Yingzi Yang, Ph.D.

Senior Investigator, Genetic Disease Research Branch
Head, Developmental Genetics Section

Selected Publications

Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS , Lu J, Shore EM, Kaplan FS., Yang Y (2013). Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nature Medicine [In Press]

Andre P, Wang Q, Wang N, Gao B, Schilit A, Halford MM, Stacker SA, Zhang X, Yang Y. The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem,  288(4):2906. 2013. [PubMed]

Regard JB, Zhong Z, Williams BO and Yang Y (2012). Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts. Cold Spring Harbor Perspectives in Biology, 4(12). 2012. [PubMed]

Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG,Yang Y. Wnt/beta-catenin signaling is differentially regulated by G? proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A, 108(50):20101-6. 2011. [Epub ahead of print]

Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y. Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2. Dev Cell, 20(2):163-76. 2011. [PubMed]

Song, H., Hu, J., Chen, W., Elliott, G., Andre, P., Gao, B., and Yang, Y. Planar cell polarity breaks the bilateral symmetry by controlling ciliary positioning. Nature, 466(7304):378-82. 2010. [PubMed]

Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, Chen Y, Park O, Chang J, Simpson RM, Wang CY, Gao B, Jiang J, Yang Y. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A, 2010, 107(4):1431-6. 2010. [PubMed]

Guo X, Mak KK, Taketo MM, Yang Y. The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One, 4(6):e6067. 2009. [PubMed]

Tzchori I, Day TF, Carolan PJ, Zhao Y, Wassif CA, Li L, Lewandoski M, Gorivodsky M, Love PE, Porter FD, Westphal H, Yang Y. LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development, 136(8):1375-85. 2009. [PubMed]

Topol L, Chen W, Song H, Day TF, Yang Y. Sox9 Inhibits Wnt Signaling by Promoting {beta}-Catenin Phosphorylation in the Nucleus. J Biol Chem, 30;284(5):3323-33. 2009. [PubMed]

Yang Y. Growth and patterning in the limb: signaling gradients make the decision. Sci Signal, 13;2(53):pe3. 2009. [PubMed]

Kinglun Kingston Mak, Henry M. Kronenberg, Pao-Tien Chuang, Susan Meckem and Yingzi Yang. Indian Hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development, 135(11):1947-56. 2008. [PubMed]

Mak KK, Bi y, Wan C, Chuang PT, Clemens T, Young M and Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell, 14(5):674-88. 2008. [PubMed]

Day TF and Yang Y. Wnt and Hedgehog Signaling Pathways in Bone Development. J Bone Joint Surg Am, 90(Supp 1):19-24. 2008. [Abstract]

Nemeth MJ, Topol L, Anderson SM, Yang Y, Bodine DM. Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation. Proc Natl Acad Sci U S A, 104(39):15436-41. 2007. [PubMed]

Yang Y. Xom as a novel partner of Lef/Tcfs during dorsal-ventral patterning of the Xenopus embryo. Cell Res, 17(4):307-8. 2007. [PubMed]

Mak, K.K., Chen, M.H., Day, T.F., Chuang, P.T. and Yang, Y. Wnt/b-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development, 133(18): 3695-707. 2006. [PubMed]

Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest, 115(7):1734-42. 2005. [PubMed]

Day T., Guo X., Garrett-Beal L., Yang Y. Wnt/b-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell, 8(5): 739-750. 2005. [PubMed]

Guo X., Day T.F., Jiang X., Garrett-Beal L., Topol L., Yang Y. Wnt/"-catenin signaling is sufficient and necessary for synovial joint formation. Genes & development, 18(19). 2004. [PubMed]

Yang Y. Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis. Birth Defects Res Part C Embryo Today, 69(4):305-17. 2003. [PubMed]

Topol L., Jiang X., Choi H., Garrett-Beal L., Carolan P.J, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent {beta}-catenin degradation. J Cell Biol, 162(5):899-908. 2003. [PubMed]

Yang Y., Topol L., Lee H., Wu J. Wnt5a and Wnt5b exhibit distinct activities in coordinating hondrocyte proliferation and differentiation. Development, (5):1003-15. 2003. [PubMed]

Kundu M., Javed A., Jeon J.P., Horner A., Eckhaus M., Muenke M., Lian J.B., Yang Y., Nuckolls GH, Stein GS, Liu PP. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet, 32(4):639-44. 2002." [PubMed]

Long F., Zhang X.M., Karp S., Yang Y., and McMahon A.P. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development, 128:5099-5108. 2001. [PubMed]

Yang Y., Guillot P., Boyd Y., Lyon M.F., and McMahon A.P. Evidence that preaxial polydactyly in Double Foot mutant is due to ectopic Indian Hedgehog signaling. Development, 125(16):3123-3132. 1998. [PubMed]

Yang Y., Drossopoulou G., Chuang P-T., Duprez D., Marti E., Bumcrot D., Vargesson N., Clarke J., Niswander L., McMahon A and Tickle C. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development, 124(21):4393-4404. 1997. [PubMed]

Yang Y. and Niswander L. Interaction between the signaling molecules WNT and SHH during vertebrate limb development: the role of dorsal ectoderm signals in anteroposterior patterning. Cell, 80:939-947. 1995. [PubMed]

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Last Updated: August 12, 2013