Myung Publications

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services

Kyungjae Myung, Ph.D.

Senior Investigator, Genetics and Molecular Biology Branch
Head, Genome Instability Section

Selected Publications

Myung K., Datta A., Chen C., Kolodner R.D. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, functions in the suppression of genome instability and homeologous recombination. Nature Genet, 27:113-116. 2001. [PubMed]

Myung K., Chen C., Kolodner R.D. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature, 411:1073-1076. 2001. [PubMed]

Myung K., Datta A., Kolodner R.D. Suppression of spontaneous chromosomal rearrangements by the S-phase checkpoint in Saccharomyces cerevisiae. Cell, 104:397-408. 2001. [PubMed]

Myung K., Kolodner R.D. Suppression of genome instability by multiple S-phase checkpoint functions. Proc Natl Acad Sci U S A, 99:4500-4507. 2002. [PubMed]

Kolodner R.D, Putnam C.D, Myung K. Maintenance of genome stability in Saccharomyces cerevisiae. Science, 297:552-557. 2002. [PubMed]

Myung K., Kolodner R.D. Induction of genome instability by DNA damage in Saccharomyces cerevisiae. DNA Repair, 2:243-258. 2003. [PubMed]

Myung K., Pennaneach, V., Kats E.S., Kolodner R.D. Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability. Proc Natl Acad Sci U S A, 100:6640-6645. 2003. [PubMed]

Myung K., Ghosh G., Fattah, F.J., Li G., Kim H., Dutia A., Pak E., Smith S., Hendrickson E.A. Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol Cell Biol, 24:5050-5059. 2004 [PubMed]

Smith S., Hwang J.-Y., Banerjee S., Majee A., Gupta A., Myung K. Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 101:9039-9044. 2004. [PubMed]

Myung K., Smith S., Kolodner R.D.. Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 101:15980-15985. 2004. [PubMed]

Banerjee S., Myung K. Increased genome instability and telomere length in the elg1-deficient S. cerevisiae mutant are regulated by S-phase checkpoints. Euk. Cell, 6:1557-66. 2004. [PubMed]

Hwang, J. Smith, S. and Myung K. The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae. Genetics, 169:1927-1937. 2005. [PubMed]

Smith S., Gupta A., Kolodner R.D., Myung K. Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11-Rad50-Xrs2 complex in Saccharomyces cerevisiae. DNA Repair, 4:606-617. 2005. [PubMed]

Banerjee S., Smith S., Myung K. Suppression of gross chromosomal rearrangements through cross talks between the yKu70-80 heterodimer and the DNA damage checkpoints. Proc. Natl. Acad. Sci USA, 103:1816-1821. 2006. [PubMed]

Motegi A., Kunts K., Majeed A., Smith S., Myung K. Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae. Mol. Cell. Biol., 26:1424-1433. 2006. [PubMed]

Budd M., Reis C., Smith S., Myung K. and Campbell J. Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase. Mol. Cell. Biol., 26:2490-2500. 2006. [PubMed]

De Piccoli, G., Cortes-Ledesma, F., Ira, G., Torres-Rosell, J., Uhle, S., Farmer, S., Hwang, J.Y., Machin, F., Ceschia, A., McAleenan, A., Cordon-Preciado, V., Clemente-Blanco, A., Vilella-Mitjana, F., Ullal, P., Jarmuz, A., Leitao, B., Bressan, D., Dotiwala, F., Papusha, A., Zhao, X., Myung, K., Haber, J.E., Aguilera, A., Aragon L. Smc5-Smc6 mediate DNA double-strand-break repair by sister-chromatid recombination. Nature Cell Biology. 8:1032-1034. 2006. [PubMed]

Motegi A., Sood R., Moinova H., Markowitz S.D., Liu P.P., Myung K. Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. J. Cell Biol., 175:703-708. Epub ahead of print. 2006. [PubMed]

Motegi, A., Myung, K. Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: a practical approach to study genomic rearrangements observed in cancer. Method, 41:168-176. 2007. [PubMed]

Banerjee S, Sikdar, N, and Myung K. Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex. Biochem Biophy Res Comm, 362:546-549. 2007. [PubMed]

Smith S, Banerjee S, Rilo R, and Myung K. Dynamic regulation of single stranded telomeres in Saccharomyces cerevisiae. Genetics, 178:693-701. 2008. [PubMed]

Banerjee S, Smith S, Oum J, Liaw H, Hwang J, Sikdar N, Motegi A, Lee SE, and Myung K. Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. J. Cell Biol, 181:1083-1093. 2008. [PubMed]

Myung K, Smith S. RAD5-dependent template switching pathway is important to suppress gross chromosomal rearrangements. J. Nat'l Cancer Inst. Monogr., 39:12-18. 2008. [PubMed]

Lee K, Myung K. PCNA modifications for regulation of post-replication repair pathways. Mol. Cells., 26:5-11. 2008. [PubMed]

Motegi A, Liaw H, Lee K, Roest H, Maas A, Moinova H, Markowitz S, Ding H, Hoeijmakers J, Myung K. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc. Natl. Acad. Sci. USA, 105:12411-12416. 2008. [PubMed]

Hwang J., Smith S., Ceschia A., Torres-Rosell J., Aragon L., and Myung K. Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. DNA Repair, 7:1426-1436. 2008. [PubMed]

Sikdar N., Banerjee S., Han Z., Smith S., Myung K. Spt2 defines a new transcription-dependent gross chromosomal rearrangement pathway. PLos Genet, 4(12):e1000290. 2008. [PubMed]

Lee S. and Myung K. Faithful after a break-up: Suppression of chromosomal translocations. Cell. & Mol. Life Sci, 66:3149-3160. 2009. [PubMed]

Sikdar N., Banerjee S., Lee K., Wincovitch S., Pak E., Dutra A., and Myung K. DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle, 8:3199-3207. 2009. [PubMed]

Yan Z, Delannoy M, Liang C, Daee D, Osman F, Oostra A, Du H, Lin T, Schuster B, Decaillet C, Stasiak A, Stasiak A, Woodcock C, Stone S, Hoatlin M, Schindler D, Joenje H, Sen R, de Winter J, Whitby M, Myung K, Constantinou A, Wang W. A histone-fold complex and FANCM constitute a DNA remodeling complex to maintain genome stability. Mol. Cell, 37:865-878. 2010. [PubMed]

Lee K-Y, Yang K, Cohn M, Sikdar N, D'Andrea A, Myung K. Human ELG1 regulates the level of ubiquitinated PCNA through its interaction with PCNA and USP1. J. Biol. Chem, 285:10362-103. 2010. [PubMed]

Krijger PHL, Lee K-Y, Wit N, Berk P, Wu X, Roest HR, Maas A, Ding H, Myung K, and Jacobs H. HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase. DNA Repair, 10:438-44. 2011. [PubMed]

Stirling PC, Bloom MS, Solanki-Patil T, Smith S, Sipahimalani P, Li S, Kofoed M, Ben-Aroya S, Myung K, Hieter P. The complete spectrum of yeast chromosome instability genes identifies candiate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genetics, 7:e1002057. 2011. [PubMed]

Liaw H, Lee D, and Myung K. DNA-PK dependent RPA2 phosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS One, 6:e21424. 2011. [PubMed]

Bell D, Sikdar N, Lee K-Y, Price J, Chaterjee R, Park H-D, Fox J, Ishiai M, Rugg ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan C, NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J, Sipahimalani P, Godwin AK, Sgroi DC, Merino MJ, Elliott G, Elkahloun A, Vinson C, Takata M, Mullikin JC, Wolfsberg TG, Hieter P, Lim D-S, and Myung K. Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genetics, 7:e1002245. 2011. [PubMed]

Fox J, Lee K-Y, and Myung K. Dynamic regulation of PCNA ubiquitylation/deubiquitylation. FEBS Letter, 585:2780-2785 .2011. [PubMed]

Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, Tice R, Austin C, and Myung K. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci, 109:5423-5428. 2012. [PubMed]

Daee D, Ferrari E, Logerich S, Branzei D, Sung P, and Myung K. Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM homolog Mph1. J. Biol. Chem., 287:26563-26575. 2012. [PubMed]

Daee D and Myung K. Fanconi-like crosslink repair in yeast. Genome Integrity, 3:7. 2012. [PubMed]

Fox J. and Myung K. Cell-based high-throughput screens for the discovery of chemotherapeutic agents. Oncotarget, 3:581-585. 2012. [PubMed]

Lee K-Y, Fu, H, Aldjem, M, Myung K. ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin. J. Cell Biol., 200:31-44. 2013. [PubMed]

Smith S, Fox J, Mejia M, Ruangpradit W, Saberi A, Kim S, Choi Y, Oh S, Wang Y, Choi K, Li L, Hendrickson E, Takeda S, Muller M and Myung K. Histone Deacetylase inhibitors synergize with defects in DNA repair to kill cancer cells. PLoS One, 9(1):e87203.  2014. [PubMed]

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Last Updated: January 30, 2014