Burgess Group
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Shawn Burgess, Ph.D.

Senior Investigator, Translational and Functional Genomics Branch
Head, Developmental Genomics Section

Selected Publications

Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W., Burgess S., Haldi M., Artzt K., Farrington S., Lin S.Y., Nissen R.M., and Hopkins N. Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat Genet, 31(2):135-40. 2002. [PubMed]

Wu X., Li Y., Crise B., Burgess S. Transcription start regions in the human genome are favored targets for MLV integration. Science, 300:1749-51. 2003. [PubMed]

Zeng J, Yan J, Wang T, Mosbrook-Davis D, Dolan KT, Christensen R, Stormo GD, Haussler D, Lathrop RH, Brachmann RK, Burgess SM. Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Nucleic Acids Res, 36:e8. 2008. [PubMed]

Behra M, Bradsher J, Sougrat R, Burgess SM. Phoenix is required for hair cell stability and efficient regeneration in the lateral line. PLoS Genet, 5:e1000455. 2009. [PubMed]

Gallardo VE, Liang J Behra M, Elkahloun A, Villablanca EJ, Russo V, Allende ML, Burgess SM. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. BMC Dev Biol, 10:120. 2010. [PubMed]

Behra MB, Gallardo VE, Elkahloun A, Xu L, Idol J, Sheehy JI, Zonies S, Shaw KM, Weinstein BM, Burgess SM. Transcriptional signature of supporting cells in the lateral line using the SCM1:EGFP transgenic zebrafish line. BMC Dev Biol, 12:6. 2012. [PubMed]

Zhou Q, Yang D,. Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron K, Kuehn H, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CR, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin J, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo K, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinum M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky J, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF, Burgess SM, Moir SL, Gadina M, Sood R, Hershfield M, Boehm* M, Kastner, DL, Aksentijevich I. Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2. N Engl J Med, 370(10):911-20. 2013. [PubMed]

Liang J, Wang D, Renaud G, Wolfsberg TG, Wilson AF, Burgess SM. The stat3/socs3 pathway is a key regulator of hair cell regeneration in zebrafish. J Neurosci, 32:10662-73. 2012. [PubMed]

Varshney GK, Huang H, Zhang S, Gildea DE, Yang Z, Wolfsberg TG, Lin S, Burgess SM. The Zebrafish Insertion Collection (ZInC): a web based, searchable collection of zebrafish mutations generated by DNA insertion. Nucleic Acids Res, 41(database issue):D861-4. 2013. [PubMed]

Varshney GK, Lu J, Gildea D, Huang H, Pei W, Yang Z, Huang SC, Schoenfeld DS, Pho N, Casero D, Hirase T, Mosbrook-Davis DM, Zhang S, Jao LE, Zhang B, Woods IG, Zimmerman S, Schier AF, Wolfsberg T, Pellegrini M, Burgess SM, Lin S. A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome Res, 23:727-35. 2013. [PubMed]

LaFave MC, Varshney GK, Gildea DE, Wolfsberg TG, Baxevanis AD, Burgess SM. MLV integration site selection is driven by strong enhancers and active promoters. Nucleic Acids Res, doi: 10.1093/nar/gkt1399. 2014.  [PubMed]

Gaurav K. Varshney, Wuhong Pei, Matthew C. LaFave, Jennifer Idol1, Lisha Xu, Viviana Gallardo, Blake Carrington, Kevin Bishop, MaryPat Jones, Mingyu Li, Ursula Harper, Sunny C. Huang1, Anupam Prakash, Wenbiao Chen, Raman Sood, Johan Ledin and Shawn M. Burgess. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome Research, 25(7):1030-42. 2015. [PubMed]

Gaurav K. Varshney, Raman Sood, Shawn M. Burgess. Understanding and Editing the Zebrafish Genome. Adv Genet, 92:1-52. 2015. [PubMed]

Gaurav K. Varshney, Suiyuan Zhang, Wuhong Pei1, Ashrifia Adomako-Ankomah, Jacob Fohtung, Katherine Schaffer, Blake Carrington, Anoo Maskeri, Claire Slevin, Tyra Wolfsberg, Johan Ledin, Raman Sood and Shawn M. Burgess,CRISPRz: a database of zebrafish validated sgRNAs. Nucleic Acids Res, 44(D1):D822-6. 2016. [PubMed]

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Last Updated: June 6, 2016