Schwartzberg Publications

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services


Pamela L. Schwartzberg, M.D., Ph.D.

Chief & Senior Investigator, Genetic Disease Research Branch
Head, Cell Signaling and Immunity Section

Selected Publications

Schwartzberg PL, Goff SP, Robertson EJ.  Germline Transmission of a Mutation in c-abl introduced by homologous recombination in Murine Embryonic Stem Cells. Science, 246:799-803. 1989. [PubMed]

Debnath J., Chamorro M., Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol, 19(2):1498-507. 1999. [PubMed]

Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science, 284(5414):638-41. 1999. [PubMed]

Sun Z, Arendt C, Ellmeirer W, Schaeffer E, Sunshine M, Annes J, Petrzilka Kupfer A, Schwartzberg PL, Littman D. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature, 404:402-407. 2002. [PubMed]

Schaeffer E, Broussard C, Debnath J, Anderson S, McVicar D, Schwartzberg P. Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med, 192:987-1000. 2000. [PubMed]

Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A, 98:7449-54. 2001. [PubMed]

Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL. Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol, 2:1183-8. 2001. [PubMed]

Crotty S, Kersh EN, Cannons J, Schwartzberg PL, Ahmed R. SAP is required for generating long-term humoral immunity. Nature, 16;421(6920):282-7. 2003. [PubMed]

Takesono A, Horai, R, Mandai M, Dombroski D, Schwartzberg, PL. Requirement for Tec family kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr. Biol, 10:917-22. 2004. [PubMed]

Finkelstein L.D., Schwartzberg P.L. Tec kinases: shaping T-cell activation through actin. Trends Cell Biol, 14:443-451. 2004. [PubMed]

Cannons JL, Hill, B. Yu, L.J., Mijares, L.A., Dombroski, D., Nichols, K.E., Antonellis, A., Koretzky, G., Gardner, K., and Schwartzberg, P.L. SAP Regulates T(H)2 Differentiation and PKC-theta;-Mediated Activation of NF-kappaB1. Immunity, 21:693-706. 2004. [Full Text]

Broussard, C, Fleishaker, C, Horai, R, Chetana, M, Lewis, CM, Venegas, AM, Sharp, L, Hedrick, S, Fowlkes, BJ and Schwartzberg, PL. Altered development of CD8+ T cell lineages in mice deficient in the Tec kinases Itk and Rlk. Immunity, 25:93-104. 2006. [PubMed]

Horai R, Mueller KL, Handon RA, Cannons JL, Anderson SM, Kirby MR, Schwartzberg PL. Requirements for selection of conventional and innate T lymphocyte lineages. Immunity, 27(5):775-85. 2007. [PubMed]

Readinger JA, Schiralli GM, Jiang JK, Thomas CJ, August A, Henderson AJ, Schwartzberg PL. Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A, 105(18):6684-9. 2008. [PubMed]

Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature, 455(7214):764-9. 2008. [PubMed]

Gomez-Rodriguez J, Sahu N, Handon R, Davidson, T, Anderson SM, Kirby MR, August A, Schwartzberg PL. Differential expression of IL-17A and IL-17F is coupled to TCR signaling via Itk-mediated regulation of NFATc1. Immunity, 31(4):587-97. 2009. [PubMed]

Cannons J, Qi H, Lu KT, Ghai M, Gomez-Rodriguez J, Cheng J, Wakeland EK, Germain RN, and Schwartzberg PL. Optimal germinal center responses require a multi-stage T:B cell adhesion process involving integrins, SLAM-associated protein and CD84. Immunity, 32:253-65. 2010. [PubMed Central]

Lu KT, Kanno Y, Cannons JL, Handon R, Elkahloun A, Anderson SM, Wei L, Sun H, O'Shea JJ, and Schwartzberg PL. Functional and epigenetic studies reveal multistep differentiation and plasticity of follicular T helper cells. Immunity, 35:622-32. 2011. [PubMed Central]

Zhao, F, Cannons JL, Dutta M, Griffiths GM, and Schwartzberg PL. Positive and Negative Signaling through SLAM receptors regulate Synapse Organization and Thresholds of Cytolysis. Immunity, 36:1003-16. 2012. [PubMed]

Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110? result in T cell senescence and human immunodeficiency. Nat Immunol, 15:88-97. 2014. [PubMed]

Gomez-Rodriguez J, Wohlfert EA, Handon R, Meylan F, Wu, JZ, Anderson SM, Kirby MR, Belkaid Y and Schwartzberg PL. Itk-mediated integration of T Cell Receptor and Cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med, 211:529-43. 2014. [PubMed]

Tsang J, Schwartzberg PL, Kotliatov Y, Biancotta A, Xhi Z, Germain RL, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F, Baylor HIPC Center and The CHI Consortium. Global analyses of human immune variation reveal baseline predictors of post-vaccination responses. Cell, 157:499-513. 2014. [PubMed]

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Last Updated: June 18, 2014