Agenda & Participants

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services


Developing a Haplotype Map of the Human Genome
for Finding Genes Related to Health and Disease

Washington, D.C.
July 18-19, 2001

Participant List

Maricela Aguilar: University of Texas Health Science Center, San Antonio
David Altshuler: Massachusetts General Hospital
Sally Ann Amero: NIH / Center for Scientific Review
Richard A. Anderson: NIH / National Institute of General Medical Sciences
Stylianos E. Antonarakis: University of Geneva Medical School
Mel Bass: Vanderbilt University
Bob Baughman: NIH / National Institute of Neurological Disorders and Stroke
David Bentley: Sanger Centre
Kate Berg: NIH / National Human Genome Research Institute
Eric Boerwinkle: University of Texas Health Science Center, Houston
George E. Bonney: Howard University
Clive Bowman: GlaxoSmithKline
Michael Boyce-Jacino: Orchid BioSciences
Joy Boyer: NIH / National Human Genome Research Institute
Lisa D. Brooks: NIH / National Human Genome Research Institute
Ken Buetow: NIH / National Cancer Institute
Andrea Califano: First Genetic Trust
Judit Camacho: NIH / National Cancer Institute
Lon Cardon: University of Oxford
Aravinda Chakravarti: Johns Hopkins University
Hemin R. Chin: NIH / National Institute of Mental Health
Mildred Cho: Stanford University
Andrew G. Clark: Pennsylvania State University
Ellen Wright Clayton: Vanderbilt University
Francis S. Collins: NIH / National Human Genome Research Institute
David J. Cutler: Johns Hopkins University
Mark J. Daly: Whitehead Institute
Camilla Day: NIH / Center for Scientific Review
Panagiotis Deloukas: Sanger Centre
Bernie Devlin: University of Pittsburgh
Anna Di Rienzo: University of Chicago
Julie A. Douglas: University of Michigan
Peter Dudley: NIH / National Eye Institute
Ian Dunham: Sanger Centre
Troy Duster: New York University
Irene A. Eckstrand: NIH / National Institute of General Medical Sciences
Margaret G. Ehm: GlaxoSmithKline
Phyllis Griffin Epps: University of Houston
Matt Farrer: Mayo Clinic
Elise Feingold: NIH / National Human Genome Research Institute
Adam Felsenfeld: NIH / National Human Genome Research Institute
Robert Finkelstein: NIH / National Institute of Neurological Disorders and Stroke
Kelly Fitzpatrick: NIH / National Human Genome Research Institute
Morris W. Foster: University of Oklahoma, Norman
Lynn Frampton: NIH / National Human Genome Research Institute
Elizabeth M. Gillanders: NIH / National Human Genome Research Institute
Maria Giovanni: NIH / National Institute of Allergy and Infectious Diseases
Judy Gobert: Salish Kootenai College
Martin Godbout: Genome Canada
David B. Goldstein: University College London
Peter Good: NIH / National Human Genome Research Institute
Bettie J. Graham: NIH / National Human Genome Research Institute
Judith H. Greenberg: NIH / National Institute of General Medical Sciences
Alan E. Guttmacher: NIH / National Human Genome Research Institute
Mark S. Guyer: NIH / National Human Genome Research Institute
Katrina Gwinn-Hardy: NIH / National Institute of Neurological Disorders and Stroke
Sandra Haller: California Newsreel
Laura Helmuth: Science
Christine Herbes-Sommers: California Newsreel
Karen Hofman: NIH / Fogarty International Center
Ken Howard: GenomeWeb
Kathy Hudson: NIH / National Human Genome Research Institute
Richard R. Hudson: University of Chicago
Tom Hudson: McGill University
Fatimah Jackson: University of Maryland
Cashell Jaquish: NIH / National Heart, Lung, and Blood Institute
James N. Jarvis: Oklahoma University
Marlene L. Jasperse: University of New Mexico
Li Jin: University of Cincinnati
Thomas M. Johnson: NIH / National Institute on Deafness and Other Communication Disorders
Elke Jordan: NIH / National Human Genome Research Institute
Norman L. Kaplan:NIH / National Institute of Environmental Health Sciences
Robert W. Karp: NIH / National Institute on Alcohol Abuse and Alcoholism
Karen Kennedy: Wellcome Trust
Kenneth K. Kidd: Yale University
Patricia King: Georgetown University
Sharon Minor King: Howard University
Raynard Kington: NIH / Office of Behavioral and Social Sciences Research
Rick A. Kittles: Howard University
Leonid Kruglyak: Fred Hutchinson Cancer Research Center
Pui-Yan Kwok: Washington University
Claude Laberge: Laval University
Eric Lai: GlaxoSmithKline
Eric Lander: Whitehead Institute
Charles H. Langley: University of California, Davis
Laura Lazzeroni: Stanford University
Tim Leshan: NIH / National Human Genome Research Institute
Jingpin Lin: NIH / National Heart, Lung, and Blood Institute
Jeffrey C. Long: NIH / National Institute on Alcohol Abuse and Alcoholism
Rochelle M. Long: NIH / National Institute of General Medical Sciences
Martha S. Lundberg: NIH / National Heart, Lung, and Blood Institute
Peter M. Lyster: NIH / Center for Scientific Review
Teri Manolio: NIH / National Heart, Lung, and Blood Institute
Monique K. Mansoura: NIH / National Human Genome Research Institute
Brad Margus: Perlegen Sciences
Gabor Marth: NIH / National Center for Biotechnology Information
Tara Matise: Rutgers University
Jean McEwen: NIH / National Human Genome Research Institute
Catherine McKeon: NIH / National Institute of Diabetes and Digestive and Kidney Diseases
Thomas Meitinger: Institute of Human Genetics, Germany
Andrew Merriwether: University of Michigan
Stephen C. Mockrin: NIH / National Heart, Lung, and Blood Institute
Steven O. Moldin: NIH / National Institute of Mental Health
Thomas H. Murray: Hastings Center
Yusuke Nakamura: University of Tokyo
Deborah A. Nickerson: University of Washington
Steven J. O'Brien: NIH / National Cancer Institute
Peter Oefner: Stanford University
Susan E. Old: NIH / National Heart, Lung, and Blood Institute
Pilar N. Ossorio: University of Wisconsin
Mary Lou Oster-Granite: NIH / National Institute of Child Health and Human Development
Jurg Ott: Rockefeller University
Sussan Paydar: NIH / National Institute of Neurological Disorders and Stroke
Jane L. Peterson: NIH / National Human Genome Research Institute
Raymond Peterson: Celadon Laboratories
Robert Pozos: San Diego State University
Bruce Rannala: University of Alberta
Rebekah S. Rasooly: NIH / National Institute of Diabetes and Digestive and Kidney Diseases
Kathleen Rand Reed: Geo Genesys
Kristin Reed: Bloomberg News
David Reich: Whitehead Institute
Brian Reid: Bloomberg News
John D. Rioux: Whitehead Institute
Jerry Roberts: NIH / National Human Genome Research Institute
Charles N. Rotimi: Howard University
Charmaine D. M. Royal: Howard University
Pamela Sankar: University of Pennsylvania
Steve Scherer: The Hospital for Sick Children, Toronto
Jeffery A. Schloss: NIH / National Human Genome Research Institute
Julie Schneider: Genaissance Pharmaceuticals
William J. Sharrock: NIH / National Institute of Arthritis and Musculoskeletal and Skin Diseases
Stephen T. Sherry: NIH / National Center for Biotechnology Information
Phyllis Sholinsky: NIH / National Heart, Lung, and Blood Institute
Mark D. Shriver: Pennsylvania State University
Charlie Sing: University of Michigan
Andrew Singleton: NIH / National Institute on Aging
Michael W. Smith: NIH / National Cancer Institute
Phillip F. Smith: NIH / National Institute of Diabetes and Digestive and Kidney Diseases
Geoff Spencer: NIH / National Human Genome Research Institute
Lincoln D. Stein: Cold Spring Harbor Laboratory
Joel Stephens: Genaissance Pharmaceuticals
Steve Sternberg: USA Today
Anne Stone: University of New Mexico
Toshihiro Tanaka: University of Tokyo
Makiko Tatebayashi: The Yoanuri Suimbun
Sharon Fontaine Terry: Genetic Alliance
Larry Thompson: NIH / National Human Genome Research Institute
Marjorie A. Tingle: NIH / National Center for Research Resources
Daniel J. Tomso: NIH / National Institute of Environmental Health Sciences
Dat Tran: NIH / Office of Science Policy
Zenta Tsuchihashi: Bristol-Myers Squibb
Jorge Velarde: Illumina
Jose Velazquez: NIH / National Institute of Environmental Health Sciences
Jerry Vovis: Genaissance Pharmaceuticals
Nicholas Wade: New York Times
David G. Wang: First Genetic Trust
Vivian Ota Wang: Arizona State University
Wendy Wang: NIH / National Cancer Institute
Robert Ward: Pharmacia
Mark Watson: Merck
Jim Weber: Marshfield Medical Research Foundation
Kenneth M. Weiss: Pennsylvania State University
Kris Wetterstrand: NIH / National Human Genome Research Institute
Benjamin Wilfond: NIH / National Human Genome Research Institute
Ron Winslow: Wall Street Journal
Gordon Wong: U.S. Genomics
Ryo Yamada: University of Tokyo
Hongyu Zhao: Yale University
Susan A. Zullo: DHHS / Office for Human Research Protections
Michael E. Zwick: Johns Hopkins University

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Agenda

Wednesday, July 18
10:30 a.m. - 12:00 noon Tutorial (optional): Aravinda Chakravarti
Genetic variation and non-random associations (linkage disequilibrium):
Concepts and measurements
12:00 noon - 1:00 p.m. Lunch on your own
1:00 p.m.- 1:10 p.m. Introduction Francis S. Collins (NHGRI),
Steve Moldin (NIMH),
Karen Kennedy (Wellcome Trust),
Martin Godbout (Genome Canada)
1:10 p.m. - 1:40 p.m. Rationale for a haplotype map: Eric Lander
What is a haplotype map? A brief look at the data. How haplotypes are used for disease-gene mapping. An explanation of why a haplotype map is useful. A resource for other studies, not for direct clinical use. Importance of ethical issues
1:40 p.m. - 2:10 p.m. Developing a haplotype map:
An overview of the population genetic issues:
Aravinda Chakravarti
Genetic definition of a population. Demographic and historical factors affecting the behavior of genes and their variants in populations (genetic isolate, founder effects, immigration, emigration and admixture). Fluidity of boundaries and changes over time. Genetic versus social definitions of populations. Group definitions, risks of group stigmatization and related ethical issues.
2:10 p.m. - 2:40 p.m. Discussion
2:40 p.m.- 2:55 p.m. Break
2:55 p.m. - 5:30 p.m. Current state of knowledge about haplotypes in populations:
Aravinda Chakravarti and Eric Lander (moderators)
David Altshuler, Andrew Clark, David Cutler, Anna Di Rienzo, Ian Dunham, Kenneth Kidd, Rick Kittles, Leonid Kruglyak, Pui-Yan Kwok, Mark Shriver, J. Claiborne Stephens
[Speakers: 7 min. talk and 4 min. discussion; 30 min. group discussion]
5:30 p.m.- 6:20 p.m. Poster session and break to get working dinner
6:20 p.m.- 7:00 p.m. Ethical and social issues relating to the inclusion of identified populations in a haplotype map project: Troy Duster
[25 min. talk and 15 min. discussion]
Consequences of inclusion vs. exclusion of certain groups. Eliminating vs. retaining ethnic identifiers in the reference set. Risks of this project conveying more meaning to race/ethnicity than it deserves.
7:00 p.m. - 9:30 p.m.

Panel and discussion on the ethical and social issues relating to the inclusion of identified populations in a haplotype map project and the meaning of consent
Panel: Ellen Wright Clayton (moderator), Mildred Cho, Phyllis Epps, Marla Jasperse, Thomas Murray, Pilar Ossorio, Charles Rotimi

Thursday, July 19
8:00 a.m. - 8:30 a.m. Breakfast

Discussion, with moderators shown
8:30 a.m. - 12:00 noon Structuring a Haplotype Map Project: David Bentley, Charmaine Royal, and David Altshuler
A) Methods for defining haplotypes and the kinds of samples needed: Leonid Kruglyak
B) What types of markers and what density? Deborah Nickerson
C) Involving communities in the research process: Morris Foster
12:00 p.m.- 12:15 p.m. Break to get working lunch
12:15 p.m. - 1:30 p.m. Organization of a haplotype map project: Francis S. Collins
Timing of the process. Need for piloting steps. How interested groups can work together.
1:30 p.m.- 2:00 p.m. Next steps: Francis S. Collins

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Last Reviewed: February 22, 2012