Rotimi Publications

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services

Charles N. Rotimi, Ph.D.

Director, Center for Research on Genomics and Global Health
Senior Investigator, Inherited Disease Research Branch

Selected Publications

Rotimi CN, Comuzzie AG, Lowe WL, Luke A, Blangero J, Cooper RS. The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. Diabetes, 48:643-644. 1999. [PubMed]

Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. The structure of haplotype blocks in the human genome. Science, 296:2225-2229. 2002. [PubMed]

Rotimi CN, Chen G, Adeyemo AA, Furbert-Harris P, Parish-Gause D, Zhou J, Berg K, Adegoke O, Amoah A, Owusu S, Acheampong J, Agyenim-Boateng K, Eghan BA Jr, Oli J, Okafor G, Ofoegbu E, Osotimehin B, Abbiyesuku F, Johnson T, Rufus T, Fasanmade O, Kittles R, Daniel H, Chen Y, Dunston G, Collina FS; the Africa America Diabetes Mellitus Study. A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Diabetes, 53:838-841. 2004. [PubMed]

Rotimi CN. Are medical and nonmedical uses of large-scale genomic markers conflating genetics and 'race'? Nat Genet, 36 Suppl:S43-47. 2004. [PubMed]

Rotimi CN. Inauguration of the African Society of Human Genetics. Nat Genet, 36:544. 2004. [PubMed]

Yuan A, Chen G, Rotimi C, Bonney GE. A statistical framework for haplotype blocks inference. J Bioinform Comput Biol, 3:1021-1038. 2005. [PubMed]

Rotimi CN, Chen G, Adeyemo AA, Jones LS, Agyenim-Boateng K, Eghan BA Jr, Zhou J, Doutamey A, Lashley K, Huang H, Fasanmade O, Akinsola FB, Ezepue F, Amoah A, Akafo S, Chen Y, Oli J, Johnson T. Genome wide scan and fine mapping for quantitative trait loci for intraocular pressure on 5q and 14q in West Africans. Invest Ophthalmol Vis Sci, 47:3262-3267. 2006. [PubMed]

Helgason A, Palsson S, Thorleifsson G, Grant SF, Emilsson V, Gunnarsdottir S, Adeyemo A, Chen Y, Chen G, Reynisdottir I, Benediktsson R, Hinney A, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Schafer H, Faruque M, Doumatey A, Zhou J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Sigurdsson G, Hebebrand J, Pedersen O, Thorsteinsdottir U, Gulcher JR, Kong A, Rotimi C, Stefansson K. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet, 39:218-225. 2007. [PubMed]

Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnson H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johansen K, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. A variant in the CDKAL1 gene influences insulin response and the risk of type 2 diabetes. Nat Genet, 39:770-775. 2007. [PubMed]

International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature, 449:851-861. 2007. [PubMed]

Rotimi CN, Jorde LB. Ancestry and disease in the age of genomic medicine. N Engl J Med, 363(16):1551-8. 2010. [PubMed]

Shriner D, Adeyemo A, Ramos E, Chen G, Rotimi CN. Mapping of disease-associated variants in admixed populations. Genome Biol, 12(5):223. 2011. [PubMed]

1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature, 491(7422):56-65. 2012. [PubMed]

A Rotimi CN. Health disparities in the genomic era: the case for diversifying ethnic representation. Genome Med, 4(8):65. 2012. [PubMed]

Ayele FT, Adeyemo A, Finan C, Hailu E, Sinnott P, Burlinson ND, Aseffa A, Rotimi CN, Newport MJ, Davey G. HLA class II locus and susceptibility to podoconiosis. N Engl J Med, 366(13):1200-8. 2012. [PubMed]

Rotimi C, Shriner D, Adeyemo A. Genome science and health disparities: a growing success story? Genome Med, 5(7):61. 2013. [PubMed]

Rotimi C, H3Africa Consortium et al. Research capacity: Enabling the genomic revolution in Africa. Science, 344(6190):1346-8. 2014. [PubMed]

Gurdasani D, Tyler-Smith C, Rotimi C, Zeggini E, Sandhu MS. The African Genome Variation Project shapes medical genetics in Africa. Nature, 517(7534):327-32. 2014. [PubMed]

Thomson R, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A, 111(20):E2130-9. 2014. [PubMed]

Bentley AR, Adeyemo A, Rotimi CN. Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans. PLoS Genet,10(3):e1004190. 2014. [PubMed]

Ng MC, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet, 10(8):e1004517. 2014.  [PubMed]

Shriner D, Tekola-Ayele F, Adeyemo A, Rotimi CN. Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry. Scientific Report, 4:6055. 2014. [PubMed]

Tekola-Ayele F, Adeyemo A, Chen G, Hailu E, Aseffa A, Davey G, Newport MJ, Rotimi CN. Novel genomic signals of recent selection in an Ethiopian population. Eur J Hum Genet, 23(8):1085-92. 2014. [PubMed]

Ramos E, Rotimi CN. Pharmacogenomics, ancestry and clinical decision making for global populations. Pharmacogenomics J, 14(3):217-22. 2014. [PubMed]

Locke AE, Kahali B et al. Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538):197-206. 2015. [PubMed]

Shungin D, Winkler TW et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538). 2015. [PubMed]

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Last Updated: August 19, 2015