Integration of Genomics in Cancer Care by Erika Santos, Ph.D., MS, RN, et al., reviews cancer etiology, hereditary cancer syndromes, epigenetics factors and the influence of genomics on cancer management. The authors use case studies to illustrate how rapidly developing genomic advances are changing cancer care.
Genomics and Autism Spectrum Disorder (ASD) by Norah Johnson, Ph.D., RN, CPNP, et al., examines ASD identification and diagnosis and its implications for the family. The authors review the genomic contributions to the risk for ASD and highlight how current research on ASD underscores the complexity of genetic processes involved.
Current and Emerging Approaches in Genomics by Yvette Conley, Ph.D., et al., focuses on technologies for collecting, analyzing and interpreting genomic information. The authors summarize information about four approaches used in genomic research with implications for clinical application, including genome sequencing, genome-wide association studies epigenomics and gene expression.
An Overview of the Genomics of Metabolic Syndrome by Jacquelyn Taylor, PhD, PNP-BC, et al., analyzes diagnostic criteria for the components of metabolic syndrome (MetS). The contributions of cardiovascular, obesity, and diabetes genomic risk factors for MetS and the number of overlapping genes and polymorphisms associated with MetS are described with guidance for nurses of what this information means in practice.
Cardiovascular Genomics by Shu-Fen Wung Ph.D., RN, ACNP-BC, FAAN et al., centers on cardiovascular genomics using clinically relevant exemplars: myocardial infarction and coronary artery disease; stroke; and sudden cardiac death. The authors discuss the benefits and limitations of genetic testing for each of these case examples, describing specific implications for nurses.
An Update of Childhood Genetic Disorders by Cynthia Prows, MSN, CNS, FAAN, et al., spotlights nurses' important role in identifying children with genetic disorders and facilitating their access to services and resources. This article illustrates genomic concepts of relevance to nurses who care for infants, children and adolescents and lists resources.
Implications of Newborn Screening for Nurses article by Jane DeLuca, Ph.D., RN, CPNP, APNG, et al., surveys newborn screening activities, current controversies and ethical considerations. It also describes nurses' roles in the newborn screening process with suggestions for nursing education and research and a summary of expected future developments in newborn screening (i.e., genome sequencing) with implications for policy, practice, education and research.
A Blueprint for Genomic Nursing Science by Dr. Calzone, et al., summarizes recommendations of a 2012 Genomic Nursing State of Science Advisory Panel for furthering genomic nursing science to improve health outcomes. They offer targeted research topics for consideration to build the evidence of the value of genomic information.