 0 [0.002-0.003] g/dl decrease 0 [0.001-0.002] g/dl decrease 0 [0.005-0.009] 1 M cell/mm^3 increase |
Affymetrix & Illumina [~2.5 million](imputed) |
N |
|
10/30/09 |
Soranzo October 11, 2009 Nat Genet A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
|
Hematological parameters |
4,627 European individuals |
9,316 European individuals |
6q23.3 6p22.1 6p21.1 9p24.1 12q24.13 22q12.3 6p21.31 7q22.1 22q12.3 17q12 6p21.32 6q21 |
HBS1L, MYB HFE BYSL, CCND3 AK3 PTPN11 FBX07 BAK1 TFR2 TMPRSS6 GSDMA, ORMDL3 Intergenic Intergenic |
rs9402686-A rs1800562-A rs11970772-T rs385893-C rs11066301-G rs9609565-G rs210135-A rs7385804-C rs5756506-C rs17609240-G rs2227139-G rs4947019-G |
NR NR NR NR NR NR NR NR NR NR NR NR |
7 x 10-42 (MCV) 1 x 10-23 (MCV) 7 x 10-19 (MCV) 9 x 10-17 (PLT) 8 x 10-12 (PLT) 4 x 10-10 (MCV) 4 x 10-10 (PLT) 5 x 10-10 (RBC) 1 x 10-9 (MCH) 9 x 10-9 (WBC) 1 x 10-7 (WBC) 8 x 10-6 (MCV) |
.82 [0.70-0.94] fl increase 1.41 [1.13-1.69] fl increase .58 [0.44-0.70] fl increase 6.26 [4.78-7.74] 10^9/l increase 4.65 [3.32-5.98] 10^9/l increase .37 [0.25-0.49] fl increase 5.44 [3.74-7.14] 10^9/l increase .01 [0.004-0.008] 10^12/l increase .14 [0.10-0.18] pg increase .02 [0.01-0.03] 10^9/l increase .02 [0.01-0.03] 10^9/l increase .01 [0.003-0.011] fl decrease |
Affymetrix and Illumina [~2.11 million] (imputed) |
N |
|
10/30/09 |
"
|
Mean platelet volume |
4,627 European individuals |
9,316 European individuals |
12q24.31 7q22.3 3p14.3 17q11.2 10q21.3 1q32.1 11p15.5 1q24.3 2p23.1 20p13 18q22.2 15q22.2 5q33.3 20p12.1 12q13.13 |
WDR66 PIK3CG ARHGEF3 TAOK1 JMJD1C TMCC2 BET1L DNM3 EHD3 SIRPA CD226 TPM1 NR NR NR |
rs7961894-T rs342293-G rs12485738-A rs2138852-T rs2393967-A rs1668873-G rs11602954-G rs10914144-C rs647316-A rs6136489-T rs893001-C rs11071720-T rs1473247-C rs6110278-T rs10506328-A |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
3 x 10-44 2 x 10-33 6 x 10-31 1 x 10-22 3 x 10-21 1 x 10-20 1 x 10-14 2 x 10-14 3 x 10-11 8 x 10-11 1 x 10-10 2 x 10-8 3 x 10-7 4 x 10-7 5 x 10-7 |
.03 [0.027-0.035] fl increase .02 [0.013-0.017] fl increase .02 [0.013-0.017] fl increase .02 [0.012-0.020] fl increase .01 [0.01-0.018] fl increase .01 [0.01-0.014] fl increase .01 [0.009-0.017] fl increase .01 [0.009-0.017] fl increase .01 [0.006-0.014] fl increase .01 [0.006-0.014] fl increase .01 [0.007-0.015] fl increase .01 [0.007-0.015] fl increase .01 [0.004-0.012] fl decrease .01 [0.005-0.013] fl increase .01 [0.004-0.012] fl increase |
Affymetrix and Illumina [~2.11 million] (imputed) |
N |
|
10/23/09 |
Weiss October 08, 2009 Nature A genome-wide linkage and association scan reveals novel loci for autism
|
Autism |
1,031 families with 1,553 affected offspring (multiple races/ethnicities) |
2,073 trios (multiple races/ethnicities) |
5p15.2 |
SEMA5A, TAS2R1 |
rs10513025-? |
NR |
3 x 10-7 |
1.81 [NR] |
Affymetrix [~365,000] |
N |
|
10/16/09 |
Rivadeneira October 04, 2009 Nat Genet Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
|
Bone mineral density (hip) |
19,195 European individuals |
NR |
5q14.3 1p31.3 7q21.3 6q25.1 11p15.2 3p22.1 11p11.2 8q24.12 17q21.31 1p36.12 16q24.1 4q22.1 17q21.31 |
MEF2C GPR177 FLJ42280 ESR1 SOX6 CTNNB1 ARHGAP1 TNFRSF11B HDAC5 ZBTB40 FOXL1 MEPE CRHR1 |
rs1366594-C rs2566755-C rs7781370-T rs2941740-G rs7117858-G rs87938-A rs7932354-T rs11995824-G rs228769-G rs6426749-C rs10048146-G rs1471403-T rs9303521-T |
0.45 0.21 0.34 0.43 0.20 0.45 0.29 0.55 0.20 0.17 0.19 0.34 0.46 |
1 x 10-13 2 x 10-12 5 x 10-12 2 x 10-10 6 x 10-10 8 x 10-10 4 x 10-9 7 x 10-9 2 x 10-8 9 x 10-8 2 x 10-7 8 x 10-7 4 x 10-6 |
.09 [0.07-0.11] sd decrease .1 [0.07-0.13] sd increase .08 [0.06-0.10] sd decrease .07 [0.05-0.09] sd increase .09 [0.06-0.12] sd increase .07 [0.05-0.09] sd decrease .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd decrease .08 [0.05-0.11] sd increase .08 [0.05-0.11] sd increase .09 [0.06-0.12] sd decrease .06 [0.04-0.08] sd increase .06 [0.04-0.07] sd decrease |
Affymetrix & Illumina [2,543,686](imputed) |
N |
|
10/16/09 |
"
|
Bone mineral density (spine) |
19,195 European individuals |
NR |
13q14.11 8q24.12 1p31.3 6q25.1 7q21.3 1p36.12 7p14.1 11p13 18q21.33 12q13.13 17q21.31 16q24.1 2p16.2 4q22.1 11q13.2 17q21.31 |
AKAP11 TNFRSF11B GPR177 ESR1 FLJ42280 ZBTB40 STARD3NL DCDC5 TNFRSF11A SP7 CRHR1 FOXL1 SPTBN1 MEPE LRP5 HDAC5 |
rs9533090-T rs2062377-T rs1430742-C rs2504063-A rs4729260-G rs7524102-G rs1524058-T rs16921914-A rs884205-A rs2016266-G rs9303521-T rs10048146-G rs11898505-A rs1471403-T rs599083-G rs228769-G |
0.50 0.44 0.21 0.40 0.32 0.17 0.40 0.27 0.27 0.32 0.46 0.19 0.34 0.34 0.31 0.20 |
5 x 10-25 4 x 10-16 3 x 10-13 6 x 10-11 2 x10-10 3 x 10-10 1 x 10-9 2 x 10-9 9 x 10-9 1 x 10-8 1 x 10-8 2 x 10-8 2 x 10-8 2 x 10-8 5 x 10-8 4 x 10-6 |
.12 [0.10-0.14] sd decrease .09 [0.07-0.11] sd increase .11 [0.07-0.14] sd increase .08 [0.06-0.10] sd decrease .08 [0.05-0.11] sd decrease .09 [0.06-0.12] sd increase .07 [0.05-0.09] sd decrease .08 [0.05-0.11] sd increase .08 [0.05-0.11] sd decrease .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd decrease .09 [0.06-0.12] sd decrease .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd decrease .07 [0.04-0.10] sd increase |
Affymetrix & Illumina [2,543,686](imputed) |
N |
|
11/04/09 |
Hicks October 02, 2009 PLoS Genet Genetic determinants of circulating sphingolipid concentrations in European populations
|
Sphingolipid Concentrations |
4,110 European individuals |
NR |
14q23.2 19p13.2 4p12 20p12.1 11q12.3 |
SGPP1 LASS4 ATP10D SPTLC3 FADS |
rs7157785-A rs7258249-G rs10938494-A rs680379-A rs1000778-A |
0.19 0.48 0.23 0.34 0.32 |
9 x 10-66 (SM 14:0Mol%) 2 x 10-27 (SM 18:1Mol%) 8 x 10-19 (GluCer) 8 x 10-15 (Cer24:0) 7 x 10-13 (SM 16:1) |
0 [0.001-0.002] mol % increase 0 [0.0007-0.001] mol % increase .06 [0.04-0.07] unit increase .1 [0.08-0.13] mol % increase .62 [0.45-0.78] unit decrease |
Illumina [318,237] |
N |
|
10/06/09 |
Roeske September 29, 2009 Mol Psychiatry First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children
|
Speech perception in dyslexia |
200 dyslexic German children |
186 dyslexic German children |
4q32.1 10q26.3 |
CTSO, TDO2, PDGFC NR |
rs4234898-T rs4751178-G |
NR NR |
5 x 10-8 (MMNb) 7 x 10-6 (MMNb) |
NR NR |
Illumina [297,086] |
N |
|
10/06/09 |
Nakanishi September 25, 2009 PLoS Genet A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1
|
Myopia (pathological) |
297 Japanese cases, 934 Japanese controls |
533 Japanese cases, 977 Japanese controls |
11q24.1 |
BLID, LOC399959 |
rs577948-G |
0.52 |
2 x 10-7 |
1.37 [1.21-1.54] |
Illumina [411,777] |
N |
|
10/05/09 |
Latourelle September 22, 2009 BMC Med Genet Genomewide Association Study for Onset Age in Parkinson Disease
|
Parkinson disease (age of onset) |
857 white familial cases, 440 white idiopathic cases |
747 Italian idiopathic cases |
11p13 15q12 18q12.1 1q23.3 2p14 |
QSER1, PRRG4 OCA2 DSG3 ATF6 AAK1 |
rs10767971-T rs17565841-A rs1941184-C rs10918270-A rs7577851-T |
NR NR NR NR NR |
5 x 10-7 3 x 10-6 4 x 10-6 8 x 10-6 9 x 10-6 |
3.24 [NR] years older 2.84 [NR] years younger 2.28 [NR] years younger 2.26 [NR] years younger 6.85 [NR] years younger |
Illumina and Perlegen [1,861,750] (imputed) |
N |
|
10/05/09 |
Gudmundsson September 20, 2009 Nat Genet Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
|
Prostate cancer |
Up to 1,968 Icelandic cases, 35,382 Icelandic controls |
Up to 11,806 European descent cases, 12,387 European descent controls |
8q24.21 8q24.21 8q24.21 11q13.2 19q13.2 3q21.3 8q24.21 17q12 |
Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic |
rs1447295-A rs16902094-G rs16901979-A rs11228565-A rs8102476-C rs10934853-A rs445114-T rs4430796-A |
0.11 0.15 0.04 0.20 0.54 0.28 0.64 0.52 |
2 x 10-19 6 x 10-15 3 x 10-14 7 x 10-12 2 x 10-11 3 x 10-10 5 x 10-10 8 x 10-6 |
1.58 [1.43-1.74] 1.21 [1.15-1.26] 1.8 [1.55-2.09] 1.23 [1.16-1.31] 1.12 [1.08-1.15] 1.12 [1.08-1.16] 1.14 [1.10-1.19] 1.19 [1.10-1.28] |
Illumina [310,520] |
N |
|
09/30/09 |
Le Clerc September 15, 2009 J Infect Dis Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03).
|
AIDS |
85 French cases, 2,049 French controls |
NR |
1p13.3 12p12.1 9p23 1q23.3 8q22.3 2q12.1 9p22.3 |
Intergenic SOX5 Intergenic RXRG Intergenic TGFBRAP1 NR |
rs4118325-G rs1522232-C rs1360517-A rs10800098-A rs3108919-C rs1020064-G rs1556032-C |
0.81 0.52 0.06 0.05 0.27 0.23 0.49 |
6 x 10-7 2 x 10-6 3 x 10-6 4 x 10-6 4 x 10-6 7 x 10-6 9 x 10-6 |
4.17 [2.17-8.33] 2.22 [1.59-3.13] 3.09 [2.00-4.78] 3.29 [2.08-5.20] 2.13 [1.56-2.91] 2.94 [1.75-5.00] 2.05 [1.48-2.84] |
Illumina [291,119] |
N |
|
09/30/09 |
Suppiah September 13, 2009 Nat Genet IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
|
Response to Hepatitis C treatment |
131 European ancestry responders, 162 European ancestry non-responders |
261 European responders, 294 European non-responders |
19q13.2 |
IL28A, IL28B |
rs8099917-G |
NR |
9 x 10-9 |
1.98 [1.57-2.52] |
Illumina [311,159] |
N |
|
09/30/09 |
Tanaka September 13, 2009 Nat Genet Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
|
Response to Hepatitis C treatment |
72 Japanese responders, 82 Japanese non-responders |
122 Japanese responders, 50 Japanese non-responders |
19q13.2 |
IL28B |
rs8099917-G |
0.12 |
3 x 10-32 |
27.1 [14.6-50.3] |
Affymetrix [621,220] |
N |
|
09/30/09 |
Heinzen September 11, 2009 J Alzheimers Dis Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease
|
Alzheimer's Disease |
331 cases, 368 controls |
NR |
19q13.32 13q13.2 1p31.1 10q24.31 6q24.3 |
TOMM40, APOE RFC3 TTLL7 PAX2 SASH1 |
rs2075650-? rs690705-? rs7539409-? rs4509693-? rs9390537-? |
0.15 0.25 0.18 0.18 0.22 |
3 x 10-11 6 x 10-7 1 x 10-6 6 x 10-6 8 x 10-6 |
NR NR NR NR NR |
Illumima [~550,000] |
N |
|
09/30/09 |
Sha September 09, 2009 BMC Med Genet Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis
|
Amyotrophic lateral sclerosis (interaction) |
276 Caucasian cases, 271 Caucasian controls |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [549,062] |
N |
|
09/29/09 |
Harold September 06, 2009 Nat Genet Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
|
Alzheimer's disease |
3,941 European ancestry cases, 7,848 European ancestry controls |
2,023 European ancestry cases, 2,340 European ancestry controls |
19q13.32 8p21.1 11q14.2 |
APOE, TOMM40 CLU PICALM |
rs2075650-? rs11136000-? rs3851179-? |
0.15 0.60 0.63 |
2 x 10-157 9 x 10-10 1 x 10-9 |
2.53 [2.37-2.71] 1.16 [1.11-1.22] 1.16 [1.11-1.22] |
Illumina [529,205] |
N |
|
09/29/09 |
Lambert September 06, 2009 Nat Genet Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
|
Alzheimer's disease |
2,032 French cases, 5,328 French controls |
3,978 European cases, 3,297 European controls |
19q13.32 1q32.2 8p21.1 |
APOE CR1 CLU |
rs2075650-? 2-SNP haplotype 3-SNP haplotype |
0.90 0.18 0.26 |
2 x 10-16 3 x 10-10 (AA) 6 x 10-10 (CCG) |
NR 1.22 [1.15-1.30] 1.22 [1.14-1.29] |
Illumina [537,029] |
N |
|
09/29/09 |
Rung September 06, 2009 Nat Genet Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
|
Type 2 diabetes and other traits |
679 French cases, 697 French controls |
5,579 European cases, 7,096 European controls |
10q25.2 6p22.3 2q36.3 4p16.1 8q24.11 5q14.3 |
TCF7L2 CDKAL1 LOC64673, IRS1 WFS1, PPP2R2C SLC30A8 LOC72901, CETN3 |
rs7903146-T rs4712523-G rs2943641-C rs4689388-T rs13266634-C rs12518099-C |
0.27 0.32 0.63 0.57 0.68 0.23 |
1 x 10-30 2 x 10-12 9 x 10-12 1 x 10-8 8 x 10-8 7 x 10-7 |
1.48 [1.39-1.57] 1.2 [1.14-1.26] 1.19 [1.13-1.25] 1.16 [1.10-1.21] 1.16 [1.10-1.22] 1.16 [1.10-1.22] |
Illumina [392,365] |
N |
|
09/29/09 |
van Es September 06, 2009 Nat Genet Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
|
Amyotrophic lateral sclerosis |
2,323 European descent cases, 9,013 European descent controls |
2,532 European descent cases, 5,940 European descent controls |
19p13.11 9p21.2 9p21.2 Xq13.3 12p12.3 11q22.1 9p21.2 Xp22.32 |
UNC13A MOBKL2B, IFNK, C9orf72 MOBKL2B, IFNK, C9orf72 NR NR NR NR NR |
rs12608932-? rs2814707-? rs3849942-? rs5937496-? rs9971637-? rs2405657-? rs774359-? rs5916687-? |
0.34 0.23 0.23 0.13 0.05 0.66 0.25 0.27 |
3 x 10-14 7 x 10-9 1 x 10-8 6 x 10-7 2 x 10-6 3 x 10-6 3 x 10-6 3 x 10-6 |
1.25 [NR] 1.22 [NR] 1.23 [NR] 1.38 [NR] 1.48 [NR] 1.19 [NR] 1.19 [NR] 1.22 [NR] |
Illumina [292,768] |
N |
|
10/02/09 |
Need September 04, 2009 Hum Mol Genet A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery
|
Cognitive performance |
1,295 individuals |
NR |
15q23 Xp22.2 3p22.3 13q34 16p12.1 17q21.32 8q24.13 21q11.2 17q25.2 14q23.2 15q21.3 2q31.1 5p15.31 11q14.2 12p13.1 15q12 1q23.2 20p12.3 21q21.3 3q27.2 16q23.3 3p25.1 7q31.1 18q22.1 1q41 3p22.1 3q26.32 9p22.2 11p12 13q12.3 14q23.2 1p32.1 1q32.1 7p15.1 12q24.23 19q12 1p36.13 3q13.33 4q28.1 7p14.1 7q31.1 8q12.1 11q13.5 6p21.2 18q12.3 Xp22.31 13q14.11 |
CORO2B HCCS ARPP-21 Intergenic Intergenic Intergenic FAM91A1 NRIP1 SEC14L1 MTHFD1 UNC13C GORASP2 Intergenic C11orf73 GRIN2B GABRB3 VANGL2 PLCB1 JAM2 EHHADH Intergenic GRIP2 IMMP2L C18orf4, DSEL FAM177B MOBP Intergenic SH3GL2 API5 FLT1 MTHFD1 JUN MDM4 CPVL CCDC64 TSHZ3 FAM131C FBXO40 FAT4 VPS41 IMMP2L TOX CAPN5 C6orf129 RIT2 VCX3B DNAJC15 |
rs11856323-? rs5934953-? rs6799705-? rs767210-? rs2203512-? rs2326017-? rs10481151-? rs2229741-? rs3744064-? rs10498514-? rs1897031-? rs4668356-? rs7729273-? rs6592284-? rs2160519-? rs8043440-? rs16832015-? rs6056209-? rs17001239-? rs7374394-? rs4082514-? rs9036-? rs10279573-? rs2124349-? rs6683071-? rs816488-? rs7612209-? rs10810865-? rs10501293-? rs17086609-? rs2295639-? rs4601609-? rs12143943-? rs2252521-? rs11064994-? rs1078373-? rs9442235-? rs3772130-? rs12639834-? rs11984145-? rs12531640-? rs960089-? rs3781684-? rs904251-? rs8085804-? rs7892812-? rs1324015-? |
0.08 0.02 0.05 0.11 0.14 0.30 0.14 0.47 0.03 0.02 0.18 0.06 0.20 0.21 0.06 0.17 0.01 0.43 0.12 0.20 0.03 0.19 0.14 0.05 0.20 0.04 0.40 0.13 0.25 0.35 0.02 0.05 0.41 0.34 0.06 0.37 0.42 0.23 0.36 0.05 0.13 0.07 0.11 0.38 0.37 0.47 0.42 |
1 x 10-7 (PAL8) 1 x 10-7 (PAL6) 2 x 10-7 (PAL8) 3 x 10-7 (PAL6) 3 x 10-7 (PRM) 3 x 10-7 (SWM strategy) 4 x 10-7 (PRM) 6 x 10-7 (SRM) 7 x 10-7 (PAL6) 8 x 10-7 (SWM strategy) 1 x 10-6 (PRM) 1 x 10-6 (PAL8) 1 x 10-6 (SSP) 2 x 10-6 (IED) 2 x 10-6 (IED) 2 x 10-6 (SRM) 2 x 10-6 (IED) 2 x 10-6 (RVP) 2 x 10-6 (PRM) 2 x 10-6 (IED) 3 x 10-6 (PC1) 3 x 10-6 (PAL6) 3 x 10-6 (IED) 4 x 10-6 (IED) 4 x 10-6 (PC1) 4 x 10-6 (IED) 4 x 10-6 (IED) 4 x 10-6 (PAL6) 5 x 10-6 (SWM Strategy) 5 x 10-6 (IED) 5 x 10-6 (SWM Strategy) 5 x 10-6 (PRM) 5 x 10-6 (PAL8) 5 x 10-6 (PAL8) 6 x 10-6 (PAL6) 6 x 10-6 (SSP) 6 x 10-6 (PC1) 6 x 10-6 (PC1) 6 x 10-6 (SWM Strategy) 6 x 10-6 (PAL8) 6 x10-6 (IED) 6 x 10-6 (PAL6) 7 x 10-6 (VRM) 7 x 10-6 (SWM Strategy) 8 x 10-6 (VRM) 8 x 10-6 (SSP) 9 x 10-6 (PC1) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Illumina [475,971] |
N |
|
09/28/09 |
Paterson September 03, 2009 Arterioscler Thromb Vasc Biol Genome-Wide Association Identifies the ABO Blood Group as a Major Locus Associated With Serum Levels of Soluble E-Selectin
|
Serum soluble E-selectin |
685 individuals with type 1 diabetes |
477 nondiabetic siblings |
9q34.2 |
ABO |
rs579459-C |
0.20 |
1 x 10-29 |
NR |
Illumina [~841,000] |
N |
|
09/28/09 |
Tonjes September 03, 2009 Hum Mol Genet Genetic Variation in GPR133 is Associated with Height - Genome Wide Association Study in the Self-contained Population of Sorbs
|
Height |
929 Sorbian individuals, 2,986 Caucasian individuals |
2,772 German individuals |
12q24.33 |
GPR133 |
rs1569019-? |
NR |
5 x 10-8 |
.95 [0.61-1.29] cm increase |
Affymetrix [390,619] |
N |
|
09/28/09 |
De Moor September 02, 2009 Med Sci Sports Exerc Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults
|
Exercise (leisure time) |
1,644 Dutch individuals, 978 European individuals |
NR |
10q23.2 18p11.32 2q33.1 |
PAPSS2 C18orf2 DNAPTP6 |
rs10887741-T rs8097348-G rs12612420-A |
NR NR NR |
4 x 10-6 7 x 10-6 8 x 10-6 |
1.32 [1.17-1.49] 1.36 [1.19-1.56] 1.43 [1.22-1.67] |
Affymetrix and Perlegen [~1.6 million] (imputed) |
N |
|
09/29/09 |
Ising September 01, 2009 Arch Gen Psychiatry A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
|
Response to antidepressant treatment |
339 German individuals |
1,193 German individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [389,251] (pooled) |
N |
|
09/28/09 |
McClay September 01, 2009 Mol Psychiatry Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics
|
Treatment response to antipsychotics |
738 cases |
NR |
4p15.1 9q33.3 12q23.1 2q14.3 1q21.3 6p24.1 15q13.3 3q28 6p21.33 |
Intergenic Intergenic ANKS1B CNTNAP5 Intergenic Intergenic TRPM1 Intergenic Intergenic |
rs17390445-? rs888219-? rs7968606-? rs17727261-? rs10888501-? rs1040994-? rs17815774-? rs7635839-? rs12526186-? |
NR NR NR NR NR NR NR NR NR |
1 x10-7 (ziprasidone) 2 x 10-7 (risperidone) 3 x 10-7 (olanzapine) 5 x 10-7 (risperidone) 1 x 10-6 (olanzapine) 2 x 10-6 (olanzapine) 3 X 10-6 (risperidone) 3 x 10-6 (olanzapine) 3 x 10-6 (risperidone) |
17 [NR] % of variance explained 11 [NR] % of variance explained 10 [NR] % of variance explained 10 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained |
Affymetrix & Perlegen [492,900] |
N |
|
09/10/09 |
Spain September 01, 2009 Cancer Res Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom
|
Colorectal cancer |
921 white cases, 929 white controls |
1,214 white cases, 1,435 white controls |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [486,303] |
N |
|
09/09/09 |
Laje August 31, 2009 Pharmacogenet Genomics Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients
|
Response to antidepressant treatment |
90 white cases, 90 white controls |
30 white cases, 1,652 white controls |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [100,864] |
N |
|
09/09/09 |
Hancock August 28, 2009 PLoS Genet Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children
|
Asthma (childhood onset) |
492 Mexican trios |
177 Mexican trios |
9q21.31 |
TLE4, CHCHD9 |
rs2378383-? |
0.78 |
7 x 10-7 |
1.64 [1.32-2.04] |
Illumina [520,767] |
N |
|
09/24/09 |
Liu August 28, 2009 PLoS ONE Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males
|
Obesity and osteoporosis |
499 Caucasian males, 501 Caucasian females |
1,370 Caucasian males, 1,985 Caucasian females |
11p15.1 11p15.1 |
SOX6 SOX6 |
rs297325-T rs4756846-T |
0.23 0.12 |
4 x 10-7 (BMI-BMD, males) 5 x 10-7 (BMI-BMD, males) |
NR NR |
Affymetrix [379,319] |
N |
|
09/09/09 |
Shuldiner August 26, 2009 JAMA Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
|
Response to clopidogrel therapy |
429 Amish individuals |
140 white, 83 African American, and 4 unspecified individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [400,230] |
N |
|
09/09/09 |
Cui August 18, 2009 Gastroenterology Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk
|
Esophageal cancer |
188 Japanese cases, 938 Japanese controls |
699 Japanese cases, 1,482 Japanese controls |
12q24.12 4q23 |
BRAP, ALDH2 ADH6, ADH1B |
rs671-A rs1229984-G |
0.36 0.35 |
3 x 10-24 8 x 10-24 |
1.67 [1.58-1.76] 1.79 [1.69-1.88] |
Illumina [359,195] |
N |
|
09/09/09 |
Ge August 16, 2009 Nature Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
|
Response to Hepatitis C treatment |
871 Caucasian, 191 African American, and 75 Hispanic participants |
NR |
19q13.2 6q21 4q34.3 |
IL28B AKD2 Intergenic |
rs12979860-C rs9400317-? rs17067123-? |
0.72 NR NR |
1 x 10-28 (combined) 7 x 10-6 (combined) 8 x 10-6 (combined) |
2 [1.8-2.3] (European-Americans) NR NR |
Illumina [565,759] |
N |
|
09/04/09 |
Papaemmanuil August 16, 2009 Nat Genet Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
|
Acute lymphoblastic leukemia (childhood) |
503 European pediatric cases, 1,438 European pediatric controls |
404 European pediatric cases, 960 European pediatric controls |
7p12.2 10q21.2 14q11.2 |
IKZF1 ARID5B CEBPE |
rs4132601-C rs7089424-C rs2239633-G |
0.28 0.34 0.52 |
1 x 10-19 7 x 10-19 3 x 10-7 |
1.69 [1.58-1.81] 1.65 [1.54-1.76] 1.34 [1.22-1.45] |
Illumina [291,473] |
N |
|
09/11/09 |
Trevino August 16, 2009 Nat Genet Germline genomic variants associated with childhood acute lymphoblastic leukemia
|
Acute lymphoblastic leukemia (childhood) |
317 European descent cases, 17,958 European descent controls |
NR |
10q21.2 7p12.2 12q24.22 6q24.1 19q13.31 1q43 2q36.1 1p31.1 3q26.32 1q31.3 1q44 10p11.21 12p13.32 18p11.32 |
ARID5B IKZF1, DDC KRTHB5 Intergenic ZNF230 RYR2 KCNE4 SIAT7C KCNMB2 Intergenic OR2C3 PARD3 C12orf5 Intergenic |
rs10821936-C rs11978267-G rs2089222-A rs11155133-G rs2191566-G rs7554607-A rs12621643-T rs10873876-T rs9290663-T rs6428370-G rs1881797-C rs563507-A rs10849033-G rs1879352-C |
0.34 0.27 0.03 0.01 0.28 0.56 0.28 0.15 0.13 0.32 0.18 0.04 0.02 0.16 |
1 x 10-15 8 x 10-11 8 x 10-8 3 x 10-7 4 x 10-7 2 x 10-6 3 x 10-6 4 x 10-6 6 x 10-6 7 x 10-6 7 x 10-6 9 x 10-6 9 x 10-6 9 x 10-6 |
1.91 [1.60-2.20] 1.69 [1.40-1.90] 2.26 [1.60-3.0] 3.62 [2.10-6.00] 1.52 [1.20-1.70] 1.49 [1.20-1.70] 1.48 [1.20-1.70] 1.55 [1.20-1.80] 1.58 [1.20-1.90] 1.43 [1.20-1.60] 1.52 [1.20-1.80] 2 [1.40-2.70] 2.55 [1.60-3.80] 1.53 [1.20-1.80] |
Affymetrix [307,944] |
N |
|
09/04/09 |
Alkelai August 13, 2009 Psychopharmacology Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients
|
Response to antipsychotic treatment |
199 cases, 198 controls |
NR |
2q24.3 |
FIGN |
rs12476047-C |
NR |
3 x 10-6 |
3.21 [1.97-5.25] |
Affymetrix & Perlegen [495,172] |
N |
|
09/09/09 |
Potkin August 07, 2009 PLoS ONE Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
|
Hippocampal atrophy |
172 cases, 209 controls |
NR |
21q21.1 5q21.3 9q21.13 14q22.1 13q31.1 20q11.23 20q13.31 5q14.1 7p12.2 7q21.11 9q21.31 12q14.3 1q21.3 20q11.23 5q14.1 12q13.11 5p14.1 5p15.1 7p21.3 11q24.3 8q24.12 |
FDPSP EFNA5 PRUNE2 FRMD6, AL079307.7 Intergenic C20orf132 ZBP1 AC104108.3, SCAMP1, LHFPL2 IKZF1, AC020743.7 MAGI2 RP11, 232A1.1 CAND1 AL157404.18, S100A5 RPN2 ARSB ARID2, SFRS2IP Intergenic AC026790.5 Intergenic Intergenic MAL2 |
rs1888414-? rs10074258-? rs10781380-? rs11626056-? rs4773460-? rs8115854-? rs2073145-? rs6881634-? rs10276619-? rs11525066-? rs10867752-? rs1082714-? rs4845552-? rs6031882-? rs337847-? rs1373549-? rs7727656-? rs682748-? rs9918508-? rs6590322-? rs1364705-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
2 x 10-7 2 x 10-7 7 x 10-7 1 x 10-6 2 x 10-6 2 x 10-6 2 x 10-6 2 x 10-6 3 x 10-6 3 x 10-6 3 x 10-6 5 x 10-6 6 x 10-6 6 x 10-6 7 x 10-6 8 x 10-6 8 x 10-6 8 x 10-6 8 x 10-6 9 x 10-6 9 x 10-6 |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Illumina [516,645] |
N |
|
09/04/09 |
Tse August 05, 2009 Am J Hum Genet Genome-wide Association Study Reveals Multiple Nasopharyngeal Carcinoma-Associated Loci within the HLA Region at Chromosome 6p21.
|
Nasopharyngeal carcinoma |
277 Han Chinese cases, 285 Han Chinese controls |
635 Han Chinese cases, 1,640 Han Chinese controls |
6p21.33 6p22.1 6p22.1 |
HLA-A GABBR1 HLA-F |
rs2517713-A rs29232-A rs3129055-G |
0.62 0.46 0.31 |
4 x 10-20 9 x 10-17 7 x 10-11 |
1.88 [1.65-2.15] 1.67 [1.48-1.88] 1.51 [1.34-1.71] |
Illumina [480,365] |
N |
|
09/14/09 |
Broderick August 04, 2009 Cancer Res Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study
|
Lung cancer |
1,952 European cases, 1,438 European controls |
5,608 European cases, 6,767 European controls |
15q25.1 6p21.33 5p15.33 10q23.31 15q15.2 3p24.1 2p14 |
CHRNA3 BAT3 CLPTM1L NR TGM5 NR NR |
rs8034191-? rs3117582-? rs4975616-? rs1926203-? rs748404-? rs1530057-? rs4254535-? |
NR NR NR NR NR NR NR |
3 x 10-26 4 x 10-10 3 x 10-9 1 x 10-6 1 x 10-6 3 x 10-6 5 x 10-6 |
1.29 [1.23-1.35] 1.24 [1.16-1.33] 1.15 [1.10-1.20] 1.12 [NR] 1.15 [1.09-1.20] 1.26 [NR] 1.12 [NR] |
Illumina [511,919] |
N |
|
09/04/09 |
Chambers August 03, 2009 Diabetes Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
|
Fasting plasma glucose |
7,474 Indian Asian individuals |
4,462 European controls |
11q21 |
MTNR1B |
rs2166706-G |
0.46 |
2 x 10-9 |
.07 (0.04-0.09) mmol/L increase |
Illumina [up to 544,390] |
N |
|
09/04/09 |
Grant August 03, 2009 J Pediatr A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24
|
Nonsyndromic cleft lip with or without cleft palate |
111 European ancestry cases, 5,951 European ancestry controls |
NR |
18q22.3 8q24.21 |
Intergenic Intergenic |
rs17085106-? rs987525-? |
0.018 0.22 |
4 x 10-8 9 x 10-8 |
4.07 [2.37-7.00] 2.09 [1.59-2.76] |
Illumina [495,858] |
N |
|
09/04/09 |
Amundadottir August 02, 2009 Nat Genet Genome-wide association study identifies variants
in the ABO locus associated with susceptibility to
pancreatic cancer
|
Pancreatic cancer |
1,771 European ancestry cases, 1,805 European ancestry controls |
2,120 European ancestry cases, 2,127 European ancestry controls |
9q34.2 |
ABO |
rs505922-T |
0.35 |
5 x 10-8 |
1.2 [1.12-1.28] |
Illumina [558,542] |
N |
|
09/04/09 |
Song August 02, 2009 Nat Genet A genome-wide association study identifies a new ovarian
cancer susceptibility locus on 9p22.2
|
Ovarian cancer |
1,817 European ancestry cases, 2,353 European ancestry controls |
6,944 European ancestry cases, 9,477 European ancestry controls |
9p22.2 |
BNC2, LOC648570, CNTLN |
rs3814113-T |
0.68 |
5 x 10-19 |
1.22 [1.16-1.27] |
Illumina [up to ~2,000,000] (imputed) |
N |
|
08/21/09 |
Wu August 02, 2009 Nat Genet Genetic variation in the prostate stem cell antigen gene
PSCA confers susceptibility to urinary bladder cancer
|
Bladder cancer |
969 Caucasian cases, 957 Caucasian controls |
5,698 US and European cases, 38,633 US and European controls |
8q24.3 |
PSCA |
rs2294008-T |
0.46 |
2 x 10-10 |
1.15 [1.10-1.20] |
Illumina [556,429] |
N |
|
09/04/09 |
Comabella August 01, 2009 Arch Neurol Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis
|
Response to interferon beta therapy |
53 responders, 53 non-responders |
49 responders, 45 non-responders |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [428,867](pooled) |
N |
|
08/21/09 |
Nakano July 22, 2009 Proc Natl Acad Sci USA Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
|
Glaucoma (primary open-angle) |
418 Japanese cases, 300 Japanese controls |
409 Japanese cases, 448 Japanese controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [331,838] |
N |
|
08/21/09 |
Skibola July 20, 2009 Nat Genet Genetics variants at 6p21.33 are associated with susceptibility to follicular lymphoma
|
Follicular lymphoma |
189 European ancestry cases, 592 European controls |
456 European ancestry cases, 2,785 European ancestry controls |
6p21.33 |
STG, PSORS1 |
rs6457327-C |
0.62 |
5 x 10-11 |
1.69 [1.43-2.00] |
Illumina [~500,000] (pooled) |
N |
|
08/12/09 |
Adeyemo July 17, 2009 PLoS Genet A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
|
Hypertension |
509 African American cases, 508 African American controls |
366 West African cases, 614 West African controls |
15q22.1 4q23 |
ALDH1A2 ADH7 |
rs1550576-? rs991316-T |
0.86 0.45 |
3 x 10-6 5 x 10-6 |
1.92 [NR] 1.62 [NR] |
Affymetrix [808,465] |
N |
|
08/04/09 |
Benjamin July 13, 2009 Nat Genet Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
|
Atrial fibrillation |
3,413 cases, 37,105 referents |
2,145 cases, 4,073 controls |
4q25 16q22.3 1p36.22 |
PITX2 ZFHX3 MTHFR, NPPA |
rs17042171-A rs2106261-T rs17375901-T |
0.12 0.174 0.053 |
4 x 10-63 2 x 10-15 6 x 10-7 |
1.65 1.25 1.26 |
Affymetrix & Illumina [~2.5 million] (imputed) |
N |
|
07/30/09 |
Gudbjartsson July 13, 2009 Nat Genet A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
|
Atrial fibrillation |
2,385 European cases, 33,752 European controls |
up to 2,427 European cases, 3,379 European controls |
4q25 16q22.3 |
Intergenic ZFHX3 |
rs2200733-? rs7193343-T |
0.12 NR |
1 x 10-14 1 x 10-10 |
1.42 [NR] 1.21 [1.14-1.29] |
Illumina [303,136] |
N |
|
07/24/09 |
Nolte July 09, 2009 PLoS ONE Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies
|
Cardiac repolarisation |
3,558 Caucasian individuals |
29,527 Caucasian individuals |
1q23.3 6q22.31 |
OLFML2B, NOS1AP SLC35F1, C6orf204, PLN |
rs12143842-T rs11153730-C |
0.25 0.50 |
1 x 10-83 2 x 10-29 |
.18 [NR] unit increase .09 [NR] unit increase |
Affymetrix & Illumina [~2,399,142] (imputed) |
N |
|
07/24/09 |
Tonjes July 08, 2009 Eur J Hum Genet Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
|
Body mass index and fat mass |
948 Sorbian individuals |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [390,619] |
N |
|
08/07/09 |
Vasan July 08, 2009 JAMA Genetic Variants Associated with Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data
|
Aortic root size |
12,612 European ancestry individuals |
4,094 European ancestry individuals |
5q23.2 17p13.3 12q14.3 12p12.2 1p21.2 15q24.1 |
CCDC100, PPIC SMG6, SRR, TSR1, SGSM2 HMGA2 PDE3A PALMD LOXL1 |
rs17470137-A rs10852932-T rs4026608-C rs10770612-G rs7543130-A rs893817-G |
0.29 0.36 0.38 0.19 0.49 0.34 |
1 x 10-11 2 x 10-11 2 x 10-9 2 x 10-8 1 x 10-7 3 x 10-6 |
.03 [0.02-0.04] cm increase .03 [0.02-0.04] cm increase .03 [0.02-0.04] cm decrease .03 [0.02-0.04] cm increase .03 [0.02-0.04] cm increase .02 [0.01-0.03] cm increase |
Affymetrix & Illumina [~2.5 million] (imputed) |
N |
|
08/07/09 |
"
|
Cardiac structure and function |
12,612 European ancestry individuals |
4,094 European ancestry individuals |
6q22.31 10q23.1 5q22.1 16q23.1 |
SLC35F1, C6orf204, PLN GRID1 SLC25A46 WWOX |
rs89107-G rs7910620-G rs17132261-T rs2059238-A |
0.50 0.01 0.02 0.22 |
1 x 10-9 (LV internal diastolic dimensions) 7 x 10-7 (LV wall thickness) 9 x 10-7 (LV wall thickness) 3 x 10-6 (LV wall thickness) |
.03 [0.02-0.04] cm decrease .17 [0.11-0.23] cm increase .06 [0.04-0.08] cm increase .02 [0.01-0.03] cm decrease |
Affymetrix & Illumina [~2.5 million] (imputed) |
N |
|
07/16/09 |
Bishop July 05, 2009 Nat Genet Genome-wide association study identifies three loci associated with melanoma risk
|
Melanoma |
1,539 European ancestry cases, 3,917 European ancestry controls |
2,312 European ancestry cases, 1,867 European ancestry controls |
16q24.3 16q24.3 11q14.3 22q13.1 9p21.3 |
MC1R MC1R TYR Intergenic CDKN2A |
rs258322-A rs4785763-A rs1393350-A rs2284063-? rs7023329-A |
0.09 0.32 0.27 0.37 0.50 |
3 x 10-27 6 x 10-22 2 x 10-14 2 x 10-9 4 x 10-7 |
1.67 [1.52-1.83] 1.36 [1.28-1.45] 1.29 [1.21-1.38] 1.2 [1.14-1.28] 1.18 [1.10-1.25] |
Illumina [~317,000] |
N |
|
07/13/09 |
Falchi July 05, 2009 Nat Genet Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
|
Cutaneous nevi |
1,524 European twins |
4,107 European individuals |
9p21.3 22q13.1 |
MTAP PLA2G6 |
rs4636294-A rs2284063-G |
0.48 0.35 |
3 x 10-15 3 x 10-8 |
.2 [0.13-0.27] increase in log nevus count .08 [-0.002-0.16] decrease in log nevus count |
Illumina [297,108] |
N |
|
07/12/09 |
Shete July 05, 2009 Nat Genet Genome-wide association study identifies five susceptibility loci for glioma
|
Glioma |
1,878 cases, 3,670 controls |
2,545 cases, 2,953 controls |
8q24.21 5p15.33 9p21.3 5p15.33 20q13.33 8q24.21 11q23.3 |
CCDC26 TERT CDKN2A, CDKN2B TERT RTEL1 CCDC26 PHLDB1 |
rs4295627-G rs2736100-G rs4977756-G rs2853676-A rs6010620-G rs891835-G rs498872-T |
0.83 0.49 0.60 0.73 0.23 0.78 0.69 |
2 x 10-18 2 x 10-17 7 x 10-15 4 x 10-14 3 x 10-12 8 x 10-11 1 x 10-8 |
1.36 [1.29-1.43] 1.27 [1.19-1.37] 1.24 [1.19-1.30] 1.26 [1.20-1.32] 1.28 [1.21-1.35] 1.24 [1.17-1.30] 1.18 [1.13-1.24] |
Illumina [454,576] |
N |
|
07/12/09 |
Wrensch July 05, 2009 Nat Genet Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
|
Glioma (high-grade) |
692 high-grade cases, 3,992 controls |
176 high-grade cases, 174 controls |
9p21.3 20q13.33 20q13.33 |
Intergenic RTEL1 RTEL1 |
rs1412829-C rs4809324-C rs6010620-G |
0.39 0.10 0.77 |
2 x 10-10 2 x 10-9 3 x 10-9 |
1.42 [1.27-1.58] 1.6 [1.37-1.87] 1.52 [1.32-1.75] |
Illumina [326,506] |
N |
|
07/24/09 |
Teichert July 04, 2009 Hum Mol Genet A genome-wide association study of acenocoumarol maintenance dosage
|
Acenocoumarol maintenance dosage |
1,451 Caucasian individuals |
287 Caucasian individuals |
10q23.33 19p13.12 10q23.33 3q22.3 |
CYP2C18 CYP4F2 CYP2C19 CNTN4 |
rs12772169-? rs2108622-? rs12767583-? rs10935268-? |
NR NR NR NR |
8 x 10-12 3 x 10-10 3 x 10-7 8 x 10-7 |
NR NR NR NR |
Illumina [~550,000] |
N |
|
07/12/09 |
Elliott July 01, 2009 JAMA Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
|
C-reactive protein |
17,967 European and Indian Asian men and women |
13,615 European and Indian Asian men and women |
1q23.2 12q24.31 19q13.32 1q21.3 1p31.3 |
CRP HNF1A APOE, APOCI, APOCII IL6R LEPR |
rs7553007-A rs1183910-T rs4420638-G rs4537545-T rs6700896-T |
NR NR NR NR NR |
8 x 10-44 1 x 10-30 5 x 10-27 2 x 10-14 3 x 10-14 |
20.7 [18.9-23.4] % decrease 13.8 [10.9-16.6] % decrease 21.8 [18.1-25.3] % decrease 11.5 [8.5-14.4] % decrease 14.8 [12.0-17.6] % decrease |
Affymetrix, Illumina & Perlegen [~1.4 million] (imputed) |
N |
|
07/24/09 |
Estrada July 01, 2009 Hum Mol Genet A genome-wide association study of northwestern Europeans involves the CNP signaling pathway in the etiology of human height variation
|
Height |
10,074 European individuals |
6,912 European individuals |
2q37.1 22q13.1 5p13.3 11q14.1 22q13.1 |
DIS3L2, ALPP, NPPC TNRC6B, ADSL C5orf23, NPR3 TMEM126B, TMEM126A SGSM3, MKL1 |
rs6717918-T rs139909-T rs10472828-C rs10898392-T rs5757949-T |
0.78 0.68 0.56 NR NR |
3 x 10-9 2 x 10-7 3 x 10-7 3 x 10-6 4 x 10-6 |
.44 [0.20-0.68] cm increase .25 [0.03-0.47] cm increase .22 [0.04-0.40] cm increase NR NR |
Affymetrix, Illumina & Perlegen [2,228,850] (imputed) |
N |
|
07/13/09 |
International Schizophrenia Consortium July 01, 2009 Nature Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
|
Schizophrenia |
3,322 European descent cases, 3,587 European descent controls |
4,692 European descent cases, 15,493 European descent controls |
6p22.1 18q21.2 3q26.33 1p21.3 |
MHC TCF4 FXR1 PTBP2 |
rs13194053-T rs17594526-T rs6782299-T rs7544736-G |
0.86 0.03 0.73 0.18 |
1 x 10-8 1 x 10-7 1 x 10-7 6 x 10-7 |
1.22 1.44 1.1 1.25 |
Affymetrix [739,995] |
N |
|
07/10/09 |
Shi July 01, 2009 Nature Common variants on chromosome 6p22.1 are associated with schizophrenia
|
Schizophrenia |
2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls |
5,327 European ancestry cases, 16,424 European ancestry controls |
6p22.1 6p21.32 |
SLC17A1, SLC17A3, BTN3A2, BTN2A2, BTN3A1, HIST1H2AG, HIST1H2BJ, PRSS16, POM121L2, ZNF184 HLA-DQA1 |
rs13194053-T rs9272219-G |
0.82 0.72 |
1 x 10-8 (EA) 7 x 10-8 (EA) |
1.28 [NR] 1.14 [NR] |
Affymetrix [up to 843,798] |
N |
|
07/10/09 |
Stefansson July 01, 2009 Nature Common variants conferring risk of schizophrenia
|
Schizophrenia |
2,663 European cases, 13,498 European controls |
10,282 European cases, 21,093 European controls |
6p22.1 6p21.32 11q24.2 18q21.2 2p16.1 5q21.1 9q33.1 |
MHC, PRSS16 MHC, NOTCH4 NRGN TCF4 VRK2 SLCO6A1 Intergenic |
rs6932590-T rs3131296-G rs12807809-T rs9960767-C rs2312147-C rs1502844-C rs1572299-A |
0.78 0.87 0.83 0.06 NR NR NR |
1 x 10-12 2 x 10-10 2 x 10-9 4 x 10-9 3 x 10-7 1 x 10-6 4 x 10-6 |
1.16 [NR] 1.19 [NR] 1.15 [NR] 1.23 [NR] 1.09 [NR] 1.09 [NR] 1.08 [NR] |
Illumina [314,868] |
N |
|
07/24/09 |
Treutlein July 01, 2009 Arch Gen Psychiatry Genome-wide association study of alcohol dependence
|
Alcohol dependence |
476 German cases, 1,358 German controls |
1,024 German cases, 996 German controls |
2q35 5q32 Xp22.2 14q24.2 4q26 6q25.1 |
PECR PPP2R2B Intergenic Intergenic CAST, ERAP1 ESR1 |
rs7590720-G rs1864982-A rs12388359-T rs36563-A rs13150562-G rs6902771-C |
0.29 0.13 0.11 0.15 0.68 0.51 |
1 x 10-8 3 x 10-6 4 x 10-6 5 x 10-6 7 x 10-6 8 x 10-6 |
1.35 [1.22-1.49] 1.36 [1.20-1.55] 1.61 [1.32-2.00] 1.33 [1.18-1.50] 1.27 [1.14-1.41] 1.24 [1.13-1.36] |
Illumina [524,396] |
N |
|
07/01/09 |
Thorleifsson June 28, 2009 Nat Genet Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density
|
Kidney stones |
1,507 Icelandic cases, 34,033 Icelandic controls |
1,520 Icelandic cases, 4,726 Icelandic controls, 746 Dutch cases, 3,751 Dutch controls |
21q22.13 |
CLDN14 |
rs219780-C |
0.79 |
4 x 10-12 |
1.25 [1.17-1.33] |
Illumina [303,120] |
N |
|
07/01/09 |
Heard-Costa June 26, 2009 PLoS Genet NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
|
Waist circumference |
31,373 Caucasian individuals |
38,641 Caucasian individuals |
16q12.2 14q31.1 18q21.32 12q13.13 5p14.3 6p12.2 11p15.4 |
FTO NRXN3 MC4R FAIM2, BCDIN3D CDH12 PKHD1 OVCH2 |
rs1558902-? rs10146997-G rs489693-? rs7138803-? rs4701252-? rs1555967-? rs7932813-? |
NR NR NR NR NR NR NR |
5 x 10-19 5 x 10-8 4 x 10-7 8 x 10-7 2 x 10-6 3 x 10-6 5 x 10-6 |
NR .65 [NR] cm increase NR NR NR NR NR |
Affymetrix & Illumina [up to 512,349] |
N |
|
07/01/09 |
Lindgren June 26, 2009 PLoS Genet Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
|
Adiposity |
38,580 European-ancestry individuals |
Up to 102,064 European-ancestry individuals |
6p12.3 8p23.1 1q41 1q42.3 |
TFAP2B MSRA LYPLAL1 TBCE |
rs987237-G rs7826222-G rs2605100-G rs6429082-C |
0.164 0.183 0.692 0.46 |
2 x 10-11 (WC) 9 x 10-9 (WC) 3 x 10-8 (WHR in women) 3 x 10-7 (WC) |
.04 [0.03-0.05] z-score unit increase .04 [0.03-0.05] z-score unit increase .04 [0.03-0.05] z-score unit increase NR |
Affymetrix & Illumina [2,573,738] (imputed) |
N |
|
07/01/09 |
Cotsapas June 24, 2009 Hum Mol Genet Common BMI-associated variants confer risk of extreme obesity
|
Obesity (extreme) |
775 Caucasian cases, 3,197 Caucasian controls |
NR |
16q12.2 10p11.21 2p16.1 6p21.31 4q26 11p14.2 3p24.2 5q23.3 10q22.1 20p12.1 3p24.3 6p21.31 2q33.3 |
FTO ZNF248 RTN4 ITPR3 TRAM1L1 MUC15 RARB FBN2 PRF1 C20orf133 RAFTLIN MLN FLJ20309 |
rs9941349-T rs7474896-T rs6726292-G rs999943-T rs10433903-T rs12295638-C rs1435703-T rs374748-G rs10999409-T rs6110577-C rs12635698-C rs2274459-A rs7603514-A |
0.43 0.14 0.73 0.72 0.66 0.10 0.06 0.11 0.45 0.16 0.15 0.17 0.20 |
6 x 10-12 9 x 10-7 1 x 10-6 1 x 10-6 3 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 5 x 10-6 5 x 10-6 5 x 10-6 6 x 10-6 8 x 10-6 |
1.48 [1.33-1.66] 1.46 [1.25-1.69] 1.39 [1.22-1.59] 1.37 [1.20-1.56] 1.33 [1.19-1.52] 1.49 [1.26-1.77] 1.66 [1.34-2.06] 1.47 [1.25-1.73] 1.3 [1.16-1.45] 1.4 [1.21-1.61] 1.41 [1.21-1.63] 1.38 [1.20-1.58] 1.36 [1.19-1.56] |
Illumina [457,251] |
N |
|
06/30/09 |
Bahlo June 14, 2009 Nat Genet Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
|
Multiple sclerosis |
1,618 European ancestry cases, 3,413 European ancestry controls |
2,256 European ancestry cases, 2,310 European ancestry controls |
6p21.32 12q14.1 1p13.1 20q13.12 16p12.1 8q24.21 1p22.1 10p15.1 |
HLA-DRB1 METTL1, CYP27B1 CD58 CD40 NR ASAP1, DDEF1 EVI5, RPL5 IL2RA |
rs9271366-G rs703842-A rs1335532-A rs6074022-G rs8049603-T rs6984045-C rs6604026-G rs2104286-G |
0.15 0.67 0.87 0.25 0.20 0.02 0.28 0.73 |
7 x 10-184 5 x 10-11 1 x 10-7 1 x 10-7 1 x 10-6 2 x 10-6 3 x 10-6 7 x 10-6 |
2.78 [NR] 1.23 [NR] 1.28 [NR] 1.2 [NR] 1.19 [NR] 1.59 [NR] 1.17 [NR] 1.16 [NR] |
Illumina [302,098] |
N |
|
06/29/09 |
De Jager June 14, 2009 Nat Genet Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
|
Multiple sclerosis |
2,624 cases, 7,220 controls |
2,215 cases, 2,116 controls |
6p21.32 6p22.1 12p13.31 1p13.1 11q12.2 16q24.1 10p15.1 2q22.1 16p13.13 5p13.1 12q24.31 10q22.3 5p13.2 12p13.31 3q25.33 |
HLA-DRB1 HLA-B TNFRSF1A CD58 CD6 IRF8 IL2RA CXCR4 CLEC16A PTGER4 MPHOSPH9 ZMIZ1 IL7R TNFRSF1A IL12A |
rs3135388-A rs2523393-A rs1800693-C rs2300747-A rs17824933-G rs17445836-G rs2104286-T rs882300-C rs11865121-C rs6896969-C rs1790100-G rs1250540-G rs6897932-C rs4149584-T rs4680534-C |
0.22 0.59 0.45 0.88 0.25 0.81 0.76 0.61 0.69 0.62 0.24 0.35 0.75 0.022 0.37 |
4 x 10-225 1 x 10-17 2 x 10-11 3 x 10-10 4 x 10-9 4 x 10-9 9 x 10-8 1 x 10-7 2 x 10-7 2 x 10-7 7 x 10-7 2 x 10-6 2 x 10-6 5 x 10-6 6 x 10-6 |
2.75 [2.46-3.07] 1.28 [1.18-1.39] 1.2 [1.10-1.31] 1.3 [1.14-1.47] 1.18 [1.07-1.30] 1.25 [1.12-1.39] 1.15 [1.04-1.27] 1.19 [1.09-1.30] 1.15 [1.04-1.25] 1.1 [1.01-1.20] 1.11 [1.00-1.22] 1.12 [1.02-1.22] 1.12 [1.02-1.23] 1.58 [1.15-2.17] 1.12 [1.02-1.22] |
Affymetrix & Illumina [~2.56 million] (imputed) |
N |
|
06/26/09 |
Malarstig June 12, 2009 Blood Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
|
Plasma homocysteine |
387 individuals from 21 Spanish families |
1,238 European individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [283,437] |
N |
|
06/19/09 |
Knauff June 09, 2009 Hum Reprod Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene
|
Premature ovarian failure |
99 Caucasian cases, 235 Caucasian controls |
60 Caucasian cases, 90 Caucasian controls |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [309,158] |
N |
|
06/19/09 |
Zhai June 08, 2009 J Med Genet A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
|
Osteoarthritis |
1,804 Caucasian individuals |
3,266 Caucasian individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [up to 535,188] |
N |
|
06/17/09 |
Gregersen June 07, 2009 Nat Genet REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
|
Rheumatoid arthritis |
2,418 cases, 4,504 controls |
2,604 cases, 2,882 controls |
1p13.2 2p16.1 2q33.2 8p23.1 9q33.2 |
PTPN22 REL CTLA4 BLK TRAF1, C5 |
rs2476601-? rs13017599-A rs231735-T rs2736340-A rs881375-? |
NR 0.34 0.51 0.24 NR |
2 x 10-21 2 x 10-12 6 x 10-9 6 x 10-9 4 x 10-8 |
NR 1.21 [1.15-1.28] 1.17 [1.11-1.23] 1.19 [1.13-1.27] NR |
Illumina [278,502] |
N |
|
06/17/09 |
Elmore June 06, 2009 J Vasc Surg Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association
|
Abdominal aortic aneurysm |
123 cases, 112 controls |
827 cases, 594 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [306,330] (pooled) |
N |
|
06/22/09 |
Kolz June 05, 2009 PLoS Genet Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations
|
Serum uric acid |
12,328 European males, 15,813 European females |
NR |
4p16.1 4p16.1 4q22.1 6p22.2 11q13.1 4q22.1 2p23.3 11q13.1 1q21.1 6p22.2 10q21.1 |
SLC2A9 SLC2A9 ABCG2 SLC17A1 SLC22A11 ABCG2 GCKR SLC22A12 PDZK1 LRRC16A, SCGN SLC16A9 |
rs734553-T rs734553-T rs2231142-T rs1183201-A rs17300741-A rs2231142-T rs780094-T rs505802-T rs12129861-A rs742132-A rs12356193-A |
0.77 0.77 0.11 0.48 0.51 0.11 0.42 0.70 0.46 0.70 0.83 |
1 x 10-192 (women) 1 x 10-41 (men) 2 x 10-18 (men) 3 x 10-14 7 x 10-14 1 x 10-10 (women) 1 x 10-9 2 x 10-9 3 x 10-9 9 x 10-9 1 x 10-8 |
.4 [0.371-0.423] mg/dl increase .22 [0.188-0.252] mg/dl increase .22 [0.171-0.270] mg/dl increase .06 [0.459-0.078] mg/dl decrease .06 [0.046-0.078] mg/dl increase .14 [0.096-0.181] mg/dl increase .05 [0.035-0.068] mg/dl increase .06 [0.038-0.074] mg/dl decrease .06 [0.042-0.083] mg/dl decrease .05 [0.036-0.072] mg/dl increase .08 [0.051-0.105] mg/dl increase |
Affymetrix and Illumina [2,493,963] (imputed) |
N |
|
06/16/09 |
Smith June 02, 2009 Mol Psychiatry Genome-wide association study of bipolar disorder in European American and African American individuals
|
Bipolar disorder |
1,001 Caucasian cases, 345 African American cases, 1,033 Caucasian controls, 670 African American controls |
1,749 Caucasian family members, 1,263 Caucasian cases, 431 Caucasian controls |
19q13.11 |
DPY19L3 |
rs2111504-T |
0.23 |
2 x 10-6 (AA) |
1.74 [NR] |
Affymetrix [702,044] |
N |
|
06/15/09 |
Daly May 31, 2009 Nat Genet HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
|
Drug-induced liver injury (flucloxacillin) |
58 cases, 282 controls |
NR |
6p21.33 3q27.3 3q11.2 12q12 9p21.2 15q26.2 |
HCP5, HLA-B ST6GAL1 OR5H2 ALG10B C9org82 MCTP2 |
rs2395029-? rs10937275-? rs1497546-? rs6582630-? rs10812428-? rs4984390-? |
0.05 0.09 0.02 0.38 0.31 0.41 |
9 x 10-33 1 x 10-8 (B*5701 positive) 2 x 10-7 1 x 10-6 1 x 10-6 4 x 10-6 |
45 [19.4-105] 4.1 [NR] 6.57 [NR] 2.82 [NR] 2.85 [NR] 3.27 [NR] |
Illumina [866,399] |
N |
|
06/14/09 |
Kanetsky May 31, 2009 Nat Genet Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
|
Testicular cancer |
277 white, non-Hispanic cases, 919 non-Hispanic controls |
371 non-Hispanic cases + 204 sets of parents, 860 non-Hispanic controls |
12q21.32 |
KITLG |
rs4474514-A |
NR |
6 x 10-15 |
3.07 [2.29-4.13] |
Affymetrix [611,254] |
N |
|
06/14/09 |
Rapley May 31, 2009 Nat Genet A genome-wide association study of testicular germ cell tumor
|
Testicular germ cell tumor |
730 cases, 1,435 controls |
571 cases, 1,806 controls |
12q21.32 12q21.32 6p21.31 5q31.3 4q24 1q24.1 |
KITLG KITLG BAK1 SPRY4 Intergenic Intergenic |
rs995030-G rs1508595-G rs210138-G rs4624820-A rs4699052-C rs4657482-A |
0.80 0.83 0.20 0.54 0.61 0.33 |
1 x 10-31 3 x 10-30 1 x 10-13 3 x 10-13 2 x 10-7 2 x 10-6 |
2.55 [2.05-3.19] 2.69 [2.10-3.44] 1.5 [1.28-1.75] 1.37 [1.19-1.58] 1.21 [1.05-1.39] 1.14 [0.99-1.31] |
Illumina [307,666] |
N |
|
06/14/09 |
Ng May 29, 2009 J Hum Genet A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.
|
Nasopharyngeal carcinoma |
111 Chinese cases, 260 Chinese controls |
168 Chinese cases, 252 Chinese controls |
3p22.2 |
ITGA9 |
rs189897-A |
0.09 |
7 x 10-8 |
3.18 [1.94-5.21] |
Illumina [533,048] |
N |
|
06/16/09 |
Aston May 28, 2009 J Androl Genome-wide Study of Single Nucleotide Polymorphisms Associated with Azoospermia and Severe Oligozoospermia
|
Male infertility |
52 oligozoospermic Caucasian males, 40 non-obstructive azoospermic Caucasian males, 80 Caucasian male controls |
NR |
12p12.2 20q13.2 3q11.2 2q22.1 12p13.32 |
PDE3A SALL4 ARL6 NXPH2 EFCAB4B |
rs10841496-? rs6068020-? rs9814870-? rs1399645-? rs10848911-? |
0.58 0.49 0.15 0.02 0.11 |
5 x 10-7 (azoospermia) 5 x 10-7 (azoospermia) 7 x 10-7 (oligozoospermia) 9 x 10-7 (azoospermia) 4 x 10-6 (azoospermia) |
NR NR NR NR NR |
Illumina [314,776] |
N |
|
06/10/09 |
Ma May 28, 2009 Ann Hum Genet A genome-wide association study of autism reveals a common novel risk locus at 5p14.1
|
Autism |
1,390 family members |
2,390 family members |
5p14.1 |
Intergenic |
rs10038113-T |
0.59 |
3 x 10-6 |
1.33 [1.11-1.43] |
Illumina [775,311] |
N |
|
06/14/09 |
Jallow May 24, 2009 Nat Genet Genome-wide and fine-resolution association anaylsis of malaria in West Africa
|
Malaria |
958 Gambian cases, 1,382 Gambian controls, all children |
1,087 Gambian cases, 2,376 Gambian controls, all children |
11p15.4 17p13.1 7p12.2 |
HBB SCO1 DDC |
rs11036238-? rs6503319-T rs1451375-? |
0.14 0.45 0.78 |
4 x 10-11 7 x 10-7 6 x 10-6 |
1.59 [1.39-1.82] 1.21 [1.12-1.31] 1.33 [1.18-1.52] |
Affymetrix [402,814] |
N |
|
06/04/09 |
Norris May 21, 2009 Obesity Genome-wide Association Study and Follow-up Analysis of Adiposity Traits in Hispanic Americans: The IRAS Family Study
|
Obesity-related traits |
229 Hispanic family members |
961 Hispanic family members |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [309,200] |
N |
|
06/21/09 |
Hirschfield May 20, 2009 N Engl J Med Primary Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants
|
Primary biliary cirrhosis |
505 cases, 1,507 controls |
up to 526 cases, 1,206 controls |
3q26.1 1p31.3 6p21.32 6p21.3 7q32.1 3q26.1 17q12 |
IL12A IL12RB2 c6orf10, BTNL2, HLA-DQB1 c6orf10, BTNL2, HLA-DQB1 IRFS-TNPO3 ARF7 IKZF3 |
rs6441286-G rs3790567-A 4-SNP haplotype-1 4-SNP haplotype-2 rs10488631-G rs4679904-G rs907092-A |
0.39 0.24 0.01 0.20 NR 0.72 0.45 |
2 x 10-14 3 x 10-11 1 x 10-10 (AACA) 7 x 10-10 (CACA) 2 x 10-7 1 x 10-6 8 x 10-6 |
1.54 [1.38-1.72] 1.51 [1.33-1.70] NR NR 1.52 [1.30-1.78] 1.38 [1.21-1.57] 1.29 [1.15-1.44] |
Illumina [305,724] |
N |
|
06/14/09 |
Arnett May 19, 2009 BMC Med Genet Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study
|
Left ventricular mass |
101 Caucasian cases, 101 Caucasian controls |
704 Caucasian siblings, 1,467 African American siblings |
5p13.2 7q21.11 |
RAI14 CD36 |
rs409045-? rs10499859-? |
0.38 0.45 |
8 x 10-7 (Caucasian) 3 x 10-6 (Caucasian) |
0 [NR] (LVMI) .09 [NR] (LVMI) |
Affymetrix [96,258] |
N |
|
06/04/09 |
Landers May 18, 2009 Proc Natl Acad Sci USA Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
|
Amyotrophic lateral sclerosis |
1,821 cases, 2,258 controls |
538 cases, 556 controls |
1q24.2 7q36.1 18q12.1 2p16.1 5q23.2 1q24.2 6p22.3 2q24.3 3p26.3 17q24.3 1p34.2 1q42.2 2p22.1 5q23.1 21q21.1 2q24.2 |
KIFAP3 ZNF746 B4GALT6 EFEMP1 CSNK1G3 SELL ATXN1 SCN7A CNTN4 SLC39A11 NT5C1A DISC1 NR SEMA6A NR RBMS1 |
rs1541160-C rs855913-A rs10438933-G rs7577894-T rs11241713-T rs3177980-G rs697739-A rs13015447-T rs2619566-G rs8066857-C rs873917-T rs16856202-A rs3099950-? rs7702057-C rs2823962-? rs10192369-T |
NR NR 0.12 0.39 NR NR NR 0.34 NR NR 0.29 0.04 NR 0.03 NR 0.47 |
2 x 10-8 (survival) 4 x 10-8 (survival) 1 x 10-6 (susceptibilty) 1 x 10-6 (site of onset) 3 x 10-6 (survival) 4 x 10-6 (survival) 4 x 10-6 (age of onset) 7 x 10-6 (site of onset) 7 x 10-6 (age of onset) 8 x 10-6 (site of onset) 8 x 10-6 (susceptibilty) 8 x 10-6 (susceptibilty) 8 x 10-6 (survival) 8 x 10-6 (site of onset) 9 x 10-6 (survival) 9 x 10-6 (susceptibilty) |
.58 [0.38-0.78] years older 1.08 [0.70-1.46] years older 1.3 [NR] 1.41 [NR] .79 [0.46-1.12] years older .51 [0.46-0.56] years older 2.04 [1.18-2.90] years younger 1.41 [NR] 3.03 [1.71-4.35] years younger 1.48 [NR] 1.16 [NR] 2 [NR] NR 2.05 [NR] NR 1.17 [NR] |
Illumina [288,357] |
N |
|
06/04/09 |
He May 17, 2009 Nat Genet Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
|
Menarche and menopause (age at onset) |
17,438 Caucasian women |
NR |
20p12.3 19q13.42 5q35.2 6q21 9q31.2 6p24.2 |
TRMT6, MCM8 BRSK1 UIMC1 LIN28B Intergenic GCM2, SYCP2L |
rs16991615-A rs1172822-T rs365132-T rs314277-A rs7861820-C rs2153157-T |
0.06 0.37 0.49 0.14 0.48 0.49 |
1 x 10-21 (age at natural menopause) 2 x 10-19 (age at natural menopause) 8 x 10-14 (age at natural menopause) 3 x 10-13 (age at menarche) 3 x 10-9 (age at menarche) 5 x 10-8 (age at natural menopause) |
1.07 [0.85-1.29] years older .49 [0.38-0.60] years younger .39 [0.29-0.49] years older .16 [0.12-0.20] years older .09 [0.06-0.12] years younger .29 [0.19-0.39] years older |
Illumina [317,759] |
N |
|
06/01/09 |
Ong May 17, 2009 Nat Genet Genetic variation in LIN28B is associated with the timing of puberty
|
Menarche (age at onset) |
4,714 women |
16,373 women |
6q21 |
LIN28B |
rs314276-C |
0.33 |
4 x 10-16 |
.14 [0.11-0.17] years younger |
Affymetrix [up to 390,631] |
N |
|
05/28/09 |
Perry May 17, 2009 Nat Genet Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
|
Menarche (age at onset) |
17,510 women |
NR |
9q31.2 6q21 |
TMEM38B, SLC44A1, FKTN, FSD1L, TAL2, ZNF462 LIN28B |
rs2090409-A rs7759938-C |
0.31 0.33 |
2 x 10-9 7 x 10-9 |
.1 [0.06-0.14] years younger .09 [0.05-0.13] years older |
Affymetrix & Illumina [~2.5 million] (imputed) |
N |
|
06/01/09 |
Perlis May 15, 2009 Am J Psychiatry A Genomewide Association Study of Response to Lithium for Prevention of Recurrence in Bipolar Disorder
|
Response to lithium treatment in bipolar disorder |
458 lithium-treated subjects, 719 non-lithium treated subjects |
359 subjects |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [~1.4 million] (imputed) |
N |
|
05/28/09 |
Stolk May 15, 2009 Nat Genet Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
|
Menopause (age at onset) |
2,979 women |
2,560 women |
19q13.42 20p12.3 13q34 9q21.31 16q24.2 11q25 8p12 7q22.3 6p21.32 3q26.2 20p12.3 2q23.3 14q32.31 |
BRSK1, TMEM224, SUV420H2 MCM8 LOC121793, ARHGEF7 NR NR NR NR NR NR NR NR NR NR |
rs1172822-T rs236114-A rs7333181-A rs2151145-? rs4843747-? rs4397868-? rs6468442-? rs17153527-? rs494620-? rs4955755-? rs2326679-? rs11889862-? rs4906172-? |
0.39 0.21 0.12 NR NR NR NR NR NR NR NR NR NR |
6 x 10-11 1 x 10-10 3 x 10-8 1 x 10-7 2 x 10-7 3 x 10-7 3 x 10-7 4 x 10-7 5 x 10-7 7 x 10-7 2 x 10-6 2 x 10-6 3 x 10-6 |
.39 [0.27-0.51] years younger .5 [0.34-0.65] years older .52 [0.34-0.70] years older .41 [0.26-0.56] years older .39 [0.24-0.54] years older .4 [0.25-0.55] years younger .39 [0.24-0.54] years younger .51 [0.31-0.71] years older .3 [0.18-0.42] years older .34 [0.21-0.47] years older .32 [0.19-0.45] years older .36 [0.21-0.51] years younger .36 [0.21-0.51] years younger |
Illumina [315,418] |
N |
|
06/01/09 |
Sulem May 15, 2009 Nat Genet Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
|
Menarche (age at onset) |
15,297 Icelandic women |
10,040 Icelandic women |
6q21 |
LIN28B, HACE1, E3 ubiquitin protein ligase 1, BVES, POPDC3 |
rs314280-T |
0.48 |
2 x 10-14 |
1.2 [0.9-1.5] months older |
Illumina [304,226] |
N |
|
05/26/09 |
Fei May 14, 2009 Arthritis Res Ther Identification of novel genetic susceptibility loci for Behcet's disease using a genome-wide association study
|
Behcet's disease |
152 cases, 170 controls |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [~500,000] (pooled) |
N |
|
06/01/09 |
Barrett May 10, 2009 Nat Genet Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
|
Type 1 diabetes |
7,514 cases, 9,045 controls |
4,267 cases, 4,670 controls, 4,342 trios |
6p21.32 1p13.2 11p15.5 10q23.31 12q24.12 12q13.2 16p13.13 22q12.2 2q33.2 16q23.1 18p11.21 10p15.1 16p11.2 6q22.32 4q27 17q12 14q24.1 9p24.2 20p13 12p13.31 19q13.32 4p15.2 17q21.2 1q32.1 21q22.3 14q32.2 7p15.2 2q24.2 Xq28 7p12.1 6q15 15q25.1 10p15.1 16p12.3 22q13.1 1p31.3 17p13.1 2p25.1 |
MHC PTPN22 INS C10orf59 SH2B3 ERBB3 CLEC16A Intergenic CTLA4 Intergenic PTPN2 IL2RA IL27 C6orf173 IL2 ORMDL3 Intergenic GLIS3 Intergenic CD69 Intergenic Intergenic Intergenic IL10 UBASH3A Intergenic Intergenic IFIH1 Intergenic COBL BACH2 CTSH PRKCQ Intergenic C1QTNF6 PGM1 Intergenic Intergenic |
rs9268645-? rs2476601-? rs7111341-? rs10509540-? rs3184504-? rs2292239-? rs12708716-? rs5753037-T rs3087243-? rs7202877-G rs1893217-? rs12251307-? rs4788084-G rs9388489-G rs4505848-? rs2290400-? rs1465788-? rs7020673-? rs2281808-? rs4763879-A rs425105-? rs10517086-A rs7221109-? rs3024505-? rs11203203-? rs4900384-G rs7804356-? rs1990760-? rs2664170-G rs4948088-? rs11755527-? rs3825932-? rs11258747-? rs12444268-A rs229541-? rs2269241-G rs16956936-? rs1534422-G |
NR NR NR 0.71 NR NR NR 0.39 NR 0.10 NR NR 0.42 0.45 NR 0.50 0.71 0.50 0.64 0.37 0.84 0.30 0.65 0.83 NR 0.29 0.76 NR 0.32 0.95 NR NR NR 0.30 NR 0.19 0.86 0.46 |
1 x 10-100 9 x 10-85 4 x 10-48 1 x 10-28 3 x 10-27 2 x 10-25 2 x 10-16 3 x 10-16 1 x 10-15 3 x 10-15 4 x 10-15 1 x 10-13 3 x 10-13 4 x 10-13 5 x 10-13 6 x 10-13 2 x 10-12 5 x 10-12 1 x 10-11 2 x 10-11 3 x 10-11 5 x 10-10 1 x 10-9 2 x 10-9 2 x 10-9 4 x 10-9 5 x 10-9 7 x 10-9 8 x 10-9 4 x 10-8 5 x 10-8 8 x 10-8 1 x 10-7 2 x 10-7 2 x 10-7 4 x 10-7 5 x 10-7 2 x 10-6 |
NR NR NR 1.33 [1.25-1.43] NR NR NR 1.1 [1.04-1.17] NR 1.28 [1.17-1.41] NR NR 1.09 [1.02-1.16] 1.17 [1.10-1.24] NR 1.15 [1.08-1.22] 1.16 [1.10-1.25] 1.14 [1.08-1.20] 1.11 [1.05-1.19] 1.09 [1.02-1.16] 1.16 [1.08-1.27] 1.09 [1.02-1.17] 1.05 [0.99-1.12] 1.19 [1.10-1.30] NR 1.09 [1.02-1.16] 1.14 [1.06-1.22] NR 1.16 [1.07-1.24] 1.3 [1.11-1.49] NR NR NR 1.1 [1.03-1.17] NR 1.1 [1.02-1.18] 1.09 [1.00-1.19] 1.08 [1.02-1.15] |
Affymetrix & Illumina [841,622] (imputed) |
N |
|
05/27/09 |
Kottgen May 10, 2009 Nat Genet Multiple loci associated with indices of renal function and chronic kidney disease
|
Renal function and chronic kidney disease |
19,877 individuals, up to 2,388 cases |
21,466 individuals, up to 1,932 cases |
16p12.3 15q21.1 4q21.1 16p12.3 |
UMOD SPATA5L1, GATM SHROOM3 UMOD |
rs12917707-T rs2467853-G rs17319721-A rs12917707-G |
0.18 0.38 0.44 0.18 |
5 x 10-16 (eGFRcrea) 6 x 10-14 (eGFRcrea) 1 x 10-12 (eGFRcrea) 2 x 10-12 (CKD) |
.02 [0.014-0.022] ml/min/1.73m2 increase .01 [0.009-0.017] ml/min/1.73m2 decrease .01 [0.008-0.016] ml/min/1.73m2 decrease 1.25 [1.18-1.33] |
Affymetrix & Illumina [~2.5 million] (imputed) |
N |
|
05/19/09 |
Levy May 10, 2009 Nat Genet Genome-wide association study of blood pressure and hypertension
|
Diastolic blood pressure |
29,136 individuals |
34,433 individuals |
12q24.12 15q24.1 12q21.33 3p22.1 10p12.33 12q24.21 11p15.1 |
SH2B3 CSK, ULK3 ATP2B1 ULK4 CACNB2 TBX3, TBX5 PLEKHA7 |
rs3184504-T rs6495122-A rs2681472-A rs9815354-A rs11014166-A rs2384550-A rs11024074-T |
0.48 0.42 0.83 0.17 0.66 0.35 0.72 |
3 x 10-14 2 x 10-10 1 x 10-9 3 x 10-9 1 x 10-8 4 x 10-8 1 x 10-6 |
.48 [0.36-0.60] mm Hg increase .4 [0.28-0.52] mm Hg increase .5 [0.34-0.66] mm Hg increase .49 [0.33-0.65] mm Hg increase .37 [0.25-0.49] mm Hg increase .35 [0.23-0.47] mm Hg decrease .33 [0.19-0.47] mm Hg decrease |
Affymetrix & Illumina [2,533,153](imputed) |
N |
|
05/19/09 |
"
|
Hypertension |
29,136 individuals |
34,433 individuals |
12q21.33 10p12.33 20q13.32 8p23.1 |
ATP2B1 CACNB2 ZNF831, EDN3 MSRA |
rs2681472-A rs11014166-A rs16982520-A rs11775334-A |
0.83 0.66 0.88 0.32 |
2 x 10-11 6 x 10-8 2 x 10-7 4 x 10-6 |
.15 [0.11-0.19] increase in log odds .09 [0.05-0.13] increase in log odds .13 [0.09-0.17] decrease in log odds .08 [0.04-0.12] increase in log odds |
Affymetrix & Illumina [2,533,153](imputed) |
N |
|
05/19/09 |
"
|
Systolic blood pressure |
29,136 individuals |
34,433 individuals |
12q21.33 10q24.32 11p15.1 12q24.12 3q26.2 10p12.33 1p36.22 |
ATP2B1 CYP17A1 PLEKHA7 SH2B3 MDS1 CACNB2 CASZ1 |
rs2681492-T rs1004467-A rs381815-T rs3184504-T rs448378-A rs11014166-A rs12046278-T |
0.80 0.90 0.26 0.48 0.52 0.66 0.64 |
4 x 10-11 1 x 10-10 2 x 10-9 5 x 10-9 1 x 10-7 7 x 10-7 5 x 10-6 |
.85 [0.60-1.10] mm Hg increase 1.05 [0.74-1.36] mm Hg increase .65 [0.43-0.87] mm Hg increase .58 [0.38-0.78] mm Hg increase .51 [0.31-0.71] mm Hg decrease .5 [0.30-0.70] mm Hg increase .53 [0.29-0.77] mm Hg decrease |
Affymetrix & Illumina [2,533,153](imputed) |
N |
|
05/19/09 |
Newton-Cheh May 10, 2009 Nat Genet Genome-wide association study identifies eight loci associated with blood pressure
|
Diastolic blood pressure |
34,433 individuals |
Up to 100,347 white individuals, up to 12,889 Indian Asian individuals |
15q24.1 4q21.21 12q24.12 10q21.2 17q21.32 3q26.2 |
CYP1A1, CYP1A2, CSK, LMAN1L, CPLX3, ARID3B FGF5, PRDM8, c4orf22 ATXN2, SH2B3 c10orf107, TMEM26, RTKN2, RHOBTB1, ARID5B ZNF652, PHB MDS1 |
rs1378942-C rs16998073-T rs653178-T rs1530440-T rs16948048-G rs1918974-T |
0.36 0.21 0.53 0.19 0.39 0.54 |
1 x 10-23 1 x 10-21 3 x 10-18 1 x 10-9 5 x 10-9 8 x 10-8 |
.43 [0.35-0.51] mm Hg increase .5 [0.40-0.60] mm Hg increase .46 [0.36-0.56] mm Hg decrease .39 [0.27-0.51] mm Hg decrease .31 [0.21-0.41] mm Hg increase .27 [0.17-0.37] mm Hg decrease |
Affymetrix & Illumina [2,497,993] (imputed) |
N |
|
05/19/09 |
"
|
Systolic blood pressure |
34,433 individuals |
Up to 100,347 white individuals, up to 12,889 Indian Asian individuals |
10q24.32 1p36.22 17q21.31 |
CYP17A1, AS3MT, CNNM2, NT5C2 MTHFR, NPPA, CLCN6, NPPB, AGTRAP PLCD3, ACBD4, HEXIM1, HEXIM2 |
rs11191548-T rs17367504-G rs12946454-T |
0.91 0.14 0.28 |
7 x 10-24 2 x 10-13 1 x 10-8 |
1.16 [0.92-1.40] mm Hg increase .85 [0.63-1.07] mm Hg decrease .57 [0.37-0.77] mm Hg increase |
Affymetrix & Illumina [2,497,993] (imputed) |
N |
|
05/21/09 |
Rich May 09, 2009 Diabetologia A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).
|
Insulin response |
229 family members |
961 family members |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [309,200] |
N |
|
05/20/09 |
Himes May 07, 2009 Am J Hum Genet Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
|
Asthma |
422 cases, 1,533 controls |
3,750 white cases, 13,365 white controls, 592 white trios, 1,903 black cases, 2,432 black controls, 929 black family members |
5q12.1 |
PDE4D |
rs1588265-C |
0.29 |
3 x 10-8 |
1.18 [1.08-1.30] |
Illumina [518,230] |
N |
|
05/21/09 |
Yang May 07, 2009 PLoS ONE Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan
|
Hypertension (young onset) |
175 Han Chinese cases, 175 Han Chinese controls |
833 Han Chinese cases, 833 Han Chinese controls |
2p22.3 |
LOC344371, MYADML, FAM98A, RASGRP3 |
4-SNP-haplotype |
NR |
3 x 10-10 |
NR |
Affymetrix [91,713] |
N |
|
05/19/09 |
Sanna May 06, 2009 Hum Mol Genet Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
|
Bilirubin levels |
4,300 individuals |
2,692 individuals |
2q37.1 12p12.2 Xq28 |
UGT1A1 SLC01B3 G6PD |
rs887829-T rs2117032-C rs766420-G |
0.30 0.47 0.18 |
1 x 10-69 3 x 10-14 9 x 10-9 |
.57 [0.50-0.63] SD decrease .13 [0.08-0.18] SD increase .18 [0.12-0.24] SD decrease |
Affymetrix [362,129] |
N |
|
05/14/09 |
Scott May 05, 2009 Proc Natl Acad Sci USA Genome-wide association and meta-analysis of
bipolar disorder in individuals of European ancestry
|
Bipolar disorder |
3,683 cases, 14,507 controls |
NR |
5q15 1p32.1 3p21.1 11q13.1 19p13.3 2p12 2q11.2 4q12 3q26.1 8p12 9q34.13 15q23 17q21.33 |
MCTP1 NF1A ITIH1, NEK4 NR NR CTNNA2 Intergenic KIT NR NR NR NR NR |
rs17418283-C rs472913-C rs1042779-A rs2242663-T rs7250872-T rs13409348-G rs6733011-G rs2537859-T rs7427021-G rs6990255-T rs2905072-A rs6494849-A rs1035050-T |
0.28 0.50 0.63 0.25 0.69 0.24 0.46 0.60 0.56 0.95 0.77 0.12 0.40 |
1 x 10-7 2 x 10-7 2 x 10-7 1 x 10-6 2 x 10-6 3 x 10-6 3 x 10-6 4 x 10-6 5 x 10-6 6 x 10-6 6 x 10-6 7 x 10-6 9 x 10-6 |
1.21 [1.13-1.30] 1.18 [1.11-1.25] 1.19 [1.11-1.27] 1.2 [1.11-1.29] 1.21 [1.12-1.31] 1.2 [1.11-1.29] 1.17 [1.10-1.25] 1.16 [1.09-1.24] 1.16 [1.09-1.24] 1.33 [1.18-1.51] 1.21 [1.11-1.32] 1.23 [1.13-1.35] 1.17 [1.09-1.25] |
Affymetrix and Illumina [2,366,197] (imputed) |
N |
|
05/12/09 |
Johnson May 04, 2009 Hum Mol Genet Genome-wide association meta-analysis for total serum bilirubin levels
|
Serum bilirubin levels |
9,264 individuals |
NR |
2q37.1 12p12.1 11p15.4 2p11.2 6p22.1 4q28.1 7q21.11 13q34 |
UGT1A1 SLCO1B1,LST-3TM12,SLCO1A2 SLC22A18 KRCC1 HIST1H2BC Intergenic SEMA3C ARHGEF7 |
rs6742078-T rs4149056-C rs16928809-A rs12714207-T rs12206204-T rs1986655-A rs4236644-A rs4773330-A |
0.32 0.15 0.09 0.03 0.02 0.17 0.26 0.12 |
5 x 10-324 7 x 10-13 1 x 10-7 5 x 10-7 8 x 10-7 2 x 10-6 2 x 10-6 8 x 10-6 |
.23 [0.21-0.25] umol/l increase in log(tbil) .05 [0.03-0.07] umol/l increase in log(tbil) .06 [0.04-0.08] umol/l increase in log(tbil) .03 [0.01-0.05] umol/l decrease in log(tbil) .18 [0.10-0.26] umol/l increase in log(tbil) .02 [0.00-0.04] umol/l decrease in log(tbil) .02 [0.00-0.04] umol/l decrease in log(tbil) .04 [0.02-0.06] umol/l decrease in log(tbil) |
Affymetrix & Illumina [2,555,103] (imputed) |
N |
|
05/07/09 |
Capasso May 03, 2009 Nat Genet Common variants in BARD1 influence susceptibility to high-risk neuroblastoma
|
Neuroblastoma (high-risk) |
397 cases, 2,043 controls |
189 cases, 1,178 controls |
2q35 |
BARD1 |
rs6435862-G |
0.29 |
9 x 10-18 |
1.68 [1.49-1.90] |
Illumina [462,866] |
N |
|
05/07/09 |
Hallmayer May 03, 2009 Nat Genet Narcolepsy is strongly associated with the T-cell receptor alpha locus
|
Narcolepsy |
807 Caucasian cases, 1,074 Caucasian controls |
363 Caucasian cases, 355 Caucasian controls, 561 Asian cases, 605 Asian controls, 133 African American cases, 144 African American controls |
14q11.2 |
TRA-alpha, TRAJ10 |
rs1154155-C |
0.14 |
3 x 10-22 |
1.69 [1.52-1.88] |
Affymetrix [549,596] |
N |
|
05/07/09 |
Takeuchi April 29, 2009 Diabetes Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
|
Type 2 diabetes |
519 Japanese cases, 503 Japanese controls |
5,629 Japanese cases, 7,370 Japanese controls |
9p21.3 11p15.5 6p22.3 8q24.11 10q22.33 10q25.2 3q27.2 |
CDKN2A, CDKN2B KCNQ1 CDKAL1 SLC30A8 HHEX TCF7L2 IGF2BP2 |
rs2383208-A rs2237892-C rs4712523-G rs13266634-C rs1111875-C rs7903146-T rs4402960-T |
0.55 0.59 0.41 0.57 0.28 0.04 0.31 |
2 x 10-29 1 x 10-26 7 x 10-20 2 x 10-14 7 x 10-12 8 x 10-12 1 x 10-6 |
1.34 [1.27-1.41] 1.33 [1.27-1.41] 1.27 [1.21-1.33] 1.22 [1.16-1.28] 1.21 [1.15-1.28] 1.54 [1.36-1.74] 1.14 [1.08-1.21] |
Illumina [482,625] |
N |
|
05/11/09 |
Wang April 28, 2009 Nature Common genetic variants on 5p14.1 associate with autism spectrum disorders
|
Autism |
3,101 family members, 1,204 cases, 6,491 controls |
1,390 family members, 108 cases, 540 controls |
5p14.1 |
CDH10,CDH9 |
rs4307059-T |
0.61 |
2 x 10-10 |
1.19 [NR] |
Illumina [474,019] |
N |
|
05/05/09 |
Cho April 26, 2009 Nat Genet A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
|
Biomedical quantitative traits |
8,842 Korean individuals |
7,861 Korean individuals |
12q24.13 7q31.31 6q22.31 1q32.2 12q21.33 16q12.2 7q31.31 12q21.33 |
C12orf51 FAM3C LOC644502 CD46, LOC148696 ATP2B1 FTO FAM3C ATP2B1 |
rs2074356-T rs7776725-C rs12110693-A rs12731740-T rs17249754-A rs9939609-A rs7776725-C rs17249754-A |
0.15 0.13 0.49 0.10 0.37 0.13 0.13 0.37 |
8 x 10-12 (waist-hip ratio) 1 x 10-11 (BD-RT) 2 x 10-9 (pulse rate) 3 x10-9 (pulse rate) 1 x 10-7 (SBP) 2 x 10-7 (BMI) 2 x 10-6 (BD-TT) 3 x10-6 (DBP) |
.01 [0.004-0.008] decrease NR .66 [0.45-0.87] beats per minute increase 1.09 [0.72-1.44] beats per minute increase 1.06 [0.67-1.45] mm Hg decrease .24 [0.14-0.32] kg/m2 increase NR .63 [0.37-0.89] mm Hg decrease |
Affymetrix [2,156,535] (imputed) |
N |
|
05/05/09 |
"
|
Height |
8,842 Korean individuals |
7,861 Korean individuals |
3q23 8q12.1 2p16.1 6p21.31 1p12 |
ZBTB38 PLAG1 EFEMP1 HMGA1 Intergenic |
rs10513137-A rs13273123-G rs3791675-G rs6918981-G rs17038182-C |
0.26 0.07 0.22 0.21 0.42 |
6 x10-12 1 x10-9 2 x10-9 3 x10-8 5 x10-7 |
.46 [0.33-0.59] cm increase .71 [0.48-0.94] cm decrease .42 [0.28-0.56] cm increase .4 [0.26-0.54] cm increase .3 [0.18-0.42] cm decrease |
Affymetrix [2,156,535] (imputed) |
N |
|
04/23/09 |
Ikram April 15, 2009 N Engl J Med Genomewide Association Studies of Stroke
|
Stroke |
19,602 Caucasian individuals |
3,004 African American individuals, 652 Caucasian cases, 3,613 Caucasian controls |
12p13.33 |
NINJ2 |
rs12425791-A |
0.19 |
1 x 10-9 (ischemic stroke) |
1.29 [1.19-1.41] |
Affymetrix & Illumina [2,194,468] |
N |
|
04/22/09 |
Poduslo April 14, 2009 Am J Med Genet B Neuropsychiatr Genet A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis
|
Aging |
89 cases, 227 controls |
NR |
2q22.1 |
LRP1B |
rs12474609-? |
NR |
6 x 10-9 |
NR |
Affymetrix [469,218] |
N |
|
05/05/09 |
Hiura April 10, 2009 Circ J Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population
|
LDL cholesterol |
900 Japanese individuals |
1,810 Japanese individuals |
16q13 |
CETP |
rs3764261-A |
0.20 |
3 x 10-12 |
6.2 mg/dl increase |
Illumina [368,274] |
N |
|
04/22/09 |
Mangino April 08, 2009 J Med Genet A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
|
Telomere length |
1,625 women |
1,165 individuals |
18q12.2 |
BRUNOL4, VPS34 |
rs2162440-G |
NR |
3 x 10-6 |
106 [62.88-149.12] base pairs shorter |
Illumina [~314,075] |
N |
|
04/14/09 |
Esparza-Gordillo April 06, 2009 Nat Genet A common variant on chromosome 11q13 is associated with atopic dermatitis
|
Atopic dermatitis |
939 cases, 975 controls, 1,097 family members |
2,637 cases, 3,957 controls |
11q13.5 |
C11orf30 |
rs7927894-A |
0.36 |
8 x 10-10 |
1.22 [1.15-1.30] |
Affymetrix [342,303] |
N |
|
04/16/09 |
Kamatani April 06, 2009 Nat Genet A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
|
Hepatitis B |
179 Japanese cases, 934 Japanese controls |
1,599 Japanese cases, 2,821 Japanese controls, 308 Thai cases, 546 Thai controls |
6p21.32 |
HLA-DPB1 |
rs9277535-G |
0.56 |
6 x 10-39 |
1.75 [1.61-1.92] |
Illumina [499,544] |
N |
|
05/11/09 |
Yamada April 05, 2009 Atherosclerosis Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study
|
Ischemic stroke |
131 cases, 135 controls |
776 cases, 5,205 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [~520,000] |
N |
|
04/22/09 |
Soranzo April 03, 2009 PLoS Genet Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
|
Height |
12,611 individuals |
7,187 individuals |
12q14.3 20q11.22 3q23 6p22.1 7p15.1 6q24.1 6p21.31 13q14.3 7p22.2 4p15.32 7q21.2 4q21.21 15q25.2 6p21.33 1p36.11 14q24.3 5p13.3 9p13.3 4q31.22 8q12.1 |
HMGA2 UQCC ZBTB38 HIST1H1D JAZF1 GPR126 HMGA1,C6orf106 DLEU7 GNA12 LCORL CDK6 PRKG2 ADAMTSL3 HLA-B CATSPER4 TMED10 NPR3 WDR40A HHIP PLAG1 |
rs8756-? rs6088813-? rs6763931-? rs10946808-? rs849141-? rs6570507-? rs1776897-? rs3118914-? rs1182188-? rs6830062-? rs2282978-? rs710841-? rs4842838-? rs13437082-? rs11809207-? rs910316-? rs10472828-? rs7871764-? rs1812175-? rs7815788-? |
0.17 0.11 0.35 0.43 0.23 0.42 0.49 0.39 0.27 0.23 0.08 0.12 0.32 0.13 0.23 0.15 0.26 0.44 0.49 0.39 |
5 x 10-14 1 x 10-13 3 x 10-12 6 x 10-12 3 x 10-11 4 x 10-11 8 x 10-11 4 x 10-10 3 x 10-9 5 x 10-9 1 x 10-8 2 x 10-8 3 x 10-8 5 x 10-8 6 x 10-8 1 x 10-7 3 x 10-7 2 x 10-6 4 x 10-6 5 x 10-6 |
.08 [0.06-0.10] SD decrease .09 [0.07-0.11] SD decrease .07 [0.05-0.09] SD increase .07 [0.04-0.10] SD increase .08 [0.06-0.10] SD increase .08 [0.06-0.10] SD decrease .12 [0.08-0.16] SD increase .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD increase .1 [0.07-0.13] SD increase .06 [0.04-0.08] SD decrease .07 [0.04-0.10] SD increase .06 [0.04-0.07] SD decrease .07 [0.04-0.10] SD decrease .07 [0.04-0.10] SD increase .05 [0.03-0.07] SD increase .06 [0.04-0.08] SD decrease .06 [0.03-0.09] SD increase .06 [0.03-0.09] SD decrease .07 [0.04-0.10] SD decrease |
Illumina [229,216] |
N |
|
04/13/09 |
Nan April 02, 2009 J Invest Dermatol Genome-Wide Association Study of Tanning Phenotype in a Population of European Ancestry
|
Tanning |
2,287 women |
870 controls |
6p25.3 11q14.3 5p13.3 16q24.3 11q14.3 16q24.3 14q32.2 12q13.13 21q22.3 5q33.1 |
EXOC2 TYR MATP MC1R GRM5 MC1R Intergenic LOC440100 PRDM15 PPARGC1B |
rs12210050-T rs1393350-A rs35391-T rs11648785-T rs10831496-G rs154659-C rs17094273-A rs7969151-A rs7279297-G rs32579-A |
NR NR NR NR NR NR NR 0.21 NR NR |
5 x 10-14 2 x 10-13 3 x 10-10 3 x 10-9 5 x 10-9 7 x 10-8 9 x 10-8 2 x 10-6 3 x 10-6 4 x 10-6 |
.22 [0.16-0.28] increase in tanning ability score .19 [0.13-0.25] increase in tanning ability score .44 [0.30-0.58] decrease in tanning ability score .14 [0.10-0.18] decrease in tanning ability score .14 [0.10-0.18] decrease in tanning ability score .14 [0.08-0.20] increase in tanning ability score .2 [0.12-0.28] increase in tanning ability score .13 [0.07-0.19] increase in tanning ability score .12 [0.06-0.18] decrease in tanning ability score .11 [0.07-0.15] decrease in tanning ability score |
Illumina [528,173] |
N |
|
04/03/09 |
Thomas March 29, 2009 Nat Genet A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
|
Breast cancer |
1,145 cases, 1,142 controls |
8,625 cases, 9,657 controls |
10q26.13 1p11.2 16q12.1 2q35 14q24.1 5q11.2 |
FGFR2 Intergenic TOX3 Intergenic RAD51L1 MAP3K1 |
rs2981579-T rs11249433-C rs3803662-T rs13387042-A rs999737-C rs16886165-G |
0.41 0.39 0.27 0.51 0.76 0.15 |
2 x 10-10 7 x 10-10 1 x 10-9 2 x 10-8 2 x 10-7 5 x 10-7 |
1.17 [1.07-1.27] 1.16 [1.09-1.24] 1.16 [1.07-1.27] 1.25 [1.15-1.37] 1.06 [1.01-1.14] 1.23 [1.12-1.35] |
Illumina [528,173] |
N |
|
03/31/09 |
Newton-Cheh March 22, 2009 Nat Genet Common variants at ten loci influence QT interval duation in the QTGEN Study
|
QT interval |
13,685 individuals |
15,854 individuals |
1q23.3 1q23.3 1q23.3 16q21 6q22.31 11p15.5 1p36.31 7q36.1 7q36.1 11p15.5 16p13.13 3p22.2 17q12 |
NOS1AP NOS1AP NOS1AP CNOT1,GINS3, NDRG4, SLC38A7, GOT2 c6orf204,SLC35F1, PLN, ASF1A KCNQ1 RNF207,NPHP4, CHDS, ACOT7, PLEKHG5, KLH21 KCNH2 KCNH2 KCNQ1 LITAF,CLEC16A, SNN, ZC3H7A, TNFRSF17 SCN5A LIG3,RFFL |
rs12143842-T rs12029454-A rs16857031-G rs37062-G rs11756438-A rs2074238-T rs846111-C rs4725982-T rs2968864-C rs12576239-T rs8049607-T rs12053903-C rs2074518-T |
0.26 0.15 0.14 0.24 0.47 0.06 0.28 0.22 0.25 0.13 0.49 0.34 0.46 |
2 x 10-78 3 x 10-45 1 x 10-34 3 x 10-25 5 x 10-22 3 x 10-17 1 x 10-16 5 x 10-16 8 x 10-16 1 x 10-15 5 x 10-15 1 x 10-14 6 x 10-12 |
3.15 [2.81-3.49] msec increase 2.98 [2.63-3.32] msec increase 2.63 [2.28-2.97] msec increase 1.75 [1.41-2.09] msec decrease 1.4 [1.06-1.74] msec increase 7.88 [6.16-9.59] msec decrease 1.75 [1.41-2.09] msec increase 1.58 [1.23-1.92] msec increase 1.4 [1.06-1.74] msec decrease 1.75 [1.41-2.09] msec increase 1.23 [0.88-1.57] msec increase 1.23 [0.88-1.57] msec decrease 1.05 [0.71-1.39] msec decrease |
Affymetrix and Illumina [up to 2,543,686] (imputed) |
N |
|
04/02/09 |
Pfeufer March 22, 2009 Nat Genet Common variants at ten loci modulate the QT interval duration in the QTSCD Study
|
QT interval |
15,842 individuals |
up to 13,602 individuals |
1q23.3 1q23.3 16q21 6q22.31 6q22.31 11p15.5 1p36.31 1q24.2 7q36.1 16p13.13 3p22.2 17q24.3 |
NOS1AP NOS1AP NDRG4 PLN PLN KCNQ1 RNF207 ATP1B1 KCNH2 LITAF SCN5A KCNJ2 |
rs12143842-T rs4657178-T rs7188697-A rs11970286-T rs12210810-C rs12296050-T rs846111-C rs10919071-A rs2968863-T rs8049607-T rs11129795-A rs17779747-T |
0.24 0.33 0.74 0.44 0.06 0.20 0.29 0.87 0.29 0.46 0.23 0.35 |
2 x 10-78 7 x 10-33 7 x 10-25 2 x 10-24 2 x 10-17 3 x 10-17 4 x 10-16 1 x 10-15 2 x 10-15 6 x 10-15 5 x 10-14 6 x 10-12 |
2.88 [2.43-3.33] ms increase 2.19 [1.76-2.62] ms increase 1.66 [1.20-2.12] ms increase 1.64 [1.25-2.03] ms increase 3.13 [2.29-3.97] ms decrease 1.44 [0.95-1.93] ms increase 1.49 [1.00-1.98] ms increase 2.05 [1.48-2.62] ms increase 1.35 [0.90-1.80] ms decrease 1.25 [0.81-1.69] ms increase 1.27 [0.82-1.72] ms decrease 1.02 [0.53-1.51] ms decrease |
Affymetrix and Illumina [unsure] (imputed) |
N |
|
04/02/09 |
Org March 20, 2009 Hum Mol Genet Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations
|
Hypertension |
364 cases, 590 controls |
1,043 cases, 1,769 controls |
16q23.3 |
CDH13 |
rs11646213-T |
0.60 |
8 x 10-6 |
1.28 [1.15-1.43] |
Affymetrix [395,912] |
N |
|
03/31/09 |
Pillai March 20, 2009 PLoS Genet A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
|
Chronic Obstructive Pulmonary Disease |
823 cases, 810 controls |
2,840 family members, 389 cases, 472 controls |
15q25.1 4q31.22 |
CHRNA3,CHRNA4,CHRNA5, IREB2, PSMA4, NP_001013641.2,Q9UD29 HHIP |
rs8034191-C rs1828591-? |
0.33 NR |
1 x 10-10 1 x 10-7 |
1.4 [1.18-1.67] 1.38 [1.17-1.63] |
Ilumina [493,609] |
N |
|
03/30/09 |
Takeuchi March 20, 2009 PLoS Genet A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose
|
Warfarin maintenance dose |
1,053 individuals |
588 individuals |
16p11.2 10q23.33 10q23.33 19p13.12 |
VKORC1 CYP2C9 CYP2C9 CYP4F2 |
rs9923231-T rs1057910-? rs1799853-? rs2108622-? |
0.40 0.07 0.11 0.24 |
3 x 10-181 3 x 10-79 1 x 10-31 3 x 10-10 |
.97 [0.91-1.02] mg/week decrease 1.11 [1.00-1.22] mg/week decrease .54 [0.45-0.63] mg/week decrease .21 [0.14-0.27] mg/week increase |
Illumina [325,997] |
N |
|
03/31/09 |
Wilk March 20, 2009 PLoS Genet A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study
|
Pulmonary function measures |
7,691 individuals |
835 individuals |
4q31.22 |
HHIP |
rs13147758-G |
0.39 |
8 x 10-11 |
.1 [NR] % increase in FEV1/FVC ratio |
Affymetrix [2,540,223] (imputed) |
N |
|
04/01/09 |
Tanaka March 18, 2009 Am J Hum Genet Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations
|
Folate pathway vitamin levels |
2,934 individuals |
686 individuals |
19q13.33 1p36.12 10p13 11q12.1 3p14.1 |
FUT2 ALPL CUBN TCN1 PRICKLE2 |
rs602662-A rs4654748-C rs11254363-A rs526934-A rs153734-T |
0.53 0.50 0.70 0.67 0.84 |
3 x 10-20 (vitamin B12) 8 x 10-18 (vitamin B6) 1 x 10-6 (vitamin B12) 2 x 10-6 (vitamin B12) 7 x 10-6 (folate) |
49.77 [37.09-62.45] pg/ml increase 1.45 [0.90-2.00] ng/ml decrease 21.49 [7.71-35.27] pg/mL decrease 27.62 [11.65-43.59] pg/mL increase .29 [0.13-0.45] ng/ml increase |
Affymetrix and Illumina [~2.5 million] (imputed) |
N |
|
03/31/09 |
Kilpivaara March 15, 2009 Nat Genet A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms
|
Myeloproliferative neoplasms |
324 cases, 2,999 controls |
NR |
9p24.1 |
JAK2 |
rs10974944-? |
NR |
4 x 10-20 |
3.1 [2.40-4.00] |
Affymetrix [62,775] |
N |
|
03/31/09 |
Cui March 14, 2009 Mol Med Genome Wide Association Study of Determinants of Anti-cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis
|
Anti-cyclic Citrullianted Peptide Antibody |
531 individuals with rheumatoid arthritis |
849 individuals with rheumatoid arthritis |
6p21.32 |
HLA-DRA, HLA-DR3,BTNL2 |
rs1980493-? |
0.13 |
5 x 10-7 |
NR |
Affymetrix [97,248] |
N |
|
03/29/09 |
Liu March 13, 2009 PLoS Genet Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche
|
Menarche (age at onset) |
477 women |
854 siblings, 762 women, 1,387 Chinese women |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [379,319] |
N |
|
03/30/09 |
Tregouet March 10, 2009 Blood Common susceptibility allele are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach
|
Venous thromboembolism |
419 cases, 1,228 controls |
1,757 cases, 1,480 controls |
9q34.2 |
ABO |
rs505922-C |
0.35 |
4 x 10-15 |
1.81 [1.56-2.11] |
Illumina [291,872] |
N |
|
03/28/09 |
Birnbaum March 08, 2009 Nat Genet Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
|
Nonsyndromic cleft lip with or without cleft palate |
224 cases, 383 controls |
246 cases, 954 controls |
8q24.21 1q32.2 |
PVT1, GSDMC IRF6 |
rs987525-A rs642961-A |
0.20 NR |
3 x 10-24 2 x 10-6 |
2.57 [2.02-3.26] NR |
Illumina [521,176] |
N |
|
03/24/09 |
Liu March 04, 2009 Am J Hum Genet Genome-wide Association and Replication Studies Identified TRHR as an Important Gene for Lean Body Mass
|
Body mass (lean) |
1,000 individuals |
1,488 individuals, 1,972 family members, 2,955 Chinese individuals |
8q23.1 |
TRHR |
rs7832552-T |
0.32 |
4 x 10-10 |
.1 [0.04-0.16] kg increase |
Affymetrix [379,319] |
N |
|
03/24/09 |
Vink March 04, 2009 Am J Hum Genet Genome-wide Association Study of Smoking Initiation and Current Smoking
|
Smoking behavior |
3,540 individuals |
6,405 individuals, 824 twin pairs |
NS |
NS |
NS |
NS |
NS |
NS |
Perlegen [427,037] |
N |
|
03/28/09 |
Hattori March 02, 2009 Am J Med Genet B Neuropsychiatr Genet Preliminary genome-wide association study of bipolar disorder in the Japanese population
|
Bipolar disorder |
107 cases, 107 controls |
395 cases, 409 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [88,671] |
N |
|
04/01/09 |
Caporaso February 27, 2009 PLoS ONE Genome-wide and candidate gene association study of cigarette smoking behaviors
|
Smoking behavior |
4,611 individuals (2,617 smokers) |
NR |
3q13.12 1p22.3 1p35.2 3q24 12q21.2 16p13.2 18q11.2 19p12 5q14.3 9p21.2 9q31.1 Xq23 14q24.1 17p13.2 Xp11.3 12q21.33 13q33.1 4q31.1 7p15.2 3q27.2 4q28.1 |
BBX AK002179 Intergenic Intergenic Intergenic Intergenic CABLES1 ZNF505 LOC133789 Intergenic Intergenic TRPC5 ACTN1 CAMKK1 MAOA Intergenic Intergenic SET7 Intergenic Intergenic Intergenic |
rs6437740-? rs7553864-? rs910696-? rs800082-? rs1402279-? rs3112740-? rs11082304-? rs10411195-? rs933688-? rs1889899-? rs10989661-? rs7050529-? rs2268983-? rs758642-? rs3027409-? rs1847461-? rs912969-? rs17050782-? rs886716-? rs6444087-? rs950063-? |
0.24 0.39 0.31 0.42 0.95 0.86 0.49 0.03 0.17 0.37 0.74 0.07 0.51 0.34 0.95 0.94 0.07 0.21 0.69 0.26 0.39 |
2 x 10-7 (CPD) 3 x 10-6 (SMKDU) 3 x 10-6 (CPD) 3 x 10-6 (PKYRS) 5 x 10-6 (EVNV) 6 x 10-6 (CPDBI) 6 x 10-6 (SMKAGE) 6 x 10-6 (CPD) 6 x 10-6 (EVNV) 6 x 10-6 (EVNV) 6 x 10-6 (CIGSTAT) 6 x 10-6 (CPD) 7 x 10-6 (CPDBI) 7 x 10-6 (CPD) 7 x 10-6 (CPDBI) 8 x 10-6 (CIGSTAT) 8 x 10-6 (SMKDU) 8 x 10-6 (SMKAGE) 8 x 10-6 (CPDBI) 9 x 10-6 (EVNV) 9 x 10-6 (SMKDU) |
.1 [NR] fewer cigarettes per day .08 [NR] more years .08 [NR] more cigarettes per day .12 [NR] more pack years 1.51 [NR] 2.16 [NR] .03 [NR] years older .21 [NR] fewer cigarettes per day 1.48 [NR] 1.26 [NR] 1.68 [NR] .06 [NR] fewer cigarettes per day 1.52 [NR] .08 [NR] more cigarettes per day 1.73 [NR] 1.8 [NR] .14 [NR] fewer years .03 [NR] years older 1.52 [NR] 1.28 [NR] .08 [NR] fewer years |
Illumina [~518,000] (pooled) |
N |
|
03/18/09 |
Pezzolesi February 27, 2009 Diabetes Genome-wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes Mellitus
|
Diabetic nephropathy |
820 cases, 885 controls |
1,304 individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [359,193] |
N |
|
03/18/09 |
Gu February 25, 2009 Nature Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
|
Cystic fibrosis severity |
160 severe lung disease patients, 160 mild lung disease patients (all homozygous for CFTR deltaF508 variant) |
101 severe lung disease patients, 381 mild lung disease patients, 1,118 family members |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [100,198] (pooled) |
N |
|
03/18/09 |
Xiong February 25, 2009 Am J Hum Genet Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups
|
Bone mineral density |
1,000 white individuals |
4,925 white individuals, 350 Chinese hip fracture cases, 350 Chinese controls, 2,955 Chinese individuals, 908 West African men |
16q23.1 1p22.2 |
ADAMTS18 TGFBR3 |
rs11864477-C rs17131547-A |
0.12 0.01 |
2 x 10-8 (hip BMD) 1 x 10-6 (spine BMD) |
1 % [NR] of variance explained 1.2 % [NR] of variance explained |
Affymetrix [379,319] |
N |
|
03/01/09 |
Schrauwen February 18, 2009 Am J Hum Genet A Genome-wide Analysis Identifies Genetic Variants in the RELN Gene Associated with Otosclerosis
|
Otosclerosis |
302 cases, 302 controls |
847 cases, 872 controls |
7q22.1 |
RELN |
rs3914132-? |
0.23 |
2 x 10-8 |
1.54 [1.32-1.79] |
Illumina [~555,000] (pooled) |
N |
|
05/07/09 |
Smith February 15, 2009 Heart Rhythm Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae
|
Electrocardiographic conduction measures |
1,262 Kosraen individuals |
NR |
3p22.2 4p16.1 3p22.2 1q32.1 4q31.3 2q31.1 6p12.2 |
SCN5A MSX1 SCN5A NR NR Intergenic NR |
rs7638909-G rs2008242-? rs2070488-A rs7512898-? rs17030434-? rs2461751-G rs283566-? |
0.40 0.15 0.33 0.41 0.43 0.44 0.16 |
2 x 10-6 (PR interval) 3 x 10-6 (PR segment) 4 x 10-6 (PR interval) 5 x 10-6 (PR segment) 5 x 10-6 (P wave duration) 8 x 10-6 (PR interval) 9 x 10-6 (P wave duration) |
4.8 [2.84-6.76] ms increase NR 5 [2.84-7.16] ms decrease NR NR 4.54 [2.58-6.50] ms increase NR |
Affymetrix [338,049] |
N |
|
02/28/09 |
Zheng February 15, 2009 Nat Genet Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
|
Breast cancer |
1,505 Chinese cases, 1,522 Chinese controls |
1,554 Chinese cases, 1,576 Chinese controls |
6q25.1 |
C6orf97 |
rs2046210-A |
0.37 |
2 x 10-15 |
1.29 [1.21-1.37] |
Affymetrix [up to 607,728] |
N |
|
02/28/09 |
Soranzo February 12, 2009 Blood A novel variant on chromosome 7Q22.3 associated with mean platelet volume, counts and function
|
Mean platelet volume |
1,221 individuals |
7,365 individuals |
7q22.3 |
Intergenic |
rs342293-G |
0.45 |
1 x 10-24 |
.02 [0.014-0.018] log fl increase |
Affymetrix [361,352] |
N |
|
03/01/09 |
Erdmann February 08, 2009 Nat Genet New susceptibility locus for coronary artery disease on chromosome 3q22.3
|
Coronary artery disease |
6,990 cases, 8,955 controls |
12,417 cases, 12,411 controls |
3q22.3 12q24.31 |
MRAS HNF1A,C12orf43 |
rs9818870-T rs2259816-T |
0.15 0.36 |
7 x 10-13 5 x 10-7 |
1.15 [1.11-1.19] 1.08 [1.05-1.11] |
Affymetrix [567,119] |
N |
|
03/01/09 |
Gudbjartsson February 08, 2009 Nat Genet Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
|
Plasma eosinophil count |
9,392 individuals |
12,118 individuals |
12q24.12 3q21.3 2q12.1 5q31.1 2q34 5q22.1 6p21.32 |
SH2B3 GATA2 IL1RL1 IL5 IKZF2 WDR36, TSLP MHC |
rs3184504-T rs4857855-T rs1420101-A rs4143832-C rs12619285-G rs2416257-G rs2269426-T |
0.38 0.82 0.41 0.16 0.74 0.85 0.76 |
7 x 10-19 (European) 9 x 10-17 (European) 5 x 10-14 (European) 1 x 10-10 (European) 5 x 10-10 (European) 1 x 10-6 (European) 3 x 10-6 (European) |
7.6 [5.9-9.3] % standard unit increase 9.4 [7.2-11.6] % standard unit increase 6.4 [4.7-8.1] % standard unit increase 7.1 [4.9-9.2] % standard unit increase 6.3 [4.3-8.3] % standard unit increase 6.1 [3.7-8.6] % standard unit increase 4.6 [2.7-6.6] % standard unit increase |
Illumina [312,179] |
N |
|
03/01/09 |
Kathiresan February 08, 2009 Nat Genet Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
|
Myocardial infarction (early onset) |
2,967 cases, 3,075 controls |
9,746 cases, 9,746 controls |
9p21.3 1p13.3 21q22.11 1q41 6p24.1 19p13.2 10q11.21 1p32.3 2q33.1 |
CDKN2A, CDKN2B CELSR2, PSRC1, SORT1 SLC5A3, MRPS6, KCNE2 MIA3 PHACTR1 LDLR CXCL12 PCSK9 WDR12 |
rs4977574-G rs646776-T rs9982601-T rs17465637-C rs12526453-C rs1122608-G rs1746048-C rs11206510-T rs6725887-C |
0.56 0.81 0.13 0.72 0.65 0.75 0.84 0.81 0.14 |
3 x 10-44 8 x 10-12 6 x 10-11 1 x 10-9 1 x 10-9 2 x 10-9 7 x 10-9 1 x 10-8 1 x 10-8 |
1.29 [1.25-1.34] 1.19 [1.13-1.26] 1.2 [1.14-1.27] 1.14 [1.10-1.19] 1.12 [1.08-1.17] 1.15 [1.10-1.20] 1.17 [1.11-1.24] 1.15 [1.10-1.21] 1.17 [1.11-1.23] |
Affymetrix [~2.5 million] (imputed) |
N |
|
04/01/09 |
Tregouet February 08, 2009 Nat Genet Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
|
Coronary artery disease |
1,926 cases, 2,938 controls |
7,073 cases, 7,325 controls |
6q25.3 6q25.3 |
SLC22A3,LPAL2,LPA SLC22A3,LPAL2,LPA |
4-SNP haplotype-2 4-SNP haplotype-1 |
0.02 0.16 |
4 x 10-15 (CCTC) 1 x 10-9 (CTTG) |
1.82 [1.57-2.12] 1.2 [1.13-1.28] |
Affymetrix [~500,000] |
N |
|
02/28/09 |
Gudmundsson February 06, 2009 Nat Genet Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
|
Thyroid cancer |
192 cases, 37,196 controls |
432 cases, 1,727 controls |
9q22.33 14q13.3 |
FOXE1 NKX2-1 |
rs965513-A rs944289-T |
0.34 0.57 |
2 x 10-27 2 x 10-9 |
1.75 [1.59-1.94] 1.37 [1.24-1.52] |
Illumina [304,083] |
N |
|
10/15/09 |
Lowe February 06, 2009 PLoS Genet Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
|
Quantitative traits |
Up to 2,906 Micronesian individuals |
NR |
11q23.3 19q13.32 19q13.32 3q25.33 10p12.33 5q13.3 7p22.2 9q22.33 10p15.3 12p13.33 19q13.32 19q13.32 20q13.12 7p14.1 7q36.3 9p21.3 2q22.2 12q24.13 12q24.31 19q13.32 5q35.3 9p21.3 10p13 10p13 2p23.3 5q13.3 5q35.1 4q21.21 10p15.3 6q16.2 6p22.3 7p21.3 7q34 |
Intergenic TOMMM40, APOC2, APOE, APOC4, APOC1 MGC2650, BLOC1S3, XTP7 SCHIP1 CACNB2 COL4A3BP, HMGCR SDK1 HEMGN, C9ORF156 ADARB2 ENSG00000118975, FKBP4 TOMM40, APOC2, APOE, APOC4, APOC1 MGC2650, BLOC1S3, XTP7 Intergenic Intergenic UBE3C Intergenic ARHGAP15 Intergenic SPPL3 TOMM40, APOC2, APOE, APOC4, APOC1 MGAT1 Intergenic ITGA8 CUBN ENSG0000173957, UBXD4, FKBP1B, FLJ21945 COL4A3BP, HMGCR Intergenic Intergenic ADARB2 Intergenic Intergenic Intergenic TRIM24 |
rs7396835-T rs4420638-G rs2159324-T rs2222328-C rs7069923-C rs3846663-T rs6462411-C rs755109-C rs6560749-T rs10848704-C rs4420638-G rs2159324-T rs6066084-A rs10486715-A rs2527866-C rs2225614-C rs10928195-C rs11066587-G rs1039302-T rs4420638-G rs655601-A rs613391-G rs7895372-G rs10508517-A rs7561273-A rs3846663-T rs254893-A rs10518224-A rs6560749-T rs6909430-G rs10498712-G rs17157663-A rs1874326-G |
0.32 0.21 0.44 0.32 0.49 0.39 0.20 0.23 0.14 0.35 0.21 0.44 0.06 0.07 0.23 0.50 0.08 0.16 0.36 0.21 0.47 0.49 0.04 0.43 0.35 0.39 0.06 0.23 0.14 0.08 0.25 0.32 0.47 |
1 x 10-9 (TG) 3 x 10-7 (TC) 4 x 10-7 (LDL-C) 8 x 10-7 (WC) 1 x 10-6 (SBP) 1 X 10-6 (LDL-C) 1 x 10-6 (TSH) 1 x 10-6 (TSH) 2 x 10-6 (BMI) 2 x 10-6 (TSH) 2 x 10-6 (CRP) 2 x 10-6 (CRP) 2 x 10-6 (% body fat) 3 x 10-6 (height) 3 x 10-6 (SBP) 3 x 10-6 (weight) 4 x 10-6 (weight) 5 x 10-6 (CRP) 5 x 10-6 (CRP) 5 x 10-6 (TG) 5 x 10-6 (HDL-C) 5 x 10-6 (WC) 6 x 10-6 (TC) 6 x 10-6 (DBP) 6 x 10-6 (CRP) 6 x 10-6 (TC) 6 x 10-6 (DBP) 7 x 10-6 (TG) 8 x 10-6 (% body fat) 8 x 10-6 (TSH) 9 x 10-6 (HDL-C) 9 x 10-6 (TC) 9 x 10-6 (weight) |
.23 [NR] mg/dL increase .28 [NR] mg/dL increase .21 [NR] mg/dL decrease .22 [NR] inch decrease .19 [NR] mm Hg increase .21 [NR] mg/dL increase .36 [NR] mIU/L decrease .31 [NR] mIU/L decrease .32 [NR] kg/m2 decrease .29 [NR] mIU/L decrease .28 [NR] mg/L decrease .19 [NR] mg/L decrease .85 [NR] % increase .44 [NR] inch decrease .27 [NR] mm Hg decrease .21 [NR] lb. decrease .36 [NR] lb. decrease .26 [NR] mg/L increase .21 [NR] mg/L increase .22 [NR] mg/dL increase .23 [NR] mg/dL increase .2 [NR] inch increase .35 [NR] mg/dL decrease .18 [NR] mm Hg decrease .22 [NR] mg/L decrease] .19 [NR] mg/dL increase .58 [NR] mm Hg decrease .19 [NR] mg/dL increase .34 [NR] % decrease .49 [NR] mIU/L decrease .23 [NR] mg/dL increase .18 [NR] mg/dL decrease .22 [NR] lb. increase |
Affymetrix [408,775] |
N |
|
08/21/09 |
Need February 06, 2009 PLoS Genet A genome-wide investigation of SNPs and CNVs in schizophrenia
|
Schizophrenia |
871 European ancestry cases, 863 European ancestry controls |
1,460 European ancestry cases, 12,995 European ancestry controls |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [312,565] (pooled) |
N |
|
02/27/09 |
Garcia-Barcelo February 05, 2009 Proc Natl Acad Sci USA Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease
|
Hirschsprung's disease |
181 Chinese cases, 346 Chinese controls |
190 Chinese cases, 510 Chinese controls |
10q21.1 8p12 |
RET, GALNACT-2, RASGEF1A NRG1 |
rs2742234-T rs16879552-G |
NR 0.39 |
4 x 10-18 2 x 10-8 |
NR 1.68 [1.40-2.00] |
Affymetrix [293,836] |
N |
|
03/31/09 |
Chio February 04, 2009 Hum Mol Genet A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
|
Amyotrophic lateral sclerosis |
553 cases, 2,338 controls |
3,149 cases, 3,335 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [545,066] |
N |
|
02/27/09 |
Liu February 03, 2009 Mol Psychiatry Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15
|
Smoking behavior |
417 Caucasian males, 423 Caucasian females |
412 African American males, 839 African American females, 3,491 Caucasian males, 4,132 Caucasian females |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [379,319] |
N |
|
02/28/09 |
Kim February 01, 2009 Clin Exp Allergy Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis
|
Asthma (toluene diisocyanate-induced) |
84 Korean cases, 263 Korean controls |
NR |
13q12.13 10q21.3 9p21.3 |
Intergenic CTNNA3 Intergenic |
rs9319321-T rs10762058-G rs16937883-G |
0.29 0.25 0.02 |
3 x 10-6 6 x 10-6 7 x 10-6 |
5.2 [2.47-10.92] 5 [2.36-10.6] 5.29 [2.41-11.61] |
Affymetrix [312,978] |
N |
|
02/27/09 |
Kim February 01, 2009 Pharmacogenomics Genome-wide association study of acute post-surgical pain in humans
|
Pain |
60 females, 52 males |
NR |
19p12 11q23.3 1p21.3 |
LOC400680, ZNF429 NR NR |
rs2562456-? rs17122021-? rs6693882-? |
NR NR NR |
2 x 10-10 (onset time of analgesia) 7 x 10-7 (maximum post-operative pain rating) 2 x 10-6 (post-operative pain onset time) |
NR NR NR |
Affymetrix [374,975] |
N |
|
03/30/09 |
Polasek February 01, 2009 Croat Med J Genome-wide association study of anthropometric traits in Korcula Island, Croatia
|
Anthropometric traits |
898 individuals |
NR |
16p11.2 14q32.13 14q23.3 5q33.3 7q22.1 1p36.32 7q22.1 13q14.3 2q31.1 5q33.3 7q22.1 2p22.3 5q33.2 |
SEZ6L2 LOC122509, FAM14B MAX SGCD ZNF498 Intergenic ZNF498 XTP498 Intergenic SGCD ZNF498 CRIM1 AMPA1, GRIA1 |
rs4787483-? rs7157940-? rs7158173-? rs157350-? rs7792939-? rs7513590-? rs7792939-? rs7792939-? rs7590983-? rs157350-? rs7792939-? rs1863080-? rs12658202-? |
0.34 0.46 0.48 0.11 0.15 0.10 0.15 0.28 0.05 0.11 0.15 0.10 0.45 |
2 x 10-6 (waist cirumference) 3 x 10-6 (weight) 4 x 10-6 (waist circumference) 4 x 10-6 (brachial circumference) 4 x 10-6 (weight) 5 x 10-6 (height) 5 x 10-6 (brachial circumference) 6 x 10-6 (brachial circumference) 6 x 10-6 (BMI) 6 x 10-6 (hip circumference) 6 x 10-6 (hip circumference) 8 x 10-6 (brachial circumference) 9 x 10-6 (height) |
.16 [0.09-0.23] mm increase .12 [0.07-0.17] kg increase .11 [0.06-0.16] mm decrease .31 [0.18-0.44] mm decrease .26 [0.15-0.37] kg increase .31 [0.17-0.45] mm decrease .26 [0.15-0.37] mm increase .17 [0.10-0.24] mm increase .46 [0.26-0.66] kg/m2 increase .31 [0.18-0.44] mm decrease .26 [0.15-0.37] mm increase .31 [0.17-0.45] mm increase .11 [0.06-0.16] mm increase |
Illumina [316,730] |
N |
|
02/25/09 |
Stefansson February 01, 2009 Nat Genet Variant in the sequence of the LINGO1 gene confers risk of essential tremor
|
Essential tremor |
452 cases, 14,378 controls |
300 cases, 1,419 controls |
15q24.3 |
LINGO1 |
rs9652490-G |
0.23 |
1 x 10-9 |
1.55 [1.35-1.79] |
Illumina [305,624] |
N |
|
03/31/09 |
Zemunik February 01, 2009 Croat Med J Genome-wide association study of biochemical traits in Korcula Island, Croatia
|
Biochemical measures |
898 individuals |
NR |
4p16.1 12q24.23 4q12 4q13.1 6q16.3 12q12 4q31.23 Xp22.31 12q21.33 12q24.23 4q23 18q12.3 Xq23 20p12.1 21q22.3 21q22.3 16q13 |
SLC2A9 KSR2 USP46 LPHN3 GRIK2 Intergenic NR3C2 Neuroligin 4 Intergenic KSR2 RAP1GDS1 SLC14A2 ZCCHC16 PCSK2 PKNOX1 PKNOX1 CETP |
rs13129697-C rs4767631-A rs346923-A rs4599440-A rs12207601-G rs871392-A rs1490453-A rs7885458-G rs10777332-A rs10444502-C rs10516430-A rs10502868-G rs5982533-G rs6044777-A rs2839619-G rs2839619-G rs7499892-A |
0.25 0.31 0.13 0.23 0.16 0.15 0.17 0.24 0.11 0.28 0.28 0.08 0.22 0.17 0.40 0.40 0.16 |
1 x 10-9 (uric acid) 6 x 10-7 (LDL cholesterol) 2 x 10-6 (triglycerides) 2 x 10-6 (HDL cholesterol) 2 x 10-6 (fibrinogen) 3 x 10-6 (HDL cholesterol) 3 x 10-6 (fibrinogen) 3 x 10-6 (fibrinogen) 5 x 10-6 (total cholesterol) 6 x 10-6 (total cholesterol) 6 x 10-6 (triglycerides) 7 x 10-6 (albumin) 7 x 10-6 (triglycerides) 8 x 10-6 (fibrinogen) 8 x 10-6 (total cholesterol) 8 x 10-6 (LDL cholesterol) 9 x 10-6 (HDL cholesterol) |
.29 [0.21-0.37] umol/l decrease .12 [0.11-0.23] mmol/L decrease .28 [0.17-0.39] mmol/L decrease .2 [0.12-0.28] mmol/L increase .26 [0.15-0.37] g/L decrease .26 [0.15-0.37] mmol/L decrease .25 [0.15-0.35] g/L increase .23 [0.13-0.33] g/L decrease .24 [0.14-0.34] mmol/L decrease .17 [0.10-0.24] mmol/L decrease .16 [0.09-0.23] mmol/L decrease .04 [0.21-0.51] g/L decrease .23 [0.13-0.33] mmol/L decrease .23 [0.13-0.33] g/L increase .13 [0.07-0.19] mmol/L increase .13 [0.08-0.18] mmol/L increase .24 [0.14-0.34] mmol/L decrease |
Illumina [316,730] |
N |
|
02/25/09 |
Timpson January 30, 2009 Hum Mol Genet Common variants in the region around Osterix are associated with bone mineral density and growth in childhood
|
Bone mineral density |
1,418 children, 135 adults |
3,875 children |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [up to 315,807] |
N |
|
02/28/09 |
Ferrucci January 29, 2009 Am J Hum Genet Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
|
Plasma carotenoid and tocopherol levels |
1,191 individuals |
2,751 individuals |
16q23.2 11q23.3 |
BCMO1 APOA5 |
rs6564851-G rs12272004-A |
0.39 0.07 |
2 x 10-24 (beta-carotene) 8 x 10-10 (alpha-tocopherol) |
.15 [0.120-0.177] umol/L increase .07 [0.049-0.095] umol/L increase |
Illumina [~500,451] (pooled) |
N |
|
02/26/09 |
Yang January 28, 2009 JAMA Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
|
Treatment response for acute lymphoblastic leukemia |
487 children |
NR |
10p12.33 2q33.1 4q31.21 20q13.12 7p14.2 7p21.2 10q26.12 11p15.1 6q25.3 5p13.2 10p14 11q21 |
ST8SIA6 C2orf47 IL15 NCOA3 ELMO1 DGKB intergenic intergenic intergenic LMBRD2 Intergenic MAML2 |
rs359312-T rs1569175-T rs17007695-C rs6125048-T rs4723619-C rs6971925-T rs2901286-A rs7128311-C rs35229355-T rs267759-A rs10508343-A rs7115578-A |
0.04 0.11 0.10 0.04 0.07 0.02 0.03 0.03 0.03 0.05 0.04 0.64 |
9 x 10-8 9 x 10-7 9 x 10-7 2 x 10-6 3 x 10-6 3 x 10-6 4 x 10-6 5 x 10-6 5 x 10-6 7 x 10-6 8 x 10-6 8 x 10-6 |
3.91 [1.52-10.10] 2.73 [1.52-4.93] 2.67 [1.53-4.68] 2.73 [1.08-6.88] 3.01 [1.50-6.03] 13.91 [2.72-70.92] 4.66 [1.58-13.7] 13.9 [2.72-71.1] 7.24 [2.46-21.30] 3.23 [1.52-6.87] 3.81 [1.40-10.40] 1.86 [1.23-2.79] |
Affymetrix [476,796] |
N |
|
02/06/09 |
Nair January 25, 2009 Nat Genet Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|
Psoriasis |
1,359 cases, 1,400 controls |
5,048 cases, 5,041 controls |
6p21.33 5q33.3 5q33.1 5q31.1 6q23.3 12q13.2 1p31.3 9q34.13 |
HLA-C IL12B TNIP1 IL13 TNFAIP3 IL23A, STAT2 IL23R TSC1 |
rs12191877-T rs2082412-G rs17728338-A rs20541-G rs610604-G rs2066808-A rs2201841-G rs1076160-T |
0.15 0.80 0.054 0.79 0.32 0.93 0.30 0.48 |
1 x 10-100 2 x 10-28 1 x 10-20 5 x 10-15 9 x 10-12 1 x 10-9 3 x 10-8 6 x 10-6 |
2.64 [NR] 1.44 [NR] 1.59 [NR] 1.27 [NR] 1.19 [NR] 1.34 [NR] 1.13 [NR] 1.09 [NR] |
Perlegen [~2.5 million] (imputed) |
N |
|
02/07/09 |
Zhang January 25, 2009 Nat Genet Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
|
Psoriasis |
1,139 Chinese cases, 1,132 Chinese controls |
5,721 Chinese cases, 7,340 Chinese controls |
1q21.3 5q33.3 6p21.33 |
LCE3D, LCE3A IL12B MHC |
rs4085613-A rs3213094-A rs1265181-? |
0.43 0.45 NR |
7 x 10-30 3 x 10-26 |
1.32 [1.25-1.39] 1.28 [1.23-1.35] 22.62 |
Illumina [494,902] |
N |
|
02/26/09 |
Otowa January 23, 2009 J Hum Genet Genome-wide association study of panic disorder in the Japanese population
|
Panic disorder |
200 Japanese cases, 200 Japanese controls |
NR |
12p13.31 1q32.1 17q25.1 12q13.13 13q32.1 6q25.1 8p21.1 1p13.3 3p26.1 12q12 19q13.33 6p12.3 14q23.1 20p13 5q21.1 12q24.33 21q21.1 |
TMEM16B PKP1 SDK2 CALCOCO1 Intergenic PLEKHG1 CLU Intergenic GRM7 Intergenic Intergenic TNFRSF21 Intergenic SMOX Intergenic Intergenic USP25 |
rs12579350-? rs860554-? rs3816995-? rs941184-? rs9302001-? rs9372078-? rs17466684-? rs12061304-? rs3749380-? rs2731006-? rs3810265-? rs2103868-? rs4901869-? rs16989303-? rs4702982-? rs7299940-? rs2823455-? |
0.01 0.05 0.03 0.03 0.20 0.11 0.09 0.10 0.25 0.29 0.07 0.26 0.02 0.21 0.16 0.29 0.03 |
4 x 10-9 5 x 10-8 2 x 10-7 3 x 10-7 3 x 10-7 5 x 10-7 7 x 10-7 1 x 10-6 2 x 10-6 4 x10-6 4 x 10-6 5 x 10-6 6 x 10-6 6 x 10-6 6 x 10-6 7 x 10-6 9 x 10-6 |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix [253,903] |
N |
|
02/25/09 |
Ling January 22, 2009 Obesity Genome-wide Linkage and Association Anaylses to Identify Genes Influencing Adiponectin Levels: The GEMS Study
|
Adiponectin levels |
997 cases, 989 controls |
NR |
3q27.3 5q35.2 |
ADIPOQ Intergenic |
rs6773957-A rs7722022-? |
0.37 NR |
5 x 10-8 9 x 10-6 |
NR NR |
Affymetrix [398,625] |
N |
|
03/03/09 |
Meyre January 18, 2009 Nat Genet Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
|
Obesity |
695 obese adults, 685 obese children, 731 lean adults, 685 lean children |
1,171 obese adults, 896 obese children, 1,114 lean adults, 1,297 lean children, 4,417 adults, 5,291 children |
16q12.2 18q21.32 16q23.2 10p13 18q11.2 |
FTO MC4R MAF PTER NPC1 |
rs1421085-C rs17782313-C rs1424233-A rs10508503-C rs1805081-A |
0.40 0.18 0.43 0.91 0.56 |
1 x 10-28 (children) 5 x 10-15 (children) 4 x 10-13 (children) 2 x 10-7 (children) 3 x 10-7 (children) |
1.39 [1.27-1.51] 1.22 [1.05-1.40] 1.12 [1.00-1.24] 1.56 [1.10-2.78] 1.33 [1.08-1.75] |
Illumina [308,846] |
N |
|
01/21/09 |
Tanaka January 16, 2009 PLoS Genet Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
|
Plasma levels of polyunsaturated fatty acids |
1,210 individuals |
1,076 individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [495,343] |
N |
|
02/27/09 |
Carrasquillo January 11, 2009 Nat Genet Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
|
Alzheimer's disease |
844 cases, 1,255 controls |
1,547 cases, 1,209 controls |
Xq21.31 |
PCDH11X |
rs2573905-? |
0.46 |
2 x 10-7 |
1.29 [1.17-1.42] |
Illumina [313,504] |
N |
|
01/21/09 |
Burgner January 09, 2009 PLoS Genet A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease
|
Kawasaki disease |
107 cases, 134 controls |
583 cases, 1,357 family members |
3q26.31 16q22.3 |
NAALADL2 ZFHX3 |
rs17531088-T rs7199343-T |
0.44 0.30 |
1 x 10-6 2 x 10-6 |
1.43 [1.32-1.53] 1.56 [1.33-1.92] |
Affymetrix [223,922] |
N |
|
02/25/09 |
Feulner January 07, 2009 Mol Psychiatry Examination of the current top candidate genes for AD in a genome-wide association study
|
Alzheimer's disease |
491 cases, 479 controls |
NR |
19q13.32 |
TOMM40, APOE |
rs157580-? |
NR |
1 x 10-40 |
NR |
Illumina [~550,000] |
N |
|
01/21/09 |
Ober January 07, 2009 J Lipid Res Genome-wide association study of plasma Lp(a)levels Identifies multiple genes on chromosome 6q
|
Plasma Lp (a) levels |
357 individuals |
1,054 individuals |
6q25.3 |
LPA |
rs6919346-? |
0.16 |
4 x 10-11 |
.66 [mg/dl decrease] |
Affymetrix [290,327] |
N |
|
01/21/09 |
Silverberg January 04, 2009 Nat Genet Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
|
Ulcerative colitis |
1,022 cases, 2,503 controls |
1,387 cases, 1,115 controls |
6p21.32 1p36.13 12q15 1p36.13 1p31.3 1p31.3 12q15 7q31.1 9q21.32 7q31.1 7q31.1 7q31.1 |
BTNL2, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1 OTUD3, PLA2G2E IFNG, IL26, IL22 RNF186 IL23R IL23R IL26 SLC26A3, DLD, LAMB1 Intergenic Intergenic SLC26A3, DLD, LAMB1 SLC26A3, DLD, LAMB1 |
rs2395185-? rs6426833-G rs1558744-A rs3806308-? rs11209026-? rs10889677-A rs2870946-G rs4598195-? rs668853-G rs4730273-? rs2158836-A rs4730276-? |
0.67 0.54 0.38 0.63 0.93 0.30 0.055 0.54 0.39 0.70 0.35 0.39 |
1 x 10-16 5 x 10-13 3 x 10-12 7 x 10-9 1 x 10-8 1 x 10-8 5 x 10-7 1 x 10-6 2 x 10-6 5 x 10-6 7 x 10-6 9 x 10-6 |
1.52 1.37 1.35 1.28 1.79 1.29 1.54 1.23 1.2 1.22 1.21 1.22 |
Illumina [280,748] |
N |
|
01/21/09 |
Beecham January 03, 2009 Am J Hum Genet Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
|
Alzheimer's disease |
492 cases, 496 controls |
238 cases, 220 controls |
12q13.11 19q13.31 1q42.2 |
FAM113B ZNF224 DISC1 |
rs11610206-? rs2061333-? rs12044355-? |
NR NR NR |
3 x 10-7 2 x 10-6 9 x 10-6 |
NR NR NR |
Illumina [~2.5 million] (imputed) |
N |
|
02/27/09 |
Hinks January 01, 2009 Arthritis Rheum Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis
|
Arthritis (juvenile idiopathic) |
279 cases, 184 controls |
up to 654 cases, 1,847 controls |
1p13.1 |
VTCN1 |
rs12046117-? |
0.09 |
1 x 10-6 |
1.58 [1.29-1.94] |
Affymetrix [88,862] |
N |
|
01/16/09 |
Limou January 01, 2009 J Infect Dis Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).
|
AIDS progression |
275 HIV positive patients, 1,438 controls |
626 patients |
6p21.33 6p21.33 6p21.33 |
HCP5, MICB, MCCD1, BAT1, LTB, TNF HLA-C ZNRD1, RNF39 |
rs2395029-G rs10484554-T rs8321-G |
0.03 0.13 NR |
3 x 10-19 6 x 10-8 5 x 10-7 |
3.47 [2.39-5.04] NR NR |
Illumina [291,119] |
N |
|
02/26/09 |
Sun January 01, 2009 Cancer Res Sequence variants at 22q13 are associated with prostate cancer risk
|
Prostate cancer |
1,235 aggressive cases, 1,599 controls |
3,629 aggressive cases, 4,255 non-aggressive cases, 5,738 controls |
22q13.1 |
TNRC6B |
rs9623117-C |
0.21 |
5 x 10-7 |
1.18 [1.11-1.26] |
Affymetrix and Illumina [~2 million] (imputed) |
N |
|
01/14/09 |
Zhang December 31, 2008 Mol Psychiatry Singleton deletions throughout the genome increase risk of bipolar disorder
|
Bipolar disorder |
1,001 cases, 1,033 controls |
NR |
Pending |
Pending |
Pending |
Pending |
Pending |
Pending |
Affymetrix [51,757 CNVs] |
Y |
|
01/14/09 |
Wang December 29, 2008 Proc Natl Acad Sci USA Whole-genome association study identifies STK39 as a hypertension susceptibility gene
|
Blood pressure |
542 individuals |
6,583 individuals |
2q24.3 |
STK39 |
rs6749447-G |
0.28 |
2 x 10-7 |
1.9 [1.2-2.6] mm Hg increase in DBP |
Affymetrix [79,447] |
N |
|
01/14/09 |
Meisinger December 24, 2008 Am J Hum Genet A genome-wide association study identifies three loci associated with mean platelet volume
|
Mean platelet volume |
1,606 individuals |
8,617 individuals |
12q24.31 17q11.2 3p14.3 |
WDR66 TAOK1 ARHGEF3 |
rs7961894-A rs2138852-C rs12485738-A |
0.11 0.47 0.30 |
7 x 10-48 7 x 10-28 4 x 10-27 |
.03 [0.03-0.04] per log fl increase .02 [0.01-0.02] per log fl decrease .02 [0.01-0.02] per log fl increase |
Affymetrix [335,152] |
N |
|
02/04/09 |
Muglia December 23, 2008 Mol Psychiatry Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts
|
Major depressive disorder |
1,359 cases, 1,782 controls |
NR |
12p13.32 |
CCND2 |
rs4238010-G |
0.02 |
6 x 10-6 |
1.72 |
Illumina and Affymetrix [494,678] (imputed) |
N |
|
06/22/09 |
Pare December 19, 2008 PLoS Genet Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
|
Glycated hemoglobin levels |
14,618 Caucasian women |
455 Caucasian men and women |
10q21.3 7p13 2q24.3 8q24.11 |
HK1 GCK G6PC2 SLC30A8 |
rs7072268-A rs730497-A rs1402837-A rs13266634-A |
0.50 0.17 0.23 0.30 |
2 x 10-25 6 x 10-12 5 x 10-10 5 x 10-8 |
.05 [NR] % increase .03 [NR] % increase .02 [NR] % increase .02 [NR] % decrease |
Illumina [337,343] |
N |
|
01/14/09 |
Benyamin December 17, 2008 Am J Hum Genet Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels
|
Serum markers of iron status |
459 twin pairs |
NR |
3q22.1 6p22.1 6p22.1 6p22.1 6p22.1 6p22.1 6p22.2 6p22.2 6p22.2 3q22.1 6q25.3 11p14.3 3q22.1 Xq24 2p14 6p22.1 3q22.1 6p22.2 22q12.3 7p14.1 18q22.2 5p12 5q14.1 6p22.2 |
TF HFE HFE HFE HIST1H2BJ BTN1A1 LRRC16 SLC17A1 LRRC16 TOPBP1 WTAP LUZP2 TF KLHL13 Q6ZNG6 TRIM38 TF LRRC16A TMPRSS6 Q4KMW4 Intergenic GHR ARSB SCGN |
rs3811647-? rs1800562-? rs1800562-? rs1800562-? rs13194491-? rs13194984-? rs2274089-? rs17270561-? rs2274089-? rs2718812-? rs4516970-? rs10500991-? rs1867504-? rs2430212-? rs1457451-? rs12216125-? rs1799852-? rs2274089-? rs4820268-? rs29880-? rs2660917-? rs13188386-? rs2052550-? rs932316-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR 0.09 NR NR NR NR NR NR NR |
3 x 10-15 (serum transferrin) 4 x 10-15 (transferrin saturation) 4 x 10-11 (serum iron) 1 x 10-10 (serum transferrin) 1 x 10-8 (transferrin saturation) 6 x 10-8 (transferrin saturation) 3 x 10-7 (serum transferrin) 5 x 10-7 (transferrin saturation) 8 x 10-7 (transferrin saturation) 1 x 10-6 (serum transferrin) 1 x 10-6 (serum ferritin) 2 x 10-6 (serum transferrin) 2 x 10-6 (serum transferrin) 2 x 10-6 (serum transferrin) 3 x 10-6 (transferrin saturation) 4 x 10-6 (transferrin saturation) 5 x 10-6 (serum transferrin) 5 x 10-6 (serum iron) 6 x 10-6 (serum iron) 7 x 10-6 (serum ferritin) 8 x 10-6 (serum ferritin) 8 x 10-6 (transferrin saturation) 8 x 10-6 (serum ferritin) 9 x 10-6 (transferrin saturation) |
.46 [0.34-0.58] SD decrease NR .66 [0.46-0.86] SD increase .68 [0.48-0.88] SD decrease NR NR NR NR NR NR NR NR NR NR NR NR .43 [0.25-0.61] SD decrease NR NR NR NR NR NR NR |
Illumina [315,887] |
N |
|
01/14/09 |
"
|
Serum markers of iron status |
411 family members |
NR |
3q22.1 6q22.33 14q23.2 |
TF RSPO3 Q6ZUR9 |
rs1830084-A rs972275-? rs973968-? |
0.36 NR NR |
1 x 10-9 (serum transferrin) 2 x 10-6 (serum ferritin) 3 x 10-6 (transferrin saturation) |
.43 [NR] SD increase NR NR |
Affymetrix [100,846] |
N |
|
01/14/09 |
Pollin December 17, 2008 Science A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
|
Triglycerides |
809 individuals |
698 individuals |
11q23.3 |
APOA1, APOC3, APOA4, APOA5, DSCAML1 |
rs10892151-A |
0.028 |
3 x 10-29 |
NR |
Affymetrix [381,934] |
N |
|
01/16/09 |
Styrkarsdottir December 14, 2008 Nat Genet New sequence variants associated with bone mineral density
|
Bone mineral density (hip) |
6,865 individuals |
8,510 individuals |
1p36.12 6q25.1 17q21.31 11p11.2 17q21.31 Xq21.2 2q12.1 3p22.1 |
Intergenic ESR1 SOST LRP4 C17orf53 NR NR NR |
rs7524102-A rs1038304-G rs1513670-A rs1007738-A rs227584-T rs2710057-T rs6735786-C rs10490823-G |
0.82 0.47 0.37 0.77 0.73 0.67 0.64 0.46 |
1 x 10-16 4 x 10-10 2 x 10-8 7 x 10-7 9 x 10-7 1 x 10-6 2 x 10-6 9 x 10-6 |
.15 [0.11-0.18] SD decrease .08 [0.06-0.11] SD decrease .08 [0.05-0.10] SD decrease .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD decrease .07 [0.04-0.09] SD decrease .07 [0.04-0.09] SD decrease .06 [0.03-0.09] SD decrease |
Illumina [305,051] |
N |
|
01/16/09 |
"
|
Bone mineral density (spine) |
6,865 individuals |
8,510 individuals |
13q14.11 6q25.1 1p36.12 12q13.13 2p16.2 2p22.2 21q11.2 |
RANKL C6orf97, ESR1 Intergenic OSX SPTBN1 LOC344382 NR |
rs9594759-T rs6929137-A rs6696981-G rs10876432-A rs11898505-G rs4670779-T rs1006899-A |
0.62 0.30 0.86 0.73 0.68 0.32 0.84 |
2 x 10-17 2 x 10-10 2 x 10-8 1 x 10-7 4 x 10-6 4 x 10-6 6 x 10-6 |
.12 [0.09-0.15] SD decrease .1 [0.07-0.13] SD decrease .12 [0.08-0.16] SD decrease .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD decrease .07 [0.04-0.10] SD decrease .09 [0.05-0.13] SD decrease |
Illumina [305,051] |
N |
|
01/15/09 |
Thorleifsson December 14, 2008 Nat Genet Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|
Body mass index |
80,969 individuals |
11,036 individuals |
16q12.2 2p25.3 16q12.2 18q21.32 19q13.11 1p31.1 3q27.2 16p11.2 11p14.1 11p14.1 1q25.2 12q13.13 1p21.3 11p14.1 |
FTO TMEM18 FTO MC4R KCTD15, CHST8 NEGR1 SFRS10, ETV5, DGKG SH2B1, ATP2A1 BDNF BDNF SEC16B, RASAL2 BCDIN3D, FAIM2 NR BDNF |
rs8050136-A rs7561317-G rs6499640-A rs12970134-A rs29941-C rs2568958-A rs7647305-C rs7498665-G rs6265-G rs925946-T rs10913469-C rs7138803-A rs10783050-C rs7481311-T |
0.41 0.84 0.41 0.30 0.69 0.58 0.77 0.44 0.85 0.34 0.20 0.37 0.36 0.24 |
1 x 10-47 4 x 10-17 4 x 10-13 1 x 10-12 7 x 10-12 1 x 10-11 7 x 10-11 3 x 10-10 5 x 10-10 9 x 10-10 6 x 10-8 1 x 10-7 4 x 10-6 8 x 10-6 |
8.04 [6.96-9.12] % SD 6.12 [4.69-7.55] % SD 5.25 [3.82-6.68] % SD 4.38 [3.16-5.60] % SD 4.18 [2.98-5.38] % SD 3.77 [2.67-4.87] % SD 4.42 [3.09-5.75] % SD 3.63 [2.49-4.77] % SD 4.58 [3.07-6.09] % SD 3.85 [2.62-5.08] % SD 3.36 [2.14-4.58] % SD 3.28 [2.06-4.50] % SD 2.6 [1.50-3.70] % SD 3.15 [1.78-4.52] % SD |
Illumina [305,846] |
N |
|
01/15/09 |
"
|
Weight |
80,969 individuals |
11,036 individuals |
16q12.2 2p25.3 16q12.2 18q21.32 16p11.2 11p14.1 3q27.2 19q13.11 1q25.2 1p31.1 6p21.33 11p14.1 12q13.13 13q12.2 1p21.3 5q23.2 11p14.1 |
FTO TMEM18 FTO MC4R SH2B1, ATP2A1 BDNF SFRS10, ETV5, DGKG KCTD15, CHST8 SEC16B, RASAL2 NEGR1 AIF1, NCR3 BDNF BCDIN3D, FAIM2 NR NR NR BDNF |
rs8050136-A rs7561317-G rs6499640-A rs12970134-A rs7498665-G rs925946-T rs7647305-C rs29941-C rs10913469-C rs2568958-A rs2844479-T rs6265-G rs7138803-A rs7336332-G rs1973993-C rs2115172-A rs7481311-T |
0.41 0.84 0.65 0.30 0.44 0.34 0.77 0.69 0.20 0.58 0.68 0.85 0.37 0.15 0.63 0.57 0.24 |
5 x 10-36 2 x 10-18 6 x 10-14 5 x 10-13 1 x 10-9 4 x 10-9 4 x 10-9 5 x 10-9 1 x 10-8 2 x 10-8 2 x 10-8 2 x 10-7 2 x 10-7 1 x 10-6 1 x 10-6 2 x 10-6 3 x 10-6 |
7.05 [5.95-8.15] % SD 6.47 [5.02-7.92] % SD 5.5 [4.07-6.93] % SD 4.66 [3.41-5.91] % SD 3.69 [2.51-4.87] % SD 3.8 [2.55-5.05] % SD 4 [2.67-5.33] % SD 3.73 [2.48-4.98] % SD 3.82 [2.51-5.13] % SD 3.37 [2.19-4.55] % SD 3.58 [2.33-4.83] % SD 4 [2.47-5.53] % SD 3.27 [2.05-4.49] % SD 4.01 [2.40-5.62] % SD 2.71 [1.61-3.81] % SD 2.71 [1.59-3.83] % SD 3.5 [2.03-4.97] % SD |
Illumina [305,846] |
N |
|
01/12/09 |
Willer December 14, 2008 Nat Genet Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
|
Body mass index |
32,387 individuals |
59,092 individuals |
16q12.2 2p25.3 18q21.32 4p13 16p11.2 11p11.2 19q13.11 1p31.1 11p15.4 20p12.3 15q25.2 |
FTO TMEM18 MC4R GNPDA2 SH2B1 MTCH2 KCTD15 NEGR1 STK33 BMP2 RKHD3 |
rs9939609-A rs6548238-C rs17782313-C rs10938397-G rs7498665-G rs10838738-G rs11084753-G rs2815752-A rs10769908-C rs2145270-T rs12324805-C |
0.41 0.84 0.21 0.45 0.41 0.34 0.67 0.62 0.53 0.65 0.31 |
4 x 10-51 1 x 10-18 5 x 10-18 3 x 10-16 5 x 10-11 5 x 10-9 2 x 10-8 6 x 10-8 1 x 10-6 6 x 10-6 7 x 10-6 |
.33 [0.27-0.39] kg/m2 increase .26 [0.19-0.34] kg/m2 increase .2 [0.12-0.28] kg/m2 increase .19 [0.13-0.25] kg/m2 .15 [0.08-0.21] kg/m2 increase .07 [0.01-0.13] kg/m2 increase .06 [-0.01-0.13] kg/m2 increase .1 [0.04-0.16] kg/m2 increase NR NR NR |
Illumina and Affymetrix
[2,399,588]
(imputed) |
N |
|
02/05/09 |
Mead December 11, 2008 Lancet Neurol Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study
|
Creutzfeldt-Jakob disease |
117 CJD cases, 3,083 controls |
506 sCJD cases, 28 iCJD cases, 151 Kuru cases, 125 Kuru-resistant cases, up to 1,137 controls |
20p13 8q21.13 |
PRNP STMN2 |
rs1799990-A rs1460163-A |
NR NR |
2 x 10-21 6 x 10-8 |
NR NR |
Affymetrix [288,908] |
N |
|
01/06/09 |
Sullivan December 09, 2008 Mol Psychiatry Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
|
Major depressive disorder |
1,738 cases, 1,802 controls |
6,079 cases, 5,893 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Perlegen [435,291] |
N |
|
01/12/09 |
Aulchenko December 07, 2008 Nat Genet Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|
Cholesterol, total |
22,562 individuals |
NR |
19p13.2 2p24.1 1p13.3 19q13.32 5q13.3 19p13.11 1p31.3 18q21.1 2p21 11q12.2 1p36.11 8q24.13 15q22.1 11q23.3 7p15.3 |
LDLR APOB CELSR2 TOMM40, APOE HMGCR NCAN DOCK7 LIPG ABCG5 FADS2, FADS3 TMEM57 TRIB1 LIPC APOA1, APOA4, APOA5, APOC3 DNAH11 |
rs2228671-G rs693-G rs646776-G rs2075650-G rs3846662-G rs2304130-G rs10889353-C rs4939883-G rs6756629-G rs174570-G rs10903129-G rs6987702-G rs1532085-G rs12272004-C rs12670798-G |
0.88 0.52 0.22 0.15 0.44 0.07 0.32 0.83 0.92 0.83 0.54 0.29 0.59 0.93 0.24 |
9 x 10-24 9 x 10-23 9 x 10-22 3 x 10-19 3 x 10-19 2 x 10-15 4 x 10-12 2 x 10-11 2 x 10-11 2 x 10-10 5 x 10-10 3 x 10-9 4 x 10-7 7 x 10-7 9 x 10-7 |
.16 [NR] SD increase .1 [NR] SD decrease .13 [NR] SD decrease .14 [NR] SD increase .09 [NR] SD increase .15 [NR] SD decrease .08 [NR] SD decrease .07 [NR] SD increase .15 [NR] SD increase .09 [NR] SD increase .06 [NR] SD increase .07 [NR] SD increase .05 [NR] SD decrease .11 [NR] SD decrease .06 [NR] SD increase |
Illumina and Affymetrix [up to ~600,000] |
N |
|
01/12/09 |
"
|
HDL cholesterol |
21,412 individuals |
NR |
16q13 15q22.1 8p21.3 16q22.1 9q31.1 18q21.1 11p11.2 2p24.1 19q13.32 11q12.2 |
CETP LIPC LPL CTCF, PRMT8 ABCA1 LIPG MADD, FOLH1 APOB TOMM40, APOE FADS2, FADS3 |
rs1532624-C rs1532085-G rs2083637-G rs2271293-G rs3905000-G rs4939883-G rs7395662-G rs6754295-C rs157580-G rs174570-G |
0.57 0.59 0.26 0.87 0.86 0.83 0.61 0.25 0.33 0.83 |
9 x 10-94 1 x 10-35 6 x 10-18 8 x 10-16 9 x 10-13 2 x 10-11 6 x 10-11 4 x 10-8 4 x 10-7 4 x 10-6 |
.21 [NR] SD decrease .13 [NR] SD decrease .11 [NR] SD increase .13 [NR] SD decrease .11 [NR] SD increase .1 [NR] SD increase .07 [NR] SD decrease .07 [NR] SD increase .06 [NR] SD increase .06 [NR] SD increase |
Illumina and Affymetrix [up to ~600,000] |
N |
|
01/12/09 |
"
|
LDL cholesterol |
17,797 individuals |
NR |
1p13.3 19q13.32 2p24.1 19p13.2 11q12.2 11q23.3 5q13.3 2p21 7p15.3 19p13.11 8q24.13 1p31.3 |
CELSR2 TOMM40, APOE APOB LDLR FADS2, FADS3 APOA1, APOA4, APOA5, APOC3 HMGCR ABCG5 DNAH11 NCAN TRIB1 DOCK7 |
rs646776-G rs157580-G rs693-G rs2228671-G rs174570-G rs12272004-C rs3846662-G rs6756629-G rs12670798-G rs2304130-G rs6987702-G rs10889353-C |
0.22 0.33 0.52 0.88 0.83 0.93 0.44 0.92 0.24 0.07 0.29 0.32 |
8 x 10-23 2 x 10-19 4 X 10-17 4 x 10-14 4 x 10-13 5 X 10-13 2 x 10-11 3 x 10-10 6 x 10-9 3 x 10-6 3 x 10-6 8 x 10-6 |
.16 [NR] SD decrease .11 [NR] SD decrease .1 [NR] SD decrease .14 [NR] SD increase .11 [NR] SD increase .18 [NR] SD decrease .08 [NR] SD increase .16 [NR] SD increase .09 [NR] SD increase .12 [NR] SD decrease .07 [NR] SD increase .06 [NR] SD decrease |
Illumina and Affymetrix [up to 600,000] |
N |
|
01/12/09 |
"
|
Triglycerides |
17,815 individuals |
NR |
2p23.3 8p21.3 11q23.3 7q11.23 1p31.3 19q13.32 2p24.1 19p13.11 |
GCKR LPL APOA1, APOA4, APOA5, APOC3 MLXIPL DOCK7 TOMM40, APOE APOB NCAN |
rs780094-G rs10096633-G rs12272004-C rs2240466-G rs1167998-C rs439401-G rs6754295-C rs2304130-G |
0.63 0.88 0.93 0.87 0.32 0.68 0.25 0.07 |
3 x 10-20 2 x 10-18 5 X 10-13 1 x 10-12 2 x 10-12 2 x 10-9 3 x 10-8 3 x 10-6 |
.1 [NR] SD decrease .17 [NR] SD increase .18 [NR] SD decrease .14 [NR] SD increase .09 [NR] SD decrease .09 [NR] SD increase .08 [NR] SD decrease .1 [NR] SD decrease |
Illumina and Affymetrix [up to 600,000] |
N |
|
01/07/09 |
Bouatia-Naji December 07, 2008 Nat Genet A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
|
Fasting plasma glucose |
2,151 individuals |
6,332 cases, 9,132 controls |
11q21 |
MTNR1B |
rs1387153-T |
0.29 |
2 x 10-36 |
.07 [0.05-0.08] mmol/l increase |
Illumina [308,846] |
N |
|
01/12/09 |
Kathiresan December 07, 2008 Nat Genet Common variants at 30 loci contribute to polygenic dyslipidemia
|
HDL cholesterol |
19,840 individuals |
Up to 20,623 individuals |
16q13 8p21.3 15q22.1 18q21.1 16q22.1 11q23.3 11q12.2 12q24.11 9p22.3 20q13.2 9q31.1 20q13.12 19p13.2 1q42.13 |
CETP LPL LIPC LIPG LCAT APOA1, APOC3, APOA4, APOA5 FADS1, FADS2, FADS3 MMAB,MVK TTC39B HNF4A ABCA1 PLTP ANGPTL4 GALNT2 |
rs173539-T rs12678919-G rs10468017-T rs4939883-T rs2271293-A rs964184-G rs174547-C rs2338104-C rs471364-C rs1800961-T rs1883025-T rs7679-C rs2967605-T rs4846914-G |
0.32 0.10 0.30 0.17 0.11 0.14 0.33 0.45 0.12 0.03 0.26 0.19 0.16 0.40 |
4 x 10-75 2 x 10-34 8 x 10-23 7 x 10-15 9 x 10-13 1 x 10-12 2 x 10-12 1 x 10-10 3 x 10-10 8 x 10-10 1 x 10-9 4 x 10-9 1 x 10-8 4 x 10-8 |
.25 [0.21-0.29] SD increase .23 [0.17-0.29] SD increase .1 [0.06-0.14] SD increase .14 [0.10-0.18] SD decrease .07 [0.01-0.13] SD increase .17 [0.11-0.23] SD decrease .09 [0.05-0.13] SD decrease .07 [0.03-0.11] SD decrease .08 [0.02-0.14] SD decrease .19 [0.09-0.29] SD decrease .08 [0.04-0.12] SD decrease .07 [0.03-0.11] SD decrease .12 [0.04-0.20] SD decrease .05 [0.01-0.09] SD decrease |
Affymetrix and Illumina [~2,600,000] (imputed) |
N |
|
01/12/09 |
"
|
LDL cholesterol |
19,840 individuals |
Up to 20,623 individuals |
1p13.3 2p24.1 19q13.32 19p13.2 2p21 5q13.3 5q33.3 20q12 12q24.31 19p13.11 1p32.3 |
CELSR2, PSRC1, SORT1 APOB APOE, APOC1, APOC4, APOC2 LDLR ABCG8 HMGCR TIMD4, HAVCR1 MAFB HNF1A NCAN, CILP2, PBX4 PCSK9 |
rs12740374-T rs515135-T rs4420638-G rs6511720-T rs6544713-T rs3846663-T rs1501908-G rs6102059-T rs2650000-A rs10401969-C rs11206510-C |
0.21 0.20 0.16 0.10 0.32 0.38 0.37 0.32 0.36 0.06 0.19 |
2 x 10-42 5 x 10-29 4 x 10-27 2 x 10-26 2 x 10-20 8 x 10-12 1 x 10-11 4 x 10-9 2 x 10-8 2 x 10-8 4 x 10-8 |
.23 [0.19-0.27] SD decrease .16 [0.12-0.20] SD decrease .29 [0.17-0.41] SD increase .26 [0.18-0.34] SD increase .15 [0.11-0.19] SD increase .07 [0.03-0.11] SD increase .07 [0.03-0.11] SD decrease .06 [0.03-0.10] SD decrease .07 [0.03-0.11] SD increase .05 [-0.03-0.13] SD decrease .09 [0.05-0.13] SD decrease |
Affymetrix and Illumina [~2,600,000] (imputed) |
N |
|
01/12/09 |
"
|
Triglycerides |
19,840 individuals |
Up to 20,623 individuals |
11q23.3 8p21.3 2p23.3 8q24.13 7q11.23 11q12.2 2p24.1 19p13.11 20q13.12 8p23.1 1p31.3 |
APOA1, APOC3, APOA4, APOA5 LPL GCKR TRIB1 MLXIPL FADS1, FADS2, FADS3 APOB NCAN,CILP2,PBX4 PLTP XKR6, AMAC1L2 ANGPTL3 |
rs964184-G rs12678919-G rs1260326-T rs2954029-T rs714052-G rs174547-C rs7557067-G rs17216525-T rs7679-C rs7819412-G rs10889353-C |
0.14 0.10 0.45 0.44 0.12 0.33 0.22 0.07 0.19 0.48 0.33 |
4 x 10-62 2 x 10-41 2 x 10-31 3 x 10-19 3 x 10-15 2 x 10-14 9 x 10-12 4 x 10-11 7 x 10-11 3 x 10-8 3 x 10-7 |
.3 [0.24-0.36] SD increase .25 [0.19-0.31] SD decrease .12 [0.08-0.16] SD increase .11 [0.07-0.15] SD decrease .16 [0.10-0.22] SD decrease .06 [0.02-0.10] SD increase .08 [0.04-0.12] SD decrease .11 [0.05-0.17] SD decrease .07 [0.03-0.11] SD increase .04 [0.001-0.08] SD decrease .05 [0.01-0.09] SD decrease |
Affymetrix and Illumina [~2,600,000] (imputed) |
N |
|
01/12/09 |
Sabatti December 07, 2008 Nat Genet Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|
HDL cholesterol |
4,763 individuals |
NR |
16q13 15q22.1 16q22.1 11p11.2 17p13.3 |
CETP LIPC LCAT NR1H3 Intergenic |
rs3764261-A rs1532085-A rs255049-G rs7120118-G rs9891572-A |
0.28 0.44 0.22 0.42 0.16 |
7 x 10-29 2 x 10-10 3 x 10-8 4 x 10-8 2 x 10-7 |
.09 [0.08-0.11] mmol/l increase .05 [0.03-0.06] mmol/l increase .05 [0.03-0.07] mmol/l increase .04 [0.03-0.05] mmol/l increase .05 [0.048-0.051] mmol/l increase |
Illumina [329,091] |
N |
|
01/12/09 |
"
|
LDL cholesterol |
4,763 individuals |
NR |
1p13.3 2p24.1 19q13.32 11q12.2 19p13.2 1q32.2 Xq12 |
CELSR2, PSRC1, SORT1 APOB APO cluster FADS1, FADS2 LDLR CR1L AR |
rs646776-G rs693-A rs157580-G rs174546-A rs11668477-G rs4844614-A rs5031002-A |
0.21 0.41 0.29 0.44 0.18 0.32 0.02 |
2 x 10-12 3 x 10-11 5 x 10-8 1 x 10-7 2 x 10-7 2 x 10-7 2 x 10-7 |
.16 [0.11-0.20] mmol/l decrease .12 [0.09-0.16] mmol/l increase .11 [0.07-0.15] mmol/l decrease .1 [0.06-0.13] mmol/l decrease .13 [0.08-0.17] mmol/l decrease .1 [0.06-0.14] mmol/l increase .3 [0.18-0.41] mmol/l increase |
Illumina [329,091] |
N |
|
01/12/09 |
"
|
Other metabolic traits |
4,763 individuals |
NR |
1q23.2 12q24.31 2p23.3 2q24.3 2p24.1 8p21.3 11q21 7p21.2 10q23.31 15q14 1p31.3 |
CRP LEF1 GCKR G6PC2, ABCB11 APOB LPL MTNR1B Intergenic PANK1 Intergenic LEPR |
rs2794520-A rs2650000-A rs1260326-A rs560887-A rs673548-A rs10096633-A rs1447352-G rs10244051-C rs11185790-A rs2624265-G rs12753193-G |
0.36 0.45 0.35 0.31 0.27 0.098 0.42 0.46 0.21 0.42 0.45 |
3 x 10-22 (CRP) 3 x 10-11 (CRP) 4 x 10-10 (TG) 6 x 10-10 (GLU) 2 x 10-8 (TG) 5 x 10-8 (TG) 6 x 10-8 (GLU) 1 x 10-7 (GLU) 3 x 10-7 (INS) 4 x 10-7 (TG) 4 x 10-7 (CRP) |
.47 [0.32-0.62] mmol/l decrease .4 [0.25-0.55] mmol/l decrease .09 [0.06-0.12] mmol/l increase .06 [0.04-0.07] mmol/l decrease .08 [0.05-0.11] mmol/l decrease .12 [0.07-0.17] mmol/l decrease .05 [0.03-0.06] mmol/l decrease .05 [0.03-0.06] mmol/l increase .31 [0.18-0.44] mmol/l decrease .07 [0.04-0.10] mmol/l increase .13 [-0.02-0.27] mmol/l decrease |
Illumina [329,091] |
N |
|
05/07/09 |
Lasky-Su December 05, 2008 Am J Med Genet B Neuropsychiatr Genet Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations
|
Attention deficit hyperactivity disorder |
909 trios |
NR |
12p11.22 3p24.3 14q23.2 2q21.2 16q22.1 13q32.3 1q41 22q12.3 2q24.1 1p31.2 2p21 3p14.1 11p13 19q13.43 3p14.2 4q13.3 2q14.1 2q14.3 8q24.3 |
Intergenic Intergenic Intergenic FLJ34870 HAS3 CLYBL Intergenic Intergenic Intergenic Intergenic OXER1 FOXP1 Intergenic ZNF544 FHIT EREG Intergenic Intergenic NAPRT1 |
rs522958-? rs11719664-? rs1514928-? rs7577925-? rs8047014-? rs7992643-? rs1018040-? rs130575-? rs1918172-? rs4147141-? rs930421-? rs17651978-? rs10767942-? rs260461-? rs6791644-? rs1350666-? rs272000-? rs17367118-? rs2290416-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
1 x 10-6 (binary) 2 x 10-6 (count) 3 x 10-6 (binary) 3 x 10-6 (binary) 4 x 10-6 (binary) 5 x 10-6 (count) 5 x 10-6 (binary) 5 x 10-6 (binary) 5 x 10-6 (count) 6 x 10-6 (count) 6 x 10-6 (binary) 6 x 10-6 (count) 8 x 10-6 (count) 8 x 10-6 (binary) 8 x 10-6 (count) 8 x 10-6 (binary) 9 x 10-6 (count) 9 x 10-6 (count) 9 x 10-6 (count) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Perlegen [429,981] |
N |
|
05/07/09 |
"
|
Hyperactive-impulsive symptoms |
909 trios |
NR |
12p11.22 6p22.3 2p21 8p21.3 1p13.2 15q14 21q21.3 3q26.1 9p24.3 19q13.43 1q41 3q26.1 18q22.1 6p22.3 |
Intergenic Intergenic OXER1 LPL Intergenic MEIS2 GRIK1 Intergenic DMRT2 LOC390980 Intergenic Intergenic Intergenic Intergenic |
rs522958-? rs41441749-? rs6719977-? rs7816032-? rs11590090-? rs8041675-? rs363512-? rs6808138-? rs17641078-? rs2014572-? rs1018040-? rs6808138-? rs13353224-? rs1202199-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
8 x 10-7 (binary) 1 x 10-6 (binary) 2 x 10-6 (binary) 2 x 10-6 (count) 3 x 10-6 (count) 4 x 10-6 (count) 4 x 10-6 (binary) 5 x 10-6 (binary) 5 x 10-6 (binary) 7 x 10-6 (count) 8 x 10-6 (binary) 8 x 10-6 (binary) 9 x 10-6 (count) 9 x 10-6 (count) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Perlegen [429,981] |
N |
|
05/07/09 |
"
|
Inattentive symptoms |
909 trios |
NR |
9q22.32 8q21.11 11q22.3 15q26.1 16q12.1 9q21.31 15q25.1 7q36.3 13q12.12 1p31.2 12q24.22 15q13.1 1p31.2 16q23.1 8p11.21 |
Intergenic Intergenic Intergenic SLCO3A1 ZNF423 Intergenic IL16 Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic |
rs11790994-? rs12679254-? rs10895959-? rs7495052-? rs17281813-? rs2769967-? rs7172689-? rs10227331-? rs17079773-? rs4650135-? rs478597-? rs1471225-? rs4147141-? rs13330107-? rs11786458-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
2 x 10-7 (binary) 2 x 10-6 (binary) 3 x 10-6 (binary) 3 x 10-6 (binary) 3 x 10-6 (binary) 3 x 10-6 (count) 4 x 10-6 (count) 4 x 10-6 (count) 5 x 10-6 (binary) 5 x 10-6 (binary) 8 x 10-6 (binary) 8 x 10-6 (count) 8 x 10-6 (binary) 9 x 10-6 (binary) 9 x 10-6 (binary) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Perlegen [429,981] |
N |
|
05/07/09 |
Lasky-Su December 05, 2008 Am J Med Genet B Neuropsychiatr Genet Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder
|
Attention deficit hyperactivity disorder (time to onset) |
930 trios |
NR |
6q15 2q36.3 7q31.1 11p15.1 3p22.3 9p23 3q29 20q13.13 14q23.1 5q35.3 8q23.3 |
Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic SULF2 Intergenic ADAMTS2 Intergenic |
rs806276-A rs1517484-C rs6968385-T rs874426-C rs9845475-G rs1325154-C rs3892715-C rs4810685-C rs1335515-C rs10039254-A rs17658378-A |
NR NR NR NR NR NR NR NR NR NR NR |
3 x 10-7 (later onset) 5 x 10-7 (earlier onset) 2 x 10-6 (earlier onset) 4 x 10-6 (earlier onset) 4 x 10-6 (later onset) 5 x 10-6 (later onset) 6 x 10-6 (earlier onset) 7 x 10-6 (earlier onset) 8 x 10-6 (earlier onset) 8 x 10-6 (later onset) 9 x 10-6 (later onset) |
NR NR NR NR NR NR NR NR NR NR NR |
Perlegen [429,981] |
N |
|
01/15/09 |
Timpson December 03, 2008 Diabetes Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
|
Type 2 diabetes |
1,924 cases, 2,938 controls |
3,757 cases, 5,346 controls |
10q25.2 16q12.2 10q25.2 11p15.1 11p15.1 6p22.3 9p21.3 8q24.11 |
TCF7L2 FTO TCF7L2 KCNJ11 KCNJ11 CDKAL CDKN2B SLC30A8 |
rs7903146-? rs8050136-? rs7903146-? rs5219-? rs5219-? rs10946398-? rs10811661-? rs13266634-? |
NR NR NR NR NR NR NR NR |
9 x 10-30 (non-obese) 2 x 10-17 (obese) 6 x 10-16 (obese) 1 x 10-9 (non-obese) 5 x 10-7 (obese) 7 x 10-7 (non-obese) 7 x 10-7 (non-obese) 7 x 10-6 (non-obese) |
1.49 [1.39-1.59] 1.3 [1.23-1.39] 1.31 [1.23-1.40] 1.25 [1.16-1.34] 1.19 [1.11-1.27] 1.18 [1.11-1.26] 1.26 [1.15-1.38] 1.18 [1.10-1.27] |
Affymetrix [393,453] |
N |
|
01/12/09 |
Friedman December 01, 2008 Hum Mol Genet grm7 variants confer susceptibility to age-related hearing impairment
|
Hearing impairment |
846 cases, 846 controls |
63 cases, 67 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix [506,627] (pooled) |
N |
|
02/26/09 |
Prokopenko December 01, 2008 Nat Genet Variants in MTNR1B influence fasting glucose levels
|
Fasting plasma glucose |
35,812 individuals |
NR |
2q24.3 11q21 7p13 |
G6PC2 MTNR1B GCK |
rs560887-C rs10830963-G rs4607517-A |
0.70 0.28 0.18 |
1 x 10-57 3 x 10-50 1 x 10-25 |
.06 [0.05-0.07] mmol/l increase .07 [0.06-0.08] mmol/l increase .06 [0.05-0.07] mmol/l increase |
Affymetrix, Illumina and Perlegen [up to 2,557,249] (imputed) |
N |
|
12/24/08 |
Gieger November 28, 2008 PLoS Genet Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
|
Serum metabolites |
284 males |
NR |
2p14 10p11.21 11q12.2 13q31.3 15q22.1 3p25.3 6q25.1 6q26 15q26.1 4q13.1 7q31.1 12q24.21 6q12 3q28 16p13.2 3q22.3 |
PLEK ANKRD30A FADS1 GPC5 LIPC ATP2B2 C6orf71 PARK2 SV2B Intergenic Intergenic Intergenic Intergenic FGF12 A2BP1 Intergenic |
rs9309413-? rs1148259-? rs174548-? rs17267292-? rs4775041-? rs6807064-? rs1591830-? rs992037-? rs886144-? rs10517480-? rs10953730-? rs2194980-? rs9354308-? rs4453795-? rs9924951-? rs1382269-? |
0.45 0.42 0.28 0.28 0.28 0.29 0.32 0.35 0.38 0.31 0.35 0.33 0.37 0.41 0.41 0.47 |
2 x 10-9 (SM) 3 x 10-9 (SM) 5 x 10-8 (PC) 1 x 10-7 (Docosahexaonic acid) 1 x 10-7 (PE) 1 x 10-7 (phenylalanine) 1 x 10-7 (sugar) 1 x 10-7 (Lysine) 2 x 10-7 (SM) 2 x 10-7 (PC) 2 x 10-7 (acylcarnitine) 3 x 10-7 (Tyrosine) 3 x 10-7 (serotonin) 4 x 10-7 (PC) 5 x 10-7 (PC) 5 x 10-7 (SM) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[187,454] |
N |
|
12/09/08 |
Terracciano November 24, 2008 Mol Psychiatry Genome-wide association scan for five major dimensions of personality
|
Personality dimensions |
3,972 individuals |
3,903 individuals |
19q13.31 4q12 2p22.1 Xp11.3 19q13.31 |
ZNF180 CLOCK THUMPD2 FUNDC1 ZNF180 |
rs644148-G rs6832769-A rs2540226-T rs6610953-G rs644148-G |
0.50 0.73 0.53 0.85 0.50 |
9 x 10-7 (openness) 2 x 10-6 (agreeableness) 3 x 10-6 (agreeableness) 6 x 10-6 (openness) 8 x 10-6 (extraversion) |
.15 [NR] SD increase .14 [NR] SD decrease .13 [NR] SD increase .15 [NR] SD increase .14 [NR] SD increase |
Affymetrix
[362,129] |
N |
|
01/07/09 |
Lei November 23, 2008 Hum Genet Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci
|
Height |
618 Chinese individuals |
2,953 Chinese individuals |
9q22.23 |
ZNP510 |
rs10816533-C |
0.29 |
2 x 10-6 |
NR |
Affymetrix [281,533] |
N |
|
01/06/09 |
Potkin November 20, 2008 Schizophr Bull A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
|
Brain imaging in schizophrenia (interaction) |
64 cases, 74 cases |
NR |
5q23.2 2q37.3 3p12.3 14q32.32 3q26.2 6q16.2 |
CTXN3, SLC12A2 GPC1 ROBO2, ROBO1 TRAF3 TNIK POU3F2 |
rs245201-? rs1574192-? rs9836484-? rs10133111-? rs2088885-? rs9491640-? |
0.32 0.38 0.32 0.20 0.47 0.06 |
9 x 10-8 4 x 10-6 4 x 10-6 5 x 10-6 6 x 10-6 9 x 10-6 |
NR NR NR NR NR NR |
Illumina [302,783] |
N |
|
12/01/08 |
COGENT Study November 16, 2008 Nat Genet Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
|
Colorectal cancer |
1,902 cases,
1,929 controls |
4,878 cases,
4,914 controls |
20p12.3 14q22.2 19q13.11 16q22.1 |
Intergenic BMP4 RHPN2 CDH1 |
rs961253-A rs4444235-C rs10411210-C rs9929218-A |
0.36 0.46 0.90 0.29 |
2 x 10-10 8 x 10-10 5 x 10-9 1 x 10-8 |
1.12 [1.08-1.16] 1.11 [1.08-1.15] 1.15 [1.10-1.20] 1.1 [1.06-1.12] |
Illumina
[up to 548,586] |
N |
|
01/16/09 |
Baranzini November 14, 2008 Hum Mol Genet Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
|
Brain lesion load |
791 cases,
883 controls |
NR |
2q37.1 14q12 19p13.11 6q25.3 |
CHRND NUBPL CPAMD8 IGF2R |
rs2602397-? rs2039485-? rs11666377-? rs6917747-? |
0.45 0.22 0.14 0.15 |
4 x 10-6 6 x 10-6 7 x 10-6 7 x 10-6 |
NR NR NR NR |
Illumina
[551,642] |
N |
|
01/16/09 |
"
|
Multiple sclerosis |
978 cases,
883 controls |
NR |
20p13 13q31.3 12q12 8p23.2 3q23 9p22.2 2q14.2 3q24 4q35.1 2p25.1 |
C20orf46 GPC5 PDZRN4 CSMD1 SLC25A36 SH3GL2 EN1 ZIC1 MGC45800 DDEF2 |
rs397020-? rs9523762-? rs1458175-? rs1529316-? rs908821-? rs1755289-? rs651477-? rs1841770-? rs7672826-? rs1109670-? |
0.52 0.35 0.49 0.47 0.71 0.61 0.26 0.53 0.34 0.26 |
8 x 10-7 1 x 10-6 2 x 10-6 2 x 10-6 3 x 10-6 3 x 10-6 7 x 10-6 8 x 10-6 8 x 10-6 9 x 10-6 |
1.41 [NR] 1.36 [NR] 1.34 [NR] 1.36 [NR] 1.37 [NR] 1.35 [NR] 1.38 [NR] 1.34 [NR] 1.37 [NR] 1.38 [NR] |
Illumina
[551,642] |
N |
|
01/16/09 |
"
|
Multiple sclerosis (age of onset) |
978 cases,
883 controls |
NR |
11q14.2 7q22.1 8q13.3 18q21.31 9q21.13 1q25.2 5q33.2 2q21.2 |
RAB38 RELN KCNB2 WDR7 RFK C1orf125 SGCD FLJ34870 |
rs1386330-? rs17157903-? rs2116078-? rs1557351-? rs2842483-? rs12047808-? rs4704970-? rs1437898-? |
0.13 0.14 0.48 0.22 0.29 0.13 0.20 0.40 |
2 x 10-6 3 x 10-6 3 x 10-6 4 x 10-6 5 x 10-6 6 x 10-6 7 x 10-6 8 x 10-6 |
NR NR NR NR NR NR NR NR |
Illumina
[551,642] |
N |
|
01/16/09 |
"
|
Multiple sclerosis (severity) |
794 cases, 883 controls |
NR |
3q25.32 4q28.3 19q13.42 4q13.2 7p21.3 11q23.3 16q22.3 6p23 7q31.2 18q22.3 19p13.2 |
FLJ16641 LOC132321 NLRP11 CENPC1 C1GALT1 MGC13125 C16orf47 JARID2 MET CBLN2 ACP5 |
rs12638253-? rs1478091-? rs299175-? rs10518025-? rs10259085-? rs180358-? rs7191888-? rs6941421-? rs10243024-? rs337718-? rs7253363-? |
0.47 0.06 0.46 0.14 0.46 0.23 0.17 0.24 0.23 0.29 0.05 |
2 x 10-6 2 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 6 x 10-6 6 x 10-6 6 x 10-6 6 x 10-6 9 x 10-6 9 x 10-6 |
NR NR NR NR NR NR NR NR NR NR NR |
Illumina
[551,642] |
N |
|
01/16/09 |
"
|
Normalized brain volume |
753 cases,
883 controls |
NR |
12p11.21 6q21 10p11.23 10q25.2 5q35.1 |
BICD1 FOXO3 SVIL MXI1 KCNIP1 |
rs261902-? rs9480865-? rs1927457-? rs716595-? rs11957313-? |
0.16 0.16 0.31 0.08 0.13 |
4 x 10-6 7 x 10-6 8 x 10-6 8 x 10-6 9 x 10-6 |
NR NR NR NR NR |
Illumina
[551,642] |
N |
|
12/09/08 |
Aulchenko November 09, 2008 Nat Genet Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
|
Multiple sclerosis |
45 cases,
195 controls |
2,634 cases,
2,930 controls |
1p36.22 |
KIF1B |
rs10492972-C |
0.27 |
3 x 10-10 |
1.34 [1.23-1.48] |
Affymetrix
[~250,000] |
N |
|
12/01/08 |
Bilguvar November 09, 2008 Nat Genet Susceptibility loci for intracranial aneurysm in European and Japanese populations
|
Intracranial aneurysm |
1,580 European cases,
6,276 European controls |
495 Japanese cases,
676 Japanese controls |
8q11.23 9q21.3 8q11.23-q12.1 2q33.1 |
SOX17 CDKN2A, CDKN2B SOX17 BOLL, PLCL1 |
rs10958409-A rs1333040-T rs9298506-A rs700651-G |
0.15 0.55 0.81 0.35 |
1 x 10-10 1 x 10-10 2 x 10-9 4 x 10-8 |
1.36 [1.24-1.49] 1.29 [1.19-1.40] 1.35 [1.22-1.49] 1.24 [1.15-1.34] |
Illumina
[289,271] |
N |
|
12/30/08 |
Drgon November 09, 2008 Mol Med Genome wide association for nicotine dependence and smoking cessation success in NIH research volunteers
|
Nicotine dependence |
220 cases, 260 controls |
2,271 cases, 1,868 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[~600,00] (pooled) |
N |
|
12/09/08 |
Pankratz November 06, 2008 Nat Genet Genomewide association study for susceptibility genes contributing to familial Parkinson disease
|
Parkinson's disease (familial) |
857 cases,
867 controls |
262 cases, 260 controls |
4p16.3 |
GAK, DGKQ |
rs1564282-T |
0.09 |
7 x 10-7 |
1.7 [NR] |
Illumina
[328,189] |
N |
|
12/09/08 |
Cronin November 05, 2008 Eur J Hum Genet Screening for replication of genome-wide SNP associations in sporadic AL
|
Amyotrophic lateral sclerosis |
958 cases,
932 controls |
309 cases,
404 controls |
7q36.2 |
DPP6 |
rs10260404-C |
0.35 |
3 x 10-6 |
1.37 [1.20-1.56] |
Illumina
[287,522] |
N |
|
12/01/08 |
Neale November 03, 2008 Am J Med Genet B Neuropsychiatr Genet Genome-wide association scan of attention deficit hyperactivity disorder
|
Attention deficit hyperactivity disorder |
909 trios |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Perlegen
[438,784] |
N |
|
11/25/08 |
Cooper November 02, 2008 Nat Genet Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
|
Type 1 diabetes |
3,561 cases,
4,646 controls |
6,225 cases,
6,946 controls,
3,064 trios |
6p21.32 1p13.2 12q24.13 12q13.2 15q25.1 16p13.13 6q15 2q33.2 10p15.1 22q13.1 18p11.21 10p15.1 16p13.13 2p23.3 |
HLA PTPN22 C12orf30 ERBB3 CTSH CLEC16A BACH2 CTLA4 PRKCQ C1QTNF6 PTPN2 IL2RA C16orf75, PRM3, TNP2 Intergenic |
rs9272346-G rs6679677-A rs17696736-G rs2292239-A rs3825932-C rs12708716-G rs11755527-G rs3087243-A rs947474-G rs229541-T rs2542151-C rs12251307-T rs416603-T rs2165738-C |
NR NR NR NR 0.32 NR 0.47 NR 0.19 0.43 NR NR 0.44 0.27 |
6 x 10-129 1 x 10-40 6 x 10-18 3 x 10-16 3 x 10-15 7 x 10-13 5 x 10-12 8 x 10-11 4 x 10-9 2 x 10-8 9 x 10-8 2 x 10-6 3 x 10-6 4 x 10-6 |
NR NR NR NR 1.16 [1.10-1.22] NR 1.13 [1.08-1.19] NR 1.1 [1.03-1.18] 1.04 [0.97-1.12] NR NR 1.06 [1.01-1.12] 1.07 [1.01-1.13] |
Affymetrix
[up to 335,565] |
N |
|
12/09/08 |
McKay November 02, 2008 Nat Genet Lung cancer susceptibility locus at 5p15.33
|
Lung cancer |
2,971 cases,
3,746 controls |
2,899 cases,
5,573 controls |
15q25.1 5p15.33 |
Intergenic TERT, CLPTM1 |
rs1051730-A rs402710-C |
NR NR |
1 x 10-15 4 x 10-6 |
1.35 [1.25-1.45] 1.18 [1.12-1.24] |
Illumina
[315,194] |
N |
|
11/25/08 |
Wang November 02, 2008 Nat Genet Common 5p15.33 and 6p21.33 variants influence lung cancer risk
|
Lung cancer |
1,952 cases,
1,438 controls |
7,579 cases,
8,236 controls |
15q25.1 6p21.33 5p15.33 |
NR BAT3,MSH5 CLPTM1L |
rs8042374-? rs3117582-C rs401681-G |
NR NR NR |
8 x 10-12 5 x 10-10 8 x 10-9 |
NR 1.24 [1.16-1.33] 1.15 [1.09-1.19] |
Illumina
[223,891] |
N |
|
12/09/08 |
Bertram October 29, 2008 Am J Hum Genet Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
|
Alzheimer's disease |
941 affected individuals,
404 unaffected individuals |
1,767 affected individuals,
838 unaffected individuals |
14q31.2 19q13.33 |
Intergenic CD33 |
rs11159647-? rs3826656-? |
NR NR |
2 x 10-6 6 x 10-6 |
NR NR |
Affymetrix
[484,522] |
N |
|
12/09/08 |
Anney October 24, 2008 Am J Med Genet B Neuropsychiatr Genet Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study
|
Attention deficit hyperactivity disorder and conduct disorder |
938 affected trios |
NR |
13q33.3 21q21.1 4q13.3 12q21.2 15q26.2 1q42.13 2p22.3 11q24.2 14q12 7q31.1 8q22.3 16q21 18q21.31 9p24.1 12q15 16q22.3 16q23.2 2p12 1q23.1 2q33.1 5q31.1 10p14 10p15.2 13q12.2 1p35.2 1q25.3 |
LIG4, ABHD13 Intergenic AMOTL1, CWC15, JMJD2D PAWR SPATA8 LOC729257 Intergenic KIRREL3 Intergenic FLJ31818, GPR85 YWHAZ Intergenic ATP8B1 PTPRD C12orf28 PKD1L3, KIAA0174, DHODH PKD1L2, C16orf46 Intergenic ETV3L, ETV3 FLJ39061, FZD7 C5orf15 A2BP1 PITRM1 GSX1, PDX1 Intergenic RGL1, GLT25D2 |
rs10492664-C rs2826340-T rs10831284-G rs7297018-A rs4533251-T rs701157-C rs6733379-G rs1557488-T rs1951082-T rs10229603-C rs931812-C rs1381102-A rs7236632-A rs10815798-A rs789560-G rs16973500-C rs4889240-T rs7595103-A rs6427356-G rs1521882-A rs1644305-A rs1291846-T rs2764980-A rs9512900-C rs2180233-C rs10797919-G |
0.84 0.17 0.13 0.19 0.15 0.45 0.28 0.18 0.43 0.31 0.74 0.40 0.86 0.48 0.87 0.86 0.45 0.64 0.28 0.82 0.41 0.19 0.51 0.37 0.31 0.59 |
1 x 10-6 2 X 10-6 2 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 5 x 10-6 5 x 10-6 5 x 10-6 5 x 10-6 6 x 10-6 6 x 10-6 6 x 10-6 7 x 10-6 7 x 10-6 7 x 10-6 7 x 10-6 8 x 10-6 8 x 10-6 8 x 10-6 9 x 10-6 9 x 10-6 9 x 10-6 9 x 10-6 9 x 10-6 |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Perlegen
[378,332] |
N |
|
12/01/08 |
Johansson October 24, 2008 Hum Mol Genet Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis
|
Height |
3,925
individuals |
38,091 individuals |
7p15.1 |
JAZF1 |
rs1635852-A |
NR |
9 x 10-10 |
.25 [0.17-0.33] cm taller |
Illumina
[NR] |
N |
|
12/09/08 |
Comabella October 22, 2008 PLoS ONE Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms
|
Multiple sclerosis |
242 cases,
242 controls |
375 cases,
375 controls |
6p21.32 |
HLA-DRB1 |
rs3129934-T |
NR |
9 x 10-11 |
3.3 [2.3-4.9] |
Affymetrix
[428,867]
(pooled) |
N |
|
11/25/08 |
Hillmer October 12, 2008 Nat Genet Susceptibility variants for male-pattern baldness on chromosome 20p11
|
Male-pattern baldness |
296 cases,
347 controls |
319 cases,
234 controls |
20p11.22 |
PAX1, BQ013595, BE789145 |
rs2180439-C |
0.43 |
3 x 10-15 |
1.82 [1.45-2.30] |
Illumina
[531,695] |
N |
|
11/25/08 |
Richards October 12, 2008 Nat Genet Male-pattern baldness susceptibility locus at 20p11
|
Male-pattern baldness |
578 cases,
547 controls |
1,351 cases,
2,485 controls |
20p11.22 Xq12 |
PAX1 AR |
rs1160312-A rs6625163-A |
0.43 NR |
1 x 10-14 (males) 5 x 10-11 |
1.6 [1.42-1.80] (males) 3.3 [2.31-4.71] |
Affymetrix
[370,102] |
N |
|
11/25/08 |
Stacey October 12, 2008 Nat Genet Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits
|
Basal cell carcinoma (cutaneous) |
930 cases,
33,117 controls |
1,216 cases,
2,844 controls |
1p36.13 1q42.13 |
PADI4, PADI6,RCC2, ARHGEF10L RHOU |
rs7538876-A rs801114-G |
0.35 0.33 |
4 x 10-12 6 x 10-12 |
1.28 [1.19-1.37] 1.28 [1.19-1.37] |
Illumina
[304,083] |
N |
|
12/01/08 |
Yuan October 10, 2008 Am J Hum Genet Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
|
Plasma levels of liver enzymes |
7,751 European white individuals |
4,704 European white and Indian Asian individua |
9p34.2 9q34.2 22q13.31 1p36.12 6p22.2 22q11.23 12q24.2 10q24.31 10q21.2 10q24.2q 10q21.3 |
ABO ADAMTS13 PNPLA3, SAMM50 NBPF3, ALPL, RAP1GAP GPLD1 GGT1, C22orf36 HNF1A, C12orf27, C12orf43 JMJD1C REEP3 CPN1, CHUK, ERLIN1 POU2F1 |
rs657152-T rs4962153-A rs2281135-T rs1780324-T rs9467160-A rs4820599-G rs1169313-C rs12355784-A rs10761779-G rs11597390-A rs9803659-C |
0.39 NR 0.18 0.43 0.24 0.31 0.38 0.48 0.49 0.36 NR |
2 x 10-30 (ALP) 8 x 10-21 (ALP) 8 x 10-16 (ALT) 7 x 10-15 (ALP) 1 x 10-11 (ALP) 4 x 10-11 (GGT) 2 x 10-10 (GGT) 5 x 10-10 (ALP) 7 x 10-10 (ALP) 2 x 10-8 (ALT) 4 x 10-6 (ALT) |
.05 [0.039-0.055] U/L decrease .06 [0.048-0.072] U/L decrease .06 [0.046-0.074] U/L increase .03 [0.023-0.039] U/L increase .03 [0.024-0.044] U/L increase .01 [0.005-0.009] U/L increase .01 [0.003-0.007] U/L decrease .03 [0.017-0.033] U/L increase .03 [0.017-0.033] U/L increase .04 [0.025-0.053] U/L decrease .03 [0.018-0.042] U/L decrease |
Affymetrix and Illumina
[up to 496,032] |
N |
|
11/25/08 |
Grant October 07, 2008 Diabetes Follow up analysis of genome-wide association data identifies novel loci for type 1 diabetes
|
Type 1 diabetes |
563 cases,
1,146 controls,
483 case-parents trios |
636 families,
3,303 cases,
4,673 controls |
21q22.3 6q15 1p22.3 9p24.2 15q14 |
UBASH3A BACH2 EDG7 GLIS3 RASGRP1 |
rs9976767-C rs3757247-A rs1983853-? rs10758593-A rs8035957-C |
NR NR NR NR NR |
2 x 10-8 1 x 10-6 2 x 10-6 3 x 10-6 4 x 10-6 |
1.16 [1.10-1.22] 1.13 [1.08-1.19] 1.2 [1.11-1.29] 1.13 [1.07-1.19] 1.14 [1.08-1.21] |
Illumina
[up to 1,000,000] |
N |
|
05/07/09 |
Lesch October 07, 2008 J Neural Transm Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
|
Attention deficit hyperactivity disorder |
343 cases, 304 controls |
NR |
13q31.3 3p22.1 9q34.13 15q23 17p13.2 9q33.1 2q14.2 1p35.1 15q26.1 16q24.1 15q26.1 10q24.1 5q13.2 9q34.11 6p21.1 10q22.1 10q25.1 20q11.22 12q23.3 6p21.1 7p15.1 22q11.22 16q23.3 2p25.3 2q33.3 5q22.2 |
GPC6 MOBP C9orf98 ITGA11 ITGAE ASTN2 MGC33657 CSMD2 AK094352 ATP2C2 MAN2A2 TLL2 MAP1B DNM1 TFEB UNC5B C10orf79 MMP24 NT5DC3 SUPT3H CREB5 PPM1F CDH13 MYT1L CRYGC REEP5 |
rs7995215-? rs864643-? rs11243897-? rs7164335-? rs220470-? rs10983238-? rs2587695-? rs2281597-? rs7175404-? rs10514604-? rs2677744-? rs10786284-? rs2199161-? rs2502731-? rs2842643-? rs16928529-? rs515910-? rs1555322-? rs4964805-? rs3799977-? rs2237349-? rs412050-? rs11646411-? rs2241685-? rs2242073-? rs469727-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
1 x 10-8 1 x 10-8 6 x 10-8 1 x 10-7 1 x 10-7 1 x 10-7 3 x 10-7 5 x 10-7 6 x 10-7 8 x 10-7 1 x 10-6 2 x 10-6 2 x 10-6 2 x 10-6 3 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 5 x 10-6 5 x 10-6 5 x 10-6 6 x 10-6 7 x 10-6 8 x 10-6 8 x 10-6 8 x 10-6 |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix [504,219](pooled) |
N |
|
12/09/08 |
Sonuga-Barke October 07, 2008 Am J Med Genet B Neuropsychiatr Genet Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan
|
Conduct disorder (interaction) |
909 trios |
NR |
5q21.1 16p13.3 4q23 2p21 10q22.3 3p25.3 8p23.1 15q26.2 18q12.3 1q22 4q22.1 17q22 2p22.2 11q23.2 6p15 |
Intergenic A2BP1 ADH1C Intergenic Intergenic SLC6A1 MFHAS1 Intergenic Intergenic RIT1 PPM1K Intergenic Intergenic ZBTB16 Intergenic |
rs13188771-A rs6500744-C rs1789891-A rs719593-T rs2395528-T rs9990174-T rs332034-A rs4321143-G rs17664267-T rs2282301-A rs893971-T rs8073783-C rs604381-A rs17116334-T rs16880441-G |
0.17 0.53 0.14 0.86 0.23 0.33 0.85 0.28 0.19 0.23 0.60 0.49 0.32 0.16 0.08 |
2 x 10-6 (int, MW) 3 x 10-6 (int, MW) 3 x 10-6 (int, MW) 5 x 10-6 (int, MC) 6 x 10-6 (int, MW) 6 x 10-6 (int, MW) 6 x 10-6 (int, MW) 7 x 10-6 (int, MC) 7 x 10-6 (int, MW) 7 x 10-6 (int, MW) 7 x 10-6 (int, MC) 8 x 10-6 (int, MW) 8 x 10-6 (int, MW) 9 x 10-6 (int, MC) 9 x 10-6 (int, MC) |
4.24 [NR] unit decrease .91 [NR] unit increase 1.47 [NR] unit increase 2.05 [NR] unit decrease 1.46 [NR] unit decrease 2.52 [NR] unit decrease 1.05 [NR] unit increase 1.13 [NR] unit increase 1.39 [NR] unit increase 2.88 [NR] unit increase 1.15 [NR] unit decrease 1.76 [NR] unit decrease 1.26 [NR] unit increase 1.3 [NR] unit increase 1.63 [NR] unit increase |
Perlegen [429,901) |
N |
|
12/09/08 |
"
|
Attention deficit hyperactivity disorder symptoms (interaction) |
909 trios |
NR |
11q21 13q12.3 6p21.2 14q24.3 21q21.1 3q27.2 8p23.2 |
PIWIL4 Intergenic KIF6 Intergenic Intergenic Intergenic Intergenic |
rs2212361-C rs1161463-C rs4714261-T rs2360997-C rs2825388-A rs10049246-G rs4875598-G |
0.26 0.79 0.17 0.86 0.40 0.59 0.34 |
9 x 10-7 (int, MW) 2 x 10-6 (int, MW) 2 x 10-6 (int, MW) 8 x 10-6 (int, MW) 8 x 10-6 (int, MC) 8 x 10-6 (int, MW) 9 x 10-6 (int, MW) |
.97 [NR] unit decrease 1.72 [NR] unit decrease .95 [NR] unit increase 1.3 [NR] unit decrease 1.06 [NR] unit increase .6 [NR] unit increase .94 [NR] unit decrease |
Perlegen
[429,981] |
N |
|
11/25/08 |
Franke October 05, 2008 Nat Genet Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
|
Ulcerative colitis |
1,167 cases,
777 controls |
1,855 cases,
3,091 controls |
6p21.32 1q32.1 |
HLA-DRA, BTNL2 IL10 |
rs9268877-T rs3024505-T |
0.45 0.15 |
6 x 10-18 1 x 10-12 |
1.45 [1.33-1.58] 1.46 [1.31-1.62] |
Affymetrix
[355,262] |
N |
|
10/14/09 |
Chasman October 01, 2008 Circ Cardiovasc Genet Genetic loci associated with plasma concentration of LDL-C, HDL-C, triglycerides, ApoA1, and ApoB among 6382 Caucasian women in genome-wide analysis with replication
|
Lipid traits |
6,382 Caucasian women |
970 Caucasian individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina [314,518] |
N |
|
11/25/08 |
Dehghan October 01, 2008 Lancet Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
|
Serum urate |
11,847 individuals |
14,867 individuals |
4p16.1 4q22.1 6p22.2 |
SLC2A9 ABCG2 SLC17A3 |
rs16890979-T rs2231142-? rs1165205-? |
0.23 0.11 0.47 |
7 x 10-168 (whites) 3 x 10-60 (whites) 4 x 10-29 (whites) |
.34 [0.30-0.38] SD decrease in serum uric acid level .24 [0.20-0.28] SD increase in serum uric acid level .09 [0.07-0.11] SD decrease in serum uric acid level |
Affymetrix and Illumina
[up to 530,683] |
N |
|
12/09/08 |
Gretarsdottir October 01, 2008 Ann Neurol Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke
|
Ischemic stroke |
1,661 cases,
10,815 controls |
4,576 cases,
19,343 controls |
4q25 |
NR |
rs2200733-T |
0.11 |
2 x 10-10 |
1.26 [1.17-1.35] |
Illumina
[310,881] |
N |
|
11/25/08 |
Mushiroda October 01, 2008 J Med Genet A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis
|
Idiopathic pulmonary fibrosis |
159 Japanese cases,
934 Japanese controls |
83 Japanese cases,
535 Japanese controls |
5p15.33 |
TERT |
rs2736100-A |
0.41 |
3 x 10-8 |
2.11 [1.61-2.78] |
Illumina
[214,508] |
N |
|
11/25/08 |
Abraham September 29, 2008 BMC Med Genomics A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
|
Alzheimer's disease |
1,082 cases,
1,239 controls |
1,400 additional controls |
19q13.32 22q13.33 |
PVRL2, TOMM40, APOE CPT1B |
rs6859-A rs727153-C |
NR 0.17 |
6 x 10-14 3 x 10-6 |
NR 1.63 [1.37-1.95] |
Illumina
[561,494]
(pooled) |
N |
|
11/25/08 |
Miyagawa September 28, 2008 Nat Genet Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
|
Narcolepsy |
222 Japanese cases,
389 Japanese controls |
748 cases,
994 controls |
22q13.33 |
CPT1B |
rs5770917-C |
0.17 |
6 x 10-8 |
1.63 [1.37-1.95] |
Affymetrix
[249,133] |
N |
|
11/25/08 |
Mick September 26, 2008 Am J Med Genet B Neuropsychiatr Genet Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
|
Attention deficit hyperactivity disorder |
187 children |
NR |
22q13.31 5p15.31 |
Intergenic Intergenic |
rs9627183-C rs11134178-T |
0.03 0.05 |
3 x 10-6 3 x 10-6 |
NR NR |
Affymetrix
[319,722] |
N |
|
12/09/08 |
Burkhardt September 18, 2008 Arterioscler Thromb Vasc Biol Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
|
LDL cholesterol |
2,346 Micronesian individuals |
1,464 European white cases,
1,467 European white controls |
5q13.3 19q13.32 |
HMGCR APOE, APOC1, APOC4, APOC2 |
rs7703051-A rs4420638-? |
0.41 NR |
1 x 10-8 2 x 10-7 |
18 [NR] % SD increase NR |
Affymetrix
[~500,000] |
N |
|
11/25/08 |
Liu September 17, 2008 J Natl Cancer Inst Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer
|
Lung cancer |
194 cases,
219 controls |
3,878 cases,
4,831 controls |
15q25.1 |
LOC123688, PSMA4, CHRNA3, CHRNA5, CHRNB4 |
rs8034191-G |
NR |
1 x 10-8 |
1.38 [1.17-1.64] |
Affymetrix
[up to 722,376] |
N |
|
11/25/08 |
Kiemeney September 14, 2008 Nat Genet Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
|
Urinary bladder cancer |
1,803 cases,
34,336 controls |
2,165 cases,
3,800 controls |
8q24.21 3q28 |
MYC, BC042052 TP63 |
rs9642880-T rs710521-A |
0.45 0.73 |
9 x 10-12 1 x 10-7 |
1.22 [1.15-1.29] 1.19 [1.12-1.27] |
Illumina
[302,140] |
N |
|
11/25/08 |
Raychaudhuri September 14, 2008 Nat Genet Common variants at CD40 and other loci confer risk of rheumatoid arthritis
|
Rheumatoid arthritis |
3,393 cases,
12,460 controls |
3,929 cases,
5,807 controls |
6p21.32 1p13.2 6q23.3 20q13.12 9p13.3 12q13.3 1p36.32 10p15.1 7q21.2 |
HLA-DRB1 PTPN22 OLIG3, TNFIP3 CD40 CCL21 KIF5A-PIP4K2C MMEL1-TNFRSF14 PRKCQ CDK6 |
rs6457620-? rs6679677-? rs6920220-? rs4810485-G rs2812378-G rs1678542-C rs3890745-T rs4750316-G rs42041-G |
0.50 0.10 0.22 0.25 0.34 0.37 0.33 0.20 0.24 |
4x10-186 6 x 10-42 2 x 10-9 8 x 10-9 3 x 10-8 9 x 10-8 1 x 10-7 4 x 10-6 4 x 10-6 |
2.55 [2.40-2.71] 1.79 [1.65-1.94] 1.24 [1.16-1.32] 1.15 [NR] 1.12 [NR] 1.12 [NR] 1.12 [NR] 1.14 [NR] 1.11 [NR] |
Illumina
[818,728]
Affymetrix
[~340,000]
(imputed) |
N |
|
11/25/08 |
Huyghe September 12, 2008 Am J Hum Genet Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait
|
Hearing impairment |
1,081 individuals |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[169,154] |
N |
|
11/25/08 |
Liu September 08, 2008 PLoS ONE Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study
|
Hip bone size |
501 women,
499 men |
1,216 women |
2q33.1 |
PLCL1 |
rs7595412-A |
0.89 |
2 x 10-6 |
5 [NR] cm2 increase in hip bone size on women |
Affymetrix
[306,823] |
N |
|
11/25/08 |
Hazra September 07, 2008 Nat Genet Common variants of FUT2 are associated with plasma vitamin B12 levels
|
Plasma level of vitamin B12 |
1,658 women |
1,059 women |
19q13.3 |
FUT2 |
rs492602-G |
0.49 |
5 x 10-17 |
.09 [0.07-0.11] pg/ml decrease |
Illumina
[528,134] |
N |
|
11/25/08 |
McArdle September 01, 2008 Arthritis Rheum Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish
|
Serum uric acid |
408 women,
460 men |
NR |
4p16.1 13q33.1 2q31.1 13q14.11 3p24.3 20p12.3 5q31.3 |
GLUT9, WDR1 NR NR NR NR NR NR |
rs16890979-? rs4771450-? rs4668338-? rs17065323-? rs6442522-? rs6085920-? rs3776331-? |
NR NR NR NR NR NR NR |
1 x 10-11 2 x 10-6 3 x 10-6 4 x 10-6 5 x 10-6 6 x 10-6 8 x 10-6 |
.44 [0.32-0.56] mg/dl decrease in uric serum levels .23 [NR] mg/dl decrease in uric acid levels 4.29 [NR] mg/dl decrease in uric acid levels 4.29 [NR] mg/dl decrease in uric acid levels .05 [NR] mg/dl increase in uric acid levels .4 [NR] mg/dl decrease in uric acid levels .3 [NR] mg/dl increase in uric acid levels |
Affymetrix
[361,034] |
N |
|
11/25/08 |
van den Oord September 01, 2008 Arch Gen Psychiatry Genomewide Association Analysis Followed by a Replication Study Implicates a Novel Candidate Gene for Neuroticism
|
Neuroticism |
1,227 individuals |
1,880 individuals |
14q21.3 8q24.23 7p21.3 |
MAMDC1 AK127771 NXPH1 |
rs12883384-? rs2705293-? rs2349775-? |
NR NR NR |
7 x 10-7 6 x 10-6 7 x 10-6 |
NR NR NR |
Affymetrix
[420,287] |
N |
|
11/25/08 |
Di Bernardo August 31, 2008 Nat Genet A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
|
Chronic lymphocytic leukemia |
505 cases, 1,438 controls |
1,024 cases,
1,677 controls |
6p25.3 11q24.1 15q23 2q13 2q37.1 19q13.32 |
IRF4 GRAMD1B Intergenic ACOXL,BCL2L11 SP140, SP110 PRKD2,STRN4 |
rs872071-G rs735665-A rs7176508-A rs17483466-G rs13397985-G rs11083846-A |
0.54 0.21 0.37 0.20 0.19 0.22 |
2 x 10-20 4 x 10-12 5 x 10-12 2 x 10-10 6 x 10-10 4 x 10-9 |
1.54 [1.41- 1.69] 1.45 [1.31-1.61] 1.37 [1.26-1.50] 1.39 [1.25-1.53] 1.41 [1.26-1.57] 1.35 [1.22-1.49] |
Illumina
[345,665] |
N |
|
11/25/08 |
Kugathasan August 31, 2008 Nat Genet Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
|
Inflammatory bowel disease |
1,011 cases,
4,250 controls |
1,922 cases,
14,124 controls |
20q13.33 21q22.2 1p31.3 16q12.1 6p21.32 9q32 |
TNFRSF6B PSMG1 IL23R NOD2 HLA-DQA1 TNFSF15 |
rs2315008-G rs2836878-? rs11209026-? rs5743289-T rs477515-? rs6478109-? |
0.69 0.72 0.94 0.17 0.69 0.69 |
9 x 10-15 4 x 10-12 7 x 10-11 4 x 10-10 1 x 10-8 3 x 10-8 |
1.36 [1.05-1.76] 1.41 [1.08-1.84] 2.56 [1.92-3.45] 1.46 [1.29-1.64] 1.38 [1.23-1.54] 1.36 [1.22-1.52] |
Illumina
[NR] |
N |
|
11/25/08 |
Galvan August 26, 2008 Int J Cancer A polygenic model with common variants may predict lung adenocarcinoma risk in humans
|
Lung adenocarcinoma |
482 cases,
522 controls |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina
[~318,000]
(pooled) |
N |
|
11/25/08 |
Weidinger August 22, 2008 PLoS Genet Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus
|
Serum IgE levels |
1,530 individuals |
9,769 individuals |
1q23.2 5q31.1 |
FCER1A RAD50 |
rs2251746-C rs2040704-? |
0.26 0.23 |
2 x 10-20 4 x 10-8 |
19.2 [NR] % decrease 13.9 [NR] % increase |
Affymetrix
[353,569] |
N |
|
11/25/08 |
Ferreira August 17, 2008 Nat Genet Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
|
Bipolar disorder |
4,387 cases,
6,209 controls |
NR |
10q21.2 12q13.12 15q14 2q11.2 9q33.3 11q14.1 15q14 3p22.3 6q25.2 9p13.3 14q11.2 14q13.1 3p24.3 3p24.3 11q24.2 15q25.1 1p21.2 9q31.3 18p11.32 3p26.2 10q22.3 |
ANK3 CACNA1C C15orf53, RASGRP1 Intergenic NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
rs10994336-T rs1006737-A rs12899449-? rs2314398-? rs4130590-? rs12290811-A rs16966460-G rs4380451-? rs17082664-G rs216345-T rs12436436-C rs8015959-T rs11720452-? rs3821396-A rs544368-T rs2278702-? rs1948368-? rs7042161-? rs7226677-G rs1601875-? rs703965-? |
0.05 0.32 0.72 0.69 0.56 0.15 0.10 0.73 0.13 0.37 0.08 0.02 0.58 0.11 0.12 0.83 0.51 0.65 0.12 0.50 0.54 |
9 x 10-9 7 x 10-8 4 x 10-7 3 x 10-6 3 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 4 x 10-6 5 x 10-6 5 x 10-6 5 x 10-6 5 x 10-6 6 x 10-6 6 x 10-6 6 x 10-6 6 x 10-6 7 x 10-6 7 x 10-6 8 x 10-6 |
1.45 [NR] 1.18 [NR] 1.2 [NR] 1.17 [NR] 1.16 [NR] 1.2 [NR] 1.26 [NR] 1.18 [NR] 1.22 [NR] 1.15 [NR] 1.3 [NR] 1.59 [NR] 1.15 [NR] 1.23 [NR] 1.22 [NR] 1.21 [NR] 1.15 [NR] 1.15 [NR] 1.24 [NR] 1.14 [NR] 1.15 [NR] |
Affymetrix
[1,769,948]
imputed |
N |
|
04/10/09 |
Unoki August 17, 2008 Nat Genet SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
|
Type 2 diabetes |
194 Japanese cases, 1,558 Japanese controls |
4,924 cases, 2,618 controls (Japanese), 1433 cases, 1,735 controls (Singaporean), 3,891 cases, 4,888 controls (Danish) |
11p15.4 6p22.3 3q27.2 |
KCNQ1 CDKAL1 IGF2BP2 |
rs2237897-C rs4712524-G rs6769511-C |
0.61 0.42 0.32 |
1 x 10-16 3 x 10-10 1 x 10-9 |
1.33 [1.24-1.41] 1.22 [1.15-1.31] 1.23 [1.15-1.31] |
Affymetrix [207,097] |
N |
|
04/03/09 |
Yasuda August 17, 2008 Nat Genet Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
|
Type 2 diabetes |
187 Japanese cases, 1,504 Japanese controls |
6,552 Asian cases, 6,621 Asian controls, 2,830 cases, 3,740 controls (Swedish) |
11p15.5 |
KCNQ1 |
rs2237892-C |
0.61 |
2 x 10-42 |
1.4 [1.34-1.47] |
Invader [82,343] |
N |
|
11/25/08 |
Shlien August 12, 2008 Proc Natl Acad Sci USA Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome
|
TP53 carriage |
53 carriers,
70 controls |
770 individuals |
Pending |
Pending |
Pending |
Pending |
Pending |
Pending |
Affymetrix
[3,884 CNVs] |
Y |
|
11/25/08 |
Hofmann August 10, 2008 Nat Genet Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
|
Sarcoidosis |
499 cases,
490 controls |
1,649 cases,
1,832 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[375,771] |
N |
|
11/25/08 |
Graham August 01, 2008 Nat Genet Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
|
Systemic lupus erythematosus |
431 cases,
2,155 controls |
740 trios |
6q23.3 2q32.3 8p23.1 16p11.2 10q11.22 17p12 4q28.3 2p16.3 |
TNFAIP3 STAT4 BLK ITGAM c10orf64 Intergenic Intergenic Intergenic |
rs5029939-? rs3821236-? rs2618476-? rs11150610-? rs11101442-? rs12949531-? rs2313132-? rs17039212-? |
0.03 0.19 0.26 0.42 0.32 0.22 0.12 0.10 |
3 x 10-12 8 x 10-11 2 x 10-8 2 x 10-6 3 x 10-6 8 x 10-6 8 x 10-6 9 x 10-6 |
2.28 [NR] 1.49 [NR] 1.29 [NR] NR NR NR NR NR |
Affymetrix
[313,238] |
N |
|
11/25/08 |
Julia August 01, 2008 Arthritis Rheum Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility
|
Rheumatoid arthritis |
400 cases,
400 controls |
410 cases,
394 controls |
6p21.32 18q23 |
HLA-DQA1, HLA-DQA2 SALL3 |
rs6457617-? rs2002842-A |
NR 0.49 |
1 x 10-9 6 x 10-6 |
NR 1.61 [NR] |
Illumina
[299,918] |
N |
|
11/25/08 |
O'Donovan July 30, 2008 Nat Genet Identification of loci associated with schizophrenia by genome-wide association and follow-up
|
Schizophrenia |
479 cases,
2,937 controls |
6,666 cases,
9,897 controls |
2q32.1 11p14.1 16p13.12 |
ZNF804A Intergenic Intergenic |
rs1344706-T rs1602565-C rs7192086-T |
0.59 0.11 0.24 |
2 x 10-7 3 x 10-6 6 x 10-6 |
1.12 [NR] 1.16 [NR] 1.12 [NR] |
Affymetrix
[362,532] |
N |
|
11/25/08 |
Schormair July 27, 2008 Nat Genet PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
|
Restless legs syndrome |
628 cases,
1,644 controls |
1,835 cases,
3,111 controls |
9p23 9p24.1 |
PTPRD PTPRD |
rs4626664-A rs1975197-T |
0.12 0.16 |
6 x 10-10 6 x 10-9 |
1.44 [1.31-1.59] 1.31 [1.20-1.44] |
Affymetrix
[208,733] |
N |
|
11/25/08 |
The SEARCH Collaborative Group July 23, 2008 N Engl J Med SLCO1B1 Variants and Statin-Induced Myopathy--A Genomewide Study
|
Response to statin therapy |
85 cases,
90 controls |
19,856 individuals |
12p12.1 |
SLCO1B1 |
rs4149056-C |
0.13 |
2 x 10-9 |
4.5 [2.60-7.70] |
Illumina
[316,184] |
N |
|
11/25/08 |
Franke July 21, 2008 Gastroenterology Genome-wide association study anaylsis in sarcoidosis and Crohn disease unravels a common susceptibility locus on 10p12.2
|
Crohn's disease and Sarcoidosis (combined) |
382 CD cases,
398 SA cases,
394 controls |
660 CD cases,
657 SA cases,
1,091 controls |
10p12.2 |
C10orf67 |
rs1398024-A |
0.25 |
4 x 10-6 |
1.23 [1.04-1.45] |
Affymetrix
[83,360] |
N |
|
11/25/08 |
Liu July 10, 2008 Mol Med Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis
|
Treatment response to TNF antagonists |
89 cases |
NR |
20q12 6q26 9p21.2 7q21.3 20p11.21 2q24.3 4p15.1 1p22.3 |
MAFB QKI IFNK PON1 CST5 LASS6 CENTD1 LMO4 |
rs6028945-T rs10945919-G rs7046653-A rs854555-A rs6138150-T rs13393173-A rs437943-G rs983332-A |
0.12 0.32 0.26 0.34 0.84 0.12 0.33 0.21 |
2 x 10-7 3 x 10-7 5 x 10-7 2 x 10-6 3 x 10-6 4 x 10-6 4 x 10-6 5 x 10-6 |
NR NR NR NR NR NR NR NR |
Illumina
[283,348] |
N |
|
11/25/08 |
Pare July 04, 2008 PLoS Genet Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women
|
Soluble ICAM-1 |
4,570 women |
2,008 women |
19p13.2 9q34.2 19p13.2 19p13.2 |
ICAM1 ABO ICAM1 ICAM1 |
rs1799969-G rs507666-G rs5498-A rs281437-? |
0.12 0.20 0.43 0.30 |
4 x 10-47 5 x 10-29 5 x 10-25 3 x 10-10 |
28.19 [NR] umol/L decrease 17.73 [NR] umol/L decrease 13.22 [NR] umol/L increase 10.1 [NR] umol/L increase |
Illumina
[336,108] |
N |
|
11/25/08 |
Bae July 02, 2008 Biochem Biophys Res Commun Identification of SNP markers for common CNV regions and association analysis of risk of subarachnoid aneurysmal hemorrhage in Japanese population
|
Subarachnoid aneurysmal hemorrhage |
203 cases, 294 controls |
NR |
Pending |
Pending |
Pending |
Pending |
Pending |
Pending |
Illumina
[317,503] |
Y |
|
11/25/08 |
Sarasquete July 01, 2008 Blood Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis
|
Osteonecrosis of the jaw |
21 cases,
64 controls |
NR |
10q23.33 |
CYP2C8 |
rs1934951-T |
0.12 |
1 x 10-6 |
12.75 [3.7-43.5] |
Affymetrix
[339,972] |
N |
|
11/25/08 |
Turner June 30, 2008 Hypertension Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic
|
Response to diuretic therapy |
194 blacks, 195 whites |
NR |
12q15 |
LYZ, YEATS4, FRS2 |
3-SNP haplotype |
NR |
6 x 10-6 |
NR |
Affymetrix
[up to 102,334] |
N |
|
11/25/08 |
Barrett June 29, 2008 Nat Genet Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|
Crohn's disease |
3,230 cases
4,829 controls |
1,339 trios, 2,325 cases, 1,809 controls |
1p31.3 2q37.1 5p13.1 16q12.1 10q21.2 5q31.1 18p11.21 10q24.2 5q33.1 13q14.11 5q33.3 3p21.31 6q27 17q21.2 1q32.1 6q21 12q12 9q32 6p22.3 11q13.5 1q23.2 21q22.3 10p11.21 1q24.3 9p24.1 17q12 7p12.2 8q24.13 21q21.1 1p13.2 |
IL23R ATG16L1 PTGER4 NOD2 ZNF365 Intergenic PTPN2 NKX2-3 IRGM Unknown IL12B MST1 CCR6 STAT3 Intergenic Unknown LRRK2, MUC19 TNFSF15 CDKAL1 C11orf30 ITLN1 ICOSLG Intergenic Intergenic JAK2 ORMDL3 Intergenic Intergenic Intergenic PTPN22 |
rs11465804-T rs3828309-G rs4613763-C rs2066847-C rs10995271-C rs2188962-T rs2542151-G rs11190140-T rs11747270-G rs3764147-G rs10045431-C rs3197999-A rs2301436-T rs744166-A rs11584383-T rs7746082-C rs11175593-T rs4263839-G rs6908425-C rs7927894-T rs2274910-C rs762421-G rs17582416-G rs9286879-G rs10758669-C rs2872507-A rs1456893-A rs1551398-A rs1736135-T rs2476601-G |
0.93 0.53 0.13 0.02 0.39 0.43 0.15 0.48 0.09 0.22 0.71 0.27 0.46 0.57 0.70 0.29 0.02 0.68 0.78 0.39 0.68 0.39 0.35 0.24 0.35 0.47 0.68 0.62 0.57 0.90 |
7 x 10-63 2 x 10-32 7 x 10-27 3 x 10-24 4 x 10-20 2 x 10-18 5 x 10-17 3 x 10-16 3 x 10-16 2 x 10-13 4 x 10-13 1 x 10-12 1 x 10-12 7 x 10-12 1 x 10-11 2 x 10-10 3 x 10-10 3 x 10-10 9 x 10-10 1 x 10-9 1 x 10-9 1 x 10-9 2 x 10-9 2 x 10-9 3 x 10-9 5x 10-9 5 x 10-9 5 x 10-9 7 x 10-9 1 x 10-8 |
2.5 [NR] 1.25 [NR] 1.32 [NR] 3.99 [NR] 1.25 [NR] 1.25 [NR] 1.35 [NR] 1.2 [NR] 1.33 [NR] 1.25 [NR] 1.11 [NR] 1.2 [NR] 1.21 [NR] 1.18 [NR] 1.18 [NR] 1.17 [NR] 1.54 [NR] 1.22 [NR] 1.21 [NR] 1.16 [NR] 1.14 [NR] 1.13 [NR] 1.16 [NR] 1.19 [NR] 1.12 [NR] 1.12 [NR] 1.2 [NR] 1.08 [NR] 1.18 [NR] 1.31 [NR] |
Affymetrix and Illumina
[635,547]
(imputed) |
N |
|
11/25/08 |
Behrens June 24, 2008 Arthritis Rheum Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis
|
Arthritis (juvenile idiopathic) |
130 cases
1,952 controls |
NR |
6p21.32 |
HLA-DRB1 |
rs2395148-? |
NR |
2 x 10-10 |
5.37 [3.02-9.56] |
Illumina
[524,684] |
N |
|
11/25/08 |
Bouatia-Naji June 19, 2008 Science A Polymorphism Within the G6PC2 Gene is Associated with Fasting Plasma Glucose Levels
|
Fasting plasma glucose |
654 normoglycemic individuals |
9,353 individuals |
2q24.3 |
G6PC2 |
rs560887-A |
0.30 |
4 x 10-23 |
.06 [0.05-0.08] mmol/l decrease |
Illumina
[392,935] |
N |
|
11/25/08 |
Cooper June 05, 2008 Blood A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
|
Warfarin maintenance dose |
181 individuals |
374 individuals |
16p11.2 10q23.33 12p13.33 |
VKORC1 CYP2C9 CACNA1C |
rs10871454-? rs4086116-? rs216013-? |
NR NR NR |
5 x 10-34 6x 10-12 9 x 10-7 |
NR NR NR |
Illumina
[538,629] |
N |
|
11/25/08 |
Chen June 04, 2008 J Clin Invest Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
|
Fasting plasma glucose |
5,088 nondiabetic individuals |
18,436 nondiabetic individuals |
2q24.3 |
G6PC2,ABCB11 |
rs563694-C |
0.34 |
4 x 10-7 |
NR |
Illumina
[315,635] |
N |
|
11/25/08 |
Uhl June 04, 2008 Arch Gen Psychiatry Molecular genetics of successful smoking cessation: convergent genome-wide association study results
|
Smoking cessation |
241 cases,
309 controls |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[~500,000]
(pooled) |
N |
|
11/25/08 |
Lavedan June 03, 2008 Mol Psychiatry Association of the NPAS3gene and five other loci with response of the antipsychotic iloperidone identified in a whole genome association study
|
Response to iloperidone treatment (PANSS-T score) |
106 individuals |
104 individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[334,563] |
N |
|
11/25/08 |
Volpi June 03, 2008 Mol Psychiatry Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia
|
Response to iloperidone treatment (QT prolongation) |
183 individuals |
NR |
10q23.1 14q12 15q26.1 18q12.2 2q31.3 4q32.3 |
NRG3 NUBPL SLCO3A1 BRUNOL4 CERKL PALLD |
rs4933824-T rs7142881-A rs3924426-T rs4799915-T rs993648-T rs17054392-C |
NR NR NR NR NR NR |
2 x 10-6 2 x 10-6 2 x 10-6 3 x 10-6 3 x 10-6 3 x 10-6 |
NR NR NR NR NR NR |
Affymetrix
[339,272] |
N |
|
11/25/08 |
Brown May 18, 2008 Nat Genet Common sequence variants on 20q11.22 confer melanoma susceptibility
|
Melanoma |
864 cases,
864 controls |
1,230 cases,
1,251 controls |
20q11.22 |
CDC91L1 |
rs910873-T |
0.09 |
1 x 10-15 |
1.75 [1.53-2.01] |
Illumina
[535,150]
(pooled) |
N |
|
11/25/08 |
Sulem May 18, 2008 Nat Genet Two newly identified genetic determinants of pigmentation in Europeans
|
Blond vs. brown hair color |
5,130 individuals |
3,330 individuals |
11q13.2 |
TPCN2 |
rs35264875-T |
0.22 |
4 x 10-30 |
2.49 [1.96-3.15] |
Illumina
[316,515] |
N |
|
11/25/08 |
"
|
Blue vs. green eyes |
5,130 individuals |
3,330 individuals |
9p23 |
TYRP1 |
rs1408799-C |
0.75 |
6 x 10-17 |
1.4 [1.25-1.57] |
Illumina
[316,515] |
N |
|
11/25/08 |
"
|
Burning and freckling |
5,130 individuals |
3,330 individuals |
20q11.22 |
ASIP |
rs1015362-G + rs4911414-T |
0.08 |
6 x 10-37 |
2.56 [2.06-3.18] |
Illumina
[316,515] |
N |
|
11/25/08 |
"
|
Freckles |
5,130 individuals |
3,330 individuals |
20q11.22 |
ASIP |
rs1015362-G + rs4911414-T |
0.08 |
8 x 10-29 |
1.95 [1.65-2.32] |
Illumina
[316,515] |
N |
|
11/25/08 |
"
|
Red vs. non-red hair color |
5,130 individuals |
3,330 individuals |
20q11.22 |
ASIP |
rs1015362-G + rs4911414-T |
0.08 |
3 x 10-9 |
1.76 [1.34-2.31] |
Illumina
[316,515] |
N |
|
11/25/08 |
"
|
Skin sensitivity to sun |
5,130 individuals |
3,330 individuals |
20q11.22 |
ASIP |
rs1015362-G + rs4911414-T |
0.08 |
2 x 10-24 |
1.76 [1.49-2.08] |
Illumina
[316,515] |
N |
|
11/25/08 |
Han May 16, 2008 PLoS Genet A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
|
Black vs. blond hair color |
2,287 women |
up to 8,465 individuals |
6p25.3 15q13.1 15q13.1 14q32.12 5p13.3 15q13.1 6p25.3 |
IRF4 HERC2 OCA2 SLC24A4 MATP Intergenic EXOC2 |
rs12203592-T rs12913832-A rs11855019-G rs12896399-G rs28777-C rs8033165-T rs6918152-A |
NR NR NR NR NR NR NR |
7 x 10-127 4 x 10-103 2 x 10-24 8 x 10-21 1 x 10-17 5 x 10-11 6 x 10-8 |
.35 [0.33-0.37] decrease in hair color score .44 [0.40-0.48] decrease in hair color score .28 [0.22-0.34] decrease in hair color score .18 [0.14-0.22] increase in hair color score .46 [0.36-0.56] decrease in hair color score .12 [0.08-0.16] increase in hair color score .11 [0.07-0.15] increase in hair color score |
Illumina
[528,173] |
N |
|
11/25/08 |
"
|
Black vs. red hair color |
2,287 women |
up to 8,465 individuals |
15q13.1 6p25.3 16q24.3 15q13.1 5p13.3 15q13.1 6p25.3 |
HERC2 IRF4 MC1R OCA2 MATP Intergenic EXOC2 |
rs12913832-A rs12203592-T rs258322-T rs11855019-G rs28777-C rs8033165-T rs6918152-A |
NR NR NR NR NR NR NR |
1 x 10-77 9 x 10-28 2 x 10-23 6 x 10-20 9 x 10-14 2 x 10-12 5 x 10-7 |
.44 [0.40-0.48] decrease in hair color score .31 [0.25-0.36] decrease in hair color score .36 [0.28-0.44] increase in hair color score .29 [0.23-0.35] decrease in hair color score .46 [0.34-0.58] decrease in hair color score .15 [0.11-0.19] increase in hair color score .11 [0.07-0.15] increase in hair color score |
Illumina
[528,173] |
N |
|
11/25/08 |
Maris May 09, 2008 N Engl J Med Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma
|
Neuroblastoma |
1,032 cases,
2,043 controls |
720 cases,
2,128 controls |
6p22.3 |
FLJ22536, FLJ44180 |
rs6939340-G |
0.50 |
9 x 10-15 |
1.37 [1.27-1.49] |
Illumina
[464,934] |
N |
|
11/25/08 |
Melzer May 09, 2008 PLoS Genet A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
|
Protein quantitative trait loci |
1,200 individuals |
NR |
1q21.3 9q34.2 17q12 11q23.1 12q12 6q26 11q23.3 17p12 12q24.11 13q12.11 18q11.2 1q21.1 22q11.23 17p13.1 6q11.1 19p13.2 17q25.3 15q15.2 16q23.2 2p12 12p12.3 1q21.1 8q21.11 9q31.2 11q24.2 12q24.33 2p13.3 5q35.1 6q23.2 6q24.3 7p21.3 11p15.5 6q22.31 10p11.21 15q21.1 18q12.1 1p21.1 9q22.2 13q12.2 2q23.1 3p12.3 6p21.33 10p12.33 1q23.2 2p15 8q24.21 2p11.2 2q13 11q14.1 |
IL6R ABO CCL4L2 IL18 PDZRN4,CNTN1 LPA PAFAH1B2 HS3ST3B1 ATP2A2 FGF3 OSBPL1A CHD1L GGT1 SHBG KHDRBS2 ANGPTL6 C17orf62 CDAN1 BCM01 CTNNA2 EPS8 CHD1L GDAP1,PI15 TMEM38B KIRREL3 GPR133 DYSF DOCK2 EYA4 SASH1 NXPH1 KCNQ1 GJA1 FZD8,ANKRD30A DUT DSC3 COL11A GADD45G,DIRAS2 SACS EPC2 ROBO1 HLA-C CACNB2 CRP LOC51057 FAM49B SH2D6 IL1RN DLG2 |
rs4129267-C rs505922-? rs4796217-T rs2250417-A rs1880887-? rs7770628-T rs7112513-? rs3848445-? rs11065611-? rs17369571-? rs9635963-? rs4950322-? rs5751901-T rs6761-? rs6455128-? rs8109578-? rs9303029-? rs16957063-? rs4889294-? rs11695685-? rs17415853-? rs4950322-? rs6472866-? rs4742971-? rs1939992-? rs10466868-? rs2900976-? rs169082-? rs9402515-? rs6930337-? rs1285407-? rs2237878-? rs4541776-? rs1779876-? rs11637235-? rs2729409-? rs10874639-? rs2081670-? rs4770433-? rs10191411-? rs9834373-? rs9461688-? rs7076247-? rs12093699-? rs11683229-? rs10092658-? rs7577642-? rs6761276-? rs3885683-? |
0.37 0.34 0.34 0.44 0.03 0.49 0.13 0.05 0.06 0.16 0.18 0.21 0.39 0.31 0.19 0.08 0.08 0.01 0.47 0.30 0.02 0.21 0.42 0.11 0.26 0.12 0.30 0.48 0.09 0.06 0.35 0.07 0.33 0.10 0.28 0.26 0.12 0.15 0.40 0.32 0.17 0.31 0.37 0.29 0.15 0.07 0.27 0.37 0.11 |
2 x 10-57 (sIL-6R) 7 x 10-40 (TNFA) 4 x 10-21 (MIPb) 7 x 10-13 (IL18) 1 x 10-10 (Alkaline phosphatase) 4 x 10-10 (LPA) 6 x 10-9 (Soluble transferrin receptor) 8 x 10-9 (Ft3) 1 x 10-7 (Alpha-1 globulin) 1 x 10-7 (IL1RA) 2 x 10-7 (SHBG) 2 x 10-7 (Resistin) 2 x 10-7 (GGT1) 3 x 10-7 (SHBG) 3 x 10-7 (GOT (AST)) 4 x 10-7 (TSH) 4 x 10-7 (Free IGF1) 5 x 10-7 (Ft4) 5 x 10-7 (IL1B) 5 x 10-7 (IL10) 7 x 10-7 (Ferritin) 7x 10-7 (Hgb) 8 x 10-7 (myoglobin) 8 x 10-7 (GPT (ALT)) 1 x 10-6 (Total IGF-1) 1 x 10-6 (Erythropoeitin) 1 x 10-6 (Albumin) 1 x 10-6 (Leptin) 1 x 10-6 (Alpha-2 macroglobulin) 1 x 10-6 (insulin) 1 x 10-6 (TGF-b1) 1 x 10-6 (Lactic dehydrogenase) 2 x 10-6 (GGT) 3 x 10-6 (Lipoprotein A) 3 x 10-6 (Adiponectin) 3 x 10-6 (Parathyroid hormone) 3 x 10-6 (Fibrinogen) 3 x 10-6 (MIP-1b) 4 x 10-6 (IL12) 4 x 10-6 (IL8) 4 x 10-6 (GP130) 4 x 10-6 (IL18) 6 x 10-6 (CRP) 6 x 10-6 (CRP) 6 x 10-6 (IL6) 6 x 10-6 (Aldolase) 7 x 10-6 (sIL-6R) 7 x 10-6 (IL1RA) 8 x 10-6 (MCP1) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Illumina
[496,032] |
N |
|
11/25/08 |
Kibriya May 08, 2008 Breast Cancer Res Treat A pilot genome-wide association study of early-onset breast cancer
|
Breast cancer |
30 cases,
30 controls |
NR |
2q37.1 |
GLG1 |
3-SNP haplotype 1 |
0.34 |
4 x 10-7 |
NR |
Affymetrix
[200,220] |
N |
|
11/25/08 |
Valdes May 08, 2008 Am J Hum Genet Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis
|
Knee osteoarthritis |
357 cases,
285 controls |
1,177 cases,
2,372 controls |
1q31.1 2q33.3 |
PTGS2, PLA2G4A PARD3B |
rs4140564-? rs1207421-? |
0.05 0.09 |
3 x 10-6 6 x 10-6 |
1.59 [1.31-1.94] 1.46 [1.24-1.73] |
Illumina
[413,461] |
N |
|
11/25/08 |
Chambers May 04, 2008 Nat Genet Common genetic variation near MC4R is associated with waist circumference and insulin resistance
|
Waist circumference and related phenotypes |
2,684 Asian Indian men |
11,955 Asian Indian and European individuals |
16q13 18q21.32 2p23.3 8p21.3 |
CETP MC4R GCKR LPL |
rs3764261-? rs12970134-A rs1260326-? rs2083637-? |
NR 0.36 NR NR |
1 x 10-27 (HDL cholesterol) 2 x 10-9 (waist circumference) 4 x 10-8 (triglycerides) 5 x 10-6 (HDL cholesterol) |
NR .88 [0.59-1.17] cm increase NR NR |
Illumina
[308,067] |
N |
|
11/25/08 |
Loos May 04, 2008 Nat Genet Common variants near MC4R are associated with fat mass, weight and risk of obesity
|
Body mass index |
16,876 individuals |
60,352 individuals |
18q21.32 16q12.2 |
MC4R FTO |
rs17782313-C rs1121980-? |
0.24 NR |
3 x 10-15 4 x 10-8 |
.05 [0.04-0.06] unit increase in log(BMI) .06 [0.04-0.08] unit increase in log(BMI) |
Affymetrix
[344,883] |
N |
|
11/25/08 |
Poduslo April 30, 2008 Am J Med Genet B Neuropsychiatr Genet Genome Screen of Late-Onset Alzheimer's Extended Pedigrees Identifies TRPC4AP by Haplotype Analysis
|
Alzheimer's disease |
29 siblings from 2 affected families,
60 unrelated controls |
199 patients, 85 spouses |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[469,218] |
N |
|
11/25/08 |
Richards April 29, 2008 Lancet Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
|
Bone mineral density |
2,094 women |
6,463 individuals |
11q13.2 8q24.12 |
LRP5 TNFRSF11B |
rs3736228-T rs4355801-A |
0.14 0.53 |
6 x 10-12 8 x 10-10 |
.13 [NR] SD decrease .09 [NR] SD decrease |
Illumina
[314,075] |
N |
|
11/25/08 |
Styrkarsdottir April 29, 2008 N Engl J Med Multiple Genetic Loci for Bone Mineral Density and Fractures
|
Bone mineral density (hip) |
5,861 individuals |
7,925 individuals |
1p36.12 8q24.12 6q25.1 13q14.11 6q25.1 18q21.33 |
ZBTB40 OPG ESR1 RANKL ESR1, C6orf97 RANK |
rs7524102-A rs6993813-C rs1038304-G rs9594738-T rs4870044-T rs3018362-A |
0.82 0.50 0.47 0.56 0.28 0.35 |
5 x 10-16 3 x 10-11 5 x 10-9 2 x 10-8 2 x 10-7 1 x 10-6 |
.15 [0.11-0.19] SD decrease .09 [0.07-0.12] SD decrease .08 [0.06-0.11] SD decrease .1 [0.06-0.13] SD decrease .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD decrease |
Illumina
[301,019] |
N |
|
11/25/08 |
"
|
Bone mineral density (spine) |
5,861 individuals |
7,925 individuals |
13q14.11 8q24.12 6p25.1 6q25.1 1p36.12 6q25.1 6p21.32 2p16.2 |
RANKL OPG ESR1 ESR1, C6orf97 ZBTB40 ESR1, C6orf97 MHC, C6orf10 SPTBN1 |
rs9594759-T rs6469804-A rs4870044-T rs1038304-G rs7524102-A rs1999805-C rs3130340-T rs11898505-G |
0.62 0.51 0.28 0.47 0.82 0.44 0.79 0.67 |
2 x 10-21 7 x 10-15 2 x 10-11 4 x 10-11 9 x 10-9 2 x 10-8 1 x 10-7 8 x 10-7 |
.17 [0.14-0.21] SD decrease .12 [0.09-0.15] SD decrease .11 [0.08-0.14] SD decrease .1 [0.07-0.13] SD decrease .11 [0.07-0.15] SD decrease .09 [0.06-0.12] SD decrease .1 [0.06-0.13] SD decrease .08 [0.05-0.11] SD decrease |
Illumina
[301,019] |
N |
|
11/25/08 |
Walsh April 25, 2008 Science Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
|
Schizophrenia |
150 cases,
268 controls |
83 children,
154 parents |
Pending |
Pending |
Pending |
Pending |
Pending |
Pending |
Illumina
[~550,000] |
Y |
|
11/25/08 |
Reiner April 24, 2008 Am J Hum Genet Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1 Alpha are Associated with C-Reactive Protein
|
C-reactive protein |
909 individuals |
5,106 individuals |
12q24.31 19q13.32 1q23.2 |
HNF1A APOE CRP |
rs1169310-A rs2075650-? rs11265260-? |
0.38 NR NR |
2 x 10-8 1 x 10-7 7 x 10-6 |
.13 [0.08-0.17] mg/l decrease in log(CRP) level NR NR |
Illumina
[317,000] |
N |
|
11/25/08 |
Ridker April 24, 2008 Am J Hum Genet Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
|
C-reactive protein |
6,345 women |
NR |
1q23.2 1p31.3 19q13.32 12q24.31 2p23.3 12q23.2 1q21.3 |
CRP LEPR APOE HNF1A GCKR Unknown IL6R |
rs3091244-? rs1892534-A rs769449-? rs7310409-A rs780094-A rs10778213-G rs8192284-? |
NR NR NR NR NR NR NR |
6 x 10-28 7 x 10-21 9 x 10-21 7 x 10-17 7 x 10-15 1 x 10-10 2 x 10-8 |
.2 [NR] mg/dl increase .17 [NR] mg/dl decrease .26 [NR] mg/dl decrease .15 [NR] mg/dl decrease .14 [NR] mg/dl increase .12 [NR] mg/dl decrease .1 [NR] mg/dl decrease |
Illumina
[336,108] |
N |
|
11/25/08 |
Ober April 09, 2008 N Engl J Med Effect of Variation in CHI31 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
|
YKL-40 levels |
632 individuals |
206 children |
1q32.1 |
CHI3L1 |
rs4950928-G |
0.29 |
1 x 10-13 |
.3 [NR] ng/ml decrease |
Affymetrix
[290,325] |
N |
|
11/25/08 |
Gudbjartsson April 06, 2008 Nat Genet Many sequence variants affecting diversity of adult human height
|
Height |
30,968 individuals |
8,541 individuals |
3q23 12q14.3 7p22.2 6q24.1 4q31.22 6p24.3 2p16.1 14q32.12 1q21.2 4p15.32 6p22.1 17q11.2 18q11.2 1q25.3 6p21.31 7q21.2 20p12.3 9q31.2 15q26.3 1q24.3 6p21.32 6p21.31 8q21.11 17q23.2 8q12.1 17q22 12q22 9q32 6q22.32 17q23.3 6p22.3 16q24.1 20q11.22 2p23.3 6q21 15q25.2 9q22.1 19p13.2 2q35 2q37.1 12p12.2 12p13.2 4q21.21 12q15 Xq21.1 6q21 22q11.23 6q22.33-6q23.1 3q26.2 13q14.3 5q31.1 6p12.3 |
ZBTB38 HMGA2 GNA12 GPR126 HHIP BMP6 EFEMP1, PNPT1 TRIP11, FBLN5, ATXN3, CPSF2 Histone class 2A,MTMR11, SV2A, SF3B4 LCORL, NCAPG Histone class 1,Butyrophilin genes CRLF3, ATAD5, CENTA2, RNF135 CABLES1, RBBP8, C18orf45 C1orf19,GLT25D2 HMGA1, LBH CDK6, PEX1, GATAD1, ERVWE1 BMP2 ZNF462 ADAMTS17 DNM3 HLA class III ANKS1A, TCP11, ZNF76, DEF6,SCUBE3 PXMP3, ZFHX4 BCAS3, NACA2, TBX2, TBX4 PLAG1, MOS, CHCHD7,RDHE2, RPS20,LYN, TGS1, PENK NOG, DGKE, TRIM25, COIL, RISK SOCS2, MRPL42, CRADD, UBE2N COL27A1 C6orf173 MAP3K3, WDR68, LYK5, MT1F NUP153, CAP2, KIF13A ZDHHC7, CRISPLD2, USP10 UQCC, GDF5, CEP250, EIF6, MMP24 ADCY3, RBJ, POMC, DNMT3A, DTNB LIN28B, HACE1, BVES, POPDC3 ADAMTSL3, SH3GL3 SPIN1, CCRK ADAMTS10, MYO1F, PRAM1, OR2Z1 IHH, CRYBA2, FEV, SLC23A3, TUBA1 NPPC, DIS3L2, COPS7B, PDE6D, PTMA PDE3A, SLCO1C1, SLCO1B3 ETV6 BMP3, PRKG2, RASGEF1B LYZ,YEATS4,FRS2,CPSF6,CCT2,LRRC10 ITM2A PPIL6, CD164, SMPD2,MNICAL1,ZBTB24 BCR, GNAZ, RTDR1, IGLL1 L3MBTL3, SAMD3 GOLIM4, SERPINI1 DLEU7 PITX1, PCBD2, CATSPER3, TXNDC15,DDX46, CAMLG SUPT3H, RUNX2 |
rs6763931-A rs8756-C rs798544-G rs3748069-A rs1812175-C rs12198986-A rs3791679-T rs7153027-A rs11205277-G rs6830062-T rs10946808-A rs3760318-C rs4800148-A rs2274432-T rs1776897-C rs2282978-C rs967417-C rs4743034-A rs4533267-A rs678962-G rs185819-T rs4713858-G rs7846385-C rs757608-T rs10958476-C rs4794665-A rs3825199-C rs946053-T rs1490388-T rs7209435-C rs12199222-T rs2326458-C rs6088792-T rs6733301-G rs314268-C rs2554380-T rs2814828-T rs7249094-G rs1052483-C rs749052-A rs11611208-A rs2187642-A rs710841-A rs11177669-A rs1474563-T rs9487094-G rs5751614-A rs6899976-G rs4345115-T rs1239947-G rs31198-T rs9395066-C |
0.45 0.52 0.72 0.74 0.86 0.50 0.81 0.52 0.44 0.89 0.70 0.63 0.79 0.37 0.07 0.29 0.53 0.23 0.28 0.22 0.52 0.86 0.27 0.35 0.23 0.48 0.24 0.52 0.42 0.27 0.33 0.26 0.26 0.87 0.34 0.78 0.25 0.59 0.91 0.94 0.06 0.39 0.27 0.31 0.58 0.69 0.49 0.28 0.63 0.35 0.75 0.48 |
1 x 10-27 2 x 10-16 7 x 10-15 5 x 10-14 1 x 10-11 2 x 10-11 6 x 10-11 1 x 10-10 1 x 10-10 1 x 10-10 6 x 10-10 2 x 10-9 4 x 10-9 8 X 10-9 1 x 10-8 1 x 10-8 2 x 10-8 2 x 10-8 3 x 10-8 3 X 10-8 3 x 10-8 4 x 10-8 5 x 10-8 6 x 10-8 7 x 10-8 1 x 10-7 2 x 10-7 2 x 10-7 6 X 10-7 7 x 10-7 7 x 10-7 8 x 10-7 8 x 10-7 8 x 10-7 8 x 10-7 9 x 10-7 9 X 10-7 1 x 10-6 1 x 10-6 1 x 10-6 2 x 10-6 2 x 10-6 2 x 10-6 3 x 10-6 3 x 10-6 4 x 10-6 6 x 10-6 6 X 10-6 7 x 10-6 8 x 10-6 8 x 10-6 8 x 10-6 |
7.4 [6.03-8.77] % SD taller 6.6 [5.03-8.17] % SD taller 5.9 [6.03-8.77] % SD taller 6.5 [5.44-9.36] % SD taller 8.3 [5.95-10.65] % SD taller 6.8 [4.84-8.76] % SD taller 5.8 [4.04-7.56] % SD taller 5.7 [3.94-7.46] % SD taller 5.1 [3.53-6.67] % SD taller 6.3 [4.34-8.26] % SD taller 5.6 [3.84-7.36] % SD taller 6 [4.04-7.96] % SD taller % SD taller 6.4 [4.24-8.56] % SD taller 5.3 [3.54-7.06] % SD taller 8.8 [5.66-11.94] % SD taller 5.8 [3.84-7.76] % SD taller 4.3 [2.73-5.87] % SD taller 5.3 [3.54-7.06] % SD taller 5.6 [3.64-7.56] % SD taller % SD taller 5.4 [3.44-7.36] % SD taller 5.2 [3.44-6.96] % SD taller 6.8 [4.45-9.15] % SD taller 5 [3.24-6.76] % SD taller 4.4 [2.83-5.97] % SD taller 5.4 [3.44-7.36] % SD taller 3.6 [2.23-4.97] % SD taller 6.2 [3.85-8.55] % SD taller 4.4 [2.83-5.97] % SD taller 4.8 [2.84-6.76] % SD taller 4.8 [2.84-6.76] % SD taller 4.4 [2.64-6.16] % SD taller 5.1 [3.14-7.06] % SD taller 4.7 [2.74-6.66] % SD taller 7.5 [4.56-10.44] % SD taller 4.6 [2.84-6.36] % SD taller 4.5 [2.74-6.26] % SD taller 5.4 [3.24-7.56] % SD taller 4.3 [2.54-6.06] % SD taller 6.9 [4.16-9.64] % SD taller 8.7 [5.17-12.23] % SD taller 11.4 [6.7-16.1] % SD taller 4.6 [2.64-6.56] % SD taller 5 [3.04-6.96] % SD taller 4.5 [2.54-6.46] % SD taller 3.5 [1.93-5.07] % SD taller 4.7 [2.74-6.66] % SD taller 4.3 [2.34-6.26] % SD taller 3.8 [2.23-5.37] % SD taller 4.4 [2.44-6.36] % SD taller 3.8 [2.23-5.37] % SD taller 4.8 [2.64-6.96] % SD taller 3.5 [1.93-5.07] % SD taller |
Illumina and Affymetrix
[up to 304,226] |
N |
|
11/25/08 |
Lettre April 06, 2008 Nat Genet Identification of ten loci associated with height highlights new biological pathways in human growth
|
Height |
15,821 individuals |
13,671 individuals |
3q23 12q14.3 6q24.3 6q22.1 20q11.22 4q31.22 14q32.12 6q21 19p13.3 15q25.2 7q36.3 7q21.2 8q12.1 9q34.11 9q33.1 17q22 16p13.3 14q13.3 |
ZBTB38 HMGA2 GPR126 HIST1H1D GDF5,UQCC HHIP TRIP11,ATXN3 LIN28B DOT1L SH3GL3,ADAMTSL3 WDR60 CDK6 CHCHD7,RDHE2 FUBP3 PAPPA ANKFN1 RAB40C NKX2-1 |
rs724016-G rs1042725-T rs4896582-A rs10946808-G rs6060369-C rs1492820-G rs8007661-T rs314277-A rs12986413-T rs2562784-G rs2730245-G rs2040494-C rs9650315-T rs7466269-G rs7869550-G rs12449568-C rs763014-C rs17104630-G |
0.48 0.49 0.27 0.28 0.36 0.48 0.30 0.13 0.45 0.17 0.33 0.50 0.13 0.33 0.24 0.47 0.43 0.04 |
8 x 10-22 3 x 10-20 2 x 10-18 4 x 10-17 1 x 10-16 1 x 10-11 6 x 10-10 1 x 10-8 3 x 10-8 6 x 10-8 3 x 10-7 4 x 10-7 4 x 10-7 8 x 10-7 1 x 10-6 2 x 10-6 5 x 10-6 8 x 10-6 |
.37 [0.29-0.45] cm taller .48 [0.58-1.09] cm shorter .38 [0.28-0.48] cm shorter .36 [0.26-0.46] cm shorter .44 [0.34-0.72] cm taller .29 [0.21-0.37] cm shorter .42 [0.30-0.54] cm shorter .41 [0.26-0.59] cm taller .31 [0.21-0.46] cm taller .34 [0.21-0.48] cm taller .32 [0.19-0.44] cm taller .26 [0.36-0.65] cm shorter .43 [0.59-1.07] cm shorter .27 [0.38-0.69] cm shorter .33 [0.45-0.82] cm shorter .25 [0.15-0.35] cm taller .24 [0.12-0.29] cm taller .42 [0.61-1.10] cm shorter |
Affymetrix and Illumina
[2,260,683]
(imputed) |
N |
|
11/25/08 |
Weedon April 06, 2008 Nat Genet Genome-wide association analysis identifies 20 loci that influence adult height
|
Height |
13,665 individuals |
16,482 individuals |
3q23
7q21.2 12q14.3
20q11.22
4p15.32 6q22.32 2p16.1 6p21.31 1p12 9q22.32 12q22 4q31.22 1q42.13 13q14.3 15q25.2 1p34.2 2q35 3q22.2 15q26.1 18q21.1 |
ZBTB38
CDK6 HMGA2
GDF5
LCORL LOC387103 EFEMP1 C6orf106 SPAG17 PTCH1 SOCS2 HHIP ZNF678 DLEU7 ADAMTSL3 SCMH1 IHH ANAPC13,CEP63 ACAN DYM |
rs6440003-A
rs2282978-C rs1042725-C
rs6060373-G
rs16896068-A rs4549631-C rs3791675-C rs2814993-A rs12735613-A rs10512248-G rs11107116-G rs6854783-A rs1390401-A rs3116602-G rs10906982-A rs6686842-C rs6724465-A rs10935120-A rs8041863-A rs8099594-A |
0.44
0.33 0.49
0.38
0.16 0.50 0.23 0.15 0.24 0.31 0.23 0.43 0.18 0.21 0.48 0.44 0.10 0.33 0.47 0.35 |
2 x 10-24
8 x 10-23 3 x 10-18
2 x 10-17
2 x 10-13 5 x 10-13 2 x 10-12 4 x 10-12 4 x 10-11 4 x 10-11 6 x 10-10 2 x 10-9 5 x 10-9 7 x 10-9 2 x 10-8 2 x 10-8 2 x 10-8 7 x 10-8 8 x 10-8 3 x 10-7 |
.07 [0.04-0.09] SD taller - among males .09 [0.06-0.12] SD taller - among males .05 [0.03-0.08] SD taller - among males .08 [0.05-0.11] SD shorter - among males .07 [0.03-0.11] SD shorter - among males .06 [0.03-0.08] SD taller - among males .09 [0.05-0.12] SD taller - among males .09 [0.05-0.13] SD taller - among males .08 [0.05-0.11] SD shorter - among males .05 [0.02-0.07] SD taller - among males .04 [0.01-0.07] SD shorter - among males .06 [0.03-0.08] SD taller - among males .04 [0.01-0.08] SD taller - among males .04 [0.00-0.07] SD shorter - among males .05 [0.02-0.07] SD taller - among males .05 [0.02-0.08] SD shorter - among males .06 [0.02-0.10] SD shorter - among males .06 [0.03-0.09] SD shorter - among males .04 [0.01-0.06] SD taller - among males .05 [0.02-0.08] SD taller - among males |
Affymetrix
[402,951] |
N |
|
11/25/08 |
Liu April 04, 2008 PLoS Genet A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease Loci
|
Psoriasis |
218 cases,
519 controls |
1,153 cases,
1,217 controls |
6p21.33 6p21.33 13q13 |
HLA-C HLA-C COG6 |
rs10484554-T rs2395029-C rs7993214-? |
0.15 0.03 0.65 |
2 x 10-39 2 x 10-26 2 x 10-6 |
2.8 [2.40-3.30] 4.1 [3.10-5.30] 1.41 [1.22-1.61] |
Illumina
[305,983] |
N |
|
11/25/08 |
Amos April 03, 2008 Nat Genet Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
|
Lung cancer |
1,154 cases,
1,137 controls |
2,724 cases,
3,694 controls |
15q25.1 1q23.2 3q28 |
CHRNA3, CHRNA5, PSMA4, LOC123688 CRP IL1RAP |
rs8034191-G rs2808630-G rs7626795-G |
NR NR NR |
3 x 10-18 7 x 10-6 8 x 10-6 |
1.3 [1.15-1.47] 1.22 [1.10-1.35] 1.16 [1.05-1.28] |
Illumina
[317,498] |
N |
|
11/25/08 |
Hung April 03, 2008 Nature A susceptibility locus for lung cancer maps to nicotinic acteylcholine receptor subunit genes on 15q25
|
Lung cancer |
1,926 cases,
2,522 controls |
2,513 cases,
4,752 controls |
15q25.1 |
CHRNA3,CHRNA5, CHRNB4, PSMA4, LOC123688 |
rs8034191-C |
0.34 |
5 x 10-20 |
1.3 [1.23-1.37] |
Illumina
[310,023] |
N |
|
11/25/08 |
Thorgeirsson April 03, 2008 Nature A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
|
Nicotine dependence |
10,995 smokers |
4,848 smokers |
15q25.1 |
CHRNA3,CHRNA5,CHRNB4 |
rs1051730-T |
0.35 |
6 x 10-20 |
.1 [0.08-0.12] increase in cigarettes per day |
Illumina
[306,207] |
N |
|
11/25/08 |
Tenesa March 30, 2008 Nat Genet Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
|
Colorectal cancer |
981 cases,
1,002 controls |
16,476 cases,
15,351 controls |
18q21.1 8q24.21 11q23.1 |
SMAD7 POU5FIP1, HsG57825, DQ515897 Intergenic |
rs4939827-T rs7014346-A rs3802842-C |
0.17 0.18 0.43 |
8 x 10-28 9 x 10-26 6 x 10-10 |
1.2 [1.16-1.24] 1.19 [1.15-1.23] 1.11 [1.08-1.15] |
Illumina
[541,628] |
N |
|
11/25/08 |
Tomlinson March 30, 2008 Nat Genet A genome-wide association study identifies colorectal cancer susceptibility loci on chromosome 10p14 and 8q23.3
|
Colorectal cancer |
922 cases, 927 controls |
17,872 cases,
17,526 controls |
8q23.3 10p14 8q24.21 15q13.3 18q21.1 |
EIF3H Intergenic Intergenic Intergenic SMAD7 |
rs16892766-A rs10795668-A rs6983267-? rs4779584-? rs4939827-? |
0.07 0.67 0.48 0.19 0.53 |
3 x 10-18 3 x 10-13 7 x 10-11 5 x 10-7 2 x 10-6 |
1.27 [1.20-1.34] 1.12 [1.10-1.16] 1.24 [1.17-1.33] 1.23 [1.14-1.34] 1.18 [1.10-1.25] |
Illumina
[547,647] |
N |
|
11/25/08 |
Zeggini March 30, 2008 Nat Genet Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
|
Type 2 diabetes |
4,549 cases,
5,579 controls |
24,194 cases,
55,598 controls |
10q25.2 7p15.1 6p22.3 10p13 12q21.1 2p21 3p14.1 1p12 10q23.33 3q27.2 12q13.2 3p25.2 9p21.3 11p15.1 6p21.1 16q12.2 |
TCF7L2 JAZF1 CDKAL1 CDC123,CAMK1D TSPAN8,LGR5 THADA ADAMTS9 NOTCH2, ADAM30 HHEX IGF2BP2 DCD SYN2, PPARG CDKN2A,CDKN2B KCNJ11 VEGFA FTO |
rs7903146-T rs864745-T rs6931514-G rs12779790-G rs7961581-C rs7578597-T rs4607103-C rs10923931-T rs5015480-C rs4402960-T rs1153188-A rs17036101-G rs7020996-C rs5215-C rs9472138-T rs8050136-A |
NR 0.50 NR 0.18 0.27 0.90 0.76 0.11 NR NR 0.73 0.93 NR NR 0.28 NR |
3 x 10-23 5 x 10-14 1 x 10-11 1 x 10-10 1 x 10-9 1 x 10-9 1 x 10-8 4 x 10-8 7 x 10-8 8 x 10-8 2 x 10-7 2 x 10-7 2 x 10-7 4 x 10-7 4 x 10-6 7 x 10-6 |
1.37 [1.28-1.47] 1.1 [1.07-1.13] 1.25 [1.17-1.33] 1.11 [1.07-1.14] 1.09 [1.06-1.12] 1.15 [1.10-1.20] 1.09 [1.06-1.12] 1.13 [1.08-1.17] 1.17 [1.11-1.24] 1.17 [1.10-1.25] 1.08 [1.05-1.11] 1.15 [1.10-1.21] 1.26 [1.15-1.38] 1.16 [1.09-1.23] 1.06 [1.04-1.09] 1.15 [1.09-1.22] |
Affymetrix and Illumina
[2,202,892]
(imputed) |
N |
|
11/25/08 |
Butcher March 25, 2008 Behav Genet The Nature of Nuture: A Genomewide Association Scan for Family Chaos
|
Environmental confusion in the home |
469 children from low chaos families,369 children from high chaos families |
3,529 children |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[117,062] (pooled) |
N |
|
11/25/08 |
Capon March 25, 2008 Hum Mol Genet Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene
|
Psoriasis |
318 cases,
288 controls |
2,361 cases,
1,927 controls |
6p21.33 20q13.13 |
HLA-C SPATA2 |
rs3134792-? rs495337-? |
NR NR |
1 x 10-9 1 x 10-8 |
NR 1.25 [1.12-1.39] |
Illumina
[~408,000]
(pooled) |
N |
|
11/25/08 |
Sullivan March 18, 2008 Mol Psychiatry Genomewide association for schizophrenia in the CATIE study: results of stage 1
|
Schizophrenia |
738 cases,
733 controls |
NR |
15q25.3 1q31.1 1p36.22 13q12.2 16p12.2 Xq28 |
AGBL1 Intergenic Intergenic Intergenic ACSM1, BUCS1 Intergenic |
rs16977195-? rs10911902-? rs4846033-? rs9512730-? rs151222-? rs2159767-? |
0.03 0.17 0.01 0.26 0.08 0.62 |
2 x 10-6 2 x 10-6 4 x 10-6 5 x 10-6 6 x 10-6 7 x 10-6 |
6.01 [NR] 1.79 [NR] 2.87 [NR] 1.52 [NR] 2.1 [NR] 1.33 [NR] |
Affymetrix
[492,900] |
N |
|
11/25/08 |
Gold March 11, 2008 Proc Natl Acad Sci USA Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33
|
Breast cancer |
249 cases,
299 controls
(Ashkenazi Jewish, non-BRCA1/2 carriers) |
1,193 cases,
1,166 controls
(Ashkenazi Jewish, non-BRCA1/2 carriers) |
6q22.33 |
ECHDC1,RNF146 |
rs2180341-G |
0.21 |
3 x 10-8 |
1.41 [1.25-1.59] |
Affymetrix
[150,080] |
N |
|
11/25/08 |
Kirov March 11, 2008 Mol Psychiatry A genome-wide association study in 574 schizophrenia trios using DNA pooling
|
Schizophrenia |
574 cases, 605 controls,
1,148 parents of cases |
NR |
12q24.23 |
CCDC60 |
rs11064768-A |
0.91 |
1 x 10-6 |
NR |
Illumina
[~550,000]
(pooled) |
N |
|
11/25/08 |
Doring March 09, 2008 Nat Genet SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
|
Serum urate |
1,644 individuals |
9,947 individuals |
4p16.1 |
SLC2A9 |
rs7442295-C |
0.40 |
3 x 10-70 |
.35 [NR] mg/dl decrease in uric acid |
Affymetrix
[335,152] |
N |
|
11/25/08 |
Vitart March 09, 2008 Nat Genet SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
|
Serum urate |
794 individuals |
706 individuals |
4p16.1 |
SLC2A9 |
rs737267-C |
0.31 |
3 x 10-9 |
.88 [NR] uM decrease in uric acid [females only] |
Illumina
[308,140] |
N |
|
11/25/08 |
Liu March 05, 2008 Hum Mol Genet Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
|
Obesity |
1,000 individuals |
896 obese individuals,
2,916 lean individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[379,319] |
N |
|
11/25/08 |
Sklar March 04, 2008 Mol Psychiatry Whole-genome association study of bipolar disorder
|
Bipolar disorder |
1,461 cases,
2,008 controls |
409 trios, 365 cases, 351 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[372,193] |
N |
|
11/25/08 |
Hunt March 02, 2008 Nat Genet Newly identified genetic risk variants for celiac disease related to the immune response
|
Celiac disease |
767 cases,
1,422 controls |
1,643 cases,
3,406 controls |
4q27 1q31.2 3q25.33 2q12.1 3q28 6q25.3 12q24.12 3p21.31 |
KIAA1109, ADAD1, IL2, IL21 RGS1 IL12A, SCHIP1 IL1RL1,IL18R1,IL18RAP, SLC9A4 LPP TAGAP SH2B3, ATXN2 CCR1, CCR3 |
rs6822844-C rs2816316-C rs17810546-G rs13015714-C rs1464510-A rs1738074-A rs653178-G rs6441961-A |
0.81 NR NR NR NR NR 0.48 0.30 |
3 x 10-13 3 x 10-11 1 x 10-9 4 x 10-9 5 x 10-9 7 x 10-8 8 x 10-8 3 x 10-7 |
1.44 [1.30-1.58] 1.39 [1.26-1.53] 1.35 [1.23-1.49] 1.28 [1.18-1.39] 1.23 [1.15-1.32] 1.21 [1.13-1.30] 1.21 [1.13-1.30] 1.21 [1.13-1.30] |
Illumina
[310,605] |
N |
|
11/25/08 |
Uhl March 01, 2008 Arch Gen Psychiatry Genome-wide association for methamphetamine dependence: convergent results from 2 samples
|
Methamphetamine dependence |
240 cases, 340 controls |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[up to 466,883]
(pooled) |
N |
|
11/25/08 |
Blauw February 29, 2008 Lancet Neurol Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screen
|
Amyotrophic lateral sclerosis |
406 cases,
404 controls |
NR |
Pending |
Pending |
Pending |
Pending |
Pending |
Pending |
Illumina
[317,503] |
Y |
|
11/25/08 |
Shifman February 15, 2008 PLoS Genet Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women
|
Schizophrenia |
660 cases,
2,271 controls |
2,274 cases,
4,401 controls |
7q22.1 |
RELN |
rs7341475-G |
0.62 |
9 x 10-7 |
1.58 [1.31-1.89] |
Affymetrix [510,552] |
N |
|
11/25/08 |
Eeles February 10, 2008 Nat Genet Multiple newly identified loci associated with prostate cancer susceptibility
|
Prostate cancer |
1,854 cases, 1,894 controls |
3,268 cases, 3,366 controls |
10q11.23 19q13.33 8q24.21 8q24.21 11q13.2 17q12 6q25.3 7q21.3 Xp11.22 3p12.1 8q24.21 17q24.3 |
MSMB KLK3 Intergenic Intergenic Intergenic HNF1B SLC22A3 LMTK2 NUDT10, NUDT11 SLC22A3 Intergenic Intergenic |
rs10993994-T rs2735839-G rs4242384-C rs6983267-G rs7931342-G rs7501939-C rs9364554-T rs6465657-C rs5945619-C rs2660753-T rs1016343-T rs1859962-G |
0.40 0.85 0.09 0.49 0.51 0.57 0.29 0.46 0.36 0.11 0.18 0.46 |
9 x 10-29 2 x 10-18 3 x 10-16 9 x 10-13 2 x 10-12 9 x 10-12 6 x 10-10 1 x 10-9 2 x 10-9 3 x 10-8 1 x 10-7 1 x 10-6 |
1.25 [1.17-1.34] 1.2 [1.10-1.33] 1.88 [NR] 1.42 [NR] 1.19 [1.11-1.27] 1.41 [NR] 1.17 [1.08-1.26] 1.12 [1.05-1.20] 1.19 [1.07-1.31] 1.18 [1.06-1.31] 1.37 [NR] 1.26 [NR] |
Illumina [541,129] |
N |
|
11/25/08 |
Gudmundsson February 10, 2008 Nat Genet Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
|
Prostate cancer |
1,854 cases,
21,372 controls |
8,239 cases,
7,590 controls |
Xp11.22 2p15 |
NUDT10, NUDT11, LOC340602, GSPT2, MAGED1 EHBP1 |
rs5945572-A rs721048-A |
0.35 0.19 |
4 x 10-13 8 x 10-9 |
1.23 [1.16-1.30] 1.15 [1.10-1.21] |
Illumina
[310,520] |
N |
|
11/25/08 |
Thomas February 10, 2008 Nat Genet Multiple loci identified in a genome-wide association study of prostate cancer
|
Prostate cancer |
1,172 cases,
1,157 controls |
3,941 cases,
3,964 controls |
8q24.21 10q11.23 8q24.21 17q12 11q13.2 10q26.13 7p15.2 |
Intergenic MSMB Intergenic HNF1B Intergenic CTBP2 JAZF1 |
rs4242382-A rs10993994-T rs6983267-G rs4430796-A rs10896449-G rs4962416-C rs10486567-G |
0.12 0.40 0.53 0.54 0.52 0.27 0.77 |
3 x 10-19 7 x 10-13 7 x 10-12 1 x 10-9 2 x 10-9 2 x 10-7 2 x 10-6 |
1.66 [1.47-1.87] 1.16 [1.04-1.29] 1.28 [1.15-1.45] 1.18 [1.04-1.32] 1.1 [0.98-1.23] 1.17 [1.05-1.30] 1.12 [1.02-1.25] |
Illumina
[527,869] |
N |
|
11/25/08 |
Sandhu February 09, 2008 Lancet LDL-cholesterol concentrations: a genome-wide association study
|
LDL cholesterol |
11,685 individuals |
5,036 individuals |
1p13.3 19q13.32 2p24.1 |
CELSR2,PSRC1 APOC1 APOB |
rs599839-G rs4420638-G rs562338-T |
0.19 0.18 0.20 |
1 x 10-33 1 x 10-20 1 x 10-9 |
.16 [0.14-0.18] mmol/L decrease .06 [0.04-0.08] mmol/L increase .04 [0.02-0.06] mmol/L decrease |
Affymetrix and Illumina [up to 461,986] |
N |
|
11/25/08 |
Uda February 05, 2008 Proc Natl Acad Sci USA Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia
|
Fetal hemoglobin levels |
4,305 individuals |
521 individuals |
2p15 11p15.4 |
BCL11A HBB
|
rs1186868-T rs4910742-A |
0.20 0.07 |
7 x 10-35 1 x 10-21 |
.48 [NR] SD decrease in HbF .58 [NR] SD decrease in HbF |
Affymetrix [362,129] |
N |
|
11/25/08 |
Kong February 02, 2008 Science Sequence Variants in the RNF212 Gene Associate with Genomewide Recombination Rate
|
Recombination rate (females) |
1,702 women |
1,663 women |
4p16.3 |
RNF212,SPON2 |
rs1670533-C |
0.23 (men and women combined) |
2 x 10-12 |
88.2 [63.7-112.7] cM increase |
Illumina
[309,241] |
N |
|
11/25/08 |
"
|
Recombination rate (males) |
1,887 men |
1,248 men |
4p16.3 |
RNF212,SPON2 |
rs3796619-T |
0.33 (men and women combined) |
3 x 10-24 |
70.7 [84.3-57.1] cM decrease |
Illumina [309,241] |
N |
|
12/11/08 |
Berrettini January 29, 2008 Mol Psychiatry Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking
|
Nicotine dependence |
7,481 individuals |
~2000 individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[460,959] |
N |
|
11/25/08 |
Kayser January 24, 2008 Am J Hum Genet Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
|
Iris color |
1,406 individuals |
8,273 individuals |
15q13.1 |
HERC2 |
rs916977-? |
NR |
1 x 10-43 |
NR |
Affymetrix and Illumina
[up to ~500,000]
(pooled) |
N |
|
11/25/08 |
Butcher January 22, 2008 Genes Brain Behav Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays
|
General cognitive ability |
458 low g, 402 high g twin children (unrelated) |
3,195 twin children (unrelated) |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[449,127] |
N |
|
11/25/08 |
Harley January 20, 2008 Nat Genet Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
|
Systemic lupus erythematosus |
720 female cases,
2,337 female controls |
1,846 female cases,
1,825 female controls |
6p21.33 16p11.2 7q32.1 11p15.5 3p14.3 1q25.1 |
HLA region ITGAM IRF5, TNPO3 KIAA1542 PXK Intergenic |
rs3131379-A rs9888739-T rs12537284-A rs4963128-? rs6445975-C rs10798269-? |
0.1 0.13 0.13 0.34 0.28 0.64 |
2 x 10-52 2 x 10-23 4 x 10-19 3 x 10-10 7 x 10-9 1 x 10-7 |
2.36 [2.11-2.64] 1.62 [1.47-1.78] 1.54 [1.40-1.70] 1.28 [1.18-1.37] 1.25 [1.16-1.35] 1.22 [1.14-1.32] |
Illumina
[317,501] |
N |
|
11/25/08 |
Hom January 20, 2008 N Engl J Med Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
|
Systemic lupus erythematosus |
1,311 cases,
3,340 controls |
793 cases,
857 controls |
6p21.32 2q32.3 7q32.1 16p11.2 8p23.1 9q34.13 5p12 18q22.3 1p31.3 |
HLA-DQA1 STAT4 IRF5, TNPO3 ITGAM, ITGAX C8orf13, BLK NTNG2 GHR SOCS6 NEGR1 |
rs2187668-A rs7574865-T rs10488631-C rs11574637-C rs13277113-A rs11243676-A rs979233-T rs17083844-A rs12141391-A |
0.11 0.23 0.12 0.19 0.23 0.07 0.46 0.03 0.02 |
3 x 10-21 9 x 10-14 2 x 10-11 3 x 10-11 1 x 10-10 3 x 10-6 4 x 10-6 6 x 10-6 7 x 10-6 |
NR NR NR 1.33 [1.22-1.46] 1.39 [1.28-1.51] NR NR NR NR |
Illumina
[502,033] |
N |
|
11/25/08 |
Kozyrev January 20, 2008 Nat Genet Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
|
Systemic lupus erythematosus |
279 cases,
515 controls |
1,757 cases,
1,540 controls |
4q24 |
BANK1 |
rs10516487-G |
0.77 |
4 x 10-10 |
1.38 [1.25-1.53] |
Affymetrix
[85,042] |
N |
|
11/25/08 |
Hakonarson January 15, 2008 Diabetes A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
|
Type 1 diabetes |
467 trios, 561 cases, 1,143 controls |
549 families, 364 trios |
12q13.2 |
RAB5B, SUOX, IKZF4, ERBB3, CDK2 |
rs1701704-C |
0.35 |
9 x 10-10 |
1.25 [1.12-1.40] |
Illumina
[543,071] |
N |
|
11/25/08 |
Byun January 14, 2008 Arch Neurol Genome-Wide Pharmacogenomic Analysis of the Response to Interferon Beta Therapy in Multiple Sclerosis
|
Response to interferon beta therapy |
206 multiple sclerosis cases |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[~100,000]
(pooled) |
N |
|
11/25/08 |
Kathiresan January 13, 2008 Nat Genet Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|
HDL cholesterol |
2,758 individuals |
18,544 individuals |
16q13 15q22.1 8p21.3 1q42.13 9q31.1 18q21.1 |
CETP LIPC LPL GALNT2 ABCA1 LIPG, ACAA2 |
rs1800775-C rs1800588-T rs328-G rs4846914-G rs3890182-A rs2156552-A |
0.51 0.21 0.09 0.40 0.13 0.18 |
1 x 10-73 2 x 10-32 9 x 10-23 2 x 10-13 3 x 10-10 2 x 10-7 |
.18 [0.16-0.20]% SD lower .14 [0.12-0.16]% SD higher .17 [0.13-0.21]% SD higher .07 [0.05-0.09] % SD lower .1 [0.06-0.14]% SD lower .07 [0.05-0.09]% SD lower |
Affymetrix
[389,878] |
N |
|
11/25/08 |
"
|
LDL cholesterol |
2,758 individuals |
18,544 individuals |
19q13.32 19p13.2 1p32.3 1p13.3 2p24.1 5q13.3 19p13.11 |
APOE, APOC1, APOC4, APOC2 LDLR PCSK9 CELSR2,PSRC1,SORT1 APOB HMGCR CILP2, PBX4 |
rs4420638-G rs6511720-T rs11591147-T rs646776-C rs693-A rs12654264-T rs16996148-T |
0.20 0.10 0.01 0.24 0.48 0.39 0.10 |
1 x 10-60 2 x 10-51 2 x 10-44 3 x 10-29 1 x 10-21 1 x 10-20 3 x 10-8 |
.19 [0.15-0.23] % SD higher .26 [0.22-0.30] % SD lower .47 [0.41-0.53] % SD lower .16 [0.14-0.18] % SD lower .12 [0.10-0.14] % SD higher .1 [0.08-0.12] % SD higher .1 [0.06-0.14] % SD lower |
Affymetrix
[389,878] |
N |
|
11/25/08 |
"
|
Triglycerides |
2,758 individuals |
18,544 individuals |
8p21.3 7q11.23 11q23.3 8q24.13 1q42.13 2p23.3 19p13.11 1p31.3 2p24.1 |
LPL BCL7B, TBL2, MLXIPL APOA1, APOC3, APOA4, APOA5, ZNF259, BUD13 TRIB1 GALNT2 GCKR CILP2, PBX4 ANGPTL3, DOCK7, ATG4C APOB |
rs328-G rs17145738-T rs28927680-G rs17321515-G rs4846914-G rs780094-T rs16996148-T rs12130333-T rs693-A |
0.09 0.13 0.07 0.49 0.40 0.34 0.10 0.22 0.48 |
2 x 10-28 7 x 10-22 2 x 10-17 4 x 10-17 7 x 10-15 3 x 10-14 4 x 10-9 2 x 10-8 2 x 10-7 |
.19 [0.15-0.23]% SD lower .14 [0.25-0.53] % SD lower .26 [0.20-0.32]% SD higher .08 [0.06-0.10] % SD lower .08 [0.06-0.10] % SD higher .13 [0.09-0.17]% SD higher .1 [0.06-0.14] % SD lower .11 [0.07-0.15] % SD lower .08 [0.04-0.12]% SD higher |
Affymetrix
[389,878] |
N |
|
11/25/08 |
Kooner January 13, 2008 Nat Genet Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
|
Triglycerides |
2,011 individuals |
10,536 individuals |
11q23.3 8p21.3 7q11.23 11q23.3 |
LOC440069, MGC13125 LPL, C8orf35, SLC18A1 MLXIPL APOA1,KIAA0999,LOC645044 |
rs1558861-C rs326-A rs3812316-C rs2075292-G |
0.18 0.78 0.95 0.24 |
2 x 10-26 5 x 10-12 1 x 10-10 5 x 10-8 |
17 [13.28-20.72] % higher 6.6 [3.66-9.54] % higher 10.5 [5.3-17.7]% higher 8.7 [5.76-11.64] % higher |
Perlegen
[up to 216,774] |
N |
|
11/25/08 |
Sanna January 13, 2008 Nat Genet Common variants in the GDF5-UQCC region are associated with variation in human height
|
Height |
6,669 individuals |
28,801 individuals |
20q11.22
4q12
15q26.1
3q23
5q14.1 |
BFZB
PDGFRA
POLG
ZBTB38
HOMER1 |
rs6060369-C
rs17690232-C
rs4932217-A
rs724016-G
rs10078095-C |
0.44
0.80
0.58
0.36
0.22 |
2 x 10-16
4 x 10-7
8 x 10-7
1 x 10-6
3 x 10-6 |
.44 [NR] cm taller .86 [NR] cm taller .66 [NR] cm taller .61 [NR] cm taller .9 [NR] cm taller |
Illumina and Affymetrix
[~2,261,000] (imputed) |
N |
|
11/25/08 |
Willer January 13, 2008 Nat Genet Newly identified loci that influence lipid concentrations and risk of coronary artery disease
|
HDL cholesterol |
8,656 individuals |
11,399 individuals |
16q13 16q13 16q13 15q22.1 8p21.3 1q42.13 18q21.1 9q31.1 12q24.11 16q22.1 |
CETP CETP CETP LIPC LPL GALNT2 LIPG ABCA1 MVK,MMAB LCAT |
rs3764261-A rs1864163-G rs9989419-G rs4775041-C rs10503669-A rs2144300-T rs2156552-T rs4149268-C rs2338104-G rs255052-A |
0.31 0.80 0.65 0.33 0.10 0.60 0.84 0.64 0.45 0.17 |
2 x 10-57 7 x 10-39 3 x 10-31 3 x 10-20 4 x 10-19 3 x 10-14 6 x 10-12 1 x 10-10 3 x 10-8 1 x 10-7 |
3.47 [NR] mg/dl higher 4.12 [NR] mg/dl higher 1.72 [NR] mg/dl higher 1.38 [NR] mg/dl higher 2.09 [NR] mg/dl higher 1.11 [NR] mg/dl higher 1.2 [NR] mg/dl higher .82 [NR] mg/dl higher .48 [NR] mg/dl higher .74 [NR] mg/dl higher |
Illumina and Affymetrix
[~2,261,000] (imputed) |
N |
|
11/25/08 |
"
|
LDL cholesterol |
8,589 individuals |
7,440-10,783 individuals |
19q13.32 1p13.3 19p13.2 2p24.1 1p32.3 19p13.11
6p21.32 |
APOE,APOC1,APOC4 CELSR2,PSRC1,SORT1 LDLR APOB PCSK9 NCAN,CILP2
B3GALT4 |
rs4420638-G rs599839-A rs6511720-G rs562338-G rs11206510-T rs16996148-G
rs2254287-G |
0.18 0.77 0.90 0.82 0.81 0.89
0.38 |
3 x 10-43 6 x 10-33 4 x 10-26 6 x 10-22 4 x 10-11 3 x 10-9
5 x 10-8 |
6.61 [NR] mg/dl higher 5.48 [NR] mg/dl higher 9.17 [NR] mg/dl higher 4.89 [NR] mg/dl higher 3.04 [NR] mg/dl higher 3.32 [NR] mg/dl higher 1.91 [NR] mg/dl higher |
Illumina and Affymetrix
[~2,261,000] (imputed) |
N |
|
11/25/08 |
"
|
Triglycerides |
8,684 individuals |
5,312-9,707 individuals |
2p23.3 11q23.3 8p21.3
8q24.13
7q11.23
1p31.3
19p13.3 15q22.1 1q42.13 |
GCKR APOA5, APOA4, APOC3, APOA1 LPL
TRIB1
MLXIPL
ANGPTL3
NCAN,CILP2 LIPC GALNT2 |
rs780094-T rs12286037-T rs10503669-C
rs17321515-A
rs17145738-C
rs1748195-C
rs16996148-G rs4775041-C rs2144300-C |
0.39 0.06 0.90
0.56
0.84
0.70
0.92 0.33 0.40 |
6 x 10-32 1 x 10-26 4 x 10-22
7 x 10-13
2 x 10-12
2 x 10-10
3 x 10-9 2 x 10-8 8 x 10-7 |
8.59 [NR] mg/dl higher 25.82 [NR] mg/dl higher 11.57 [NR] mg/dl higher 6.42 [NR] mg/dl higher 8.21 [NR] mg/dl higher 7.12 [NR] mg/dl higher 6.1 [NR] mg/dl higher 3.62 [NR] mg/dl higher 4.25 [NR] mg/dl higher |
Illumina and Affymetrix
[~2,261,000]] (imputed) |
N |
|
11/25/08 |
Wallace January 10, 2008 Am J Hum Genet Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
|
LDL cholesterol |
1,955 hypertensive individuals |
2,033 individuals in 519 families;
1,461 twins (1/pair selected randomly) |
11q23.3 1p13.3 2p23.3 |
APOA1,APOC3,APOA5 CELSR2,PSRC1 GCKR |
rs6589566-G rs599839-G rs780094-T |
0.06 0.24 0.39 |
3 x 10-11 1 x 10-7 5 x 10-7 |
NR .95 [0.93-0.97] NR |
Affymetrix
[400,496] |
N |
|
11/25/08 |
"
|
Serum urate |
1,955 hypertensive individuals |
2,033 individuals in 519 families;
1,461 twins (1/pair selected randomly) |
4p16.1 |
SLC2A9,WDR1 |
rs7442295-A |
0.79 |
2 X 10-15 |
.02 [0.02-0.03] mMol/L higher |
Affymetrix [400,496] |
N |
|
11/25/08 |
Hinney December 26, 2007 PLoS ONE Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
|
Obesity (early onset extreme) |
487 young cases,
442 controls |
2,269 individuals in 644 families |
16q12.2 |
FTO |
rs1121980-T |
0.41 |
1 x 10-7 |
1.66 [1.37-2.01] |
Affymetrix
[440,794] |
N |
|
11/25/08 |
Duggan December 19, 2007 J Natl Cancer Inst Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP
|
Prostate cancer |
1,235 cases,
1,599 controls |
1,242 cases,
917 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina & Affymetrix
[60,275] |
N |
|
11/25/08 |
van Es December 16, 2007 Nat Genet Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
|
Amyotrophic lateral sclerosis |
737 cases,
721 controls |
1,030 cases,
1,195 controls |
7q36.2 15q22.1 2p24.2 |
DPP6 LIPC Intergenic |
rs10260404-C rs3825776-? rs7580332-? |
0.35 0.29 0.45 |
5 x 10-8 9 x 10-6 9 x 10-6 |
1.3 [1.18-1.43] 1.34 [1.20-1.46] 1.22 [1.09-1.35] |
Illumina
[311,946] |
N |
|
11/25/08 |
Cronin December 07, 2007 Hum Mol Genet A genome-wide association study of sporadic ALS in a homogenous Irish population
|
Amyotrophic lateral sclerosis |
221 cases,
211 controls |
737 cases,
721 controls |
7q36.2 |
DPP6 |
rs10260404-? |
0.37 |
3 x 10-6 |
1.37 [1.20-1.56] |
Illumina
[497,917] |
N |
|
11/25/08 |
Suzuki November 17, 2007 Pharmacogenet Genomics A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis
|
Coronary spasm |
50 Japanese female cases,
50 Japanese female controls |
151 Japanese female cases, 160 Japanese female controls |
14q21.1 |
Intergenic |
rs10498345-T |
0.30 |
9 x 10-7 |
2.33 [1.64-3.23] |
Affymetrix
[97,552] |
N |
|
11/25/08 |
Li November 12, 2007 Arch Neurol Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
|
Alzheimer's disease |
753 cases,
736 controls |
418 cases,
249 controls |
19q13.32 |
APOE, APOC |
rs4420638-? |
NR |
2 x 10-44 |
NR |
Affymetrix
[469,438] |
N |
|
11/25/08 |
Li November 09, 2007 PLoS Genet The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts
|
Serum urate |
4,305 Sardinian individuals |
1,301 Tuscan individuals |
4p16.1 |
GLUT9 |
rs6855911-A |
0.74 |
2 x 10-16 |
.32 [NR] mg/dl higher |
Affymetrix [362,129] |
N |
|
11/25/08 |
Plenge November 04, 2007 Nat Genet Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
|
Rheumatoid arthritis |
397 cases,
1,211 Framingham individuals |
2,283 cases,
3,258 controls |
6q23.3 6q23.3 |
TNFAIP3, OLIG3 TNFAIP3, OLIG3 |
rs10499194-C rs6920220-? |
0.71 0.20 |
1 x 10-9 1 x 10-7 |
1.33 [1.15-1.52] 1.22 [NR] |
Affymetrix
[79,853] |
N |
|
11/25/08 |
Webster November 01, 2007 Neurodegener Dis Sorl1 as an Alzheimer's disease predisposition gene?
|
Alzheimer's disease |
664 cases,
422 controls |
NR |
19q13.32 |
APOE |
rs4420638-? |
NR |
1 x 10-39 |
NR |
Affymetrix
[~502,627] |
N |
|
11/25/08 |
Sulem October 21, 2007 Nat Genet Genetic determinants of hair, eye and skin pigmentation in Europeans
|
Blond vs. brown hair color |
2,986 individuals |
3,932 individuals |
14q32.12 15q13.1 12q21.33 16q24.3 |
SLC24A4 OCA2 KITLG MC1R |
rs12896399-T rs1667394-A rs12821256-C rs1805007-T |
0.44 0.88 0.14 0.08 |
1 x 10-48 6 x 10-35 4 x 10-30 2 x 10-13 |
2.56 [2.12-3.09] 4.94 [3.16-7.71] 2.32 [1.86-2.92] 2.34 [1.69-3.24] |
Illumina
[317,511] |
N |
|
02/16/09 |
"
|
Blue vs. brown eyes |
2,986 individuals |
3,932 individuals |
15q13.1 |
OCA2 |
rs1667394-A |
0.88 |
1 x 10-241 |
29.43 [21.47-40.35] |
Illumina
[317,511] |
N |
|
11/25/08 |
"
|
Blue vs. green eyes |
2,986 individuals |
3,932 individuals |
15q13.1 14q32.12 11q14.3 |
OCA2 SLC24A4 TYR |
rs1667394-A rs12896399-T rs1393350-A |
0.98 0.40 0.23 |
2 x 10-53 4 x 10-38 3 x 10-12 |
6.74 [4.61-9.83] 2.06 [1.76-2.42] 1.52 [1.28-1.81] |
Illumina
[317,511] |
N |
|
11/25/08 |
"
|
Freckles |
2,986 individuals |
3,932 individuals |
16q24.3 6p25.3 11q14.3 |
MC1R SEC5L1,IRF4 TYR |
rs1805007-T rs1540771-A rs1042602-C |
0.05 0.42 0.67 |
1 x 10-96 4 x 10-18 2 x 10-11 |
4.37 [3.56-5.37] 1.4 [1.26-1.57] 1.32 [1.17-1.49] |
Illumina
[317,511] |
N |
|
02/16/09 |
"
|
Red vs non-red hair color |
2,986 individuals |
3,932 individuals |
16q24.3 |
MC1R |
rs1805007-T |
NR |
2 x 10-142 |
12.47 [9.37-16.60] |
Illumina
[317,511] |
N |
|
02/16/09 |
"
|
Skin sensitivity to sun |
2,986 individuals |
3,932 individuals |
16q24.3 11q14.3 |
MC1R TYR |
rs1805007-T rs1393350-A |
0.06 0.27 |
2 x 10-55 2 x 10-6 |
2.94 [2.42-3.58] 1.26 [1.11-1.43] |
Illumina
[317,511] |
N |
|
11/25/08 |
Stokowski October 15, 2007 Am J Hum Genet A genomewide association study of skin pigmentation in a South Asian population
|
Skin pigmentation |
363 with maxL* < 56 and 374 with maxL* > 63; 20% tails of distribution |
116 low maxL*, 115 high maxL* individuals |
15q21.1 5p13.3 11q14.3 |
SLC24A5 SLC45A2 TYR |
rs1834640-G rs16891982-C rs1042602-C |
0.08 0.83 0.84 |
1 x 10-50 3 x 10-11 4 x 10-10 |
12.5 [8.33-20.0] 4.86 [2.88-8.21] 4.36 [2.64-7.20] |
Perlegen [1,502,205] (pooled) |
N |
|
11/25/08 |
Broderick October 14, 2007 Nat Genet A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
|
Colorectal cancer |
940 cases,
965 controls |
7,473 cases,
5,984 controls |
18q21.1 |
SMAD7 |
rs4939827-T |
0.52 |
1 x 10-12 |
1.16 [1.09-1.27] |
Illumina
[547,647] |
N |
|
11/25/08 |
Cervino October 08, 2007 Ann NY Acad Sci A genome-wide study of lupus: preliminary analysis and data release
|
Lupus |
51 cases,
114 controls |
NR |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[241,701] |
N |
|
11/25/08 |
Benjamin September 19, 2007 BMC Med Genet Genome-wide association with select biomarker traits in the Framingham Heart Study
|
Select biomarker traits |
1,012 individuals
(Framingham) |
NR |
1q23.2 1q23.2 1q23.2 1p31.1
19q12 10q26.2 15q21.3 4q31.1 5q23.2 6q15 1q23.2 9q21.32 10q21.1 13q14.11 6q21 7p13 1q23.2 11q23.2 13q21.1 7p21.3 14q23.2 |
FCER1A,OR10J3 OR10J1 CRP Intergenic
ZNF536 PTPRE, MKI67 Intergenic CLGN, ELMOD2 Intergenic Intergenic IGSF4B Intergenic Intergenic Intergenic Intergenic Intergenic IGSF4B DRD2 Intergenic Intergenic Intergenic |
rs2494250-? rs4128725-? rs2794520-? rs7552393-?
rs746961-? rs2387326-? rs10518765-? rs17532515-? rs1119582-? rs10485165-? rs10489849-? rs1998303-? rs583012-? rs10492681-? rs1417352-? rs1486139-? rs1474747-? rs1079596-? rs10507577-? rs7778619-? rs8005745-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
1 x 10-14 (MCP1) 4 x 10-12 (MCP1) 3 x 10-8 (CRP average 2,6,7) 5 x 10-7 (TNFA)
8 x 10-7 (CRP6) 1 x 10-6 (VitKPhylloq) 1 x 10-6 (AlkPhos) 1 x 10-6 (Bilirubin) 1 x 10-6 (CRP average 2,6,7) 1 x 10-6 (VitD25OH) 1 x 10-6 (MCP1) 1 x 10-6 (AAT) 2 x 10-6 (CRP2) 2 x 10-6 (ALT2) 2 x 10-6 (ANP6) 2 x 10-6 (ANP6) 3 x 10-6 (MCP1) 3 x 10-6 (ANP6) 3 x 10-6 (VitD25OH) 3 x 10-6 (CD40L) 4 x 10-6 (CD40L) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Fox September 19, 2007 BMC Med Genet Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
|
Body mass index |
1,341 individuals
(Framingham) |
NR |
7q32.3 7q23.3 13q21.32 |
Intergenic Intergenic Intergenic |
rs1106683-? rs1106684-? rs1333026-? |
NR NR NR |
1 x 10-7 2 x 10-6 8 x 10-6 |
NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Waist circumference traits |
1,341 individuals
(Framingham) |
NR |
8q21.1 3q13.31 |
GDAP1 Intergenic |
rs4471028-? rs1875517-? |
NR NR |
2 x 10-7 2 x 10-6 |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Gottlieb September 19, 2007 BMC Med Genet Genome-wide association of sleep and circadian phenotypes
|
Sleep duration |
738 individuals
(Framingham) |
NR |
3p22.1
13q21.2 |
MYR1P
Intergenic |
rs6599077-?
rs10492604-? |
NR NR |
1 x 10-7
4 x 10-6 |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Sleepiness |
738 individuals
(Framingham) |
NR |
5q11.2
8q13.3 |
PDE4D
EYA1 |
rs1823068-?
rs2218488-? |
NR NR |
3 x 10-8 (sleepiness)
3 x 10-6 (sleepiness) |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Hwang September 19, 2007 BMC Med Genet A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study
|
Cystatin C |
810-1,010 individuals
depending on measure
(Framingham) |
NR |
20p11.21 |
CST9L, CST9, CST3 |
rs1158167-? |
NR |
9 x 10-9 |
NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Thyroid stimulating hormone |
810-1,010 individuals
depending on measure
(Framingham) |
NR |
7p15.3
6q21
7p15.3 |
Intergenic
HACE1
RAPGEF5 |
rs6977660-?
rs9322817-?
rs10499559-? |
NR NR NR |
4 x 10-6
7 x 10-6
8 x 10-6 |
NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Urinary albumin excretion |
810-1,010 individuals
depending on measure
(Framingham |
NR |
11q23.2 21q21.3 |
FAM55B Intergenic |
rs1712790-? rs9305354-? |
NR NR |
2 x 10-6 8 x 10-6 |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Kathiresan September 19, 2007 BMC Med Genet A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
|
Blood lipid traits |
1,087 individuals
(Framingham) |
~8,100 individuals |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Kiel September 19, 2007 BMC Med Genet Genome-wide association with bone mass and geometry in the Framingham Heart Study
|
Bone mineral density |
1,141 individuals
(Framingham) |
NR |
13q21.31 16q23.3 10p15.2 12q21.1 20q11.23 4p16.1 3p24.1 7q35 |
Intergenic Intergenic Intergenic Intergenic CTNNBL1 Intergenic RBMS3 CNTNAP2 |
rs9317284-? rs4087296-? rs2165468-? rs10506701-? rs4811196-? rs9291683-? rs10510628-? rs2214681-? |
NR NR NR NR NR NR NR NR |
2 x 10-7 (FNBMDm) 3 x 10-7 (TRBMDf) 1 x 10-6 (FNBMDm) 1 x 10-6 (TRBMD) 1 x 10-6 (TRBMDf) 2 x 10-6 (BUA) 3 x 10-6 (TRBMDm) 3 x 10-6 (BUA) |
NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Hip geometry |
1,141 individuals
(Framingham) |
NR |
12q21.31
5p14.1
8p12 5q14.3 3q12.3 1p11.2 3p14.3 5q13.2 11q14.1 18q12.1 3p14.1 12p13.31 13q13.3 6p24.1 11q23.2 3p24.3 |
Intergenic
Intergenic
NRG1 GPR98 Intergenic Intergenic ERC2 ZNF366 Intergenic Intergenic Intergenic VAMP1 Intergenic PHACTR1 Intergenic KCNH8 |
rs10506821-?
rs2548003-?
rs10503887-? rs10514345-? rs991258-? rs6600671-? rs2054989-? rs10515148-? rs1452928-? rs4131805-? rs922948-? rs10492096-? rs1590305-? rs4715166-? rs638882-? rs2053506-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
2 x 10-7 (ShaftW1f)
2 x 10-7 (NeckZ1rf)
2 x 10-7 (ShaftZ1R) 2 x 10-7 (NeckZ1) 5 x 10-7 (ShaftW1) 6 x 10-7 (NeckZ1rf) 6 x 10-7 (NeckW1rf) 6 x 10-7 (NeckZ1rf) 7 x 10-7 (ShaftW1f) 2 x 10-6 (NSAm) 2 x 10-6 (ShaftW1f) 3 x 10-6 (ShaftZ1rf) 3 x 10-6 (NeckZ1rm) 3 x 10-6 (NeckW1rf) 4 x 10-6 (NeckZ1rf) 4 x 10-6 (NeckZ1) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Larson September 19, 2007 BMC Med Genet Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
|
Atrial fibrillation |
1,341-1,345 individuals, depending on measure
(Framingham) |
NR |
13q14 15q23
11q22.1 |
Intergenic Intergenic
CNTN5 |
rs958546-? rs4776472-?
rs10501920-? |
NR NR NR |
5x10-6 8x10-6
9x10-6 |
NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Heart failure |
1,341-1,345 individuals, depending on measure
(Framingham |
NR |
10q25.3 |
KIAA1598 |
rs740363-? |
NR |
9 X 10-6 |
NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Major CVD |
1,341-1,345 individuals, depending on measure
(Framingham) |
NR |
6p24.1 |
Intergenic |
rs499818-? |
NR |
7x10-6 (major CVD) |
NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Levy September 19, 2007 BMC Med Genet Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
|
Blood pressure |
644-1,327 individuals, depending on measure
(Framingham) |
NR |
16q23.3 2q36.3 1p31.3
14q24.3
8q13.3 3p26.3 5q22.1 14q24.3 6q15 |
CDH13 CCL20, WDR69 Intergenic
Intergenic
Intergenic CNTN4 CAMK4 C14orf118 Intergenic |
rs3096277-? rs7591163-? rs10493340-?
rs935334-?
rs1963982-? rs4370013-? rs10491334-? rs2121070-? rs2509458-? |
NR NR NR NR NR NR NR NR NR |
1 x 10-9 (SBPLTA) 3 x 10-7 (DBPLTA) 2x10-6 (SBP)
3x10-6 (DBP)
3x10-6 (DBP) 4 x 10-6 (DBP) 4 x 10-6 (DBP) 5 x 10-6 (DBP) 7 x 10-6 (DBP) |
NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Tonometry |
644-1,327 individuals, depending on measure
(Framingham |
NR |
3p24.1 13q13.3 20q13.13 8p22 2q14.3 5q14.3 17p12 1q25.1 3q24 3p22.3 9q31.2 6q25.2 7q33 |
TGFBR2 GPC6 PREX1 VPS37A CNTNAP5 MEF2C HS3ST3A1 TNR SLC9A9 Intergenic Intergenic SYNE1 EXOC4 |
rs3773643-? rs6492654-? rs6063312-? rs3793427-? rs1367248-? rs770189-? rs10521232-? rs3766680-? rs1371924-? rs10514688-? rs7042864-? rs1322512-? rs10488172-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR |
2 x 10-7 (MAPLTA) 2 x 10-6 (RWLTA) 2 x 10-6 (RW) 2 x 10-6 (FWLTA) 3 x 10-6 (CF-PWVLTA) 3 x 10-6 (CB-PWV) 4 x 10-6 (CF-PWVLTA) 4 x 10-6 (FWLTA) 4 x 10-6 (RWLTA) 6 x 10-6 (CB-PWV) 6 x 10-6 (CB-PWV) 8 x 10-6 (MAP) 8 x 10-6 (RWLTA) |
NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Lunetta September 19, 2007 BMC Med Genet Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
|
Aging traits |
1,345 individuals
(Framingham) |
NR |
2p12
12p11.22
11q14.3 2p12 12q24.23 2q24.1 7q21.11 1q42.3 15q25.3 3q25.31 |
Intergenic
Intergenic
Intergenic Intergenic CCDC60 GALNT13 Intergenic GNG4 KLHL25 KCNAB1 |
rs10496265-?
rs1463605-?
rs1528753-? rs10496262-? rs7137869-? rs958672-? rs2371208-? rs291353-? rs7176093-? rs3772255-? |
NR NR NR NR NR NR NR NR NR NR |
1 x 10-8 (age at natural menopause)
7 x 10-8 (biologic age)
8 x 10-8 (age at death) 3 x 10-7 (age at natural menopause) 6 x 10-7 (walking speed exam 7) 2 x 10-6 (age at natural menopause) 3 x 10-6 (age at death) 6 x 10-6 (age at natural menopause) 7 x 10-6 (biologic age) 8 x 10-6 (biologic age) |
NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Lunetta September 19, 2007 BMC Med Genet Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
|
Morbidity-free survival |
1,345 individuals
(Framingham) |
NR |
1q24.2 5p15.32 6p24.3 8p22 16q21 |
DPT Intergenic Intergenic Intergenic Intergenic |
rs1412337-? rs32566-? rs10484246-? rs4831837-? rs2639889-? |
NR NR NR NR NR |
2 x 10-9 2 x 10-9 8 x 10-8 5 x 10-7 9 x 10-7 |
NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Meigs September 19, 2007 BMC Med Genet Genome-wide association with diabetes-related traits in the Framingham Heart Study
|
Diabetes (incident) |
1,087 individuals
(Framingham) |
NR |
2q32.3 |
TMEFF2 |
rs10497721-? |
NR |
7 x 10-7 |
NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Diabetes related insulin traits |
1,087 individuals
(Framingham) |
NR |
14q12
14q12 7p15.1 13q21.33 |
Intergenic
Intergenic CPVL Intergenic |
rs2877832-?
rs2877832-? rs10486607-? rs2066219-? |
NR NR NR NR |
2 x 10-6 (FI)
3 x 10-6 (HOMA-IR) 8 x 10-6 (HbA1C) 9 x 10-6 (ISI_0-120) |
NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Fasting plasma glucose |
1,087 individuals
(Framingham) |
NR |
8p11.21
3p24.1 4q27 4q27 5q23.3 8p11.21 |
ZMAT4
Intergenic PRDM5 PRDM5 Intergenic ZMAT4 |
rs2722425-?
rs10510634-? rs180730-? rs180730-? rs7731657-? rs2722425-? |
NR NR NR NR NR NR |
2 x 10-8 (tFPG)
5 x 10-6 (tFPG) 5 x 10-6 (FPG) 6 x 10-6 (tFPG) 7 x 10-6 (tFPG) 9 x 10-6 (FPG) |
NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Murabito September 19, 2007 BMC Med Genet A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study
|
Breast cancer |
1,345 individuals
(Framingham) |
NR |
17q21.33
5q34
12q21.1 18q21.2
13q32.1 7q11.22 2p16.1 15q21.1 21q21.3 |
COL1A1
Intergenic
Intergenic Intergenic
ABCC4 Intergenic Intergenic FBN1 GRIK1 |
rs2075555-?
rs6556756-?
rs1154865-? rs1978503-?
rs1926657-? rs10263639-? rs10490113-? rs1876206-? rs458685-? |
NR NR NR NR NR NR NR NR NR |
8 x 10-8
5 x 10-7
7 x 10-7 1 x 10-6
2 x 10-6 3 x 10-6 5 x 10-6 6 x 10-6 6 x 10-6 |
NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Prostate cancer |
1,345 individuals
(Framingham) |
NR |
13q33.1 3p22.2
5q14.3
6p12.2
3q24 |
Intergenic CTDSPL
HAPLN1
PKHD1
Intergenic |
rs1529276-? rs9311171-?
rs4466137-?
rs10498792-?
rs345013-? |
NR NR NR NR NR |
2 x 10-6 2 x 10-6
3 x 10-6
3 x 10-6
5 x 10-6 |
NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Newton-Cheh September 19, 2007 BMC Med Genet Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
|
Electrocardiographic traits |
548-1,175 individuals, depending on measure
(Framingham) |
NR |
2q22.1 13q12.2 |
Intergenic RPL21 |
rs882300-? rs10507380-? |
NR NR |
3 x 10-7 (PR interval) 8 x 10-6 (QT interval) |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Heart rate variability traits |
548-1,175 individuals, depending on measure
(Framingham) |
NR |
4q34
13q13.3 |
NEIL3
DCAMKL1 |
rs1395479-?
rs9315385-? |
NR NR |
7x10-6 (LF/HF)
8x10-6 (TP) |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
O'Donnell September 19, 2007 BMC Med Genet Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
|
Coronary artery calcification |
673-984 individuals, depending on measure
(Framingham) |
NR |
1p22.2
14q24.2 12q23.2 |
Intergenic
NUMB DR1M |
rs2390582-?
rs10483853-? rs10507130-? |
NR NR NR |
1 x 10-6
6 x 10-6 7 x 10-6 |
NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Subclinical atherosclerosis traits (other) |
673-984 individuals, depending on measure (Framingham) |
NR |
2q33.2
10q11.22
5p15.2 1q31.1 5p15.2 4q28.1 11q14.3 5p15.2 |
ABI2
LRRC18
DNAH5 Intergenic DNAH5 Intergenic Intergenic DNAH5 |
rs1376877-?
rs3849150-?
rs2896103-? rs1400544-? rs7715811-? rs1320267-? rs1350445-? rs1502050-? |
NR NR NR NR NR NR NR NR |
4 x 10-7 (ICA IMT)
2 x 10-6 (AAC)
5 x 10-6 (ABI) 6 x 10-6 (CCA IMT) 6 x 10-6 (ABI) 7 x 10-6 (ABI) 9 x 10-6 (ABI) 9 x 10-6 (ABI) |
NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Seshadri September 19, 2007 BMC Med Genet Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
|
Cognitive test performance |
705 individuals
(Framingham) |
NR |
1p22.2
21q21.3
4q13.2 14q24.3 6p23 12q23.3 5q32 11q14.1 17q22 11q25 1q42.2 12p11.1 9q22.2 2q22.1 |
Intergenic
Intergenic
Intergenic Intergenic Intergenic POLR3B, RFX4 Intergenic Intergenic PPM1E NCAPD3 TARBP1 Intergenic DIRAS2 Intergenic |
rs2179965-?
rs2832077-?
rs1155865-? rs2352904-? rs6914079-? rs3891355-? rs9325032-? rs530965-? rs9303401-? rs1031381-? rs10489896-? rs9300212-? rs1831521-? rs934299-? |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
1 x 10-6 (F3)
2 x 10-6 (F3)
2 x 10-6 (Nam) 2 x 10-6 (F2) 2 x 10-6 (F2) 3 x 10-6 (Sim) 3 x 10-6 (F2) 4 x 10-6 (Nam) 5 x 10-6 (NAM) 6 x 10-6 (F3) 6 x 10-6 (F2) 8 x 10-6 (WRAT) 8 x 10-6 (Nam) 9 x 10-6 (F3) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Volumetric brain MRI |
705 individuals
(Framingham) |
NR |
20q13.33 11p13 11q23.2 11q22.1 4q31.3 |
CDH4 EHF NNMT CNTN5 Intergenic |
rs1970546-? rs5028798-? rs2847476-? rs952700-? rs360929-? |
NR NR NR NR NR |
4 x 10-8 (ATCBV) 3 x 10-6 (ATBV) 3 x 10-6 (ALLV) 6 x 10-6 (AFBV) 9 x 10-6 (ALTHBV) |
NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Vasan September 19, 2007 BMC Med Genet Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
|
Echocardiographic traits |
1,238 individuals
(Framingham) |
NR |
4p15.31
6q15 4p15.31 8q13.3 1q31.1 2q36.1 1p31.3 5q14.3 |
SLIT2
SPACA1 SLIT2 KCNB2 FAM5C Intergenic PDE4B Intergenic |
rs1379659-?
rs366676-? rs666088-? rs10504543-? rs1935881-? rs10498091-? rs10493389-? rs4920799-? |
NR NR NR NR NR NR NR NR |
1 x 10-7 (LVDD)
2 x 10-6 (LVFS) 5 x 10-6 (LVDD) 5 x 10-6 (LVSD) 6 x 10-6 (LAD) 6 x 10-6 (LVM) 7 x 10-6 (LAD) 7 x 10-6 (LVDD) |
NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Endothelial function traits |
1,238 individuals
(Framingham) |
NR |
10q24.33 |
OBFC1 |
rs3814219-? |
NR |
9 x 10-7 (BABF) |
NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Exercise treadmill test traits |
1,238 individuals
(Framingham) |
NR |
4q25
1q43 11q22.3 8p12 |
NOLA1
RYR2 Intergenic WRN |
rs6847149-?
rs2819770-? rs746463-? rs2553268-? |
NR NR NR NR |
3 x 10-6 (S2EHR)
4 x 10-6 (S2EHR) 5 x 10-6 (P3MRSBP) 6 x 10-6 (S2ESBP) |
NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Wilk September 19, 2007 BMC Med Genet Framingham Heart Study genome-wide association: results for pulmonary function measures
|
Mean forced vital capacity from 2 exams |
1,097-1,222 individuals,
depending on measure
(Framingham) |
NR |
7q21.3
4q25 |
COL1A2
Intergenic |
rs441051-?
rs10516541-? |
NR NR |
2 x 10-6 (meanfvc)
4 x 10-6 (meanfvc) |
NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Pulmonary function traits (other) |
1,097-1,222 individuals, depending on measure (Framingham) |
NR |
15q11.2
21q22.3
15q26.1 2q36.3 8q11.22 14q22.1 14q23.1 1q21.3 17p12 7q34 |
SNRPN
ADARB1
FLJ32831 RHBDD1 SNTG1 NID2 Intergenic IL6R CDRT4 Intergenic |
rs3867498-?
rs2838815-?
rs1455782-? rs3820928-? rs310558-? rs730532-? rs808225-? rs4129267-? rs2906966-? rs357394-? |
NR NR NR NR NR NR NR NR NR NR |
1 x 10-6 (fev1slope)
3 x 10-6 (meanratio)
4 x 10-6 (ppfvc) 5 x 10-6 (ppfev1) 5 x 10-6 (ppratio) 6 x 10-6 (ppfef) 7 x 10-6 (ppfefrat) 7 x 10-6 (ppfef) 8 x 10-6 (ppfev1) 9 x 10-6 (ppfvc) |
NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Yang September 19, 2007 BMC Med Genet Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
|
Factor VII |
1,000 individuals
(Framingham) |
NR |
13q34 7p22.2 1p36.32 3p26.1 |
MCF2L, AB116074, AK092739, AK123267, AB0023600, F7, CR603372, F10, PROZ Intergenic Intergenic Intergenic |
rs561241-? rs10488360-? rs966321-? rs4591494-? |
0.12 0.30 0.47 0.19 |
5 x 10-16 7 x 10-6 8 x 10-6 9 x 10-6 |
NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
"
|
Hemostatic factors and hematological phenotypes |
1,000 individuals
(Framingham |
NR |
11q11 14q21.3 1q23.2 2p16.2 1p31.1 8q24.13 5q21.3 11q24.1 1p34.3 12q14.2 4p15.33 10p11.21 14q32.2 20p12.3 2p16.2 5q21.1 6q25.1 6q25.1 |
OR5AP2, OR5AR1, OR9G1, OR9G4 MAMDC1 OR10J1,OR10J5 Intergenic NEGR1 Intergenic Intergenic Intergenic FLJ11730, BC016328 Intergenic Intergenic ANKRD30A Intergenic Intergenic Intergenic Intergenic Intergenic MAP3K7IP2 |
rs1397048-? rs7159841-? rs4133289-? rs1160297-? rs10493485-? rs7844723-? rs4460176-? rs565229-? rs9253-? rs10506458-? rs10489087-? rs1200821-? rs10484128-? rs6108011-? rs2357013-? rs1829883-? rs636864-? rs727979-? |
0.4 0.21 0.19 0.43 0.29 0.45 0.29 0.10 0.18 0.13 0.13 0.47 0.15 0.28 0.45 0.41 0.21 0.14 |
7 x 10-8 (MCH) 2 x 10-7 (Viscosity) 2 x 10-7 (Hgb) 1 x 10-6 (Hgb) 2 x 10-6 (tPA) 2 x 10-6 (Hgb) 3 x 10-6 (PAI-1) 4 x 10-6 (pltcoll) 4 x 10-6 (RBCC) 5 x 10-6 (pltcoll) 5 x 10-6 (RBCC) 6 x 10-6 (MCH) 6 x 10-6 (pltadp) 6 x 10-6 (RBCC) 6 x 10-6 (Hgb) 6 x 10-6 (MCH) 6 x 10-6 (RBCC) 8 x 10-6 (RBCC) |
NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR |
Affymetrix
[70,897] |
N |
|
11/25/08 |
Florez September 10, 2007 Diabetes A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets
|
Type 2 diabetes and 6 quantitative traits |
1,087 family members |
1,465 unrelated individuals; 2,175 cases and 2,412 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[66,543] |
N |
|
11/25/08 |
Hanson September 10, 2007 Diabetes A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array
|
Type 2 diabetes |
300 cases,
334 controls,
121 nondiabetic siblings, 140 diabetic siblings |
1,207 cases,
1,627 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[80,044] |
N |
|
11/25/08 |
Hayes September 10, 2007 Diabetes Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies
|
Type 2 diabetes |
281 cases,
280 controls |
~1,979 cases,
~3,092 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[88,142] |
N |
|
11/25/08 |
Rampersaud September 10, 2007 Diabetes Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
|
Type 2 diabetes |
124 cases,
295 controls |
2,142 cases,
2,117 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix
[82,485] |
N |
|
11/25/08 |
van Es September 07, 2007 Lancet Neurol ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
|
Amyotrophic lateral sclerosis |
737 cases,
721 controls |
1,030 cases,
1,195 controls |
12p11 |
ITPR2 |
rs2306677-? |
0.07 |
3 x 10-6 |
1.58 [1.30-1.91] |
Illumina
[311,946] |
N |
|
11/25/08 |
Plenge September 05, 2007 N Engl J Med TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
|
Rheumatoid arthritis |
1,493 cases,
1,831 controls |
1,053 cases,
1,858 controls |
6p21.32 9q34 1p13.2 |
HLA-DRB1 TRAF1-C5 PTPN22 |
rs660895-? rs3761847-G rs2476601-? |
0.21 0.41 0.10 |
1 x 10-108 4 x 10-14 2 x 10-11 |
3.62 [NR] 1.32 [1.23-1.42] 1.72 [NR] |
Illumina [297,086] |
N |
|
11/25/08 |
Raelson September 05, 2007 Proc Natl Acad Sci USA Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
|
Crohn's disease |
382 trios |
750 cases,
828 controls,
521 trios |
16q12.1 1p31.3 1p31.3 |
NOD2 IL23R IL23R |
rs5743289-? 17 marker haplotype-1 17 marker haplotype-2 |
NR 0.23 0.97 |
6 x 10-17 1 x 10-8 2 x 10-7 |
NR 1.38 [1.23-1.53] 2.56 [1.75-3.70] |
Perlegen [164,279] |
N |
|
11/25/08 |
Menzel September 02, 2007 Nat Genet A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
|
F-cell distribution |
179 adults in upper and lower 5% |
90 adults |
11p15.5
6q23.3 2p15.1 |
HBB
Intergenic BCL11A |
NR
rs9399137-? rs1427407-? |
0.33
0.23 0.14 |
2 x 10-38
3 x 10-36 6 x 10-31 |
10.2 [NR] % of variance explained 15.8 [NR] % of variance explained 13.1 [NR] % of variance explained |
Illumina
[308,015] |
N |
|
11/25/08 |
Weedon September 02, 2007 Nat Genet A common variant of HMGA2 is associated with adult and childhood height in the general population
|
Height |
4,921 individuals |
29,098 individuals (19,064 adults) |
12q14.3 |
HMGA2 |
rs1042725-C |
0.51 |
6 x 10-16 |
.4 [NR] cm per copy in adult height |
Affymetrix [364,301] |
N |
|
11/25/08 |
Thorleifsson August 09, 2007 Science Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma
|
Glaucoma (exfoliation) |
75 cases,
14,474 controls |
254 cases,
198 controls |
15q24.1 |
LOXL1 |
rs3825942-G |
0.85 |
3 x 10-21 |
20.1 [10.80-37.41] |
Illumina
[304,250] |
N |
|
11/25/08 |
Franke August 08, 2007 PLoS ONE Systematic association mapping identifies NELL1 as a novel IBD disease gene
|
Crohn's disease |
393 cases,
399 controls |
1,248 trios, 2,920 cases, 1,961 controls |
16q12.1 5p13.1 11p15.1 |
CARD15 PTGER4 NELL1 |
rs2076756-? rs1992660-? rs1793004-? |
0.27 0.39 0.27 |
1 x 10-21 4 x 10-7 3 x 10-6 |
1.71 [1.42-2.05] 1.42 [1.24-1.67] 1.3 [1.12-1.52] |
Affymetrix
[92,387] |
N |
|
11/25/08 |
Dunckley August 01, 2007 N Engl J Med Whole-genome analysis of sporadic amyotrophic lateral sclerosis
|
Amyotrophic lateral sclerosis |
386 cases,
542 controls |
901 cases,
1,025 controls |
NS |
NS |
NS |
NS |
NS |
NS |
Affymetrix and
Illumina
[776,955] |
N |
|
11/25/08 |
Maeda August 01, 2007 Kidney Int Suppl Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population
|
Diabetic nephropathy |
94 cases,
94 controls |
NR |
7p14.2 |
ELMO1 |
rs741301-? |
NR |
8 x 10-6 |
2.67 [1.71-4.16] |
NR
[~80,000] |
N |
|
11/25/08 |
Shifman July 31, 2007 Mol Psychiatry A whole genome association study of neuroticism using DNA pooling
|
Neuroticism |
1,038 cases,
1,016 controls |
831 cases,
702 controls |
5q11.2 |
PDE4D |
rs702543-A |
0.55 |
2 x 10-6 |
1.27 [1.15-1.40] |
Affymetrix
[452,574] (pooled) |
N |
|
11/25/08 |
Hafler July 29, 2007 N Engl J Med Risk alleles for multiple sclerosis identified by a genomewide study
|
Multiple sclerosis |
931 trios, 2,431 controls |
609 trios, 2,322 cases, 2,987 controls |
6p21.32 10p15.1 5p13.2 16p13 1p22 9q33 |
HLA-DRA IL2RA IL7RA KIAA0350 RPL5 DBC1 |
rs3135388-A rs12722489-C rs6897932-C rs6498169-G rs6604026-C rs10984447-A |
0.23 0.85 0.75 0.37 0.29 0.77 |
9 x 10-81 3 x 10-8 3 x 10-7 4 x 10-6 8 x 10-6 8 x 10-6 |
1.99 [1.84-2.15] 1.25 [1.11-1.36] 1.18 [1.11-1.26] 1.14 [1.08-1.21] 1.15 [1.08-1.22] 1.17 [1.09-1.25] |
Affymetrix
[334,923] |
N |
|
11/25/08 |
Moffatt July 26, 2007 Nature Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
|
Asthma |
994 cases,
1,243 controls |
2,320 cases,
3,301 controls |
17q12 |
ORMDL3 |
rs7216389-T |
0.52 |
9 x 10-11 |
1.45 [1.17-1.81] |
Illumina
[307,328] |
N |
|
11/25/08 |
Scuteri July 20, 2007 PLoS Genet Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits
|
Obesity-related traits |
4,741 individuals |
3,205 individuals |
16q12.2 16q12.2 16q12.2 |
FTO FTO FTO |
rs9930506-A rs9930506-A rs9930506-A |
0.54 0.54 0.54 |
3 x 10-8 (hip) 9 x 10-7 (weight) 9 x 10-7 (BMI) |
.16 [NR] SD lower (hip) .12 [NR] SD lower (weight) .13 [NR] SD lower (BMI) |
Affymetrix
[362,129] |
N |
|
11/25/08 |
Fellay July 19, 2007 Science A whole-genome association study of major determinants for host control of HIV-1
|
HIV1 viral setpoint |
486 patients |
140 patients |
NS |
NS |
NS |
NS |
NS |
NS |
Illumina
[535,101] |
N |
|
11/25/08 |
Stefansson July 19, 2007 N Engl J Med A genetic risk factor for periodic limb movements in sleep
|
Restless legs syndrome |
306 cases,
15,664 controls |
311 cases,
1,895 controls |
6p21.2 |
BTBD9 |
rs3923809-A |
0.66 |
1 x 10-17 |
1.9 [1.50-2.20] |
Illumina
[306,937] |
N |
|
11/25/08 |
Samani July 18, 2007 N Engl J Med Genomewide association analysis of coronary artery disease
|
Coronary disease |
1,926 cases,
2,938 controls |
875 cases,
1,644 controls |
9p21.3 1p13.3 6q25.1 10q11.21 15q22.33 2q36.3 1q41 |
Intergenic PSRC1 MTHFD1L CXCL12 SMAD3 pseudogene MIA3 |
rs1333049-C rs599839-A rs6922269-A rs501120-T rs17228212-C rs2943634-C rs17465637-C |
0.47 0.23 0.25 0.13 0.30 0.65 0.29 |
3 x 10-19 4 x 10-9 3 x 10-8 9 x 10-8 2 x 10-7 2 x 10-7 1 x 10-6 |
1.36 [1.27-1.46] 1.29 [1.18-1.40] 1.23 [1.15-1.33] 1.33 [1.20-1.48] 1.21 [1.13-1.30] 1.21 [1.13-1.30] 1.2 [1.12-1.30] |
Affymetrix [377,857] |
N |
|
11/25/08 |
Winkelmann July 18, 2007 Nat Genet Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
|
Restless legs syndrome |
401 cases,
1,644 controls |
1,158 cases,
1,178 controls |
2p14 6p21.2 15q23 |
MEIS1 BTBD9 MAP2K5, LBXCOR1 |
rs2300478-G rs9296249-T rs12593813-G |
0.24 0.76 0.67 |
3 x 10-28 4 x 10-18 1 x 10-15 |
1.74 [1.57-1.92] 1.67 [1.49-1.89] 1.5 [1.36-1.66] |
Affymetrix
[236,758] |
N |
|
11/25/08 |
Buch July 15, 2007 Nat Genet A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
|
Gallstones |
280 cases,
360 controls |
2,000 cases,
1,202 controls |
2p21 |
ABCG8 |
rs11887534-C |
0.10 |
1 x 10-14 |
2.2 [1.80-2.60] |
Affymetrix
[382,492] |
N |
|
11/25/08 |
Hakonarson July 15, 2007 Nature A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
|
Type 1 diabetes |
467 trios, 561 cases,
1,143 controls |
2,350 individuals in 549 families; 390 trios |
6p21.32 16p13.13 11p15.5 1p13.2 |
HLA-E KIAA0350 INS PTPN22 |
rs2647044-A rs2903692-G rs1004446-C rs2476601-A |
0.13 0.62 0.65 0.09 |
1 x 10-16 7 x 10-11 4 x 10-9 1 x 10-7 |
8.3 [6.97-9.89] 1.54 [1.32-1.79] 1.61 [1.37-1.89] 1.8 [1.44-2.24] |
Illumina
[543,071] |
N |
|
11/25/08 |
Tomlinson July 08, 2007 Nat Genet A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
|
Colorectal cancer |
930 cases,
960 controls |
7,334 cases,
5,246 controls |
8q24.21 |
Intergenic |
rs6983267-G |
0.49 |
1 x 10-14 |
1.27 [1.16-1.39] |
Illumina
[547,647] |
N |
|
11/25/08 |
Zanke July 08, 2007 Nat Genet Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
|
Colorectal cancer |
1,257 cases,
1,336 controls |
6,223 cases,
6,443 controls |
8q24.21 |
ORF DQ515897 |
rs10505477-A |
0.50 |
3 x 10-11 |
1.17 [1.12-1.23] |
Illumina and Affymetrix
[99,632] |
N |
|
11/25/08 |
Gudbjartsson July 01, 2007 Nature Variants conferring risk of atrial fibrillation on chromosome 4q25
|
Atrial fibrillation/atrial flutter |
550 cases,
4,476 controls |
3,363 cases,
17,616 controls |
4q25 4q25 |
PITX2,ENPEP PITX2,ENPEP |
rs2200733-T rs10033464-T |
0.11 0.08 |
3 x 10-41 7 x 10-11 |
1.72 [1.59-1.86] 1.39 [1.26-1.53] |
Illumina
[316,515] |
N |
|
11/25/08 |
Gudmundsson July 01, 2007 Nat Genet Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
|
Prostate cancer |
1,501 cases,
11,290 controls |
1,992 cases,
3,058 controls |
17q12 17q24.3 |
TCF2 Intergenic |
rs4430796-A rs1859962-G |
0.49 0.46 |
1 x 10-11 3 x 10-10 |
1.22 [1.15-1.30] 1.2 [1.14-1.27] |
Illumina
[310,520] |
N |
|
11/25/08 |
Salonen June 26, 2007 Am J Hum Genet Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium
|
Type 2 diabetes |
500 cases,
497 controls |
2,573 cases,
2,776 controls |
10q25.2 2q12.1 |
TCF7L2 Intergenic |
rs7903146-A rs6712932-? |
NR NR |
5 x 10-8 6 x 10-6 |
1.71 [1.41-2.08] 1.52 [1.27-1.82] |
Illumina
[315,917] |
N |
|
11/25/08 |
van Heel June 10, 2007 Nat Genet A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
|
Celiac disease |
778 cases,
1,422 controls |
991 cases,
1,489 controls |
6p21.32 4q27 |
HLA-DQA1 KIAA1109,TENR,IL2,IL21 |
rs2187668-A rs6822844-G |
0.14 0.82 |
1 x 10-19 1 x 10-14 |
7.04 [6.08-8.15] 1.59 [1.41-1.75] |
Illumina
[310,605] |
N |
|
11/25/08 |
Reiman June 07, 2007 Neuron GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
|
Alzheimer's disease (late onset) |
446 cases,
290 controls |
415 cases,
260 controls |
11q14.1 |
GAB2 |
rs2373115-G |
0.70 |
1 x 10-10 |
4.06 [2.81-14.69] |
Affymetrix
[312,316] |
N |
|
11/25/08 |
WTCCC June 07, 2007 Nature Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
|
Bipolar disorder |
1,868 cases,
2,938 controls |
NR |
16p12.1 6p21 3q27 14q23.1 20p13 2q37 14q32.33 |
PALB2,NDUFAB1,DCTN5 NR NR NR NR NR NR |
rs420259-A < |