Nigel P. Crawford, M.B. Ch.B., Ph.D.

Investigator, Genetics and Molecular Biology Branch
Head, Metastasis Genetics Section

Selected Publications

Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, Lukes L, Rowe WH, Zhang J, Ambs S, Lowy DR, Anton-Culver H, Hunter KW. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS Genet, 3(11):e214. 2007. [PubMed]

Crawford NP, Lukes L, Walker RC, Officewala JS, Williams R, Hunter KW. The Diasporin Pathway: a transcriptional network that is invoked in metastasis and predicts breast cancer survival. Clin Exp Metastasis, 25:357-369. 2008. [PubMed]

Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, Lee MP, Ozato K, Hunter KW. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci USA, 105: 6380-6385. 2008. [PubMed]

Crawford NP, Yang H, Mattaini KR, Hunter KW. The metastasis efficiency modifier Ribosomal RNA Processing 1 Homolog B (RRP1B) is a chromatin-associated factor. J Biol Chem, 284:28660-73. 2009. [PubMed]

Kanaan Z, Eichenberger MR, Young M, Colliver D, Crawford N, Cobbs GA, Hein DW, Galandiuk S. An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia. Int J Biol Markers, 25:27-31. 2010. [PubMed]

Alsarraj J, Walker RC, Webster JD, Geiger TR, Crawford NP, Simpson RM, Ozato K, Hunter KW. Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion. Cancer Res, 71:3121-31. 2011. [PubMed]

Collaborative Cross Consortium. The genome architecture of the collaborative cross mouse genetic reference population. Genetics, 190:389-401. 2012. [PubMed]

Kanaan Z, Rai SN, Eichenberger MR, Barnes C, Dworkin AM, Weller C, Cohen E, Roberts H, Keskey B, Petras RE, Crawford NP, Galandiuk S. Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer. Hum Mutat, 33:551-60. 2012. [PubMed]

Patel SJ, Molinolo AA, Gutkind S, Crawford NPS. Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma. PLoS One, 8: e61848. 2013. [PubMed]

Ono M, Inkson CA, Sonn R, Kilts TM, de Castro LF, Maeda A, Fisher LW, Robey PG, Berendsen AD, Li L, McCartney-Francis N, Brown AC, Crawford NPS, Molinolo A, Jain A, Fedarko NS, Young MF. WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS One, 8: e71709. 2013. [PubMed]

Alsarraj J, Faraji F, Geiger TR, Mattaini K, Williams M, Wu J, Ha N-H, Merlino T, Walker RC, Bosley A, Xiao Z, Andresson T, Esposito D, Smithers N, Lugo D, Prinjha R, Dey A, Crawford NPS, Ozato K, Gardner K and Hunter KW. BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane. PLoS One, 8:e80746. 2013. [PubMed]

Lee M, Dworkin AM, Gildea D, Trivedi NS, NISC Comparative Sequencing Program, Moorhead GB, Crawford NPS. RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1. Oncogene, 33:1818-27. 2014.  [PubMed]

Lee M, Dworkin AM, Lichtenberg J, Andreas J. Patel SJ, Gildea D, Trivedi N, Bodine DM, Crawford NPS. The breast cancer metastasis suppressor RRP1B modulates metastasis through regulation of global histone methylation. Mol Can Res, 12:1818-28. 2014. [PubMed]

Williams KA, Lee M, Hu Y, Andreas J. Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NPS. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLOS Genetics, 10.1371/journal.pgen.1004809. 2014. [PubMed]

Phenotype-driven chemical screening in zebrafish for collective cell migration inhibitors identifies multiple potential pathways for targeting metastasis. Gallardo VE, Varshney GK, Lee M, Bupp S, Xu L, Shinn P, Crawford NPS, Inglese J, Burgess SM. Dis Model Mech,  8:565-76. 2015. [PubMed]

Lee M, Beggs SM, Gildea D, Bupp S, Lichtenberg J, Trivedi NS, NISC Comparative Sequencing Program, Hu Y, Bodine DM, Crawford NPS. Necdin is a Breast Cancer Metastasis Suppressor that Regulates the Transcription of c-Myc. Oncotarget, Aug. 19, 2015 [In Press]

Lee M, Williams KA, Hu Y, Andreas J. Patel SJ, Zhang S, Crawford NPS. GNL3 and SKA3, are Novel Susceptibility Genes for Aggressive Prostate Cancer. Clin Exp Metastasis, Oct. 1, 2015. [In Press]

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Last Updated: October 5, 2015