Dark Matter of Genomic Associations With Complex Diseases:
Explaining the Unexplained Heritability From Genome-Wide Association Studies

 

Background Materials

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  • Maher B. Personal genomes: The case of the missing heritability. Nature, 6;456(7218):18-21. 2008. [PubMed]
     
  • Mardis ER. The impact of next-generation sequencing technology on genetics. Trends Genet, (3):133-41. 2008. [PubMed]
     
  • McCarroll SA. Extending genome-wide association studies to copy-number variation. Hum Mol Genet, 17(R2):R135-42. Review. 2008. [PubMed]
     
  • Visscher PM, Hill WG, Wray NR. Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet, (4):255-66. Review. 2008. [PubMed]
     
  • Weiss KM. Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. Genetics, (4):1741-56. Review. 2008. [PubMed]
     
  • Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature, 447(7143):433-40. 2007. [PubMed]
     
  • Brem RB, Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A, 102(5):1572-7. 2005. [PubMed]

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Last Updated: January 30, 2014