Clinical Center Genomics Opportunity (CCGO)

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services

Clinical Center Genomics Opportunity (CCGO)

NIH Clinical CenterThe NIH Office of Intramural Research (OIR), the National Human Genome Research Institute (NHGRI), the Deputy Director of Intramural Research, and the NIH Clinical Center are co-sponsoring a program to promote precision medicine and spur the development of infrastructure to support clinical genomics in the NIH Clinical Center.  The program provides an exciting opportunity for the Institutes that participate in the NIH Clinical Center to develop capabilities within their Institutes to effectively use genomic data in clinical research and clinical care.

Genomics is a rapidly changing discipline and new technologic capabilities are being developed at an ever-increasing pace.  Our near-term objective is to build infrastructure and approaches with today's technology, with a vision that this will evolve toward comprehensive genomic evaluations in the future. To initiate this program, we will offer partnering institutes access to subsidized exome sequence data on a total of 1,000 NIH Clinical Center patients.

The program includes generous support from several sources: a monetary subsidy of $600 per exome from the Director's Challenge Innovation Award Program that is administered by OIR, reduced fee sequencing at the NIH Intramural Sequencing Center, clinical support from NHGRI regarding incidental findings analysis and counseling, and support from the NIH Clinical Center for sample processing. There will be no cost to the investigator for the exome sequencing.

We are aiming to partner with a handful of Investigators in this pilot development program.  Investigators are encouraged to propose projects for consideration that will be selected, based on several attributes.  The goal is to select a set of projects that optimally exploit NIH Clinical Center phenotyping resources, leverage clinical, scientific, and bioinformatic resources within the Institutes, have a strong potential for scientific discovery, and will catalyze infrastructure development within the NIH Clinical Center and Institutes for clinical genomic sequencing in the future.


Application Criteria and Process

Applicants should be Principal Investigators (PIs), tenured or tenure track, from Institutes that participate in the NIH Clinical Center.  The ideal PI would be an investigator who is knowledgeable in genetics, but who does not currently have a major research program in clinical genomics.

Target attributes of the proposals:

How to Apply

Please forward all application materials to Leslie G. Biesecker, M.D. at

Projects will be reviewed by a committee that is proposed to include:

Leslie Biesecker and Teri Manolio, NHGRI (co-chairs)
David Adams, Staff Clinician, NHGRI
Ivona Aksentijevich, NHGRI, Staff Scientist
Lawrence Brody, NHGRI, Director of the NHGRI Division of Genomics and Society
Brian Brooks, National Eye Institute (NHGRI Adjunct Investigator)
Kenneth Fischbeck, National Institute for Neurological Disorders and Stroke (NHGRI Adjunct Investigator)
Sergio Rosenzweig, NIH Clinical Center
Wendy Rubinstein, National Center for Biotechnology Information (NHGRI Adjunct Investigator)
Jeffery Schloss, NHGRI, Director of the NHGRI Division of Genome Sciences


Leslie G. Biesecker, M.D.
National Human Genome Research Institute (NHGRI)
National Institutes of Health

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Last Updated: May 9, 2014