Heidi J. Sofia, Ph.D., M.P.H.

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services


Heidi J. Sofia, Ph.D.

Heidi J. Sofia
Program Director
Computational Biology

Division of Genomic Medicine


M.P.H. University of California, Berkeley, 1987
Ph.D. University of Wisconsin, Madison, 1993

phone (301) 496-7531
fax (301) 480-2770
e-mail sofiahj@mail.nih.gov
5635 FISHERS LN
Room 4111, MSC 9305
ROCKVILLE, MD 20892-9305

Selected Publications

The Cancer Genome Atlas (TCGA)


Dr. Heidi Sofia joined the Division of Extramural Research in 2010, and is part of the National Human Genome Research Institute (NHGRI) team responsible for The Cancer Genome Atlas (TCGA), jointly managed with the National Cancer Institute. The TCGA project is designed to set the foundation for understanding cancer as a genomic disease, by characterizing mutation, copy number, and structural variation across many tumor types, in the context of gene expression, epigenetic regulation, and impact on cellular networks. Dr. Sofia contributes to oversight of data analysis, bioinformatics and computational aspects of the project.

Dr. Sofia also manages a portfolio of grants in informatics tools for next-generation sequencing, and participates in the National Institutes of Health (NIH) Common Fund initiative on biomedical computing, serving as the lead science officer for one of the national centers.

Prior to joining NHGRI, Dr. Sofia worked in genome projects and as a computational biologist for ten years at Pacific Northwest National Laboratory (PNNL), one of the Department of Energy (DOE) science labs, in genomic analysis, information visualization and novel toolkit development for biology. She contributed to research in information management, cyberinfrastructure, and data-intensive and high-performance computing through the novel features of driving biological problems.

Dr. Sofia received a B.A. in biochemistry and Masters of Public Health from Univerisity of California Berkeley, and a Ph.D. from the University of Wisconsin, Madison, and was a National Center for Biotechnology Information (NCBI) GenBank Fellow.

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Last Updated: October 1, 2012