Online Education Kit: 1998: M. Tuberculosis Bacterium Sequenced

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services


1998: M. Tuberculosis Bacterium Sequenced

Illustration of M. tuberculosisThe complete genome sequence of Mycobacterium tuberculosis was published in June 1998. M. tuberculosis is the bacterium that causes the chronic infectious disease tuberculosis. Although treatments for tuberculosis are available, the incidence of this disease is increasing throughout the world, and strains that are resistant to antibiotics are becoming more prevalent. The World Health Organization considers tuberculosis a global emergency. The complete sequence of the approximately 4,400,000-base-pair Mycobacterium tuberculosis genome is expected to help scientists develop better therapies, ranging from treatments for the illness to vaccines to prevent it.

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Reference:

Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature, 393: 537-44. 1998. [Full Text]

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Last Reviewed: May 28, 2013