The NIH MINI Study: Metabolism, Infection and Immunity in Inborn Errors of Metabolism
Viral infections play a significant role in precipitating life-threatening acute metabolic decompensation in patients with inborn errors of metabolism (IEM). The standard of care for these patients is routine vaccination for seasonal and H1N1 influenza viruses. However, nutritional deficiencies and their underlying causes may affect the efficacy of vaccination. At the present time, the medical community does not completely appreciate the dietary complications that may occur in patients with IEM and the impact of those dietary complications on the function of the immune system.
We hope to recruit interested IEM patients to study (1) their nutritional and immunologic status and (2) whether or not they are able to develop immunity to Hepatitis A and influenza viruses following a vaccine that will be offered in accordance with standard of care for this patient population.
To learn more about our study, please explore the MINI Study Web pages. Alternately, please download our study brochure: (The NIH MINI Study)
Peter J. McGuire, M.S., M.D.
National Human Genome Research Institute (NHGRI)
National Institutes of Health
Last Updated: August 15, 2013