Harold E. Varmus, M.D.

Senior Investigator, Cancer Genetics and Comparative Genomics Branch
Head, Cancer Biology and Genetics Section

Selected Publications

Varmus H, Pao W, Politi K, Podsypanina K, Du YCN. Oncogenes come of age. Cold Spring Harb Symp Quant Biol, 70:1-9. 2005. [PubMed]

Pao W, Miller VA, Politi K, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus HE. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med, 2:3 e73. 2005. [PubMed]

Politi K, Zakowski MF, Fan P, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev, 20:1496-1510. 2006. [PubMed]

Du YCN, Lewis BC, Hanahan D, Varmus HE. Assessing tumor progression factors by somatic gene transfer in a mouse model: Bcl-xL promotes islet tumor cell invasion. PLoS Biol, 5:e276. 2007. [PubMed]

Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA,... Varmus HE,... Meyerson M. Characterizing the cancer genome in lung adenocarcinoma. Nature, 450:893-898. 2007. [PubMed]

Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H. Seeding and propagation of untransformed mouse mammary cells in the lung. Science, 321:1841-1844. 2008. [PubMed]

Podsypanina K, Politi K, Beverly LJ, Varmus HE. Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc Natl Acad Sci USA, 105:5242-5247. 2008. [PubMed]

Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE,... Varmus HE. Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proc Natl Acad Sci USA, 105:14112-14117. 2008. [PubMed]

Beverly LJ, Varmus HE. MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene, 28:1274-1279. 2009. [PubMed]

Asimakopoulos F, Varmus HE. Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. J Virol, 83:4835-4843. 2009. [PubMed]

Jechlinger M, Podsypanina K, Varmus H. Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes Dev, 23:1677-1688. 2009. [PubMed]

Somwar R, Shum D, Djaballah H, Varmus H. Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells. J Biomol Screen, 14:1176-1184. 2009. [PubMed]

Politi K, Fan PD, Shen R, Zakowski M, Varmus H. Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Dis Model Mech, 3:111-119. 2010. [PubMed]

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Posted: January 24, 2011