Online Education Kit: 1992: Second-generation Genetic Map of Human Genome

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services


1992: Second-generation Genetic Map of Human Genome

Image of a microsatellite (October 1992)

A team from France built a low-resolution, microsatellite genetic map of the entire human genome.

The first genetic map that spanned the entire human genome with microsatellite markers was an improvement over earlier genetic maps using RFLPs (restriction fragment length polymorphisms) as markers, since microsatellites are more easily discovered and distinguished.

Each generation of genetic map helped geneticists more quickly locate disease genes on chromosomes. That a genetic marker is always inherited along with a certain disease gene indicates that the gene is located near the marker.

More Information

Facts About Genetic Mapping

To view the PDF on this page, you will need Adobe Reader. Download Adobe Reader

Reference:

Weissenbach, J., Gyapay, G., Dib, C., Vignal, A., Morissette, J., Millasseau, P., Vaysseix, G., et al. A second-generation linkage map of the human genome. Nature, 359:794-801. 1992. [PubMed]

Previous Event | Next Event

Top of page

Last Updated: May 6, 2013