Genome-wide association studies have identified many genetic variants related to disease and have highlighted the need to further explore initial findings in non-European populations. The Population Architecture using Genomics and Epidemiology (PAGE) Consortium (RFA HG-07-014 and RFA HG-07-015) was formed in July 2008 and was renewed for a second phase (PAGE II) in September, 2013 (RFA HG-12-010 and RFA HG-12-015).
The first phase of PAGE examined putative causal genetic variants across approximately 100,000 African Americans, Asian Americans, American Indians, European Americans, Hispanic Americans, and Native Hawaiians from four groups representing nine large U.S.-based cohorts. Two genotyping approaches were employed - targeted genotyping of selected SNPs identified in genome-wide association studies of common disease, and a large-scale effort focused on the Metabochip array, which facilitated trans-ethnic fine mapping of several diseases of public health importance. PAGE II will add to these achievements by focusing analysis and genotyping efforts entirely on approximately 50,000 non-European ancestry individuals to better characterize how genetic factors influence susceptibility to disease. In September 2013, the NHGRI announced new awards to four research groups representing six national cohorts. By coordinating genotyping and phenotype harmonization across groups, PAGE is defining the epidemiological architecture of cross-population allele frequencies, relative risks, and distribution of phenotypes associated with particular variants and their environmental modifiers.
The Steering Committee is the governing body for the consortium and is composed of the Principal Investigators from each institution and the NIH Project Scientist.
Chair: Chris Haiman, Ph.D., University of Southern California
The External Scientific Panel provides input to the NHGRI Director about the progress and direction of the Network. Chair: Julie Buring, Sc.D., Harvard University
Mercedes Carnethon, Ph.D., Northwestern University
Deborah Nickerson, Ph.D., University of Washington
Christopher O'Donnell, M.D., National Heart, Lung, and Blood Institute, Harvard Medical School
Gloria Petersen, Ph.D., Mayo Clinic
PAGE II Working Groups will address issues related to array design and logistics, phenotype harmonization (diabetes/obesity, CVD, cancer, inflammation/autoimmunity, exposures), SNP selection and quality control, and ethnicity and ancestry
PAGE Standing Committees coordinate ongoing activities such as Publications and Presentations.
PAGE Project Groups perform cross-study analyses and write manuscripts. PAGE I Project Groups focused on cancer, cardiovascular disease, lipids, obesity, type 2 diabetes, menopause/menarche, the Metabochip and phenotype-wide association study (PheWAS). PAGE II Project Groups are TBD.