Nigel P. Crawford, M.B. Ch.B., Ph.D.

Investigator, Genetics and Molecular Biology Branch
Head, Metastasis Genetics Section

Selected Publications

Crawford NP, Colliver DW, Funke AA, Young MN, Kelley S, Cobbs GA, Petras RE, Galandiuk S. Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers. Hum Mutat, 25:156-166. 2005. [PubMed]

Crawford NP, Eichenberger MR, Colliver DW, Lewis RK, Cobbs GA, Petras RE, Galandiuk S. Evaluation of SLC11A1 as an Inflammatory Bowel Disease Candidate Gene. BMC Med Genet, 9:10. 2005. [PubMed]

Yang H, Crawford N, Lukes L, Finney R, Lancaster M, Hunter KW. Metastasis predictive signature profiles pre-exist in normal tissues. Clin Exp Metastasis, 22:593-603. 2005. [PubMed]

Colliver DW, Crawford NP, Eichenberger MR, Zacharius W, Petras RE, Stromberg AJ, Galandiuk S. Molecular profiling of ulcerative colitis-associated neoplastic progression. Exp Mol Pathol, 80:1-10. 2005. [PubMed]

Crawford NP, Ziogas A, Peel DJ, Hess J, Anton-Culver H, Hunter KW. Germline polymorphisms of SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res, 8:R16. 2006. [PubMed]

Crawford NP, Hunter KW.  New perspectives on hereditary influences in metastatic progression. Trends Genet, 22:555-61. 2006. [PubMed]

Crawford NP, Colliver DW, Eichenberger MR, Funke AA, Kolodko V, Cobbs GA, Petras RE, Galandiuk S. CARD15 genotype-phenotype relationships in a small inflammatory bowel disease population with severe disease affection status. Digest Dis Sci, 52:2716-2724. 2007. [PubMed]

Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, Lukes L, Rowe WH, Zhang J, Ambs S, Lowy DR, Anton-Culver H, Hunter KW. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS Genet, 3:e214. 2007. [PubMed]

Crawford NP, Lukes L, Walker RC, Officewala JS, Williams R, Hunter KW. The Diasporin Pathway: a transcriptional network that is invoked in metastasis and predicts breast cancer survival. Clin Exp Metastasis, 25:357-369. 2008. [PubMed]

Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, Lee MP, Ozato K, Hunter KW. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci USA, 105:6380-6385. 2008. [PubMed]

Hunter KW, Crawford NP.  The Future of QTL Mapping to Diagnose Disease in Mice in the Age of Whole-Genome Association Studies. Annu Rev Genet, 42:131-41. 2008. [PubMed]

Lukes L, Crawford NP, Walker R, Hunter KW. The origins of breast cancer prognostic gene expression profiles. Cancer Res, 69:310-318. 2009. [PubMed]

Crawford NP, Yang H, Hunter KW. The metastasis efficiency modifier Ribosomal RNA Processing 1 Homolog B (RRP1B) is a chromatin-associated factor. J Biol Chem, 284:28660-28673. 2009. [PubMed]

Alsarraj J, Walker RC, Webster JD, Geiger TR, Crawford NP, Simpson RM, Ozato K, Hunter KW. Deletion of the Proline-Rich Region of the Murine Metastasis Susceptibility Gene Brd4 Promotes Epithelial-to-Mesenchymal Transition- and Stem Cell-Like Conversion. Cancer Res, 71:3121-31. 2011. [PubMed]

Collaborative Cross Consortium. The genome architecture of the collaborative cross mouse genetic reference population. Genetics, 190:389-401. 2012. [PubMed]

Kanaan Z, Rai SN, Eichenberger MR, Barnes C, Dworkin AM, Weller C, Cohen E, Roberts H, Keskey B, Petras RE, Crawford NP, Galandiuk S. Differential MicroRNA Expression Tracks Neoplastic Progression in Inflammatory Bowel Disease-Associated Colorectal Cancer. Hum Mutat, 33:551-60. 2012. [PubMed]

Patel SJ, Molinolo AA, Gutkind S, Crawford NPS. Germline Genetic Variation Modulates Tumor Progression and Metastasis in a Mouse Model of Neuroendocrine Prostate Carcinoma. PLoS One 8, e61848. 2013. [PubMed]

Ono M, Inkson CA, Sonn R, Kilts TM, de Castro LF, Maeda A, Fisher LW, Robey PG, Berendsen AD, Li L, McCartney-Francis N, Brown AC, Crawford NPS, Molinolo A, Jain A, Fedarko NS, Young MF.  WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS ONE 8, e71709. 2013. [PubMed]

Lee M, Dworkin AM, Gildea D, Trivedi NS, NISC Comparative Sequencing Program, Moorhead GB, Crawford NPS. RRP1B is a Metastasis Modifier That Regulates the Expression of Alternative mRNA Isoforms through Interactions with SRSF1. Oncogene, 3;33:1818-27. 2014. [PubMed]

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Last Reviewed: July 9, 2014