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A Catalog of Published Genome-Wide Association Studies

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits PDF file
Click here to read our recent Proceedings of the Academy of Sciences (PNAS) article on catalog methods and analysis.

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Published Genome-Wide Associations
Credit: Darryl Leja and Teri Manolio

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The genome-wide association study (GWAS) publications listed here include only those attempting to assay at least 100,000 single nucleotide polymorphisms (SNPs) in the initial stage. Publications are organized from most to least recent date of publication, indexing from online publication if available. Studies focusing only on candidate genes are excluded from this catalog. Studies are identified through weekly PubMed literature searches, daily NIH-distributed compilations of news and media reports, and occasional comparisons with an existing database of GWAS literature (HuGE Navigator).

SNP-trait associations listed here are limited to those with p-values < 1.0 x 10-5 (see full methods for additional details). Multipliers of powers of 10 in p-values are rounded to the nearest single digit; odds ratios and allele frequencies are rounded to two decimals. Standard errors are converted to 95 percent confidence intervals where applicable. Allele frequencies, p-values, and odds ratios derived from the largest sample size, typically a combined analysis (initial plus replication studies), are recorded below if reported; otherwise statistics from the initial study sample are recorded. For quantitative traits, information on % variance explained, SD increment, or unit difference is reported where available. Odds ratios < 1 in the original paper are converted to OR > 1 for the alternate allele. Where results from multiple genetic models are available, we prioritized effect sizes (OR's or beta-coefficients) as follows: 1) genotypic model, per-allele estimate; 2) genotypic model, heterozygote estimate, 3) allelic model, allelic estimate.

Gene regions corresponding to SNPs were identified from the UCSC Genome Browser. Gene names and risk alleles are those reported by the authors in the original paper. Only one SNP within a gene or region of high linkage disequilibrium is recorded unless there was evidence of independent association.

Occasionally the term "pending" is used to denote one or more studies that we identified as an eligible GWAS, but for which SNP information has not yet been extracted; studies of CNVs are also noted as pending.

How to cite the GWAS Catalog:
Hindorff LA, Junkins HA, Mehta JP, and Manolio TA. A Catalog of Published Genome-Wide Association Studies. Available at: www.genome.gov/gwastudies. Accessed [date of access].

How to cite the GWAS Catalog paper:
Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, and Manolio TA. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA. [May 27, 2009.]

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Full Description of Methods
MS-Excel Format: This table is also available for download in MS-Excel Format. To save the file, use an .xls extension. For a description of the Excel spreadsheet column headings, go to: Excel Spreadsheet Heading Descriptions.
GWAS Catalog 11-26-08: For an archived Excel spreadsheet of the catalog data restricted to the most statistically significant SNP associations that were not known at the time each study was published, go to: GWAS Catalog 11-26-08
List of Abbreviations Used on This Page
GWAS Catalog Related Resources

For questions or comments about this page, send an e-mail to: gwas_table@mail.nih.gov

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Journal:
First Author: (last name)
Disease/Trait:	(string search) or Multiple Diseases (hold Ctrl-key when selecting multiple entries)
Chromosomal Region: (e.g., "13q21.31")
Gene: (e.g., "LRP5")
SNP: (e.g., "rs20755555")
OR greater than:
p-Value threshold: Enter the exponent. For example, enter "5" for p<10^-5


As of 11/05/09, this table includes 425 publications and 1974 SNPs.

Date Added to Catalog (since 11/25/08)	First Author/Date/ Journal/Study	Disease/Trait	Initial Sample Size	Replication Sample Size	Region	Reported Gene(s)	Strongest SNP-Risk Allele	Risk Allele Frequency in Controls	P-value	OR or beta-coefficient and [95% CI]	Platform [SNPs passing QC]	CNV
11/05/09	Benyamin October 11, 2009 Nat Genet Common variants in TMPRSS6 are associated with iron status and erythrocyte volume	Serum markers of iron status	4,818 Australian siblings	3,470 Dutch individuals	22q12.3 6p22.1 22q12.3 6p22.1	TMPRSS6 HFE TMPRSS6 HFE	rs855791-T rs1800562-A rs855791-T rs1800562-A	0.42 0.08 0.42 0.08	1 x 10^-10 (MCV) 2 x 10^-8 (MCV) 5 x 10^-7 (Hgb) 5 x 10^-7 (Hgb)	.13 [0.09-0.17] SD decrease .22 [0.14-0.30] SD increase .1 [0.06-0.14] SD decrease .2 [0.12-0.28] SD increase	Illumina & Perlegen [427,037]	N
11/05/09	Chambers October 11, 2009 Nat Genet Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels	Hemoglobin levels	6,316 Europeans, 9,685 Indian Asians	5,187 Europeans, 6,721 Indian Asians	22q12.3 6p22.1	TMPRSS6 HFE	rs855791-A rs198846-A	0.53 NR	2 x 10^-13 1 x 10^-8	.13 [0.09-0.17] g/dl decrease NS	Affymetrix, Illumina & Perlegen [NR]	N
11/03/09	Ganesh October 11, 2009 Nat Genet Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium	Hematocrit	24,167 European ancestry individuals	9,456 European ancestry individuals	6q23.3 2p21 7q36.1 10q21.3 22q12.3 12q24.12 7q22.1 6p22.1	HBS1L, MYB PRKCE PRKAG2 HK1 TMPRSS6 SH2B3, ATXN2 TFR2 HFE	rs9483788-C rs10168349-C rs10224002-G rs16926246-T rs2413450-T rs11065987-G rs7385804-C rs1800562-A	NR NR NR NR NR NR NR NR	3 x 10^-15 4 x 10^-15 6 x 10^-15 1 x 10^-13 2 x 10^-13 1 x 10^-12 4 x 10^-10 2 x 10^-9	.22 [0.16-0.28] % increase .19 [0.14-0.23] % increase .2 [0.15-0.25] % increase .33 [0.24-0.42] % increase .17 [0.13-0.22] % decrease .17 [0.12-0.22] % decrease .15 [0.10-0.20] % decrease .31 [0.21-0.41] % increase	Affymetrix & Illumina [~2.5 million](imputed)	N
11/03/09	"	Hemoglobin	24,167 European ancestry individuals	9,456 European ancestry individuals	22q12.3 6p22.1 7q36.1 2p21 12q24.12 10q21.3 20q13.2	TMPRSS6 HFE PRKAG2 PRKCE TRAFD1 HK1 TSHZ2	rs855791-A rs1800562-A rs10224002-G rs10495928-G rs11065987-A rs16926246-T rs6013509-A	NR NR NR NR NR NR NR	3 x 10^-25 6 x 10^-19 3 x 10^-15 7 x 10^-13 1 x 10^-11 2 x 10^-11 1 x 10^-10	.09 [0.07-0.11] g/dl decrease .16 [0.13-0.20] g/dl increase .07 [0.05-0.09] g/dl increase .06 [0.05-0.08] g/dl increase .06 [0.04-0.08] g/dl increase .11 [0.08-0.14] g/dl increase .06 [0.05-0.08] g/dl decrease	Affymetrix & Illumina [~2.5 million](imputed)	N
11/03/09	"	Mean corpuscular hemoglobin	24,167 European ancestry individuals	9,456 European ancestry individuals	6q23.3 6p22.2 22q12.3 6p21.1 6q24.1 9p24.1 3q29 19p13.13 16p13.3	HBS1L, MYB SLC17A3 TMPRSS6 CCND3, BYSL CITED2 RCL1 TFRC GCDH ITFG3	rs7776054-G rs1408272-G rs2413450-T rs9349205-A rs628751-C rs10758658-A rs11915082-A rs11085824-G rs1122794-A	NR NR NR NR NR NR NR NR NR	7 x 10^-69 4 x 10^-39 9 x 10^-34 8 x 10^-20 1 x 10^-17 2 x 10^-14 8 x 10^-13 1 x 10^-11 3 x 10^-10	.01 [0.009-0.0111] pg decrease .02 [0.01-0.02] pg decrease .01 [0.0005-0.007] pg decrease .01 [0.004-0.006] pg decrease 0 [0.003-0.005] pg decrease 0 [0.004-0.006] pg decrease 0 [0.003-0.005] pg increase 0 [0.003-0.005] pg decrease 0 [0.003-0.006] pg increase	Affymetrix & Illumina [~2.5 million](imputed)	N
11/03/09	"	Mean corpuscular volume	24,167 European ancestry individuals	9,456 European ancestry individuals	6q23.3 6p22.1 22q12.3 6p21.1 6q24.1 9p24.1 22q13.33 4q12 2p16.1 3q29 7p12.2 16p13.3 19p13.13 7q22.1 10q11.21 6q21 14q23.3	HBS1L, MYB HFE TMPRSS6 CCND3, BYSL CITED2 RCL1 ECGF1 KIT BCL11A TFRC IKZF1 ITFG3 RTBDN TFR2 MARCH8 CD164 FNTB	rs4895441-G rs1800562-A rs2413450-T rs9349205-A rs643381-A rs10758658-A rs131794-A rs172629-G rs2540917-C rs9859260-C rs12718597-A rs7189020-T rs7255045-A rs7786877-G rs11239550-G rs9374080-C rs4466998-A	NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR	7 x 10^-86 1 x 10^-46 3 x 10^-41 1 x 10^-31 5 x 10^-25 3 x 10^-20 1 x 10^-15 1 x 10^-15 1 x 10^-14 8 x 10^-14 5 x 10^-13 2 x 10^-12 2 x 10^-12 3 x 10^-11 1 x 10^-10 4 x 10^-10 5 x 10^-8	.01 [0.007-0.009] fl decrease .01 [0.010-0.014] fl increase .01 [0.004-0.006] fl decrease .01 [0.004-0.006] fl decrease 0 [0.003-0.005] fl decrease 0 [0.003-0.005] fl decrease 0 [0.003-0.005] fl decrease 0 [0.003-0.006] fl decrease 0 [0.002-0.004] fl decrease 0 [0.002-0.004] fl increase 0 [0.002-0.004] fl increase 0 [0.002-0.004] fl decrease 0 [0.002-0.004] fl decrease 0 [0.002-0.004] fl increase 0 [0.002-0.003] fl decrease 0 [0.002-0.003] fl decrease 0 [0.001-0.003] fl increase	Affymetrix & Illumina [~2.5 million](imputed)	N
11/03/09	"	Other erythrocyte phenotypes	24,167 European ancestry individuals	9,456 European ancestry individuals	6q23.3 6q23.3 1q23.1 7q22.1	HBS1L, MYB HBS1L, MYB SPTA1 EPO	rs9483788-G rs9373124-C rs857721-A rs2075671-A	NR NR NR NR	1 x 10^-47 (RBC) 7 x 10^-14 (MCHC) 1 x 10^-10 (MCHC) 1 x 10^-9 (RBC)	0 [0.012-0.016] 1 M cells/mm^3 increase 0 [0.002-0.003] g/dl decrease 0 [0.001-0.002] g/dl decrease 0 [0.005-0.009] 1 M cell/mm^3 increase	Affymetrix & Illumina [~2.5 million](imputed)	N
10/30/09	Soranzo October 11, 2009 Nat Genet A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium	Hematological parameters	4,627 European individuals	9,316 European individuals	6q23.3 6p22.1 6p21.1 9p24.1 12q24.13 22q12.3 6p21.31 7q22.1 22q12.3 17q12 6p21.32 6q21	HBS1L, MYB HFE BYSL, CCND3 AK3 PTPN11 FBX07 BAK1 TFR2 TMPRSS6 GSDMA, ORMDL3 Intergenic Intergenic	rs9402686-A rs1800562-A rs11970772-T rs385893-C rs11066301-G rs9609565-G rs210135-A rs7385804-C rs5756506-C rs17609240-G rs2227139-G rs4947019-G	NR NR NR NR NR NR NR NR NR NR NR NR	7 x 10^-42 (MCV) 1 x 10^-23 (MCV) 7 x 10^-19 (MCV) 9 x 10^-17 (PLT) 8 x 10^-12 (PLT) 4 x 10^-10 (MCV) 4 x 10^-10 (PLT) 5 x 10^-10 (RBC) 1 x 10^-9 (MCH) 9 x 10^-9 (WBC) 1 x 10^-7 (WBC) 8 x 10^-6 (MCV)	.82 [0.70-0.94] fl increase 1.41 [1.13-1.69] fl increase .58 [0.44-0.70] fl increase 6.26 [4.78-7.74] 10^9/l increase 4.65 [3.32-5.98] 10^9/l increase .37 [0.25-0.49] fl increase 5.44 [3.74-7.14] 10^9/l increase .01 [0.004-0.008] 10^12/l increase .14 [0.10-0.18] pg increase .02 [0.01-0.03] 10^9/l increase .02 [0.01-0.03] 10^9/l increase .01 [0.003-0.011] fl decrease	Affymetrix and Illumina [~2.11 million] (imputed)	N
10/30/09	"	Mean platelet volume	4,627 European individuals	9,316 European individuals	12q24.31 7q22.3 3p14.3 17q11.2 10q21.3 1q32.1 11p15.5 1q24.3 2p23.1 20p13 18q22.2 15q22.2 5q33.3 20p12.1 12q13.13	WDR66 PIK3CG ARHGEF3 TAOK1 JMJD1C TMCC2 BET1L DNM3 EHD3 SIRPA CD226 TPM1 NR NR NR	rs7961894-T rs342293-G rs12485738-A rs2138852-T rs2393967-A rs1668873-G rs11602954-G rs10914144-C rs647316-A rs6136489-T rs893001-C rs11071720-T rs1473247-C rs6110278-T rs10506328-A	NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR	3 x 10^-44 2 x 10^-33 6 x 10^-31 1 x 10^-22 3 x 10^-21 1 x 10^-20 1 x 10^-14 2 x 10^-14 3 x 10^-11 8 x 10^-11 1 x 10^-10 2 x 10^-8 3 x 10^-7 4 x 10^-7 5 x 10^-7	.03 [0.027-0.035] fl increase .02 [0.013-0.017] fl increase .02 [0.013-0.017] fl increase .02 [0.012-0.020] fl increase .01 [0.01-0.018] fl increase .01 [0.01-0.014] fl increase .01 [0.009-0.017] fl increase .01 [0.009-0.017] fl increase .01 [0.006-0.014] fl increase .01 [0.006-0.014] fl increase .01 [0.007-0.015] fl increase .01 [0.007-0.015] fl increase .01 [0.004-0.012] fl decrease .01 [0.005-0.013] fl increase .01 [0.004-0.012] fl increase	Affymetrix and Illumina [~2.11 million] (imputed)	N
10/23/09	Weiss October 08, 2009 Nature A genome-wide linkage and association scan reveals novel loci for autism	Autism	1,031 families with 1,553 affected offspring (multiple races/ethnicities)	2,073 trios (multiple races/ethnicities)	5p15.2	SEMA5A, TAS2R1	rs10513025-?	NR	3 x 10^-7	1.81 [NR]	Affymetrix [~365,000]	N
10/16/09	Rivadeneira October 04, 2009 Nat Genet Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies	Bone mineral density (hip)	19,195 European individuals	NR	5q14.3 1p31.3 7q21.3 6q25.1 11p15.2 3p22.1 11p11.2 8q24.12 17q21.31 1p36.12 16q24.1 4q22.1 17q21.31	MEF2C GPR177 FLJ42280 ESR1 SOX6 CTNNB1 ARHGAP1 TNFRSF11B HDAC5 ZBTB40 FOXL1 MEPE CRHR1	rs1366594-C rs2566755-C rs7781370-T rs2941740-G rs7117858-G rs87938-A rs7932354-T rs11995824-G rs228769-G rs6426749-C rs10048146-G rs1471403-T rs9303521-T	0.45 0.21 0.34 0.43 0.20 0.45 0.29 0.55 0.20 0.17 0.19 0.34 0.46	1 x 10^-13 2 x 10^-12 5 x 10^-12 2 x 10^-10 6 x 10^-10 8 x 10^-10 4 x 10^-9 7 x 10^-9 2 x 10^-8 9 x 10^-8 2 x 10^-7 8 x 10^-7 4 x 10^-6	.09 [0.07-0.11] sd decrease .1 [0.07-0.13] sd increase .08 [0.06-0.10] sd decrease .07 [0.05-0.09] sd increase .09 [0.06-0.12] sd increase .07 [0.05-0.09] sd decrease .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd decrease .08 [0.05-0.11] sd increase .08 [0.05-0.11] sd increase .09 [0.06-0.12] sd decrease .06 [0.04-0.08] sd increase .06 [0.04-0.07] sd decrease	Affymetrix & Illumina [2,543,686](imputed)	N
10/16/09	"	Bone mineral density (spine)	19,195 European individuals	NR	13q14.11 8q24.12 1p31.3 6q25.1 7q21.3 1p36.12 7p14.1 11p13 18q21.33 12q13.13 17q21.31 16q24.1 2p16.2 4q22.1 11q13.2 17q21.31	AKAP11 TNFRSF11B GPR177 ESR1 FLJ42280 ZBTB40 STARD3NL DCDC5 TNFRSF11A SP7 CRHR1 FOXL1 SPTBN1 MEPE LRP5 HDAC5	rs9533090-T rs2062377-T rs1430742-C rs2504063-A rs4729260-G rs7524102-G rs1524058-T rs16921914-A rs884205-A rs2016266-G rs9303521-T rs10048146-G rs11898505-A rs1471403-T rs599083-G rs228769-G	0.50 0.44 0.21 0.40 0.32 0.17 0.40 0.27 0.27 0.32 0.46 0.19 0.34 0.34 0.31 0.20	5 x 10^-25 4 x 10^-16 3 x 10^-13 6 x 10^-11 2 x10^-10 3 x 10^-10 1 x 10^-9 2 x 10^-9 9 x 10^-9 1 x 10^-8 1 x 10^-8 2 x 10^-8 2 x 10^-8 2 x 10^-8 5 x 10^-8 4 x 10^-6	.12 [0.10-0.14] sd decrease .09 [0.07-0.11] sd increase .11 [0.07-0.14] sd increase .08 [0.06-0.10] sd decrease .08 [0.05-0.11] sd decrease .09 [0.06-0.12] sd increase .07 [0.05-0.09] sd decrease .08 [0.05-0.11] sd increase .08 [0.05-0.11] sd decrease .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd decrease .09 [0.06-0.12] sd decrease .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd increase .07 [0.05-0.09] sd decrease .07 [0.04-0.10] sd increase	Affymetrix & Illumina [2,543,686](imputed)	N
11/04/09	Hicks October 02, 2009 PLoS Genet Genetic determinants of circulating sphingolipid concentrations in European populations	Sphingolipid Concentrations	4,110 European individuals	NR	14q23.2 19p13.2 4p12 20p12.1 11q12.3	SGPP1 LASS4 ATP10D SPTLC3 FADS	rs7157785-A rs7258249-G rs10938494-A rs680379-A rs1000778-A	0.19 0.48 0.23 0.34 0.32	9 x 10^-66 (SM 14:0Mol%) 2 x 10^-27 (SM 18:1Mol%) 8 x 10^-19 (GluCer) 8 x 10^-15 (Cer24:0) 7 x 10^-13 (SM 16:1)	0 [0.001-0.002] mol % increase 0 [0.0007-0.001] mol % increase .06 [0.04-0.07] unit increase .1 [0.08-0.13] mol % increase .62 [0.45-0.78] unit decrease	Illumina [318,237]	N
10/06/09	Roeske September 29, 2009 Mol Psychiatry First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children	Speech perception in dyslexia	200 dyslexic German children	186 dyslexic German children	4q32.1 10q26.3	CTSO, TDO2, PDGFC NR	rs4234898-T rs4751178-G	NR NR	5 x 10^-8 (MMNb) 7 x 10^-6 (MMNb)	NS NS	Illumina [297,086]	N
10/06/09	Nakanishi September 25, 2009 PLoS Genet A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1	Myopia (pathological)	297 Japanese cases, 934 Japanese controls	533 Japanese cases, 977 Japanese controls	11q24.1	BLID, LOC399959	rs577948-G	0.52	2 x 10^-7	1.37 [1.21-1.54]	Illumina [411,777]	N
10/05/09	Latourelle September 22, 2009 BMC Med Genet Genomewide Association Study for Onset Age in Parkinson Disease	Parkinson disease (age of onset)	857 white familial cases, 440 white idiopathic cases	747 Italian idiopathic cases	11p13 15q12 18q12.1 1q23.3 2p14	QSER1, PRRG4 OCA2 DSG3 ATF6 AAK1	rs10767971-T rs17565841-A rs1941184-C rs10918270-A rs7577851-T	NR NR NR NR NR	5 x 10^-7 3 x 10^-6 4 x 10^-6 8 x 10^-6 9 x 10^-6	3.24 [NR] years older 2.84 [NR] years younger 2.28 [NR] years younger 2.26 [NR] years younger 6.85 [NR] years younger	Illumina and Perlegen [1,861,750] (imputed)	N
10/05/09	Gudmundsson September 20, 2009 Nat Genet Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility	Prostate cancer	Up to 1,968 Icelandic cases, 35,382 Icelandic controls	Up to 11,806 European descent cases, 12,387 European descent controls	8q24.21 8q24.21 8q24.21 11q13.2 19q13.2 3q21.3 8q24.21 17q12	Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic Intergenic	rs1447295-A rs16902094-G rs16901979-A rs11228565-A rs8102476-C rs10934853-A rs445114-T rs4430796-A	0.11 0.15 0.04 0.20 0.54 0.28 0.64 0.52	2 x 10^-19 6 x 10^-15 3 x 10^-14 7 x 10^-12 2 x 10^-11 3 x 10^-10 5 x 10^-10 8 x 10^-6	1.58 [1.43-1.74] 1.21 [1.15-1.26] 1.8 [1.55-2.09] 1.23 [1.16-1.31] 1.12 [1.08-1.15] 1.12 [1.08-1.16] 1.14 [1.10-1.19] 1.19 [1.10-1.28]	Illumina [310,520]	N
09/30/09	Le Clerc September 15, 2009 J Infect Dis Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03).	AIDS	85 French cases, 2,049 French controls	NR	1p13.3 12p12.1 9p23 1q23.3 8q22.3 2q12.1 9p22.3	Intergenic SOX5 Intergenic RXRG Intergenic TGFBRAP1 NR	rs4118325-G rs1522232-C rs1360517-A rs10800098-A rs3108919-C rs1020064-G rs1556032-C	0.81 0.52 0.06 0.05 0.27 0.23 0.49	6 x 10^-7 2 x 10^-6 3 x 10^-6 4 x 10^-6 4 x 10^-6 7 x 10^-6 9 x 10^-6	4.17 [2.17-8.33] 2.22 [1.59-3.13] 3.09 [2.00-4.78] 3.29 [2.08-5.20] 2.13 [1.56-2.91] 2.94 [1.75-5.00] 2.05 [1.48-2.84]	Illumina [291,119]	N
09/30/09	Suppiah September 13, 2009 Nat Genet IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy	Response to Hepatitis C treatment	131 European ancestry responders, 162 European ancestry non-responders	261 European responders, 294 European non-responders	19q13.2	IL28A, IL28B	rs8099917-G	NR	9 x 10^-9	1.98 [1.57-2.52]	Illumina [311,159]	N
09/30/09	Tanaka September 13, 2009 Nat Genet Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C	Response to Hepatitis C treatment	72 Japanese responders, 82 Japanese non-responders	122 Japanese responders, 50 Japanese non-responders	19q13.2	IL28B	rs8099917-G	0.12	3 x 10^-32	27.1 [14.6-50.3]	Affymetrix [621,220]	N
09/30/09	Heinzen September 11, 2009 J Alzheimers Dis Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease	Alzheimer's Disease	331 cases, 368 controls	NR	19q13.32 13q13.2 1p31.1 10q24.31 6q24.3	TOMM40, APOE RFC3 TTLL7 PAX2 SASH1	rs2075650-? rs690705-? rs7539409-? rs4509693-? rs9390537-?	0.15 0.25 0.18 0.18 0.22	3 x 10^-11 6 x 10^-7 1 x 10^-6 6 x 10^-6 8 x 10^-6	NS NS NS NS NS	Illumima [~550,000]	N
09/30/09	Sha September 09, 2009 BMC Med Genet Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis	Amyotrophic lateral sclerosis (interaction)	276 Caucasian cases, 271 Caucasian controls	NR	NS	NS	NS	NS	NS	NS	Illumina [549,062]	N
09/29/09	Harold September 06, 2009 Nat Genet Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease	Alzheimer's disease	3,941 European ancestry cases, 7,848 European ancestry controls	2,023 European ancestry cases, 2,340 European ancestry controls	19q13.32 8p21.1 11q14.2	APOE, TOMM40 CLU PICALM	rs2075650-? rs11136000-? rs3851179-?	0.15 0.60 0.63	2 x 10^-157 9 x 10^-10 1 x 10^-9	2.53 [2.37-2.71] 1.16 [1.11-1.22] 1.16 [1.11-1.22]	Illumina [529,205]	N
09/29/09	Lambert September 06, 2009 Nat Genet Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease	Alzheimer's disease	2,032 French cases, 5,328 French controls	3,978 European cases, 3,297 European controls	19q13.32 1q32.2 8p21.1	APOE CR1 CLU	rs2075650-? 2-SNP haplotype 3-SNP haplotype	0.90 0.18 0.26	2 x 10^-16 3 x 10^-10 (AA) 6 x 10^-10 (CCG)	NS 1.22 [1.15-1.30] 1.22 [1.14-1.29]	Illumina [537,029]	N
09/29/09	Rung September 06, 2009 Nat Genet Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	Type 2 diabetes and other traits	679 French cases, 697 French controls	5,579 European cases, 7,096 European controls	10q25.2 6p22.3 2q36.3 4p16.1 8q24.11 5q14.3	TCF7L2 CDKAL1 LOC64673, IRS1 WFS1, PPP2R2C SLC30A8 LOC72901, CETN3	rs7903146-T rs4712523-G rs2943641-C rs4689388-T rs13266634-C rs12518099-C	0.27 0.32 0.63 0.57 0.68 0.23	1 x 10^-30 2 x 10^-12 9 x 10^-12 1 x 10^-8 8 x 10^-8 7 x 10^-7	1.48 [1.39-1.57] 1.2 [1.14-1.26] 1.19 [1.13-1.25] 1.16 [1.10-1.21] 1.16 [1.10-1.22] 1.16 [1.10-1.22]	Illumina [392,365]	N
09/29/09	van Es September 06, 2009 Nat Genet Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	2,323 European descent cases, 9,013 European descent controls	2,532 European descent cases, 5,940 European descent controls	19p13.11 9p21.2 9p21.2 Xq13.3 12p12.3 11q22.1 9p21.2 Xp22.32	UNC13A MOBKL2B, IFNK, C9orf72 MOBKL2B, IFNK, C9orf72 NR NR NR NR NR	rs12608932-? rs2814707-? rs3849942-? rs5937496-? rs9971637-? rs2405657-? rs774359-? rs5916687-?	0.34 0.23 0.23 0.13 0.05 0.66 0.25 0.27	3 x 10^-14 7 x 10^-9 1 x 10^-8 6 x 10^-7 2 x 10^-6 3 x 10^-6 3 x 10^-6 3 x 10^-6	1.25 [NR] 1.22 [NR] 1.23 [NR] 1.38 [NR] 1.48 [NR] 1.19 [NR] 1.19 [NR] 1.22 [NR]	Illumina [292,768]	N
10/02/09	Need September 04, 2009 Hum Mol Genet A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery	Cognitive performance	1,295 individuals	NR	15q23 Xp22.2 3p22.3 13q34 16p12.1 17q21.32 8q24.13 21q11.2 17q25.2 14q23.2 15q21.3 2q31.1 5p15.31 11q14.2 12p13.1 15q12 1q23.2 20p12.3 21q21.3 3q27.2 16q23.3 3p25.1 7q31.1 18q22.1 1q41 3p22.1 3q26.32 9p22.2 11p12 13q12.3 14q23.2 1p32.1 1q32.1 7p15.1 12q24.23 19q12 1p36.13 3q13.33 4q28.1 7p14.1 7q31.1 8q12.1 11q13.5 6p21.2 18q12.3 Xp22.31 13q14.11	CORO2B HCCS ARPP-21 Intergenic Intergenic Intergenic FAM91A1 NRIP1 SEC14L1 MTHFD1 UNC13C GORASP2 Intergenic C11orf73 GRIN2B GABRB3 VANGL2 PLCB1 JAM2 EHHADH Intergenic GRIP2 IMMP2L C18orf4, DSEL FAM177B MOBP Intergenic SH3GL2 API5 FLT1 MTHFD1 JUN MDM4 CPVL CCDC64 TSHZ3 FAM131C FBXO40 FAT4 VPS41 IMMP2L TOX CAPN5 C6orf129 RIT2 VCX3B DNAJC15	rs11856323-? rs5934953-? rs6799705-? rs767210-? rs2203512-? rs2326017-? rs10481151-? rs2229741-? rs3744064-? rs10498514-? rs1897031-? rs4668356-? rs7729273-? rs6592284-? rs2160519-? rs8043440-? rs16832015-? rs6056209-? rs17001239-? rs7374394-? rs4082514-? rs9036-? rs10279573-? rs2124349-? rs6683071-? rs816488-? rs7612209-? rs10810865-? rs10501293-? rs17086609-? rs2295639-? rs4601609-? rs12143943-? rs2252521-? rs11064994-? rs1078373-? rs9442235-? rs3772130-? rs12639834-? rs11984145-? rs12531640-? rs960089-? rs3781684-? rs904251-? rs8085804-? rs7892812-? rs1324015-?	0.08 0.02 0.05 0.11 0.14 0.30 0.14 0.47 0.03 0.02 0.18 0.06 0.20 0.21 0.06 0.17 0.01 0.43 0.12 0.20 0.03 0.19 0.14 0.05 0.20 0.04 0.40 0.13 0.25 0.35 0.02 0.05 0.41 0.34 0.06 0.37 0.42 0.23 0.36 0.05 0.13 0.07 0.11 0.38 0.37 0.47 0.42	1 x 10^-7 (PAL8) 1 x 10^-7 (PAL6) 2 x 10^-7 (PAL8) 3 x 10^-7 (PAL6) 3 x 10^-7 (PRM) 3 x 10^-7 (SWM strategy) 4 x 10^-7 (PRM) 6 x 10^-7 (SRM) 7 x 10^-7 (PAL6) 8 x 10^-7 (SWM strategy) 1 x 10^-6 (PRM) 1 x 10^-6 (PAL8) 1 x 10^-6 (SSP) 2 x 10^-6 (IED) 2 x 10^-6 (IED) 2 x 10^-6 (SRM) 2 x 10^-6 (IED) 2 x 10^-6 (RVP) 2 x 10^-6 (PRM) 2 x 10^-6 (IED) 3 x 10^-6 (PC1) 3 x 10^-6 (PAL6) 3 x 10^-6 (IED) 4 x 10^-6 (IED) 4 x 10^-6 (PC1) 4 x 10^-6 (IED) 4 x 10^-6 (IED) 4 x 10^-6 (PAL6) 5 x 10^-6 (SWM Strategy) 5 x 10^-6 (IED) 5 x 10^-6 (SWM Strategy) 5 x 10^-6 (PRM) 5 x 10^-6 (PAL8) 5 x 10^-6 (PAL8) 6 x 10^-6 (PAL6) 6 x 10^-6 (SSP) 6 x 10^-6 (PC1) 6 x 10^-6 (PC1) 6 x 10^-6 (SWM Strategy) 6 x 10^-6 (PAL8) 6 x10^-6 (IED) 6 x 10^-6 (PAL6) 7 x 10^-6 (VRM) 7 x 10^-6 (SWM Strategy) 8 x 10^-6 (VRM) 8 x 10^-6 (SSP) 9 x 10^-6 (PC1)	NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS	Illumina [475,971]	N
09/28/09	Paterson September 03, 2009 Arterioscler Thromb Vasc Biol Genome-Wide Association Identifies the ABO Blood Group as a Major Locus Associated With Serum Levels of Soluble E-Selectin	Serum soluble E-selectin	685 individuals with type 1 diabetes	477 nondiabetic siblings	9q34.2	ABO	rs579459-C	0.20	1 x 10^-29	NS	Illumina [~841,000]	N
09/28/09	Tonjes September 03, 2009 Hum Mol Genet Genetic Variation in GPR133 is Associated with Height - Genome Wide Association Study in the Self-contained Population of Sorbs	Height	929 Sorbian individuals, 2,986 Caucasian individuals	2,772 German individuals	12q24.33	GPR133	rs1569019-?	NR	5 x 10^-8	.95 [0.61-1.29] cm increase	Affymetrix [390,619]	N
09/28/09	De Moor September 02, 2009 Med Sci Sports Exerc Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults	Exercise (leisure time)	1,644 Dutch individuals, 978 European individuals	NR	10q23.2 18p11.32 2q33.1	PAPSS2 C18orf2 DNAPTP6	rs10887741-T rs8097348-G rs12612420-A	NR NR NR	4 x 10^-6 7 x 10^-6 8 x 10^-6	1.32 [1.17-1.49] 1.36 [1.19-1.56] 1.43 [1.22-1.67]	Affymetrix and Perlegen [~1.6 million] (imputed)	N
09/29/09	Ising September 01, 2009 Arch Gen Psychiatry A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression	Response to antidepressant treatment	339 German individuals	1,193 German individuals	NS	NS	NS	NS	NS	NS	Illumina [389,251] (pooled)	N
09/28/09	McClay September 01, 2009 Mol Psychiatry Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics	Treatment response to antipsychotics	738 cases	NR	4p15.1 9q33.3 12q23.1 2q14.3 1q21.3 6p24.1 15q13.3 3q28 6p21.33	Intergenic Intergenic ANKS1B CNTNAP5 Intergenic Intergenic TRPM1 Intergenic Intergenic	rs17390445-? rs888219-? rs7968606-? rs17727261-? rs10888501-? rs1040994-? rs17815774-? rs7635839-? rs12526186-?	NR NR NR NR NR NR NR NR NR	1 x10^-7 (ziprasidone) 2 x 10^-7 (risperidone) 3 x 10^-7 (olanzapine) 5 x 10^-7 (risperidone) 1 x 10^-6 (olanzapine) 2 x 10^-6 (olanzapine) 3 X 10^-6 (risperidone) 3 x 10^-6 (olanzapine) 3 x 10^-6 (risperidone)	17 [NR] % of variance explained 11 [NR] % of variance explained 10 [NR] % of variance explained 10 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained 9 [NR] % of variance explained	Affymetrix & Perlegen [492,900]	N
09/10/09	Spain September 01, 2009 Cancer Res Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom	Colorectal cancer	921 white cases, 929 white controls	1,214 white cases, 1,435 white controls	NS	NS	NS	NS	NS	NS	Illumina [486,303]	N
09/09/09	Laje August 31, 2009 Pharmacogenet Genomics Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients	Response to antidepressant treatment	90 white cases, 90 white controls	30 white cases, 1,652 white controls	NS	NS	NS	NS	NS	NS	Illumina [100,864]	N
09/09/09	Hancock August 28, 2009 PLoS Genet Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children	Asthma (childhood onset)	492 Mexican trios	177 Mexican trios	9q21.31	TLE4, CHCHD9	rs2378383-?	0.78	7 x 10^-7	1.64 [1.32-2.04]	Illumina [520,767]	N
09/24/09	Liu August 28, 2009 PLoS ONE Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males	Obesity and osteoporosis	499 Caucasian males, 501 Caucasian females	1,370 Caucasian males, 1,985 Caucasian females	11p15.1 11p15.1	SOX6 SOX6	rs297325-T rs4756846-T	0.23 0.12	4 x 10^-7 (BMI-BMD, males) 5 x 10^-7 (BMI-BMD, males)	NS NS	Affymetrix [379,319]	N
09/09/09	Shuldiner August 26, 2009 JAMA Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy	Response to clopidogrel therapy	429 Amish individuals	140 white, 83 African American, and 4 unspecified individuals	NS	NS	NS	NS	NS	NS	Affymetrix [400,230]	N
09/09/09	Cui August 18, 2009 Gastroenterology Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk	Esophageal cancer	188 Japanese cases, 938 Japanese controls	699 Japanese cases, 1,482 Japanese controls	12q24.12 4q23	BRAP, ALDH2 ADH6, ADH1B	rs671-A rs1229984-G	0.36 0.35	3 x 10^-24 8 x 10^-24	1.67 [1.58-1.76] 1.79 [1.69-1.88]	Illumina [359,195]	N
09/09/09	Ge August 16, 2009 Nature Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance	Response to Hepatitis C treatment	871 Caucasian, 191 African American, and 75 Hispanic participants	NR	19q13.2 6q21 4q34.3	IL28B AKD2 Intergenic	rs12979860-C rs9400317-? rs17067123-?	0.72 NR NR	1 x 10^-28 (combined) 7 x 10^-6 (combined) 8 x 10^-6 (combined)	2 [1.8-2.3] (European-Americans) NS NS	Illumina [565,759]	N
09/04/09	Papaemmanuil August 16, 2009 Nat Genet Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia	Acute lymphoblastic leukemia (childhood)	503 European pediatric cases, 1,438 European pediatric controls	404 European pediatric cases, 960 European pediatric controls	7p12.2 10q21.2 14q11.2	IKZF1 ARID5B CEBPE	rs4132601-C rs7089424-C rs2239633-G	0.28 0.34 0.52	1 x 10^-19 7 x 10^-19 3 x 10^-7	1.69 [1.58-1.81] 1.65 [1.54-1.76] 1.34 [1.22-1.45]	Illumina [291,473]	N
09/11/09	Trevino August 16, 2009 Nat Genet Germline genomic variants associated with childhood acute lymphoblastic leukemia	Acute lymphoblastic leukemia (childhood)	317 European descent cases, 17,958 European descent controls	NR	10q21.2 7p12.2 12q24.22 6q24.1 19q13.31 1q43 2q36.1 1p31.1 3q26.32 1q31.3 1q44 10p11.21 12p13.32 18p11.32	ARID5B IKZF1, DDC KRTHB5 Intergenic ZNF230 RYR2 KCNE4 SIAT7C KCNMB2 Intergenic OR2C3 PARD3 C12orf5 Intergenic	rs10821936-C rs11978267-G rs2089222-A rs11155133-G rs2191566-G rs7554607-A rs12621643-T rs10873876-T rs9290663-T rs6428370-G rs1881797-C rs563507-A rs10849033-G rs1879352-C	0.34 0.27 0.03 0.01 0.28 0.56 0.28 0.15 0.13 0.32 0.18 0.04 0.02 0.16	1 x 10^-15 8 x 10^-11 8 x 10^-8 3 x 10^-7 4 x 10^-7 2 x 10^-6 3 x 10^-6 4 x 10^-6 6 x 10^-6 7 x 10^-6 7 x 10^-6 9 x 10^-6 9 x 10^-6 9 x 10^-6	1.91 [1.60-2.20] 1.69 [1.40-1.90] 2.26 [1.60-3.0] 3.62 [2.10-6.00] 1.52 [1.20-1.70] 1.49 [1.20-1.70] 1.48 [1.20-1.70] 1.55 [1.20-1.80] 1.58 [1.20-1.90] 1.43 [1.20-1.60] 1.52 [1.20-1.80] 2 [1.40-2.70] 2.55 [1.60-3.80] 1.53 [1.20-1.80]	Affymetrix [307,944]	N
09/04/09	Alkelai August 13, 2009 Psychopharmacology Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients	Response to antipsychotic treatment	199 cases, 198 controls	NR	2q24.3	FIGN	rs12476047-C	NR	3 x 10^-6	3.21 [1.97-5.25]	Affymetrix & Perlegen [495,172]	N
09/09/09	Potkin August 07, 2009 PLoS ONE Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease	Hippocampal atrophy	172 cases, 209 controls	NR	21q21.1 5q21.3 9q21.13 14q22.1 13q31.1 20q11.23 20q13.31 5q14.1 7p12.2 7q21.11 9q21.31 12q14.3 1q21.3 20q11.23 5q14.1 12q13.11 5p14.1 5p15.1 7p21.3 11q24.3 8q24.12	FDPSP EFNA5 PRUNE2 FRMD6, AL079307.7 Intergenic C20orf132 ZBP1 AC104108.3, SCAMP1, LHFPL2 IKZF1, AC020743.7 MAGI2 RP11, 232A1.1 CAND1 AL157404.18, S100A5 RPN2 ARSB ARID2, SFRS2IP Intergenic AC026790.5 Intergenic Intergenic MAL2	rs1888414-? rs10074258-? rs10781380-? rs11626056-? rs4773460-? rs8115854-? rs2073145-? rs6881634-? rs10276619-? rs11525066-? rs10867752-? rs1082714-? rs4845552-? rs6031882-? rs337847-? rs1373549-? rs7727656-? rs682748-? rs9918508-? rs6590322-? rs1364705-?	NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR	2 x 10^-7 2 x 10^-7 7 x 10^-7 1 x 10^-6 2 x 10^-6 2 x 10^-6 2 x 10^-6 2 x 10^-6 3 x 10^-6 3 x 10^-6 3 x 10^-6 5 x 10^-6 6 x 10^-6 6 x 10^-6 7 x 10^-6 8 x 10^-6 8 x 10^-6 8 x 10^-6 8 x 10^-6 9 x 10^-6 9 x 10^-6	NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS	Illumina [516,645]	N
09/04/09	Tse August 05, 2009 Am J Hum Genet Genome-wide Association Study Reveals Multiple Nasopharyngeal Carcinoma-Associated Loci within the HLA Region at Chromosome 6p21.	Nasopharyngeal carcinoma	277 Han Chinese cases, 285 Han Chinese controls	635 Han Chinese cases, 1,640 Han Chinese controls	6p21.33 6p22.1 6p22.1	HLA-A GABBR1 HLA-F	rs2517713-A rs29232-A rs3129055-G	0.62 0.46 0.31	4 x 10^-20 9 x 10^-17 7 x 10^-11	1.88 [1.65-2.15] 1.67 [1.48-1.88] 1.51 [1.34-1.71]	Illumina [480,365]	N
09/14/09	Broderick August 04, 2009 Cancer Res Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study	Lung cancer	1,952 European cases, 1,438 European controls	5,608 European cases, 6,767 European controls	15q25.1 6p21.33 5p15.33 10q23.31 15q15.2 3p24.1 2p14	CHRNA3 BAT3 CLPTM1L NR TGM5 NR NR	rs8034191-? rs3117582-? rs4975616-? rs1926203-? rs748404-? rs1530057-? rs4254535-?	NR NR NR NR NR NR NR	3 x 10^-26 4 x 10^-10 3 x 10^-9 1 x 10^-6 1 x 10^-6 3 x 10^-6 5 x 10^-6	1.29 [1.23-1.35] 1.24 [1.16-1.33] 1.15 [1.10-1.20] 1.12 [NR] 1.15 [1.09-1.20] 1.26 [NR] 1.12 [NR]	Illumina [511,919]	N
09/04/09	Chambers August 03, 2009 Diabetes Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites	Fasting plasma glucose	7,474 Indian Asian individuals	4,462 European controls	11q21	MTNR1B	rs2166706-G	0.46	2 x 10^-9	.07 (0.04-0.09) mmol/L increase	Illumina [up to 544,390]	N
09/04/09	Grant August 03, 2009 J Pediatr A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24	Nonsyndromic cleft lip with or without cleft palate	111 European ancestry cases, 5,951 European ancestry controls	NR	18q22.3 8q24.21	Intergenic Intergenic	rs17085106-? rs987525-?	0.018 0.22	4 x 10^-8 9 x 10^-8	4.07 [2.37-7.00] 2.09 [1.59-2.76]	Illumina [495,858]	N
09/04/09	Amundadottir August 02, 2009 Nat Genet Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer	Pancreatic cancer	1,771 European ancestry cases, 1,805 European ancestry controls	2,120 European ancestry cases, 2,127 European ancestry controls	9q34.2	ABO	rs505922-T	0.35	5 x 10^-8	1.2 [1.12-1.28]	Illumina [558,542]	N
09/04/09	Song August 02, 2009 Nat Genet A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2	Ovarian cancer	1,817 European ancestry cases, 2,353 European ancestry controls	6,944 European ancestry cases, 9,477 European ancestry controls	9p22.2	BNC2, LOC648570, CNTLN	rs3814113-T	0.68	5 x 10^-19	1.22 [1.16-1.27]	Illumina [up to ~2,000,000] (imputed)	N
08/21/09	Wu August 02, 2009 Nat Genet Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer	Bladder cancer	969 Caucasian cases, 957 Caucasian controls	5,698 US and European cases, 38,633 US and European controls	8q24.3	PSCA	rs2294008-T	0.46	2 x 10^-10	1.15 [1.10-1.20]	Illumina [556,429]	N
09/04/09	Comabella August 01, 2009 Arch Neurol Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis	Response to interferon beta therapy	53 responders, 53 non-responders	49 responders, 45 non-responders	NS	NS	NS	NS	NS	NS	Affymetrix [428,867](pooled)	N
08/21/09	Nakano July 22, 2009 Proc Natl Acad Sci USA Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population	Glaucoma (primary open-angle)	418 Japanese cases, 300 Japanese controls	409 Japanese cases, 448 Japanese controls	NS	NS	NS	NS	NS	NS	Affymetrix [331,838]	N
08/21/09	Skibola July 20, 2009 Nat Genet Genetics variants at 6p21.33 are associated with susceptibility to follicular lymphoma	Follicular lymphoma	189 European ancestry cases, 592 European controls	456 European ancestry cases, 2,785 European ancestry controls	6p21.33	STG, PSORS1	rs6457327-C	0.62	5 x 10^-11	1.69 [1.43-2.00]	Illumina [~500,000] (pooled)	N
08/12/09	Adeyemo July 17, 2009 PLoS Genet A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans	Hypertension	509 African American cases, 508 African American controls	366 West African cases, 614 West African controls	15q22.1 4q23	ALDH1A2 ADH7	rs1550576-? rs991316-T	0.86 0.45	3 x 10^-6 5 x 10^-6	1.92 [NR] 1.62 [NR]	Affymetrix [808,465]	N
08/04/09	Benjamin July 13, 2009 Nat Genet Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry	Atrial fibrillation	3,413 cases, 37,105 referents	2,145 cases, 4,073 controls	4q25 16q22.3 1p36.22	PITX2 ZFHX3 MTHFR, NPPA	rs17042171-A rs2106261-T rs17375901-T	0.12 0.174 0.053	4 x 10^-63 2 x 10^-15 6 x 10^-7	1.65 1.25 1.26	Affymetrix & Illumina [~2.5 million] (imputed)	N
07/30/09	Gudbjartsson July 13, 2009 Nat Genet A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke	Atrial fibrillation	2,385 European cases, 33,752 European controls	up to 2,427 European cases, 3,379 European controls	4q25 16q22.3	Intergenic ZFHX3	rs2200733-? rs7193343-T	0.12 NR	1 x 10^-14 1 x 10^-10	1.42 [NR] 1.21 [1.14-1.29]	Illumina [303,136]	N
07/24/09	Nolte July 09, 2009 PLoS ONE Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies	Cardiac repolarisation	3,558 Caucasian individuals	29,527 Caucasian individuals	1q23.3 6q22.31	OLFML2B, NOS1AP SLC35F1, C6orf204, PLN	rs12143842-T rs11153730-C	0.25 0.50	1 x 10^-83 2 x 10^-29	.18 [NR] unit increase .09 [NR] unit increase	Affymetrix & Illumina [~2,399,142] (imputed)	N
07/24/09	Tonjes July 08, 2009 Eur J Hum Genet Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany	Body mass index and fat mass	948 Sorbian individuals	NR	NS	NS	NS	NS	NS	NS	Affymetrix [390,619]	N
08/07/09	Vasan July 08, 2009 JAMA Genetic Variants Associated with Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data	Aortic root size	12,612 European ancestry individuals	4,094 European ancestry individuals	5q23.2 17p13.3 12q14.3 12p12.2 1p21.2 15q24.1	CCDC100, PPIC SMG6, SRR, TSR1, SGSM2 HMGA2 PDE3A PALMD LOXL1	rs17470137-A rs10852932-T rs4026608-C rs10770612-G rs7543130-A rs893817-G	0.29 0.36 0.38 0.19 0.49 0.34	1 x 10^-11 2 x 10^-11 2 x 10^-9 2 x 10^-8 1 x 10^-7 3 x 10^-6	.03 [0.02-0.04] cm increase .03 [0.02-0.04] cm increase .03 [0.02-0.04] cm decrease .03 [0.02-0.04] cm increase .03 [0.02-0.04] cm increase .02 [0.01-0.03] cm increase	Affymetrix & Illumina [~2.5 million] (imputed)	N
08/07/09	"	Cardiac structure and function	12,612 European ancestry individuals	4,094 European ancestry individuals	6q22.31 10q23.1 5q22.1 16q23.1	SLC35F1, C6orf204, PLN GRID1 SLC25A46 WWOX	rs89107-G rs7910620-G rs17132261-T rs2059238-A	0.50 0.01 0.02 0.22	1 x 10^-9 (LV internal diastolic dimensions) 7 x 10^-7 (LV wall thickness) 9 x 10^-7 (LV wall thickness) 3 x 10^-6 (LV wall thickness)	.03 [0.02-0.04] cm decrease .17 [0.11-0.23] cm increase .06 [0.04-0.08] cm increase .02 [0.01-0.03] cm decrease	Affymetrix & Illumina [~2.5 million] (imputed)	N
07/16/09	Bishop July 05, 2009 Nat Genet Genome-wide association study identifies three loci associated with melanoma risk	Melanoma	1,539 European ancestry cases, 3,917 European ancestry controls	2,312 European ancestry cases, 1,867 European ancestry controls	16q24.3 16q24.3 11q14.3 22q13.1 9p21.3	MC1R MC1R TYR Intergenic CDKN2A	rs258322-A rs4785763-A rs1393350-A rs2284063-? rs7023329-A	0.09 0.32 0.27 0.37 0.50	3 x 10^-27 6 x 10^-22 2 x 10^-14 2 x 10^-9 4 x 10^-7	1.67 [1.52-1.83] 1.36 [1.28-1.45] 1.29 [1.21-1.38] 1.2 [1.14-1.28] 1.18 [1.10-1.25]	Illumina [~317,000]	N
07/13/09	Falchi July 05, 2009 Nat Genet Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi	Cutaneous nevi	1,524 European twins	4,107 European individuals	9p21.3 22q13.1	MTAP PLA2G6	rs4636294-A rs2284063-G	0.48 0.35	3 x 10^-15 3 x 10^-8	.2 [0.13-0.27] increase in log nevus count .08 [-0.002-0.16] decrease in log nevus count	Illumina [297,108]	N
07/12/09	Shete July 05, 2009 Nat Genet Genome-wide association study identifies five susceptibility loci for glioma	Glioma	1,878 cases, 3,670 controls	2,545 cases, 2,953 controls	8q24.21 5p15.33 9p21.3 5p15.33 20q13.33 8q24.21 11q23.3	CCDC26 TERT CDKN2A, CDKN2B TERT RTEL1 CCDC26 PHLDB1	rs4295627-G rs2736100-G rs4977756-G rs2853676-A rs6010620-G rs891835-G rs498872-T	0.83 0.49 0.60 0.73 0.23 0.78 0.69	2 x 10^-18 2 x 10^-17 7 x 10^-15 4 x 10^-14 3 x 10^-12 8 x 10^-11 1 x 10^-8	1.36 [1.29-1.43] 1.27 [1.19-1.37] 1.24 [1.19-1.30] 1.26 [1.20-1.32] 1.28 [1.21-1.35] 1.24 [1.17-1.30] 1.18 [1.13-1.24]	Illumina [454,576]	N
07/12/09	Wrensch July 05, 2009 Nat Genet Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility	Glioma (high-grade)	692 high-grade cases, 3,992 controls	176 high-grade cases, 174 controls	9p21.3 20q13.33 20q13.33	Intergenic RTEL1 RTEL1	rs1412829-C rs4809324-C rs6010620-G	0.39 0.10 0.77	2 x 10^-10 2 x 10^-9 3 x 10^-9	1.42 [1.27-1.58] 1.6 [1.37-1.87] 1.52 [1.32-1.75]	Illumina [326,506]	N
07/24/09	Teichert July 04, 2009 Hum Mol Genet A genome-wide association study of acenocoumarol maintenance dosage	Acenocoumarol maintenance dosage	1,451 Caucasian individuals	287 Caucasian individuals	10q23.33 19p13.12 10q23.33 3q22.3	CYP2C18 CYP4F2 CYP2C19 CNTN4	rs12772169-? rs2108622-? rs12767583-? rs10935268-?	NR NR NR NR	8 x 10^-12 3 x 10^-10 3 x 10^-7 8 x 10^-7	NS NS NS NS	Illumina [~550,000]	N
07/12/09	Elliott July 01, 2009 JAMA Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease	C-reactive protein	17,967 European and Indian Asian men and women	13,615 European and Indian Asian men and women	1q23.2 12q24.31 19q13.32 1q21.3 1p31.3	CRP HNF1A APOE, APOCI, APOCII IL6R LEPR	rs7553007-A rs1183910-T rs4420638-G rs4537545-T rs6700896-T	NR NR NR NR NR	8 x 10^-44 1 x 10^-30 5 x 10^-27 2 x 10^-14 3 x 10^-14	20.7 [18.9-23.4] % decrease 13.8 [10.9-16.6] % decrease 21.8 [18.1-25.3] % decrease 11.5 [8.5-14.4] % decrease 14.8 [12.0-17.6] % decrease	Affymetrix, Illumina & Perlegen [~1.4 million] (imputed)	N
07/24/09	Estrada July 01, 2009 Hum Mol Genet A genome-wide association study of northwestern Europeans involves the CNP signaling pathway in the etiology of human height variation	Height	10,074 European individuals	6,912 European individuals	2q37.1 22q13.1 5p13.3 11q14.1 22q13.1	DIS3L2, ALPP, NPPC TNRC6B, ADSL C5orf23, NPR3 TMEM126B, TMEM126A SGSM3, MKL1	rs6717918-T rs139909-T rs10472828-C rs10898392-T rs5757949-T	0.78 0.68 0.56 NR NR	3 x 10^-9 2 x 10^-7 3 x 10^-7 3 x 10^-6 4 x 10^-6	.44 [0.20-0.68] cm increase .25 [0.03-0.47] cm increase .22 [0.04-0.40] cm increase NS NS	Affymetrix, Illumina & Perlegen [2,228,850] (imputed)	N
07/13/09	International Schizophrenia Consortium July 01, 2009 Nature Common polygenic variation contributes to risk of schizophrenia and bipolar disorder	Schizophrenia	3,322 European descent cases, 3,587 European descent controls	4,692 European descent cases, 15,493 European descent controls	6p22.1 18q21.2 3q26.33 1p21.3	MHC TCF4 FXR1 PTBP2	rs13194053-T rs17594526-T rs6782299-T rs7544736-G	0.86 0.03 0.73 0.18	1 x 10^-8 1 x 10^-7 1 x 10^-7 6 x 10^-7	1.22 1.44 1.1 1.25	Affymetrix [739,995]	N
07/10/09	Shi July 01, 2009 Nature Common variants on chromosome 6p22.1 are associated with schizophrenia	Schizophrenia	2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls	5,327 European ancestry cases, 16,424 European ancestry controls	6p22.1 6p21.32	SLC17A1, SLC17A3, BTN3A2, BTN2A2, BTN3A1, HIST1H2AG, HIST1H2BJ, PRSS16, POM121L2, ZNF184 HLA-DQA1	rs13194053-T rs9272219-G	0.82 0.72	1 x 10^-8 (EA) 7 x 10^-8 (EA)	1.28 [NR] 1.14 [NR]	Affymetrix [up to 843,798]	N
07/10/09	Stefansson July 01, 2009 Nature Common variants conferring risk of schizophrenia	Schizophrenia	2,663 European cases, 13,498 European controls	10,282 European cases, 21,093 European controls	6p22.1 6p21.32 11q24.2 18q21.2 2p16.1 5q21.1 9q33.1	MHC, PRSS16 MHC, NOTCH4 NRGN TCF4 VRK2 SLCO6A1 Intergenic	rs6932590-T rs3131296-G rs12807809-T rs9960767-C rs2312147-C rs1502844-C rs1572299-A	0.78 0.87 0.83 0.06 NR NR NR	1 x 10^-12 2 x 10^-10 2 x 10^-9 4 x 10^-9 3 x 10^-7 1 x 10^-6 4 x 10^-6	1.16 [NR] 1.19 [NR] 1.15 [NR] 1.23 [NR] 1.09 [NR] 1.09 [NR] 1.08 [NR]	Illumina [314,868]	N
07/24/09	Treutlein July 01, 2009 Arch Gen Psychiatry Genome-wide association study of alcohol dependence	Alcohol dependence	476 German cases, 1,358 German controls	1,024 German cases, 996 German controls	2q35 5q32 Xp22.2 14q24.2 4q26 6q25.1	PECR PPP2R2B Intergenic Intergenic CAST, ERAP1 ESR1	rs7590720-G rs1864982-A rs12388359-T rs36563-A rs13150562-G rs6902771-C	0.29 0.13 0.11 0.15 0.68 0.51	1 x 10^-8 3 x 10^-6 4 x 10^-6 5 x 10^-6 7 x 10^-6 8 x 10^-6	1.35 [1.22-1.49] 1.36 [1.20-1.55] 1.61 [1.32-2.00] 1.33 [1.18-1.50] 1.27 [1.14-1.41] 1.24 [1.13-1.36]	Illumina [524,396]	N
07/01/09	Thorleifsson June 28, 2009 Nat Genet Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density	Kidney stones	1,507 Icelandic cases, 34,033 Icelandic controls	1,520 Icelandic cases, 4,726 Icelandic controls, 746 Dutch cases, 3,751 Dutch controls	21q22.13	CLDN14	rs219780-C	0.79	4 x 10^-12	1.25 [1.17-1.33]	Illumina [303,120]	N
07/01/09	Heard-Costa June 26, 2009 PLoS Genet NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium	Waist circumference	31,373 Caucasian individuals	38,641 Caucasian individuals	16q12.2 14q31.1 18q21.32 12q13.13 5p14.3 6p12.2 11p15.4	FTO NRXN3 MC4R FAIM2, BCDIN3D CDH12 PKHD1 OVCH2	rs1558902-? rs10146997-G rs489693-? rs7138803-? rs4701252-? rs1555967-? rs7932813-?	NR NR NR NR NR NR NR	5 x 10^-19 5 x 10^-8 4 x 10^-7 8 x 10^-7 2 x 10^-6 3 x 10^-6 5 x 10^-6	NS .65 [NR] cm increase NS NS NS NS NS	Affymetrix & Illumina [up to 512,349]	N
07/01/09	Lindgren June 26, 2009 PLoS Genet Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution	Adiposity	38,580 European-ancestry individuals	Up to 102,064 European-ancestry individuals	6p12.3 8p23.1 1q41 1q42.3	TFAP2B MSRA LYPLAL1 TBCE	rs987237-G rs7826222-G rs2605100-G rs6429082-C	0.164 0.183 0.692 0.46	2 x 10^-11 (WC) 9 x 10^-9 (WC) 3 x 10^-8 (WHR in women) 3 x 10^-7 (WC)	.04 [0.03-0.05] z-score unit increase .04 [0.03-0.05] z-score unit increase .04 [0.03-0.05] z-score unit increase NS	Affymetrix & Illumina [2,573,738] (imputed)	N
07/01/09	Cotsapas June 24, 2009 Hum Mol Genet Common BMI-associated variants confer risk of extreme obesity	Obesity (extreme)	775 Caucasian cases, 3,197 Caucasian controls	NR	16q12.2 10p11.21 2p16.1 6p21.31 4q26 11p14.2 3p24.2 5q23.3 10q22.1 20p12.1 3p24.3 6p21.31 2q33.3	FTO ZNF248 RTN4 ITPR3 TRAM1L1 MUC15 RARB FBN2 PRF1 C20orf133 RAFTLIN MLN FLJ20309	rs9941349-T rs7474896-T rs6726292-G rs999943-T rs10433903-T rs12295638-C rs1435703-T rs374748-G rs10999409-T rs6110577-C rs12635698-C rs2274459-A rs7603514-A	0.43 0.14 0.73 0.72 0.66 0.10 0.06 0.11 0.45 0.16 0.15 0.17 0.20	6 x 10^-12 9 x 10^-7 1 x 10^-6 1 x 10^-6 3 x 10^-6 4 x 10^-6 4 x 10^-6 4 x 10^-6 5 x 10^-6 5 x 10^-6 5 x 10^-6 6 x 10^-6 8 x 10^-6	1.48 [1.33-1.66] 1.46 [1.25-1.69] 1.39 [1.22-1.59] 1.37 [1.20-1.56] 1.33 [1.19-1.52] 1.49 [1.26-1.77] 1.66 [1.34-2.06] 1.47 [1.25-1.73] 1.3 [1.16-1.45] 1.4 [1.21-1.61] 1.41 [1.21-1.63] 1.38 [1.20-1.58] 1.36 [1.19-1.56]	Illumina [457,251]	N
06/30/09	Bahlo June 14, 2009 Nat Genet Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20	Multiple sclerosis	1,618 European ancestry cases, 3,413 European ancestry controls	2,256 European ancestry cases, 2,310 European ancestry controls	6p21.32 12q14.1 1p13.1 20q13.12 16p12.1 8q24.21 1p22.1 10p15.1	HLA-DRB1 METTL1, CYP27B1 CD58 CD40 NR ASAP1, DDEF1 EVI5, RPL5 IL2RA	rs9271366-G rs703842-A rs1335532-A rs6074022-G rs8049603-T rs6984045-C rs6604026-G rs2104286-G	0.15 0.67 0.87 0.25 0.20 0.02 0.28 0.73	7 x 10^-184 5 x 10^-11 1 x 10^-7 1 x 10^-7 1 x 10^-6 2 x 10^-6 3 x 10^-6 7 x 10^-6	2.78 [NR] 1.23 [NR] 1.28 [NR] 1.2 [NR] 1.19 [NR] 1.59 [NR] 1.17 [NR] 1.16 [NR]	Illumina [302,098]	N
06/29/09	De Jager June 14, 2009 Nat Genet Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci	Multiple sclerosis	2,624 cases, 7,220 controls	2,215 cases, 2,116 controls	6p21.32 6p22.1 12p13.31 1p13.1 11q12.2 16q24.1 10p15.1 2q22.1 16p13.13 5p13.1 12q24.31 10q22.3 5p13.2 12p13.31 3q25.33	HLA-DRB1 HLA-B TNFRSF1A CD58 CD6 IRF8 IL2RA CXCR4 CLEC16A PTGER4 MPHOSPH9 ZMIZ1 IL7R TNFRSF1A IL12A	rs3135388-A rs2523393-A rs1800693-C rs2300747-A rs17824933-G rs17445836-G rs2104286-T rs882300-C rs11865121-C rs6896969-C rs1790100-G rs1250540-G rs6897932-C rs4149584-T rs4680534-C	0.22 0.59 0.45 0.88 0.25 0.81 0.76 0.61 0.69 0.62 0.24 0.35 0.75 0.022 0.37	4 x 10^-225 1 x 10^-17 2 x 10^-11 3 x 10^-10 4 x 10^-9 4 x 10^-9 9 x 10^-8 1 x 10^-7 2 x 10^-7 2 x 10^-7 7 x 10^-7 2 x 10^-6 2 x 10^-6 5 x 10^-6 6 x 10^-6	2.75 [2.46-3.07] 1.28 [1.18-1.39] 1.2 [1.10-1.31] 1.3 [1.14-1.47] 1.18 [1.07-1.30] 1.25 [1.12-1.39] 1.15 [1.04-1.27] 1.19 [1.09-1.30] 1.15 [1.04-1.25] 1.1 [1.01-1.20] 1.11 [1.00-1.22] 1.12 [1.02-1.22] 1.12 [1.02-1.23] 1.58 [1.15-2.17] 1.12 [1.02-1.22]	Affymetrix & Illumina [~2.56 million] (imputed)	N
06/26/09	Malarstig June 12, 2009 Blood Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study	Plasma homocysteine	387 individuals from 21 Spanish families	1,238 European individuals	NS	NS	NS	NS	NS	NS	Illumina [283,437]	N
06/19/09	Knauff June 09, 2009 Hum Reprod Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene	Premature ovarian failure	99 Caucasian cases, 235 Caucasian controls	60 Caucasian cases, 90 Caucasian controls	NS	NS	NS	NS	NS	NS	Illumina [309,158]	N
06/19/09	Zhai June 08, 2009 J Med Genet A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium	Osteoarthritis	1,804 Caucasian individuals	3,266 Caucasian individuals	NS	NS	NS	NS	NS	NS	Illumina [up to 535,188]	N
06/17/09	Gregersen June 07, 2009 Nat Genet REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis	Rheumatoid arthritis	2,418 cases, 4,504 controls	2,604 cases, 2,882 controls	1p13.2 2p16.1 2q33.2 8p23.1 9q33.2	PTPN22 REL CTLA4 BLK TRAF1, C5	rs2476601-? rs13017599-A rs231735-T rs2736340-A rs881375-?	NR 0.34 0.51 0.24 NR	2 x 10^-21 2 x 10^-12 6 x 10^-9 6 x 10^-9 4 x 10^-8	NS 1.21 [1.15-1.28] 1.17 [1.11-1.23] 1.19 [1.13-1.27] NS	Illumina [278,502]	N
06/17/09	Elmore June 06, 2009 J Vasc Surg Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association	Abdominal aortic aneurysm	123 cases, 112 controls	827 cases, 594 controls	NS	NS	NS	NS	NS	NS	Affymetrix [306,330] (pooled)	N
06/22/09	Kolz June 05, 2009 PLoS Genet Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations	Serum uric acid	12,328 European males, 15,813 European females	NR	4p16.1 4p16.1 4q22.1 6p22.2 11q13.1 4q22.1 2p23.3 11q13.1 1q21.1 6p22.2 10q21.1	SLC2A9 SLC2A9 ABCG2 SLC17A1 SLC22A11 ABCG2 GCKR SLC22A12 PDZK1 LRRC16A, SCGN SLC16A9	rs734553-T rs734553-T rs2231142-T rs1183201-A rs17300741-A rs2231142-T rs780094-T rs505802-T rs12129861-A rs742132-A rs12356193-A	0.77 0.77 0.11 0.48 0.51 0.11 0.42 0.70 0.46 0.70 0.83	1 x 10^-192 (women) 1 x 10^-41 (men) 2 x 10^-18 (men) 3 x 10^-14 7 x 10^-14 1 x 10^-10 (women) 1 x 10^-9 2 x 10^-9 3 x 10^-9 9 x 10^-9 1 x 10^-8	.4 [0.371-0.423] mg/dl increase .22 [0.188-0.252] mg/dl increase .22 [0.171-0.270] mg/dl increase .06 [0.459-0.078] mg/dl decrease .06 [0.046-0.078] mg/dl increase .14 [0.096-0.181] mg/dl increase .05 [0.035-0.068] mg/dl increase .06 [0.038-0.074] mg/dl decrease .06 [0.042-0.083] mg/dl decrease .05 [0.036-0.072] mg/dl increase .08 [0.051-0.105] mg/dl increase	Affymetrix and Illumina [2,493,963] (imputed)	N
06/16/09	Smith June 02, 2009 Mol Psychiatry Genome-wide association study of bipolar disorder in European American and African American individuals	Bipolar disorder	1,001 Caucasian cases, 345 African American cases, 1,033 Caucasian controls, 670 African American controls	1,749 Caucasian family members, 1,263 Caucasian cases, 431 Caucasian controls	19q13.11	DPY19L3	rs2111504-T	0.23	2 x 10^-6 (AA)	1.74 [NR]	Affymetrix [702,044]	N
06/15/09	Daly May 31, 2009 Nat Genet HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin	Drug-induced liver injury (flucloxacillin)	58 cases, 282 controls	NR	6p21.33 3q27.3 3q11.2 12q12 9p21.2 15q26.2	HCP5, HLA-B ST6GAL1 OR5H2 ALG10B C9org82 MCTP2	rs2395029-? rs10937275-? rs1497546-? rs6582630-? rs10812428-? rs4984390-?	0.05 0.09 0.02 0.38 0.31 0.41	9 x 10^-33 1 x 10^-8 (B*5701 positive) 2 x 10^-7 1 x 10^-6 1 x 10^-6 4 x 10^-6	45 [19.4-105] 4.1 [NR] 6.57 [NR] 2.82 [NR] 2.85 [NR] 3.27 [NR]	Illumina [866,399]	N
06/14/09	Kanetsky May 31, 2009 Nat Genet Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer	Testicular cancer	277 white, non-Hispanic cases, 919 non-Hispanic controls	371 non-Hispanic cases + 204 sets of parents, 860 non-Hispanic controls	12q21.32	KITLG	rs4474514-A	NR	6 x 10^-15	3.07 [2.29-4.13]	Affymetrix [611,254]	N
06/14/09	Rapley May 31, 2009 Nat Genet A genome-wide association study of testicular germ cell tumor	Testicular germ cell tumor	730 cases, 1,435 controls	571 cases, 1,806 controls	12q21.32 12q21.32 6p21.31 5q31.3 4q24 1q24.1	KITLG KITLG BAK1 SPRY4 Intergenic Intergenic	rs995030-G rs1508595-G rs210138-G rs4624820-A rs4699052-C rs4657482-A	0.80 0.83 0.20 0.54 0.61 0.33	1 x 10^-31 3 x 10^-30 1 x 10^-13 3 x 10^-13 2 x 10^-7 2 x 10^-6	2.55 [2.05-3.19] 2.69 [2.10-3.44] 1.5 [1.28-1.75] 1.37 [1.19-1.58] 1.21 [1.05-1.39] 1.14 [0.99-1.31]	Illumina [307,666]	N
06/14/09	Ng May 29, 2009 J Hum Genet A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.	Nasopharyngeal carcinoma	111 Chinese cases, 260 Chinese controls	168 Chinese cases, 252 Chinese controls	3p22.2	ITGA9	rs189897-A	0.09	7 x 10^-8	3.18 [1.94-5.21]	Illumina [533,048]	N
06/16/09	Aston May 28, 2009 J Androl Genome-wide Study of Single Nucleotide Polymorphisms Associated with Azoospermia and Severe Oligozoospermia	Male infertility	52 oligozoospermic Caucasian males, 40 non-obstructive azoospermic Caucasian males, 80 Caucasian male controls	NR	12p12.2 20q13.2 3q11.2 2q22.1 12p13.32	PDE3A SALL4 ARL6 NXPH2 EFCAB4B	rs10841496-? rs6068020-? rs9814870-? rs1399645-? rs10848911-?	0.58 0.49 0.15 0.02 0.11	5 x 10^-7 (azoospermia) 5 x 10^-7 (azoospermia) 7 x 10^-7 (oligozoospermia) 9 x 10^-7 (azoospermia) 4 x 10^-6 (azoospermia)	NS NS NS NS NS	Illumina [314,776]	N
06/10/09	Ma May 28, 2009 Ann Hum Genet A genome-wide association study of autism reveals a common novel risk locus at 5p14.1	Autism	1,390 family members	2,390 family members	5p14.1	Intergenic	rs10038113-T	0.59	3 x 10^-6	1.33 [1.11-1.43]	Illumina [775,311]	N
06/14/09	Jallow May 24, 2009 Nat Genet Genome-wide and fine-resolution association anaylsis of malaria in West Africa	Malaria	958 Gambian cases, 1,382 Gambian controls, all children	1,087 Gambian cases, 2,376 Gambian controls, all children	11p15.4 17p13.1 7p12.2	HBB SCO1 DDC	rs11036238-? rs6503319-T rs1451375-?	0.14 0.45 0.78	4 x 10^-11 7 x 10^-7 6 x 10^-6	1.59 [1.39-1.82] 1.21 [1.12-1.31] 1.33 [1.18-1.52]	Affymetrix [402,814]	N
06/04/09	Norris May 21, 2009 Obesity Genome-wide Association Study and Follow-up Analysis of Adiposity Traits in Hispanic Americans: The IRAS Family Study	Obesity-related traits	229 Hispanic family members	961 Hispanic family members	NS	NS	NS	NS	NS	NS	Illumina [309,200]	N
06/21/09	Hirschfield May 20, 2009 N Engl J Med Primary Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants	Primary biliary cirrhosis	505 cases, 1,507 controls	up to 526 cases, 1,206 controls	3q26.1 1p31.3 6p21.32 6p21.3 7q32.1 3q26.1 17q12	IL12A IL12RB2 c6orf10, BTNL2, HLA-DQB1 c6orf10, BTNL2, HLA-DQB1 IRFS-TNPO3 ARF7 IKZF3	rs6441286-G rs3790567-A 4-SNP haplotype-1 4-SNP haplotype-2 rs10488631-G rs4679904-G rs907092-A	0.39 0.24 0.01 0.20 NR 0.72 0.45	2 x 10^-14 3 x 10^-11 1 x 10^-10 (AACA) 7 x 10^-10 (CACA) 2 x 10^-7 1 x 10^-6 8 x 10^-6	1.54 [1.38-1.72] 1.51 [1.33-1.70] NS NS 1.52 [1.30-1.78] 1.38 [1.21-1.57] 1.29 [1.15-1.44]	Illumina [305,724]	N
06/14/09	Arnett May 19, 2009 BMC Med Genet Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study	Left ventricular mass	101 Caucasian cases, 101 Caucasian controls	704 Caucasian siblings, 1,467 African American siblings	5p13.2 7q21.11	RAI14 CD36	rs409045-? rs10499859-?	0.38 0.45	8 x 10^-7 (Caucasian) 3 x 10^-6 (Caucasian)	0 [NR] (LVMI) .09 [NR] (LVMI)	Affymetrix [96,258]	N
06/04/09	Landers May 18, 2009 Proc Natl Acad Sci USA Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	1,821 cases, 2,258 controls	538 cases, 556 controls	1q24.2 7q36.1 18q12.1 2p16.1 5q23.2 1q24.2 6p22.3 2q24.3 3p26.3 17q24.3 1p34.2 1q42.2 2p22.1 5q23.1 21q21.1 2q24.2	KIFAP3 ZNF746 B4GALT6 EFEMP1 CSNK1G3 SELL ATXN1 SCN7A CNTN4 SLC39A11 NT5C1A DISC1 NR SEMA6A NR RBMS1	rs1541160-C rs855913-A rs10438933-G rs7577894-T rs11241713-T rs3177980-G rs697739-A rs13015447-T rs2619566-G rs8066857-C rs873917-T rs16856202-A rs3099950-? rs7702057-C rs2823962-? rs10192369-T	NR NR 0.12 0.39 NR NR NR 0.34 NR NR 0.29 0.04 NR 0.03 NR 0.47	2 x 10^-8 (survival) 4 x 10^-8 (survival) 1 x 10^-6 (susceptibilty) 1 x 10^-6 (site of onset) 3 x 10^-6 (survival) 4 x 10^-6 (survival) 4 x 10^-6 (age of onset) 7 x 10^-6 (site of onset) 7 x 10^-6 (age of onset) 8 x 10^-6 (site of onset) 8 x 10^-6 (susceptibilty) 8 x 10^-6 (susceptibilty) 8 x 10^-6 (survival) 8 x 10^-6 (site of onset) 9 x 10^-6 (survival) 9 x 10^-6 (susceptibilty)	.58 [0.38-0.78] years older 1.08 [0.70-1.46] years older 1.3 [NR] 1.41 [NR] .79 [0.46-1.12] years older .51 [0.46-0.56] years older 2.04 [1.18-2.90] years younger 1.41 [NR] 3.03 [1.71-4.35] years younger 1.48 [NR] 1.16 [NR] 2 [NR] NS 2.05 [NR] NS 1.17 [NR]	Illumina [288,357]	N
06/04/09	He May 17, 2009 Nat Genet Genome-wide association studies identify loci associated with age at menarche and age at natural menopause	Menarche and menopause (age at onset)	17,438 Caucasian women	NR	20p12.3 19q13.42 5q35.2 6q21 9q31.2 6p24.2	TRMT6, MCM8 BRSK1 UIMC1 LIN28B Intergenic GCM2, SYCP2L	rs16991615-A rs1172822-T rs365132-T rs314277-A rs7861820-C rs2153157-T	0.06 0.37 0.49 0.14 0.48 0.49	1 x 10^-21 (age at natural menopause) 2 x 10^-19 (age at natural menopause) 8 x 10^-14 (age at natural menopause) 3 x 10^-13 (age at menarche) 3 x 10^-9 (age at menarche) 5 x 10^-8 (age at natural menopause)	1.07 [0.85-1.29] years older .49 [0.38-0.60] years younger .39 [0.29-0.49] years older .16 [0.12-0.20] years older .09 [0.06-0.12] years younger .29 [0.19-0.39] years older	Illumina [317,759]	N
06/01/09	Ong May 17, 2009 Nat Genet Genetic variation in LIN28B is associated with the timing of puberty	Menarche (age at onset)	4,714 women	16,373 women	6q21	LIN28B	rs314276-C	0.33	4 x 10^-16	.14 [0.11-0.17] years younger	Affymetrix [up to 390,631]	N
05/28/09	Perry May 17, 2009 Nat Genet Meta-analysis of genome-wide association data identifies two loci influencing age at menarche	Menarche (age at onset)	17,510 women	NR	9q31.2 6q21	TMEM38B, SLC44A1, FKTN, FSD1L, TAL2, ZNF462 LIN28B	rs2090409-A rs7759938-C	0.31 0.33	2 x 10^-9 7 x 10^-9	.1 [0.06-0.14] years younger .09 [0.05-0.13] years older	Affymetrix & Illumina [~2.5 million] (imputed)	N
06/01/09	Perlis May 15, 2009 Am J Psychiatry A Genomewide Association Study of Response to Lithium for Prevention of Recurrence in Bipolar Disorder	Response to lithium treatment in bipolar disorder	458 lithium-treated subjects, 719 non-lithium treated subjects	359 subjects	NS	NS	NS	NS	NS	NS	Affymetrix [~1.4 million] (imputed)	N
05/28/09	Stolk May 15, 2009 Nat Genet Loci at chromosomes 13, 19 and 20 influence age at natural menopause.	Menopause (age at onset)	2,979 women	2,560 women	19q13.42 20p12.3 13q34 9q21.31 16q24.2 11q25 8p12 7q22.3 6p21.32 3q26.2 20p12.3 2q23.3 14q32.31	BRSK1, TMEM224, SUV420H2 MCM8 LOC121793, ARHGEF7 NR NR NR NR NR NR NR NR NR NR	rs1172822-T rs236114-A rs7333181-A rs2151145-? rs4843747-? rs4397868-? rs6468442-? rs17153527-? rs494620-? rs4955755-? rs2326679-? rs11889862-? rs4906172-?	0.39 0.21 0.12 NR NR NR NR NR NR NR NR NR NR	6 x 10^-11 1 x 10^-10 3 x 10^-8 1 x 10^-7 2 x 10^-7 3 x 10^-7 3 x 10^-7 4 x 10^-7 5 x 10^-7 7 x 10^-7 2 x 10^-6 2 x 10^-6 3 x 10^-6	.39 [0.27-0.51] years younger .5 [0.34-0.65] years older .52 [0.34-0.70] years older .41 [0.26-0.56] years older .39 [0.24-0.54] years older .4 [0.25-0.55] years younger .39 [0.24-0.54] years younger .51 [0.31-0.71] years older .3 [0.18-0.42] years older .34 [0.21-0.47] years older .32 [0.19-0.45] years older .36 [0.21-0.51] years younger .36 [0.21-0.51] years younger	Illumina [315,418]	N
06/01/09	Sulem May 15, 2009 Nat Genet Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche	Menarche (age at onset)	15,297 Icelandic women	10,040 Icelandic women	6q21	LIN28B, HACE1, E3 ubiquitin protein ligase 1, BVES, POPDC3	rs314280-T	0.48	2 x 10^-14	1.2 [0.9-1.5] months older	Illumina [304,226]	N
05/26/09	Fei May 14, 2009 Arthritis Res Ther Identification of novel genetic susceptibility loci for Behcet's disease using a genome-wide association study	Behcet's disease	152 cases, 170 controls	NR	NS	NS	NS	NS	NS	NS	Affymetrix [~500,000] (pooled)	N
06/01/09	Barrett May 10, 2009 Nat Genet Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes	Type 1 diabetes	7,514 cases, 9,045 controls	4,267 cases, 4,670 controls, 4,342 trios	6p21.32 1p13.2 11p15.5 10q23.31 12q24.12 12q13.2 16p13.13 22q12.2 2q33.2 16q23.1 18p11.21 10p15.1 16p11.2 6q22.32 4q27 17q12 14q24.1 9p24.2 20p13 12p13.31 19q13.32 4p15.2 17q21.2 1q32.1 21q22.3 14q32.2 7p15.2 2q24.2 Xq28 7p12.1 6q15 15q25.1 10p15.1 16p12.3 22q13.1 1p31.3 17p13.1 2p25.1	MHC PTPN22 INS C10orf59 SH2B3 ERBB3 CLEC16A Intergenic CTLA4 Intergenic PTPN2 IL2RA IL27 C6orf173 IL2 ORMDL3 Intergenic GLIS3 Intergenic CD69 Intergenic Intergenic Intergenic IL10 UBASH3A Intergenic Intergenic IFIH1 Intergenic COBL BACH2 CTSH PRKCQ Intergenic C1QTNF6 PGM1 Intergenic Intergenic	rs9268645-? rs2476601-? rs7111341-? rs10509540-? rs3184504-? rs2292239-? rs12708716-? rs5753037-T rs3087243-? rs7202877-G rs1893217-? rs12251307-? rs4788084-G rs9388489-G rs4505848-? rs2290400-? rs1465788-? rs7020673-? rs2281808-? rs4763879-A rs425105-? rs10517086-A rs7221109-? rs3024505-? rs11203203-? rs4900384-G rs7804356-? rs1990760-? rs2664170-G rs4948088-? rs11755527-? rs3825932-? rs11258747-? rs12444268-A rs229541-? rs2269241-G rs16956936-? rs1534422-G	NR NR NR 0.71 NR NR NR 0.39 NR 0.10 NR NR 0.42 0.45 NR 0.50 0.71 0.50 0.64 0.37 0.84 0.30 0.65 0.83 NR 0.29 0.76 NR 0.32 0.95 NR NR NR 0.30 NR 0.19 0.86 0.46	1 x 10^-100 9 x 10^-85 4 x 10^-48 1 x 10^-28 3 x 10^-27 2 x 10^-25 2 x 10^-16 3 x 10^-16 1 x 10^-15 3 x 10^-15 4 x 10^-15 1 x 10^-13 3 x 10^-13 4 x 10^-13 5 x 10^-13 6 x 10^-13 2 x 10^-12 5 x 10^-12 1 x 10^-11 2 x 10^-11 3 x 10^-11 5 x 10^-10 1 x 10^-9 2 x 10^-9 2 x 10^-9 4 x 10^-9 5 x 10^-9 7 x 10^-9 8 x 10^-9 4 x 10^-8 5 x 10^-8 8 x 10^-8 1 x 10^-7 2 x 10^-7 2 x 10^-7 4 x 10^-7 5 x 10^-7 2 x 10^-6	NS NS NS 1.33 [1.25-1.43] NS NS NS 1.1 [1.04-1.17] NS 1.28 [1.17-1.41] NS NS 1.09 [1.02-1.16] 1.17 [1.10-1.24] NS 1.15 [1.08-1.22] 1.16 [1.10-1.25] 1.14 [1.08-1.20] 1.11 [1.05-1.19] 1.09 [1.02-1.16] 1.16 [1.08-1.27] 1.09 [1.02-1.17] 1.05 [0.99-1.12] 1.19 [1.10-1.30] NS 1.09 [1.02-1.16] 1.14 [1.06-1.22] NS 1.16 [1.07-1.24] 1.3 [1.11-1.49] NS NS NS 1.1 [1.03-1.17] NS 1.1 [1.02-1.18] 1.09 [1.00-1.19] 1.08 [1.02-1.15]	Affymetrix & Illumina [841,622] (imputed)	N
05/27/09	Kottgen May 10, 2009 Nat Genet Multiple loci associated with indices of renal function and chronic kidney disease	Renal function and chronic kidney disease	19,877 individuals, up to 2,388 cases	21,466 individuals, up to 1,932 cases	16p12.3 15q21.1 4q21.1 16p12.3	UMOD SPATA5L1, GATM SHROOM3 UMOD	rs12917707-T rs2467853-G rs17319721-A rs12917707-G	0.18 0.38 0.44 0.18	5 x 10^-16 (eGFRcrea) 6 x 10^-14 (eGFRcrea) 1 x 10^-12 (eGFRcrea) 2 x 10^-12 (CKD)	.02 [0.014-0.022] ml/min/1.73m2 increase .01 [0.009-0.017] ml/min/1.73m2 decrease .01 [0.008-0.016] ml/min/1.73m2 decrease 1.25 [1.18-1.33]	Affymetrix & Illumina [~2.5 million] (imputed)	N
05/19/09	Levy May 10, 2009 Nat Genet Genome-wide association study of blood pressure and hypertension	Diastolic blood pressure	29,136 individuals	34,433 individuals	12q24.12 15q24.1 12q21.33 3p22.1 10p12.33 12q24.21 11p15.1	SH2B3 CSK, ULK3 ATP2B1 ULK4 CACNB2 TBX3, TBX5 PLEKHA7	rs3184504-T rs6495122-A rs2681472-A rs9815354-A rs11014166-A rs2384550-A rs11024074-T	0.48 0.42 0.83 0.17 0.66 0.35 0.72	3 x 10^-14 2 x 10^-10 1 x 10^-9 3 x 10^-9 1 x 10^-8 4 x 10^-8 1 x 10^-6	.48 [0.36-0.60] mm Hg increase .4 [0.28-0.52] mm Hg increase .5 [0.34-0.66] mm Hg increase .49 [0.33-0.65] mm Hg increase .37 [0.25-0.49] mm Hg increase .35 [0.23-0.47] mm Hg decrease .33 [0.19-0.47] mm Hg decrease	Affymetrix & Illumina [2,533,153](imputed)	N
05/19/09	"	Hypertension	29,136 individuals	34,433 individuals	12q21.33 10p12.33 20q13.32 8p23.1	ATP2B1 CACNB2 ZNF831, EDN3 MSRA	rs2681472-A rs11014166-A rs16982520-A rs11775334-A	0.83 0.66 0.88 0.32	2 x 10^-11 6 x 10^-8 2 x 10^-7 4 x 10^-6	.15 [0.11-0.19] increase in log odds .09 [0.05-0.13] increase in log odds .13 [0.09-0.17] decrease in log odds .08 [0.04-0.12] increase in log odds	Affymetrix & Illumina [2,533,153](imputed)	N
05/19/09	"	Systolic blood pressure	29,136 individuals	34,433 individuals	12q21.33 10q24.32 11p15.1 12q24.12 3q26.2 10p12.33 1p36.22	ATP2B1 CYP17A1 PLEKHA7 SH2B3 MDS1 CACNB2 CASZ1	rs2681492-T rs1004467-A rs381815-T rs3184504-T rs448378-A rs11014166-A rs12046278-T	0.80 0.90 0.26 0.48 0.52 0.66 0.64	4 x 10^-11 1 x 10^-10 2 x 10^-9 5 x 10^-9 1 x 10^-7 7 x 10^-7 5 x 10^-6	.85 [0.60-1.10] mm Hg increase 1.05 [0.74-1.36] mm Hg increase .65 [0.43-0.87] mm Hg increase .58 [0.38-0.78] mm Hg increase .51 [0.31-0.71] mm Hg decrease .5 [0.30-0.70] mm Hg increase .53 [0.29-0.77] mm Hg decrease	Affymetrix & Illumina [2,533,153](imputed)	N
05/19/09	Newton-Cheh May 10, 2009 Nat Genet Genome-wide association study identifies eight loci associated with blood pressure	Diastolic blood pressure	34,433 individuals	Up to 100,347 white individuals, up to 12,889 Indian Asian individuals	15q24.1 4q21.21 12q24.12 10q21.2 17q21.32 3q26.2	CYP1A1, CYP1A2, CSK, LMAN1L, CPLX3, ARID3B FGF5, PRDM8, c4orf22 ATXN2, SH2B3 c10orf107, TMEM26, RTKN2, RHOBTB1, ARID5B ZNF652, PHB MDS1	rs1378942-C rs16998073-T rs653178-T rs1530440-T rs16948048-G rs1918974-T	0.36 0.21 0.53 0.19 0.39 0.54	1 x 10^-23 1 x 10^-21 3 x 10^-18 1 x 10^-9 5 x 10^-9 8 x 10^-8	.43 [0.35-0.51] mm Hg increase .5 [0.40-0.60] mm Hg increase .46 [0.36-0.56] mm Hg decrease .39 [0.27-0.51] mm Hg decrease .31 [0.21-0.41] mm Hg increase .27 [0.17-0.37] mm Hg decrease	Affymetrix & Illumina [2,497,993] (imputed)	N
05/19/09	"	Systolic blood pressure	34,433 individuals	Up to 100,347 white individuals, up to 12,889 Indian Asian individuals	10q24.32 1p36.22 17q21.31	CYP17A1, AS3MT, CNNM2, NT5C2 MTHFR, NPPA, CLCN6, NPPB, AGTRAP PLCD3, ACBD4, HEXIM1, HEXIM2	rs11191548-T rs17367504-G rs12946454-T	0.91 0.14 0.28	7 x 10^-24 2 x 10^-13 1 x 10^-8	1.16 [0.92-1.40] mm Hg increase .85 [0.63-1.07] mm Hg decrease .57 [0.37-0.77] mm Hg increase	Affymetrix & Illumina [2,497,993] (imputed)	N
05/21/09	Rich May 09, 2009 Diabetologia A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).	Insulin response	229 family members	961 family members	NS	NS	NS	NS	NS	NS	Illumina [309,200]	N
05/20/09	Himes May 07, 2009 Am J Hum Genet Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene	Asthma	422 cases, 1,533 controls	3,750 white cases, 13,365 white controls, 592 white trios, 1,903 black cases, 2,432 black controls, 929 black family members	5q12.1	PDE4D	rs1588265-C	0.29	3 x 10^-8	1.18 [1.08-1.30]	Illumina [518,230]	N
05/21/09	Yang May 07, 2009 PLoS ONE Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan	Hypertension (young onset)	175 Han Chinese cases, 175 Han Chinese controls	833 Han Chinese cases, 833 Han Chinese controls	2p22.3	LOC344371, MYADML, FAM98A, RASGRP3	4-SNP-haplotype	NR	3 x 10^-10	NS	Affymetrix [91,713]	N
05/19/09	Sanna May 06, 2009 Hum Mol Genet Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia	Bilirubin levels	4,300 individuals	2,692 individuals	2q37.1 12p12.2 Xq28	UGT1A1 SLC01B3 G6PD	rs887829-T rs2117032-C rs766420-G	0.30 0.47 0.18	1 x 10^-69 3 x 10^-14 9 x 10^-9	.57 [0.50-0.63] SD decrease .13 [0.08-0.18] SD increase .18 [0.12-0.24] SD decrease	Affymetrix [362,129]	N
05/14/09	Scott May 05, 2009 Proc Natl Acad Sci USA Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry	Bipolar disorder	3,683 cases, 14,507 controls	NR	5q15 1p32.1 3p21.1 11q13.1 19p13.3 2p12 2q11.2 4q12 3q26.1 8p12 9q34.13 15q23 17q21.33	MCTP1 NF1A ITIH1, NEK4 NR NR CTNNA2 Intergenic KIT NR NR NR NR NR	rs17418283-C rs472913-C rs1042779-A rs2242663-T rs7250872-T rs13409348-G rs6733011-G rs2537859-T rs7427021-G rs6990255-T rs2905072-A rs6494849-A rs1035050-T	0.28 0.50 0.63 0.25 0.69 0.24 0.46 0.60 0.56 0.95 0.77 0.12 0.40	1 x 10^-7 2 x 10^-7 2 x 10^-7 1 x 10^-6 2 x 10^-6 3 x 10^-6 3 x 10^-6 4 x 10^-6 5 x 10^-6 6 x 10^-6 6 x 10^-6 7 x 10^-6 9 x 10^-6	1.21 [1.13-1.30] 1.18 [1.11-1.25] 1.19 [1.11-1.27] 1.2 [1.11-1.29] 1.21 [1.12-1.31] 1.2 [1.11-1.29] 1.17 [1.10-1.25] 1.16 [1.09-1.24] 1.16 [1.09-1.24] 1.33 [1.18-1.51] 1.21 [1.11-1.32] 1.23 [1.13-1.35] 1.17 [1.09-1.25]	Affymetrix and Illumina [2,366,197] (imputed)	N
05/12/09	Johnson May 04, 2009 Hum Mol Genet Genome-wide association meta-analysis for total serum bilirubin levels	Serum bilirubin levels	9,264 individuals	NR	2q37.1 12p12.1 11p15.4 2p11.2 6p22.1 4q28.1 7q21.11 13q34	UGT1A1 SLCO1B1,LST-3TM12,SLCO1A2 SLC22A18 KRCC1 HIST1H2BC Intergenic SEMA3C ARHGEF7	rs6742078-T rs4149056-C rs16928809-A rs12714207-T rs12206204-T rs1986655-A rs4236644-A rs4773330-A	0.32 0.15 0.09 0.03 0.02 0.17 0.26 0.12	5 x 10^-324 7 x 10^-13 1 x 10^-7 5 x 10^-7 8 x 10^-7 2 x 10^-6 2 x 10^-6 8 x 10^-6	.23 [0.21-0.25] umol/l increase in log(tbil) .05 [0.03-0.07] umol/l increase in log(tbil) .06 [0.04-0.08] umol/l increase in log(tbil) .03 [0.01-0.05] umol/l decrease in log(tbil) .18 [0.10-0.26] umol/l increase in log(tbil) .02 [0.00-0.04] umol/l decrease in log(tbil) .02 [0.00-0.04] umol/l decrease in log(tbil) .04 [0.02-0.06] umol/l decrease in log(tbil)	Affymetrix & Illumina [2,555,103] (imputed)	N
05/07/09	Capasso May 03, 2009 Nat Genet Common variants in BARD1 influence susceptibility to high-risk neuroblastoma	Neuroblastoma (high-risk)	397 cases, 2,043 controls	189 cases, 1,178 controls	2q35	BARD1	rs6435862-G	0.29	9 x 10^-18	1.68 [1.49-1.90]	Illumina [462,866]	N
05/07/09	Hallmayer May 03, 2009 Nat Genet Narcolepsy is strongly associated with the T-cell receptor alpha locus	Narcolepsy	807 Caucasian cases, 1,074 Caucasian controls	363 Caucasian cases, 355 Caucasian controls, 561 Asian cases, 605 Asian controls, 133 African American cases, 144 African American controls	14q11.2	TRA-alpha, TRAJ10	rs1154155-C	0.14	3 x 10^-22	1.69 [1.52-1.88]	Affymetrix [549,596]	N
05/07/09	Takeuchi April 29, 2009 Diabetes Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population	Type 2 diabetes	519 Japanese cases, 503 Japanese controls	5,629 Japanese cases, 7,370 Japanese controls	9p21.3 11p15.5 6p22.3 8q24.11 10q22.33 10q25.2 3q27.2	CDKN2A, CDKN2B KCNQ1 CDKAL1 SLC30A8 HHEX TCF7L2 IGF2BP2	rs2383208-A rs2237892-C rs4712523-G rs13266634-C rs1111875-C rs7903146-T rs4402960-T	0.55 0.59 0.41 0.57 0.28 0.04 0.31	2 x 10^-29 1 x 10^-26 7 x 10^-20 2 x 10^-14 7 x 10^-12 8 x 10^-12 1 x 10^-6	1.34 [1.27-1.41] 1.33 [1.27-1.41] 1.27 [1.21-1.33] 1.22 [1.16-1.28] 1.21 [1.15-1.28] 1.54 [1.36-1.74] 1.14 [1.08-1.21]	Illumina [482,625]	N
05/11/09	Wang April 28, 2009 Nature Common genetic variants on 5p14.1 associate with autism spectrum disorders	Autism	3,101 family members, 1,204 cases, 6,491 controls	1,390 family members, 108 cases, 540 controls	5p14.1	CDH10,CDH9	rs4307059-T	0.61	2 x 10^-10	1.19 [NR]	Illumina [474,019]	N
05/05/09	Cho April 26, 2009 Nat Genet A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits	Biomedical quantitative traits	8,842 Korean individuals	7,861 Korean individuals	12q24.13 7q31.31 6q22.31 1q32.2 12q21.33 16q12.2 7q31.31 12q21.33	C12orf51 FAM3C LOC644502 CD46, LOC148696 ATP2B1 FTO FAM3C ATP2B1	rs2074356-T rs7776725-C rs12110693-A rs12731740-T rs17249754-A rs9939609-A rs7776725-C rs17249754-A	0.15 0.13 0.49 0.10 0.37 0.13 0.13 0.37	8 x 10^-12 (waist-hip ratio) 1 x 10^-11 (BD-RT) 2 x 10^-9 (pulse rate) 3 x10^-9 (pulse rate) 1 x 10^-7 (SBP) 2 x 10^-7 (BMI) 2 x 10^-6 (BD-TT) 3 x10^-6 (DBP)	.01 [0.004-0.008] decrease NS .66 [0.45-0.87] beats per minute increase 1.09 [0.72-1.44] beats per minute increase 1.06 [0.67-1.45] mm Hg decrease .24 [0.14-0.32] kg/m2 increase NS .63 [0.37-0.89] mm Hg decrease	Affymetrix [2,156,535] (imputed)	N
05/05/09	"	Height	8,842 Korean individuals	7,861 Korean individuals	3q23 8q12.1 2p16.1 6p21.31 1p12	ZBTB38 PLAG1 EFEMP1 HMGA1 Intergenic	rs10513137-A rs13273123-G rs3791675-G rs6918981-G rs17038182-C	0.26 0.07 0.22 0.21 0.42	6 x10^-12 1 x10^-9 2 x10^-9 3 x10^-8 5 x10^-7	.46 [0.33-0.59] cm increase .71 [0.48-0.94] cm decrease .42 [0.28-0.56] cm increase .4 [0.26-0.54] cm increase .3 [0.18-0.42] cm decrease	Affymetrix [2,156,535] (imputed)	N
04/23/09	Ikram April 15, 2009 N Engl J Med Genomewide Association Studies of Stroke	Stroke	19,602 Caucasian individuals	3,004 African American individuals, 652 Caucasian cases, 3,613 Caucasian controls	12p13.33	NINJ2	rs12425791-A	0.19	1 x 10^-9 (ischemic stroke)	1.29 [1.19-1.41]	Affymetrix & Illumina [2,194,468]	N
04/22/09	Poduslo April 14, 2009 Am J Med Genet B Neuropsychiatr Genet A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis	Aging	89 cases, 227 controls	NR	2q22.1	LRP1B	rs12474609-?	NR	6 x 10^-9	NS	Affymetrix [469,218]	N
05/05/09	Hiura April 10, 2009 Circ J Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population	LDL cholesterol	900 Japanese individuals	1,810 Japanese individuals	16q13	CETP	rs3764261-A	0.20	3 x 10^-12	6.2 mg/dl increase	Illumina [368,274]	N
04/22/09	Mangino April 08, 2009 J Med Genet A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length	Telomere length	1,625 women	1,165 individuals	18q12.2	BRUNOL4, VPS34	rs2162440-G	NR	3 x 10^-6	106 [62.88-149.12] base pairs shorter	Illumina [~314,075]	N
04/14/09	Esparza-Gordillo April 06, 2009 Nat Genet A common variant on chromosome 11q13 is associated with atopic dermatitis	Atopic dermatitis	939 cases, 975 controls, 1,097 family members	2,637 cases, 3,957 controls	11q13.5	C11orf30	rs7927894-A	0.36	8 x 10^-10	1.22 [1.15-1.30]	Affymetrix [342,303]	N
04/16/09	Kamatani April 06, 2009 Nat Genet A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians	Hepatitis B	179 Japanese cases, 934 Japanese controls	1,599 Japanese cases, 2,821 Japanese controls, 308 Thai cases, 546 Thai controls	6p21.32	HLA-DPB1	rs9277535-G	0.56	6 x 10^-39	1.75 [1.61-1.92]	Illumina [499,544]	N
05/11/09	Yamada April 05, 2009 Atherosclerosis Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study	Ischemic stroke	131 cases, 135 controls	776 cases, 5,205 controls	NS	NS	NS	NS	NS	NS	Affymetrix [~520,000]	N
04/22/09	Soranzo April 03, 2009 PLoS Genet Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size	Height	12,611 individuals	7,187 individuals	12q14.3 20q11.22 3q23 6p22.1 7p15.1 6q24.1 6p21.31 13q14.3 7p22.2 4p15.32 7q21.2 4q21.21 15q25.2 6p21.33 1p36.11 14q24.3 5p13.3 9p13.3 4q31.22 8q12.1	HMGA2 UQCC ZBTB38 HIST1H1D JAZF1 GPR126 HMGA1,C6orf106 DLEU7 GNA12 LCORL CDK6 PRKG2 ADAMTSL3 HLA-B CATSPER4 TMED10 NPR3 WDR40A HHIP PLAG1	rs8756-? rs6088813-? rs6763931-? rs10946808-? rs849141-? rs6570507-? rs1776897-? rs3118914-? rs1182188-? rs6830062-? rs2282978-? rs710841-? rs4842838-? rs13437082-? rs11809207-? rs910316-? rs10472828-? rs7871764-? rs1812175-? rs7815788-?	0.17 0.11 0.35 0.43 0.23 0.42 0.49 0.39 0.27 0.23 0.08 0.12 0.32 0.13 0.23 0.15 0.26 0.44 0.49 0.39	5 x 10^-14 1 x 10^-13 3 x 10^-12 6 x 10^-12 3 x 10^-11 4 x 10^-11 8 x 10^-11 4 x 10^-10 3 x 10^-9 5 x 10^-9 1 x 10^-8 2 x 10^-8 3 x 10^-8 5 x 10^-8 6 x 10^-8 1 x 10^-7 3 x 10^-7 2 x 10^-6 4 x 10^-6 5 x 10^-6	.08 [0.06-0.10] SD decrease .09 [0.07-0.11] SD decrease .07 [0.05-0.09] SD increase .07 [0.04-0.10] SD increase .08 [0.06-0.10] SD increase .08 [0.06-0.10] SD decrease .12 [0.08-0.16] SD increase .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD increase .1 [0.07-0.13] SD increase .06 [0.04-0.08] SD decrease .07 [0.04-0.10] SD increase .06 [0.04-0.07] SD decrease .07 [0.04-0.10] SD decrease .07 [0.04-0.10] SD increase .05 [0.03-0.07] SD increase .06 [0.04-0.08] SD decrease .06 [0.03-0.09] SD increase .06 [0.03-0.09] SD decrease .07 [0.04-0.10] SD decrease	Illumina [229,216]	N
04/13/09	Nan April 02, 2009 J Invest Dermatol Genome-Wide Association Study of Tanning Phenotype in a Population of European Ancestry	Tanning	2,287 women	870 controls	6p25.3 11q14.3 5p13.3 16q24.3 11q14.3 16q24.3 14q32.2 12q13.13 21q22.3 5q33.1	EXOC2 TYR MATP MC1R GRM5 MC1R Intergenic LOC440100 PRDM15 PPARGC1B	rs12210050-T rs1393350-A rs35391-T rs11648785-T rs10831496-G rs154659-C rs17094273-A rs7969151-A rs7279297-G rs32579-A	NR NR NR NR NR NR NR 0.21 NR NR	5 x 10^-14 2 x 10^-13 3 x 10^-10 3 x 10^-9 5 x 10^-9 7 x 10^-8 9 x 10^-8 2 x 10^-6 3 x 10^-6 4 x 10^-6	.22 [0.16-0.28] increase in tanning ability score .19 [0.13-0.25] increase in tanning ability score .44 [0.30-0.58] decrease in tanning ability score .14 [0.10-0.18] decrease in tanning ability score .14 [0.10-0.18] decrease in tanning ability score .14 [0.08-0.20] increase in tanning ability score .2 [0.12-0.28] increase in tanning ability score .13 [0.07-0.19] increase in tanning ability score .12 [0.06-0.18] decrease in tanning ability score .11 [0.07-0.15] decrease in tanning ability score	Illumina [528,173]	N
04/03/09	Thomas March 29, 2009 Nat Genet A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)	Breast cancer	1,145 cases, 1,142 controls	8,625 cases, 9,657 controls	10q26.13 1p11.2 16q12.1 2q35 14q24.1 5q11.2	FGFR2 Intergenic TOX3 Intergenic RAD51L1 MAP3K1	rs2981579-T rs11249433-C rs3803662-T rs13387042-A rs999737-C rs16886165-G	0.41 0.39 0.27 0.51 0.76 0.15	2 x 10^-10 7 x 10^-10 1 x 10^-9 2 x 10^-8 2 x 10^-7 5 x 10^-7	1.17 [1.07-1.27] 1.16 [1.09-1.24] 1.16 [1.07-1.27] 1.25 [1.15-1.37] 1.06 [1.01-1.14] 1.23 [1.12-1.35]	Illumina [528,173]	N
03/31/09	Newton-Cheh March 22, 2009 Nat Genet Common variants at ten loci influence QT interval duation in the QTGEN Study	QT interval	13,685 individuals	15,854 individuals	1q23.3 1q23.3 1q23.3 16q21 6q22.31 11p15.5 1p36.31 7q36.1 7q36.1 11p15.5 16p13.13 3p22.2 17q12	NOS1AP NOS1AP NOS1AP CNOT1,GINS3, NDRG4, SLC38A7, GOT2 c6orf204,SLC35F1, PLN, ASF1A KCNQ1 RNF207,NPHP4, CHDS, ACOT7, PLEKHG5, KLH21 KCNH2 KCNH2 KCNQ1 LITAF,CLEC16A, SNN, ZC3H7A, TNFRSF17 SCN5A LIG3,RFFL	rs12143842-T rs12029454-A rs16857031-G rs37062-G rs11756438-A rs2074238-T rs846111-C rs4725982-T rs2968864-C rs12576239-T rs8049607-T rs12053903-C rs2074518-T	0.26 0.15 0.14 0.24 0.47 0.06 0.28 0.22 0.25 0.13 0.49 0.34 0.46	2 x 10^-78 3 x 10^-45 1 x 10^-34 3 x 10^-25 5 x 10^-22 3 x 10^-17 1 x 10^-16 5 x 10^-16 8 x 10^-16 1 x 10^-15 5 x 10^-15 1 x 10^-14 6 x 10^-12	3.15 [2.81-3.49] msec increase 2.98 [2.63-3.32] msec increase 2.63 [2.28-2.97] msec increase 1.75 [1.41-2.09] msec decrease 1.4 [1.06-1.74] msec increase 7.88 [6.16-9.59] msec decrease 1.75 [1.41-2.09] msec increase 1.58 [1.23-1.92] msec increase 1.4 [1.06-1.74] msec decrease 1.75 [1.41-2.09] msec increase 1.23 [0.88-1.57] msec increase 1.23 [0.88-1.57] msec decrease 1.05 [0.71-1.39] msec decrease	Affymetrix and Illumina [up to 2,543,686] (imputed)	N
04/02/09	Pfeufer March 22, 2009 Nat Genet Common variants at ten loci modulate the QT interval duration in the QTSCD Study	QT interval	15,842 individuals	up to 13,602 individuals	1q23.3 1q23.3 16q21 6q22.31 6q22.31 11p15.5 1p36.31 1q24.2 7q36.1 16p13.13 3p22.2 17q24.3	NOS1AP NOS1AP NDRG4 PLN PLN KCNQ1 RNF207 ATP1B1 KCNH2 LITAF SCN5A KCNJ2	rs12143842-T rs4657178-T rs7188697-A rs11970286-T rs12210810-C rs12296050-T rs846111-C rs10919071-A rs2968863-T rs8049607-T rs11129795-A rs17779747-T	0.24 0.33 0.74 0.44 0.06 0.20 0.29 0.87 0.29 0.46 0.23 0.35	2 x 10^-78 7 x 10^-33 7 x 10^-25 2 x 10^-24 2 x 10^-17 3 x 10^-17 4 x 10^-16 1 x 10^-15 2 x 10^-15 6 x 10^-15 5 x 10^-14 6 x 10^-12	2.88 [2.43-3.33] ms increase 2.19 [1.76-2.62] ms increase 1.66 [1.20-2.12] ms increase 1.64 [1.25-2.03] ms increase 3.13 [2.29-3.97] ms decrease 1.44 [0.95-1.93] ms increase 1.49 [1.00-1.98] ms increase 2.05 [1.48-2.62] ms increase 1.35 [0.90-1.80] ms decrease 1.25 [0.81-1.69] ms increase 1.27 [0.82-1.72] ms decrease 1.02 [0.53-1.51] ms decrease	Affymetrix and Illumina [unsure] (imputed)	N
04/02/09	Org March 20, 2009 Hum Mol Genet Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations	Hypertension	364 cases, 590 controls	1,043 cases, 1,769 controls	16q23.3	CDH13	rs11646213-T	0.60	8 x 10^-6	1.28 [1.15-1.43]	Affymetrix [395,912]	N
03/31/09	Pillai March 20, 2009 PLoS Genet A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci	Chronic Obstructive Pulmonary Disease	823 cases, 810 controls	2,840 family members, 389 cases, 472 controls	15q25.1 4q31.22	CHRNA3,CHRNA4,CHRNA5, IREB2, PSMA4, NP_001013641.2,Q9UD29 HHIP	rs8034191-C rs1828591-?	0.33 NR	1 x 10^-10 1 x 10^-7	1.4 [1.18-1.67] 1.38 [1.17-1.63]	Ilumina [493,609]	N
03/30/09	Takeuchi March 20, 2009 PLoS Genet A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose	Warfarin maintenance dose	1,053 individuals	588 individuals	16p11.2 10q23.33 10q23.33 19p13.12	VKORC1 CYP2C9 CYP2C9 CYP4F2	rs9923231-T rs1057910-? rs1799853-? rs2108622-?	0.40 0.07 0.11 0.24	3 x 10^-181 3 x 10^-79 1 x 10^-31 3 x 10^-10	.97 [0.91-1.02] mg/week decrease 1.11 [1.00-1.22] mg/week decrease .54 [0.45-0.63] mg/week decrease .21 [0.14-0.27] mg/week increase	Illumina [325,997]	N
03/31/09	Wilk March 20, 2009 PLoS Genet A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study	Pulmonary function measures	7,691 individuals	835 individuals	4q31.22	HHIP	rs13147758-G	0.39	8 x 10^-11	.1 [NR] % increase in FEV1/FVC ratio	Affymetrix [2,540,223] (imputed)	N
04/01/09	Tanaka March 18, 2009 Am J Hum Genet Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations	Folate pathway vitamin levels	2,934 individuals	686 individuals	19q13.33 1p36.12 10p13 11q12.1 3p14.1	FUT2 ALPL CUBN TCN1 PRICKLE2	rs602662-A rs4654748-C rs11254363-A rs526934-A rs153734-T	0.53 0.50 0.70 0.67 0.84	3 x 10^-20 (vitamin B12) 8 x 10^-18 (vitamin B6) 1 x 10^-6 (vitamin B12) 2 x 10^-6 (vitamin B12) 7 x 10^-6 (folate)	49.77 [37.09-62.45] pg/ml increase 1.45 [0.90-2.00] ng/ml decrease 21.49 [7.71-35.27] pg/mL decrease 27.62 [11.65-43.59] pg/mL increase .29 [0.13-0.45] ng/ml increase	Affymetrix and Illumina [~2.5 million] (imputed)	N
03/31/09	Kilpivaara March 15, 2009 Nat Genet A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms	Myeloproliferative neoplasms	324 cases, 2,999 controls	NR	9p24.1	JAK2	rs10974944-?	NR	4 x 10^-20	3.1 [2.40-4.00]	Affymetrix [62,775]	N
03/31/09	Cui March 14, 2009 Mol Med Genome Wide Association Study of Determinants of Anti-cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis	Anti-cyclic Citrullianted Peptide Antibody	531 individuals with rheumatoid arthritis	849 individuals with rheumatoid arthritis	6p21.32	HLA-DRA, HLA-DR3,BTNL2	rs1980493-?	0.13	5 x 10^-7	NS	Affymetrix [97,248]	N
03/29/09	Liu March 13, 2009 PLoS Genet Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche	Menarche (age at onset)	477 women	854 siblings, 762 women, 1,387 Chinese women	NS	NS	NS	NS	NS	NS	Affymetrix [379,319]	N
03/30/09	Tregouet March 10, 2009 Blood Common susceptibility allele are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach	Venous thromboembolism	419 cases, 1,228 controls	1,757 cases, 1,480 controls	9q34.2	ABO	rs505922-C	0.35	4 x 10^-15	1.81 [1.56-2.11]	Illumina [291,872]	N
03/28/09	Birnbaum March 08, 2009 Nat Genet Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24	Nonsyndromic cleft lip with or without cleft palate	224 cases, 383 controls	246 cases, 954 controls	8q24.21 1q32.2	PVT1, GSDMC IRF6	rs987525-A rs642961-A	0.20 NR	3 x 10^-24 2 x 10^-6	2.57 [2.02-3.26] NS	Illumina [521,176]	N
03/24/09	Liu March 04, 2009 Am J Hum Genet Genome-wide Association and Replication Studies Identified TRHR as an Important Gene for Lean Body Mass	Body mass (lean)	1,000 individuals	1,488 individuals, 1,972 family members, 2,955 Chinese individuals	8q23.1	TRHR	rs7832552-T	0.32	4 x 10^-10	.1 [0.04-0.16] kg increase	Affymetrix [379,319]	N
03/24/09	Vink March 04, 2009 Am J Hum Genet Genome-wide Association Study of Smoking Initiation and Current Smoking	Smoking behavior	3,540 individuals	6,405 individuals, 824 twin pairs	NS	NS	NS	NS	NS	NS	Perlegen [427,037]	N
03/28/09	Hattori March 02, 2009 Am J Med Genet B Neuropsychiatr Genet Preliminary genome-wide association study of bipolar disorder in the Japanese population	Bipolar disorder	107 cases, 107 controls	395 cases, 409 controls	NS	NS	NS	NS	NS	NS	Affymetrix [88,671]	N
04/01/09	Caporaso February 27, 2009 PLoS ONE Genome-wide and candidate gene association study of cigarette smoking behaviors	Smoking behavior	4,611 individuals (2,617 smokers)	NR	3q13.12 1p22.3 1p35.2 3q24 12q21.2 16p13.2 18q11.2 19p12 5q14.3 9p21.2 9q31.1 Xq23 14q24.1 17p13.2 Xp11.3 12q21.33 13q33.1 4q31.1 7p15.2 3q27.2 4q28.1	BBX AK002179 Intergenic Intergenic Intergenic Intergenic CABLES1 ZNF505 LOC133789 Intergenic Intergenic TRPC5 ACTN1 CAMKK1 MAOA Intergenic Intergenic SET7 Intergenic Intergenic Intergenic	rs6437740-? rs7553864-? rs910696-? rs800082-? rs1402279-? rs3112740-? rs11082304-? rs10411195-? rs933688-? rs1889899-? rs10989661-? rs7050529-? rs2268983-? rs758642-? rs3027409-? rs1847461-? rs912969-? rs17050782-? rs886716-? rs6444087-? rs950063-?	0.24 0.39 0.31 0.42 0.95 0.86 0.49 0.03 0.17 0.37 0.74 0.07 0.51 0.34 0.95 0.94 0.07 0.21 0.69 0.26 0.39	2 x 10^-7 (CPD) 3 x 10^-6 (SMKDU) 3 x 10^-6 (CPD) 3 x 10^-6 (PKYRS) 5 x 10^-6 (EVNV) 6 x 10^-6 (CPDBI) 6 x 10^-6 (SMKAGE) 6 x 10^-6 (CPD) 6 x 10^-6 (EVNV) 6 x 10^-6 (EVNV) 6 x 10^-6 (CIGSTAT) 6 x 10^-6 (CPD) 7 x 10^-6 (CPDBI) 7 x 10^-6 (CPD) 7 x 10^-6 (CPDBI) 8 x 10^-6 (CIGSTAT) 8 x 10^-6 (SMKDU) 8 x 10^-6 (SMKAGE) 8 x 10^-6 (CPDBI) 9 x 10^-6 (EVNV) 9 x 10^-6 (SMKDU)	.1 [NR] fewer cigarettes per day .08 [NR] more years .08 [NR] more cigarettes per day .12 [NR] more pack years 1.51 [NR] 2.16 [NR] .03 [NR] years older .21 [NR] fewer cigarettes per day 1.48 [NR] 1.26 [NR] 1.68 [NR] .06 [NR] fewer cigarettes per day 1.52 [NR] .08 [NR] more cigarettes per day 1.73 [NR] 1.8 [NR] .14 [NR] fewer years .03 [NR] years older 1.52 [NR] 1.28 [NR] .08 [NR] fewer years	Illumina [~518,000] (pooled)	N
03/18/09	Pezzolesi February 27, 2009 Diabetes Genome-wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes Mellitus	Diabetic nephropathy	820 cases, 885 controls	1,304 individuals	NS	NS	NS	NS	NS	NS	Affymetrix [359,193]	N
03/18/09	Gu February 25, 2009 Nature Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease	Cystic fibrosis severity	160 severe lung disease patients, 160 mild lung disease patients (all homozygous for CFTR deltaF508 variant)	101 severe lung disease patients, 381 mild lung disease patients, 1,118 family members	NS	NS	NS	NS	NS	NS	Affymetrix [100,198] (pooled)	N
03/18/09	Xiong February 25, 2009 Am J Hum Genet Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups	Bone mineral density	1,000 white individuals	4,925 white individuals, 350 Chinese hip fracture cases, 350 Chinese controls, 2,955 Chinese individuals, 908 West African men	16q23.1 1p22.2	ADAMTS18 TGFBR3	rs11864477-C rs17131547-A	0.12 0.01	2 x 10^-8 (hip BMD) 1 x 10^-6 (spine BMD)	1 % [NR] of variance explained 1.2 % [NR] of variance explained	Affymetrix [379,319]	N
03/01/09	Schrauwen February 18, 2009 Am J Hum Genet A Genome-wide Analysis Identifies Genetic Variants in the RELN Gene Associated with Otosclerosis	Otosclerosis	302 cases, 302 controls	847 cases, 872 controls	7q22.1	RELN	rs3914132-?	0.23	2 x 10^-8	1.54 [1.32-1.79]	Illumina [~555,000] (pooled)	N
05/07/09	Smith February 15, 2009 Heart Rhythm Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae	Electrocardiographic conduction measures	1,262 Kosraen individuals	NR	3p22.2 4p16.1 3p22.2 1q32.1 4q31.3 2q31.1 6p12.2	SCN5A MSX1 SCN5A NR NR Intergenic NR	rs7638909-G rs2008242-? rs2070488-A rs7512898-? rs17030434-? rs2461751-G rs283566-?	0.40 0.15 0.33 0.41 0.43 0.44 0.16	2 x 10^-6 (PR interval) 3 x 10^-6 (PR segment) 4 x 10^-6 (PR interval) 5 x 10^-6 (PR segment) 5 x 10^-6 (P wave duration) 8 x 10^-6 (PR interval) 9 x 10^-6 (P wave duration)	4.8 [2.84-6.76] ms increase NS 5 [2.84-7.16] ms decrease NS NS 4.54 [2.58-6.50] ms increase NS	Affymetrix [338,049]	N
02/28/09	Zheng February 15, 2009 Nat Genet Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1	Breast cancer	1,505 Chinese cases, 1,522 Chinese controls	1,554 Chinese cases, 1,576 Chinese controls	6q25.1	C6orf97	rs2046210-A	0.37	2 x 10^-15	1.29 [1.21-1.37]	Affymetrix [up to 607,728]	N
02/28/09	Soranzo February 12, 2009 Blood A novel variant on chromosome 7Q22.3 associated with mean platelet volume, counts and function	Mean platelet volume	1,221 individuals	7,365 individuals	7q22.3	Intergenic	rs342293-G	0.45	1 x 10^-24	.02 [0.014-0.018] log fl increase	Affymetrix [361,352]	N
03/01/09	Erdmann February 08, 2009 Nat Genet New susceptibility locus for coronary artery disease on chromosome 3q22.3	Coronary artery disease	6,990 cases, 8,955 controls	12,417 cases, 12,411 controls	3q22.3 12q24.31	MRAS HNF1A,C12orf43	rs9818870-T rs2259816-T	0.15 0.36	7 x 10^-13 5 x 10^-7	1.15 [1.11-1.19] 1.08 [1.05-1.11]	Affymetrix [567,119]	N
03/01/09	Gudbjartsson February 08, 2009 Nat Genet Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction	Plasma eosinophil count	9,392 individuals	12,118 individuals	12q24.12 3q21.3 2q12.1 5q31.1 2q34 5q22.1 6p21.32	SH2B3 GATA2 IL1RL1 IL5 IKZF2 WDR36, TSLP MHC	rs3184504-T rs4857855-T rs1420101-A rs4143832-C rs12619285-G rs2416257-G rs2269426-T	0.38 0.82 0.41 0.16 0.74 0.85 0.76	7 x 10^-19 (European) 9 x 10^-17 (European) 5 x 10^-14 (European) 1 x 10^-10 (European) 5 x 10^-10 (European) 1 x 10^-6 (European) 3 x 10^-6 (European)	7.6 [5.9-9.3] % standard unit increase 9.4 [7.2-11.6] % standard unit increase 6.4 [4.7-8.1] % standard unit increase 7.1 [4.9-9.2] % standard unit increase 6.3 [4.3-8.3] % standard unit increase 6.1 [3.7-8.6] % standard unit increase 4.6 [2.7-6.6] % standard unit increase	Illumina [312,179]	N
03/01/09	Kathiresan February 08, 2009 Nat Genet Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants	Myocardial infarction (early onset)	2,967 cases, 3,075 controls	9,746 cases, 9,746 controls	9p21.3 1p13.3 21q22.11 1q41 6p24.1 19p13.2 10q11.21 1p32.3 2q33.1	CDKN2A, CDKN2B CELSR2, PSRC1, SORT1 SLC5A3, MRPS6, KCNE2 MIA3 PHACTR1 LDLR CXCL12 PCSK9 WDR12	rs4977574-G rs646776-T rs9982601-T rs17465637-C rs12526453-C rs1122608-G rs1746048-C rs11206510-T rs6725887-C	0.56 0.81 0.13 0.72 0.65 0.75 0.84 0.81 0.14	3 x 10^-44 8 x 10^-12 6 x 10^-11 1 x 10^-9 1 x 10^-9 2 x 10^-9 7 x 10^-9 1 x 10^-8 1 x 10^-8	1.29 [1.25-1.34] 1.19 [1.13-1.26] 1.2 [1.14-1.27] 1.14 [1.10-1.19] 1.12 [1.08-1.17] 1.15 [1.10-1.20] 1.17 [1.11-1.24] 1.15 [1.10-1.21] 1.17 [1.11-1.23]	Affymetrix [~2.5 million] (imputed)	N
04/01/09	Tregouet February 08, 2009 Nat Genet Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease	Coronary artery disease	1,926 cases, 2,938 controls	7,073 cases, 7,325 controls	6q25.3 6q25.3	SLC22A3,LPAL2,LPA SLC22A3,LPAL2,LPA	4-SNP haplotype-2 4-SNP haplotype-1	0.02 0.16	4 x 10^-15 (CCTC) 1 x 10^-9 (CTTG)	1.82 [1.57-2.12] 1.2 [1.13-1.28]	Affymetrix [~500,000]	N
02/28/09	Gudmundsson February 06, 2009 Nat Genet Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations	Thyroid cancer	192 cases, 37,196 controls	432 cases, 1,727 controls	9q22.33 14q13.3	FOXE1 NKX2-1	rs965513-A rs944289-T	0.34 0.57	2 x 10^-27 2 x 10^-9	1.75 [1.59-1.94] 1.37 [1.24-1.52]	Illumina [304,083]	N
10/15/09	Lowe February 06, 2009 PLoS Genet Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae	Quantitative traits	Up to 2,906 Micronesian individuals	NR	11q23.3 19q13.32 19q13.32 3q25.33 10p12.33 5q13.3 7p22.2 9q22.33 10p15.3 12p13.33 19q13.32 19q13.32 20q13.12 7p14.1 7q36.3 9p21.3 2q22.2 12q24.13 12q24.31 19q13.32 5q35.3 9p21.3 10p13 10p13 2p23.3 5q13.3 5q35.1 4q21.21 10p15.3 6q16.2 6p22.3 7p21.3 7q34	Intergenic TOMMM40, APOC2, APOE, APOC4, APOC1 MGC2650, BLOC1S3, XTP7 SCHIP1 CACNB2 COL4A3BP, HMGCR SDK1 HEMGN, C9ORF156 ADARB2 ENSG00000118975, FKBP4 TOMM40, APOC2, APOE, APOC4, APOC1 MGC2650, BLOC1S3, XTP7 Intergenic Intergenic UBE3C Intergenic ARHGAP15 Intergenic SPPL3 TOMM40, APOC2, APOE, APOC4, APOC1 MGAT1 Intergenic ITGA8 CUBN ENSG0000173957, UBXD4, FKBP1B, FLJ21945 COL4A3BP, HMGCR Intergenic Intergenic ADARB2 Intergenic Intergenic Intergenic TRIM24	rs7396835-T rs4420638-G rs2159324-T rs2222328-C rs7069923-C rs3846663-T rs6462411-C rs755109-C rs6560749-T rs10848704-C rs4420638-G rs2159324-T rs6066084-A rs10486715-A rs2527866-C rs2225614-C rs10928195-C rs11066587-G rs1039302-T rs4420638-G rs655601-A rs613391-G rs7895372-G rs10508517-A rs7561273-A rs3846663-T rs254893-A rs10518224-A rs6560749-T rs6909430-G rs10498712-G rs17157663-A rs1874326-G	0.32 0.21 0.44 0.32 0.49 0.39 0.20 0.23 0.14 0.35 0.21 0.44 0.06 0.07 0.23 0.50 0.08 0.16 0.36 0.21 0.47 0.49 0.04 0.43 0.35 0.39 0.06 0.23 0.14 0.08 0.25 0.32 0.47	1 x 10^-9 (TG) 3 x 10^-7 (TC) 4 x 10^-7 (LDL-C) 8 x 10^-7 (WC) 1 x 10^-6 (SBP) 1 X 10^-6 (LDL-C) 1 x 10^-6 (TSH) 1 x 10^-6 (TSH) 2 x 10^-6 (BMI) 2 x 10^-6 (TSH) 2 x 10^-6 (CRP) 2 x 10^-6 (CRP) 2 x 10^-6 (% body fat) 3 x 10^-6 (height) 3 x 10^-6 (SBP) 3 x 10^-6 (weight) 4 x 10^-6 (weight) 5 x 10^-6 (CRP) 5 x 10^-6 (CRP) 5 x 10^-6 (TG) 5 x 10^-6 (HDL-C) 5 x 10^-6 (WC) 6 x 10^-6 (TC) 6 x 10^-6 (DBP) 6 x 10^-6 (CRP) 6 x 10^-6 (TC) 6 x 10^-6 (DBP) 7 x 10^-6 (TG) 8 x 10^-6 (% body fat) 8 x 10^-6 (TSH) 9 x 10^-6 (HDL-C) 9 x 10^-6 (TC) 9 x 10^-6 (weight)	.23 [NR] mg/dL increase .28 [NR] mg/dL increase .21 [NR] mg/dL decrease .22 [NR] inch decrease .19 [NR] mm Hg increase .21 [NR] mg/dL increase .36 [NR] mIU/L decrease .31 [NR] mIU/L decrease .32 [NR] kg/m2 decrease .29 [NR] mIU/L decrease .28 [NR] mg/L decrease .19 [NR] mg/L decrease .85 [NR] % increase .44 [NR] inch decrease .27 [NR] mm Hg decrease .21 [NR] lb. decrease .36 [NR] lb. decrease .26 [NR] mg/L increase .21 [NR] mg/L increase .22 [NR] mg/dL increase .23 [NR] mg/dL increase .2 [NR] inch increase .35 [NR] mg/dL decrease .18 [NR] mm Hg decrease .22 [NR] mg/L decrease] .19 [NR] mg/dL increase .58 [NR] mm Hg decrease .19 [NR] mg/dL increase .34 [NR] % decrease .49 [NR] mIU/L decrease .23 [NR] mg/dL increase .18 [NR] mg/dL decrease .22 [NR] lb. increase	Affymetrix [408,775]	N
08/21/09	Need February 06, 2009 PLoS Genet A genome-wide investigation of SNPs and CNVs in schizophrenia	Schizophrenia	871 European ancestry cases, 863 European ancestry controls	1,460 European ancestry cases, 12,995 European ancestry controls	NS	NS	NS	NS	NS	NS	Illumina [312,565] (pooled)	N
02/27/09	Garcia-Barcelo February 05, 2009 Proc Natl Acad Sci USA Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease	Hirschsprung's disease	181 Chinese cases, 346 Chinese controls	190 Chinese cases, 510 Chinese controls	10q21.1 8p12	RET, GALNACT-2, RASGEF1A NRG1	rs2742234-T rs16879552-G	NR 0.39	4 x 10^-18 2 x 10^-8	NS 1.68 [1.40-2.00]	Affymetrix [293,836]	N
03/31/09	Chio February 04, 2009 Hum Mol Genet A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	553 cases, 2,338 controls	3,149 cases, 3,335 controls	NS	NS	NS	NS	NS	NS	Illumina [545,066]	N
02/27/09	Liu February 03, 2009 Mol Psychiatry Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15	Smoking behavior	417 Caucasian males, 423 Caucasian females	412 African American males, 839 African American females, 3,491 Caucasian males, 4,132 Caucasian females	NS	NS	NS	NS	NS	NS	Affymetrix [379,319]	N
02/28/09	Kim February 01, 2009 Clin Exp Allergy Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis	Asthma (toluene diisocyanate-induced)	84 Korean cases, 263 Korean controls	NR	13q12.13 10q21.3 9p21.3	Intergenic CTNNA3 Intergenic	rs9319321-T rs10762058-G rs16937883-G	0.29 0.25 0.02	3 x 10^-6 6 x 10^-6 7 x 10^-6	5.2 [2.47-10.92] 5 [2.36-10.6] 5.29 [2.41-11.61]	Affymetrix [312,978]	N
02/27/09	Kim February 01, 2009 Pharmacogenomics Genome-wide association study of acute post-surgical pain in humans	Pain	60 females, 52 males	NR	19p12 11q23.3 1p21.3	LOC400680, ZNF429 NR NR	rs2562456-? rs17122021-? rs6693882-?	NR NR NR	2 x 10^-10 (onset time of analgesia) 7 x 10^-7 (maximum post-operative pain rating) 2 x 10^-6 (post-operative pain onset time)	NS NS NS	Affymetrix [374,975]	N
03/30/09	Polasek February 01, 2009 Croat Med J Genome-wide association study of anthropometric traits in Korcula Island, Croatia	Anthropometric traits	898 individuals	NR	16p11.2 14q32.13 14q23.3 5q33.3 7q22.1 1p36.32 7q22.1 13q14.3 2q31.1 5q33.3 7q22.1 2p22.3 5q33.2	SEZ6L2 LOC122509, FAM14B MAX SGCD ZNF498 Intergenic ZNF498 XTP498 Intergenic SGCD ZNF498 CRIM1 AMPA1, GRIA1	rs4787483-? rs7157940-? rs7158173-? rs157350-? rs7792939-? rs7513590-? rs7792939-? rs7792939-? rs7590983-? rs157350-? rs7792939-? rs1863080-? rs12658202-?	0.34 0.46 0.48 0.11 0.15 0.10 0.15 0.28 0.05 0.11 0.15 0.10 0.45	2 x 10^-6 (waist cirumference) 3 x 10^-6 (weight) 4 x 10^-6 (waist circumference) 4 x 10^-6 (brachial circumference) 4 x 10^-6 (weight) 5 x 10^-6 (height) 5 x 10^-6 (brachial circumference) 6 x 10^-6 (brachial circumference) 6 x 10^-6 (BMI) 6 x 10^-6 (hip circumference) 6 x 10^-6 (hip circumference) 8 x 10^-6 (brachial circumference) 9 x 10^-6 (height)	.16 [0.09-0.23] mm increase .12 [0.07-0.17] kg increase .11 [0.06-0.16] mm decrease .31 [0.18-0.44] mm decrease .26 [0.15-0.37] kg increase .31 [0.17-0.45] mm decrease .26 [0.15-0.37] mm increase .17 [0.10-0.24] mm increase .46 [0.26-0.66] kg/m2 increase .31 [0.18-0.44] mm decrease .26 [0.15-0.37] mm increase .31 [0.17-0.45] mm increase .11 [0.06-0.16] mm increase	Illumina [316,730]	N
02/25/09	Stefansson February 01, 2009 Nat Genet Variant in the sequence of the LINGO1 gene confers risk of essential tremor	Essential tremor	452 cases, 14,378 controls	300 cases, 1,419 controls	15q24.3	LINGO1	rs9652490-G	0.23	1 x 10^-9	1.55 [1.35-1.79]	Illumina [305,624]	N
03/31/09	Zemunik February 01, 2009 Croat Med J Genome-wide association study of biochemical traits in Korcula Island, Croatia	Biochemical measures	898 individuals	NR	4p16.1 12q24.23 4q12 4q13.1 6q16.3 12q12 4q31.23 Xp22.31 12q21.33 12q24.23 4q23 18q12.3 Xq23 20p12.1 21q22.3 21q22.3 16q13	SLC2A9 KSR2 USP46 LPHN3 GRIK2 Intergenic NR3C2 Neuroligin 4 Intergenic KSR2 RAP1GDS1 SLC14A2 ZCCHC16 PCSK2 PKNOX1 PKNOX1 CETP	rs13129697-C rs4767631-A rs346923-A rs4599440-A rs12207601-G rs871392-A rs1490453-A rs7885458-G rs10777332-A rs10444502-C rs10516430-A rs10502868-G rs5982533-G rs6044777-A rs2839619-G rs2839619-G rs7499892-A	0.25 0.31 0.13 0.23 0.16 0.15 0.17 0.24 0.11 0.28 0.28 0.08 0.22 0.17 0.40 0.40 0.16	1 x 10^-9 (uric acid) 6 x 10^-7 (LDL cholesterol) 2 x 10^-6 (triglycerides) 2 x 10^-6 (HDL cholesterol) 2 x 10^-6 (fibrinogen) 3 x 10^-6 (HDL cholesterol) 3 x 10^-6 (fibrinogen) 3 x 10^-6 (fibrinogen) 5 x 10^-6 (total cholesterol) 6 x 10^-6 (total cholesterol) 6 x 10^-6 (triglycerides) 7 x 10^-6 (albumin) 7 x 10^-6 (triglycerides) 8 x 10^-6 (fibrinogen) 8 x 10^-6 (total cholesterol) 8 x 10^-6 (LDL cholesterol) 9 x 10^-6 (HDL cholesterol)	.29 [0.21-0.37] umol/l decrease .12 [0.11-0.23] mmol/L decrease .28 [0.17-0.39] mmol/L decrease .2 [0.12-0.28] mmol/L increase .26 [0.15-0.37] g/L decrease .26 [0.15-0.37] mmol/L decrease .25 [0.15-0.35] g/L increase .23 [0.13-0.33] g/L decrease .24 [0.14-0.34] mmol/L decrease .17 [0.10-0.24] mmol/L decrease .16 [0.09-0.23] mmol/L decrease .04 [0.21-0.51] g/L decrease .23 [0.13-0.33] mmol/L decrease .23 [0.13-0.33] g/L increase .13 [0.07-0.19] mmol/L increase .13 [0.08-0.18] mmol/L increase .24 [0.14-0.34] mmol/L decrease	Illumina [316,730]	N
02/25/09	Timpson January 30, 2009 Hum Mol Genet Common variants in the region around Osterix are associated with bone mineral density and growth in childhood	Bone mineral density	1,418 children, 135 adults	3,875 children	NS	NS	NS	NS	NS	NS	Illumina [up to 315,807]	N
02/28/09	Ferrucci January 29, 2009 Am J Hum Genet Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study	Plasma carotenoid and tocopherol levels	1,191 individuals	2,751 individuals	16q23.2 11q23.3	BCMO1 APOA5	rs6564851-G rs12272004-A	0.39 0.07	2 x 10^-24 (beta-carotene) 8 x 10^-10 (alpha-tocopherol)	.15 [0.120-0.177] umol/L increase .07 [0.049-0.095] umol/L increase	Illumina [~500,451] (pooled)	N
02/26/09	Yang January 28, 2009 JAMA Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia	Treatment response for acute lymphoblastic leukemia	487 children	NR	10p12.33 2q33.1 4q31.21 20q13.12 7p14.2 7p21.2 10q26.12 11p15.1 6q25.3 5p13.2 10p14 11q21	ST8SIA6 C2orf47 IL15 NCOA3 ELMO1 DGKB intergenic intergenic intergenic LMBRD2 Intergenic MAML2	rs359312-T rs1569175-T rs17007695-C rs6125048-T rs4723619-C rs6971925-T rs2901286-A rs7128311-C rs35229355-T rs267759-A rs10508343-A rs7115578-A	0.04 0.11 0.10 0.04 0.07 0.02 0.03 0.03 0.03 0.05 0.04 0.64	9 x 10^-8 9 x 10^-7 9 x 10^-7 2 x 10^-6 3 x 10^-6 3 x 10^-6 4 x 10^-6 5 x 10^-6 5 x 10^-6 7 x 10^-6 8 x 10^-6 8 x 10^-6	3.91 [1.52-10.10] 2.73 [1.52-4.93] 2.67 [1.53-4.68] 2.73 [1.08-6.88] 3.01 [1.50-6.03] 13.91 [2.72-70.92] 4.66 [1.58-13.7] 13.9 [2.72-71.1] 7.24 [2.46-21.30] 3.23 [1.52-6.87] 3.81 [1.40-10.40] 1.86 [1.23-2.79]	Affymetrix [476,796]	N
02/06/09	Nair January 25, 2009 Nat Genet Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways	Psoriasis	1,359 cases, 1,400 controls	5,048 cases, 5,041 controls	6p21.33 5q33.3 5q33.1 5q31.1 6q23.3 12q13.2 1p31.3 9q34.13	HLA-C IL12B TNIP1 IL13 TNFAIP3 IL23A, STAT2 IL23R TSC1	rs12191877-T rs2082412-G rs17728338-A rs20541-G rs610604-G rs2066808-A rs2201841-G rs1076160-T	0.15 0.80 0.054 0.79 0.32 0.93 0.30 0.48	1 x 10^-100 2 x 10^-28 1 x 10^-20 5 x 10^-15 9 x 10^-12 1 x 10^-9 3 x 10^-8 6 x 10^-6	2.64 [NR] 1.44 [NR] 1.59 [NR] 1.27 [NR] 1.19 [NR] 1.34 [NR] 1.13 [NR] 1.09 [NR]	Perlegen [~2.5 million] (imputed)	N
02/07/09	Zhang January 25, 2009 Nat Genet Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21	Psoriasis	1,139 Chinese cases, 1,132 Chinese controls	5,721 Chinese cases, 7,340 Chinese controls	1q21.3 5q33.3 6p21.33	LCE3D, LCE3A IL12B MHC	rs4085613-A rs3213094-A rs1265181-?	0.43 0.45 NR	7 x 10^-30 3 x 10^-26	1.32 [1.25-1.39] 1.28 [1.23-1.35] 22.62	Illumina [494,902]	N
02/26/09	Otowa January 23, 2009 J Hum Genet Genome-wide association study of panic disorder in the Japanese population	Panic disorder	200 Japanese cases, 200 Japanese controls	NR	12p13.31 1q32.1 17q25.1 12q13.13 13q32.1 6q25.1 8p21.1 1p13.3 3p26.1 12q12 19q13.33 6p12.3 14q23.1 20p13 5q21.1 12q24.33 21q21.1	TMEM16B PKP1 SDK2 CALCOCO1 Intergenic PLEKHG1 CLU Intergenic GRM7 Intergenic Intergenic TNFRSF21 Intergenic SMOX Intergenic Intergenic USP25	rs12579350-? rs860554-? rs3816995-? rs941184-? rs9302001-? rs9372078-? rs17466684-? rs12061304-? rs3749380-? rs2731006-? rs3810265-? rs2103868-? rs4901869-? rs16989303-? rs4702982-? rs7299940-? rs2823455-?	0.01 0.05 0.03 0.03 0.20 0.11 0.09 0.10 0.25 0.29 0.07 0.26 0.02 0.21 0.16 0.29 0.03	4 x 10^-9 5 x 10^-8 2 x 10^-7 3 x 10^-7 3 x 10^-7 5 x 10^-7 7 x 10^-7 1 x 10^-6 2 x 10^-6 4 x10^-6 4 x 10^-6 5 x 10^-6 6 x 10^-6 6 x 10^-6 6 x 10^-6 7 x 10^-6 9 x 10^-6	NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS NS	Affymetrix [253,903]	N
02/25/09	Ling January 22, 2009 Obesity Genome-wide Linkage and Association Anaylses to Identify Genes Influencing Adiponectin Levels: The GEMS Study	Adiponectin levels	997 cases, 989 controls	NR	3q27.3 5q35.2	ADIPOQ Intergenic	rs6773957-A rs7722022-?	0.37 NR	5 x 10^-8 9 x 10^-6	NS NS	Affymetrix [398,625]	N
03/03/09	Meyre January 18, 2009 Nat Genet Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations	Obesity	695 obese adults, 685 obese children, 731 lean adults, 685 lean children	1,171 obese adults, 896 obese children, 1,114 lean adults, 1,297 lean children, 4,417 adults, 5,291 children	16q12.2 18q21.32 16q23.2 10p13 18q11.2	FTO MC4R MAF PTER NPC1	rs1421085-C rs17782313-C rs1424233-A rs10508503-C rs1805081-A	0.40 0.18 0.43 0.91 0.56	1 x 10^-28 (children) 5 x 10^-15 (children) 4 x 10^-13 (children) 2 x 10^-7 (children) 3 x 10^-7 (children)	1.39 [1.27-1.51] 1.22 [1.05-1.40] 1.12 [1.00-1.24] 1.56 [1.10-2.78] 1.33 [1.08-1.75]	Illumina [308,846]	N
01/21/09	Tanaka January 16, 2009 PLoS Genet Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study	Plasma levels of polyunsaturated fatty acids	1,210 individuals	1,076 individuals	NS	NS	NS	NS	NS	NS	Illumina [495,343]	N
02/27/09	Carrasquillo January 11, 2009 Nat Genet Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease	Alzheimer's disease	844 cases, 1,255 controls	1,547 cases, 1,209 controls	Xq21.31	PCDH11X	rs2573905-?	0.46	2 x 10^-7	1.29 [1.17-1.42]	Illumina [313,504]	N
01/21/09	Burgner January 09, 2009 PLoS Genet A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease	Kawasaki disease	107 cases, 134 controls	583 cases, 1,357 family members	3q26.31 16q22.3	NAALADL2 ZFHX3	rs17531088-T rs7199343-T	0.44 0.30	1 x 10^-6 2 x 10^-6	1.43 [1.32-1.53] 1.56 [1.33-1.92]	Affymetrix [223,922]	N
02/25/09	Feulner January 07, 2009 Mol Psychiatry Examination of the current top candidate genes for AD in a genome-wide association study	Alzheimer's disease	491 cases, 479 controls	NR	19q13.32	TOMM40, APOE	rs157580-?	NR	1 x 10^-40	NS	Illumina [~550,000]	N
01/21/09	Ober January 07, 2009 J Lipid Res Genome-wide association study of plasma Lp(a)levels Identifies multiple genes on chromosome 6q	Plasma Lp (a) levels	357 individuals	1,054 individuals	6q25.3	LPA	rs6919346-?	0.16	4 x 10^-11	.66 [mg/dl decrease]	Affymetrix [290,327]	N
01/21/09	Silverberg January 04, 2009 Nat Genet Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study	Ulcerative colitis	1,022 cases, 2,503 controls	1,387 cases, 1,115 controls	6p21.32 1p36.13 12q15 1p36.13 1p31.3 1p31.3 12q15 7q31.1 9q21.32 7q31.1 7q31.1 7q31.1	BTNL2, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1 OTUD3, PLA2G2E IFNG, IL26, IL22 RNF186 IL23R IL23R IL26 SLC26A3, DLD, LAMB1 Intergenic Intergenic SLC26A3, DLD, LAMB1 SLC26A3, DLD, LAMB1	rs2395185-? rs6426833-G rs1558744-A rs3806308-? rs11209026-? rs10889677-A rs2870946-G rs4598195-? rs668853-G rs4730273-? rs2158836-A rs4730276-?	0.67 0.54 0.38 0.63 0.93 0.30 0.055 0.54 0.39 0.70 0.35 0.39	1 x 10^-16 5 x 10^-13 3 x 10^-12 7 x 10^-9 1 x 10^-8 1 x 10^-8 5 x 10^-7 1 x 10^-6 2 x 10^-6 5 x 10^-6 7 x 10^-6 9 x 10^-6	1.52 1.37 1.35 1.28 1.79 1.29 1.54 1.23 1.2 1.22 1.21 1.22	Illumina [280,748]	N
01/21/09	Beecham January 03, 2009 Am J Hum Genet Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease	Alzheimer's disease	492 cases, 496 controls	238 cases, 220 controls	12q13.11 19q13.31 1q42.2	FAM113B ZNF224 DISC1	rs11610206-? rs2061333-? rs12044355-?	NR NR NR	3 x 10^-7 2 x 10^-6 9 x 10^-6	NS NS NS	Illumina [~2.5 million] (imputed)	N
02/27/09	Hinks January 01, 2009 Arthritis Rheum Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis	Arthritis (juvenile idiopathic)	279 cases, 184 controls	up to 654 cases, 1,847 controls	1p13.1	VTCN1	rs12046117-?	0.09	1 x 10^-6	1.58 [1.29-1.94]	Affymetrix [88,862]	N
01/16/09	Limou January 01, 2009 J Infect Dis Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).	AIDS progression	275 HIV positive patients, 1,438 controls	626 patients	6p21.33 6p21.33 6p21.33	HCP5, MICB, MCCD1, BAT1, LTB, TNF HLA-C ZNRD1, RNF39	rs2395029-G rs10484554-T rs8321-G	0.03 0.13 NR	3 x 10^-19 6 x 10^-8 5 x 10^-7	3.47 [2.39-5.04] NS NS	Illumina [291,119]	N
02/26/09	Sun January 01, 2009 Cancer Res Sequence variants at 22q13 are associated with prostate cancer risk	Prostate cancer	1,235 aggressive cases, 1,599 controls	3,629 aggressive cases, 4,255 non-aggressive cases, 5,738 controls	22q13.1	TNRC6B	rs9623117-C	0.21	5 x 10^-7	1.18 [1.11-1.26]	Affymetrix and Illumina [~2 million] (imputed)	N
01/14/09	Zhang December 31, 2008 Mol Psychiatry Singleton deletions throughout the genome increase risk of bipolar disorder	Bipolar disorder	1,001 cases, 1,033 controls	NR	Pending	Pending	Pending	Pending	Pending	Pending	Affymetrix [51,757 CNVs]	Y
01/14/09	Wang December 29, 2008 Proc Natl Acad Sci USA Whole-genome association study identifies STK39 as a hypertension susceptibility gene	Blood pressure	542 individuals	6,583 individuals	2q24.3	STK39	rs6749447-G	0.28	2 x 10^-7	1.9 [1.2-2.6] mm Hg increase in DBP	Affymetrix [79,447]	N
01/14/09	Meisinger December 24, 2008 Am J Hum Genet A genome-wide association study identifies three loci associated with mean platelet volume	Mean platelet volume	1,606 individuals	8,617 individuals	12q24.31 17q11.2 3p14.3	WDR66 TAOK1 ARHGEF3	rs7961894-A rs2138852-C rs12485738-A	0.11 0.47 0.30	7 x 10^-48 7 x 10^-28 4 x 10^-27	.03 [0.03-0.04] per log fl increase .02 [0.01-0.02] per log fl decrease .02 [0.01-0.02] per log fl increase	Affymetrix [335,152]	N
02/04/09	Muglia December 23, 2008 Mol Psychiatry Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts	Major depressive disorder	1,359 cases, 1,782 controls	NR	12p13.32	CCND2	rs4238010-G	0.02	6 x 10^-6	1.72	Illumina and Affymetrix [494,678] (imputed)	N
06/22/09	Pare December 19, 2008 PLoS Genet Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study	Glycated hemoglobin levels	14,618 Caucasian women	455 Caucasian men and women	10q21.3 7p13 2q24.3 8q24.11	HK1 GCK G6PC2 SLC30A8	rs7072268-A rs730497-A rs1402837-A rs13266634-A	0.50 0.17 0.23 0.30	2 x 10^-25 6 x 10^-12 5 x 10^-10 5 x 10^-8	.05 [NR] % increase .03 [NR] % increase .02 [NR] % increase .02 [NR] % decrease	Illumina [337,343]	N
01/14/09	Benyamin December 17, 2008 Am J Hum Genet Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels	Serum markers of iron status	459 twin pairs	NR	3q22.1 6p22.1 6p22.1 6p22.1 6p22.1 6p22.1 6p22.2 6p22.2 6p22.2 3q22.1 6q25.3 11p14.3 3q22.1 Xq24 2p14 6p22.1 3q22.1 6p22.2 22q12.3 7p14.1 18q22.2 5p12 5q14.1 6p22.2	TF HFE HFE HFE HIST1H2BJ BTN1A1 LRRC16 SLC17A1 LRRC16 TOPBP1 WTAP LUZP2 TF KLHL13 Q6ZNG6 TRIM38 TF LRRC16A TMPRSS6 Q4KMW4 Intergenic GHR ARSB SCGN	rs3811647-? rs1800562-? rs1800562-? rs1800562-? rs13194491-? rs13194984-? rs2274089-? rs17270561-? rs2274089-? rs2718812-? rs4516970-? rs10500991-? rs1867504-? rs2430212-? rs1457451-? rs12216125-? rs1799852-? rs2274089-? rs4820268-? rs29880-? rs2660917-? rs13188386-? rs2052550-? rs932316-?	NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR 0.09 NR NR NR NR NR NR NR	3 x 10^-15 (serum transferrin) 4 x 10^-15 (transferrin saturation) 4 x 10^-11 (serum iron) 1 x 10^-10 (serum transferrin) 1 x 10^-8 (transferrin saturation) 6 x 10^-8 (transferrin saturation) 3 x 10^-7 (serum transferrin) 5 x 10^-7 (transferrin saturation) 8 x 10^-7 (transferrin saturation) 1 x 10^-6 (serum transferrin) 1 x 10^-6 (serum ferritin) 2 x 10^-6 (serum transferrin) 2 x 10^-6 (serum transferrin) 2 x 10^-6 (serum transferrin) 3 x 10^-6 (transferrin saturation) 4 x 10^-6 (transferrin saturation) 5 x 10^-6 (serum transferrin) 5 x 10^-6 (serum iron) 6 x 10^-6 (serum iron) 7 x 10^-6 (serum ferritin) 8 x 10^-6 (serum ferritin) 8 x 10^-6 (transferrin saturation) 8 x 10^-6 (serum ferritin) 9 x 10^-6 (transferrin saturation)	.46 [0.34-0.58] SD decrease NS .66 [0.46-0.86] SD increase .68 [0.48-0.88] SD decrease NS NS NS NS NS NS NS NS NS NS NS NS .43 [0.25-0.61] SD decrease NS NS NS NS NS NS NS	Illumina [315,887]	N
01/14/09	"	Serum markers of iron status	411 family members	NR	3q22.1 6q22.33 14q23.2	TF RSPO3 Q6ZUR9	rs1830084-A rs972275-? rs973968-?	0.36 NR NR	1 x 10^-9 (serum transferrin) 2 x 10^-6 (serum ferritin) 3 x 10^-6 (transferrin saturation)	.43 [NR] SD increase NS NS	Affymetrix [100,846]	N
01/14/09	Pollin December 17, 2008 Science A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection	Triglycerides	809 individuals	698 individuals	11q23.3	APOA1, APOC3, APOA4, APOA5, DSCAML1	rs10892151-A	0.028	3 x 10^-29	NS	Affymetrix [381,934]	N
01/16/09	Styrkarsdottir December 14, 2008 Nat Genet New sequence variants associated with bone mineral density	Bone mineral density (hip)	6,865 individuals	8,510 individuals	1p36.12 6q25.1 17q21.31 11p11.2 17q21.31 Xq21.2 2q12.1 3p22.1	Intergenic ESR1 SOST LRP4 C17orf53 NR NR NR	rs7524102-A rs1038304-G rs1513670-A rs1007738-A rs227584-T rs2710057-T rs6735786-C rs10490823-G	0.82 0.47 0.37 0.77 0.73 0.67 0.64 0.46	1 x 10^-16 4 x 10^-10 2 x 10^-8 7 x 10^-7 9 x 10^-7 1 x 10^-6 2 x 10^-6 9 x 10^-6	.15 [0.11-0.18] SD decrease .08 [0.06-0.11] SD decrease .08 [0.05-0.10] SD decrease .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD decrease .07 [0.04-0.09] SD decrease .07 [0.04-0.09] SD decrease .06 [0.03-0.09] SD decrease	Illumina [305,051]	N
01/16/09	"	Bone mineral density (spine)	6,865 individuals	8,510 individuals	13q14.11 6q25.1 1p36.12 12q13.13 2p16.2 2p22.2 21q11.2	RANKL C6orf97, ESR1 Intergenic OSX SPTBN1 LOC344382 NR	rs9594759-T rs6929137-A rs6696981-G rs10876432-A rs11898505-G rs4670779-T rs1006899-A	0.62 0.30 0.86 0.73 0.68 0.32 0.84	2 x 10^-17 2 x 10^-10 2 x 10^-8 1 x 10^-7 4 x 10^-6 4 x 10^-6 6 x 10^-6	.12 [0.09-0.15] SD decrease .1 [0.07-0.13] SD decrease .12 [0.08-0.16] SD decrease .08 [0.05-0.11] SD decrease .07 [0.04-0.10] SD decrease .07 [0.04-0.10] SD decrease .09 [0.05-0.13] SD decrease	Illumina [305,051]	N
01/15/09	Thorleifsson December 14, 2008 Nat Genet Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity	Body mass index	80,969 individuals	11,036 individuals	16q12.2 2p25.3 16q12.2 18q21.32 19q13.11 1p31.1 3q27.2 16p11.2 11p14.1 11p14.1 1q25.2 12q13.13 1p21.3 11p14.1	FTO TMEM18 FTO MC4R KCTD15, CHST8 NEGR1 SFRS10, ETV5, DGKG SH2B1, ATP2A1 BDNF BDNF SEC16B, RASAL2 BCDIN3D, FAIM2 NR BDNF	rs8050136-A rs7561317-G rs6499640-A rs12970134-A rs29941-C rs2568958-A rs7647305-C rs7498665-G rs6265-G rs925946-T rs10913469-C rs7138803-A rs10783050-C rs7481311-T	0.41 0.84 0.41 0.30 0.69 0.58 0.77 0.44 0.85 0.34 0.20 0.37 0.36 0.24	1 x 10^-47 4 x 10^-17 4 x 10^-13 1 x 10^-12 7 x 10^-12 1 x 10^-11 7 x 10^-11 3 x 10^-10 5 x 10^-10 9 x 10^-10 6 x 10^-8 1 x 10^-7 4 x 10^-6 8 x 10^-6	8.04 [6.96-9.12] % SD 6.12 [4.69-7.55] % SD 5.25 [3.82-6.68] % SD 4.38 [3.16-5.60] % SD 4.18 [2.98-5.38] % SD 3.77 [2.67-4.87] % SD 4.42 [3.09-5.75] % SD 3.63 [2.49-4.77] % SD 4.58 [3.07-6.09] % SD 3.85 [2.62-5.08] % SD 3.36 [2.14-4.58] % SD 3.28 [2.06-4.50] % SD 2.6 [1.50-3.70] % SD 3.15 [1.78-4.52] % SD	Illumina [305,846]	N
01/15/09	"	Weight	80,969 individuals	11,036 individuals	16q12.2 2p25.3 16q12.2 18q21.32 16p11.2 11p14.1 3q27.2 19q13.11 1q25.2 1p31.1 6p21.33 11p14.1 12q13.13 13q12.2 1p21.3 5q23.2 11p14.1	FTO TMEM18 FTO MC4R SH2B1, ATP2A1 BDNF SFRS10, ETV5, DGKG KCTD15, CHST8 SEC16B, RASAL2 NEGR1 AIF1, NCR3 BDNF BCDIN3D, FAIM2 NR NR NR BDNF	rs8050136-A rs7561317-G rs6499640-A rs12970134-A rs7498665-G rs925946-T rs7647305-C rs29941-C rs10913469-C rs2568958-A rs2844479-T rs6265-G rs7138803-A rs7336332-G rs1973993-C rs2115172-A rs7481311-T	0.41 0.84 0.65 0.30 0.44 0.34 0.77 0.69 0.20 0.58 0.68 0.85 0.37 0.15 0.63 0.57 0.24	5 x 10^-36 2 x 10^-18 6 x 10^-14 5 x 10^-13 1 x 10^-9 4 x 10^-9 4 x 10^-9 5 x 10^-9 1 x 10^-8 2 x 10^-8 2 x 10^-8 2 x 10^-7 2 x 10^-7 1 x 10^-6 1 x 10^-6 2 x 10^-6 3 x 10^-6	7.05 [5.95-8.15] % SD 6.47 [5.02-7.92] % SD 5.5 [4.07-6.93] % SD 4.66 [3.41-5.91] % SD 3.69 [2.51-4.87] % SD 3.8 [2.55-5.05] % SD 4 [2.67-5.33] % SD 3.73 [2.48-4.98] % SD 3.82 [2.51-5.13] % SD 3.37 [2.19-4.55] % SD 3.58 [2.33-4.83] % SD 4 [2.47-5.53] % SD 3.27 [2.05-4.49] % SD 4.01 [2.40-5.62] % SD 2.71 [1.61-3.81] % SD 2.71 [1.59-3.83] % SD 3.5 [2.03-4.97] % SD	Illumina [305,846]	N
01/12/09	Willer December 14, 2008 Nat Genet Six new loci associated with body mass index highlight a neuronal influence on body weight regulation	Body mass index	32,387 individuals	59,092 individuals	16q12.2 2p25.3 18q21.32 4p13 16p11.2 11p11.2 19q13.11 1p31.1 11p15.4 20p12.3 15q25.2	FTO TMEM18 MC4R GNPDA2 SH2B1 MTCH2 KCTD15 NEGR1 STK33 BMP2 RKHD3	rs9939609-A rs6548238-C rs17782313-C rs10938397-G rs7498665-G rs10838738-G rs11084753-G rs2815752-A rs10769908-C rs2145270-T rs12324805-C	0.41 0.84 0.21 0.45 0.41 0.34 0.67 0.62 0.53 0.65 0.31	4 x 10^-51 1 x 10^-18 5 x 10^-18 3 x 10^-16 5 x 10^-11 5 x 10^-9 2 x 10^-8 6 x 10^-8 1 x 10^-6 6 x 10^-6 7 x 10^-6	.33 [0.27-0.39] kg/m2 increase .26 [0.19-0.34] kg/m2 increase .2 [0.12-0.28] kg/m2 increase .19 [0.13-0.25] kg/m2 .15 [0.08-0.21] kg/m2 increase .07 [0.01-0.13] kg/m2 increase .06 [-0.01-0.13] kg/m2 increase .1 [0.04-0.16] kg/m2 increase NS NS NS	Illumina and Affymetrix [2,399,588] (imputed)	N
02/05/09	Mead December 11, 2008 Lancet Neurol Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study	Creutzfeldt-Jakob disease	117 CJD cases, 3,083 controls	506 sCJD cases, 28 iCJD cases, 151 Kuru cases, 125 Kuru-resistant cases, up to 1,137 controls	20p13 8q21.13	PRNP STMN2	rs1799990-A rs1460163-A	NR NR	2 x 10^-21 6 x 10^-8	NS NS	Affymetrix [288,908]	N
01/06/09	Sullivan December 09, 2008 Mol Psychiatry Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo	Major depressive disorder	1,738 cases, 1,802 controls	6,079 cases, 5,893 controls	NS	NS	NS	NS	NS	NS	Perlegen [435,291]	N
01/12/09	Aulchenko December 07, 2008 Nat Genet Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts	Cholesterol, total	22,562 individuals	NR	19p13.2 2p24.1 1p13.3 19q13.32 5q13.3 19p13.11 1p31.3 18q21.1 2p21 11q12.2 1p36.11 8q24.13 15q22.1 11q23.3 7p15.3	LDLR APOB CELSR2 TOMM40, APOE HMGCR NCAN DOCK7 LIPG ABCG5 FADS2, FADS3 TMEM57 TRIB1 LIPC APOA1, APOA4, APOA5, APOC3 DNAH11	rs2228671-G rs693-G rs646776-G rs2075650-G rs3846662-G rs2304130-G rs10889353-C rs4939883-G rs6756629-G rs174570-G rs10903129-G rs6987702-G rs1532085-G rs12272004-C rs12670798-G	0.88 0.52 0.22 0.15 0.44 0.07 0.32 0.83 0.92 0.83 0.54 0.29 0.59 0.93 0.24	9 x 10^-24 9 x 10^-23 9 x 10^-22 3 x 10^-19 3 x 10^-19 2 x 10^-15 4 x 10^-12 2 x 10^-11 2 x 10^-11 2 x 10^-10 5 x 10^-10 3 x 10^-9 4 x 10^-7 7 x 10^-7 9 x 10^-7	.16 [NR] SD increase .1 [NR] SD decrease .13 [NR] SD decrease .14 [NR] SD increase .09 [NR] SD increase .15 [NR] SD decrease .08 [NR] SD decrease .07 [NR] SD increase .15 [NR] SD increase .09 [NR] SD increase .06 [NR] SD increase .07 [NR] SD increase .05 [NR] SD decrease .11 [NR] SD decrease .06 [NR] SD increase	Illumina and Affymetrix [up to ~600,000]	N
01/12/09	"	HDL cholesterol	21,412 individuals	NR	16q13 15q22.1 8p21.3 16q22.1 9q31.1 18q21.1 11p11.2 2p24.1 19q13.32 11q12.2	CETP LIPC LPL CTCF, PRMT8 ABCA1 LIPG MADD, FOLH1 APOB TOMM40, APOE FADS2, FADS3	rs1532624-C rs1532085-G rs2083637-G rs2271293-G rs3905000-G rs4939883-G rs7395662-G rs6754295-C rs157580-G rs174570-G	0.57 0.59 0.26 0.87 0.86 0.83 0.61 0.25 0.33 0.83	9 x 10^-94 1 x 10^-35 6 x 10^-18 8 x 10^-16 9 x 10^-13 2 x 10^-11 6 x 10^-11 4 x 10^-8 4 x 10^-7 4 x 10^-6	.21 [NR] SD decrease .13 [NR] SD decrease .11 [NR] SD increase .13 [NR] SD decrease .11 [NR] SD increase .1 [NR] SD increase .07 [NR] SD decrease .07 [NR] SD increase .06 [NR] SD increase .06 [NR] SD increase	Illumina and Affymetrix [up to ~600,000]	N
01/12/09	"	LDL cholesterol	17,797 individuals	NR	1p13.3 19q13.32 2p24.1 19p13.2 11q12.2 11q23.3 5q13.3 2p21 7p15.3 19p13.11 8q24.13 1p31.3	CELSR2 TOMM40, APOE APOB LDLR FADS2, FADS3 APOA1, APOA4, APOA5, APOC3 HMGCR ABCG5 DNAH11 NCAN TRIB1 DOCK7	rs646776-G rs157580-G rs693-G rs2228671-G rs174570-G rs12272004-C rs3846662-G rs6756629-G rs12670798-G rs2304130-G rs6987702-G rs10889353-C	0.22 0.33 0.52 0.88 0.83 0.93 0.44 0.92 0.24 0.07 0.29 0.32	8 x 10^-23 2 x 10^-19 4 X 10^-17 4 x 10^-14 4 x 10^-13 5 X 10^-13 2 x 10^-11 3 x 10^-10 6 x 10^-9 3 x 10^-6 3 x 10^-6 8 x 10^-6	.16 [NR] SD decrease .11 [NR] SD decrease .1 [NR] SD decrease .14 [NR] SD increase .11 [NR] SD increase .18 [NR] SD decrease .08 [NR] SD increase .16 [NR] SD increase .09 [NR] SD increase .12 [NR] SD decrease .07 [NR] SD increase .06 [NR] SD decrease	Illumina and Affymetrix [up to 600,000]	N
01/12/09	"	Triglycerides	17,815 individuals	NR	2p23.3 8p21.3 11q23.3 7q11.23 1p31.3 19q13.32 2p24.1 19p13.11	GCKR LPL APOA1, APOA4, APOA5, APOC3 MLXIPL DOCK7 TOMM40, APOE APOB NCAN	rs780094-G rs10096633-G rs12272004-C rs2240466-G rs1167998-C rs439401-G rs6754295-C rs2304130-G	0.63 0.88 0.93 0.87 0.32 0.68 0.25 0.07	3 x 10^-20 2 x 10^-18 5 X 10^-13 1 x 10^-12 2 x 10^-12 2 x 10^-9 3 x 10^-8 3 x 10^-6	.1 [NR] SD decrease .17 [NR] SD increase .18 [NR] SD decrease .14 [NR] SD increase .09 [NR] SD decrease .09 [NR] SD increase .08 [NR] SD decrease .1 [NR] SD decrease	Illumina and Affymetrix [up to 600,000]	N
01/07/09	Bouatia-Naji December 07, 2008 Nat Genet A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk	Fasting plasma glucose	2,151 individuals	6,332 cases, 9,132 controls	11q21	MTNR1B	rs1387153-T	0.29	2 x 10^-36	.07 [0.05-0.08] mmol/l increase	Illumina [308,846]	N
01/12/09	Kathiresan December 07, 2008 Nat Genet Common variants at 30 loci contribute to poly