Kyungjae Myung, Ph.D.

Senior Investigator, Genetics and Molecular Biology Branch
Head, Genome Instability Section

Selected Publications

Myung K., Chen C., Kolodner R.D. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature, 411:1073-1076. 2001. [PubMed]

Myung K., Datta A., Kolodner R.D. Suppression of spontaneous chromosomal rearrangements by the S-phase checkpoint in Saccharomyces cerevisiae. Cell, 104:397-408. 2001. [PubMed]

Kolodner R.D, Putnam C.D, Myung K. Maintenance of genome stability in Saccharomyces cerevisiae. Science, 297:552-557. 2002. [PubMed]

Smith S., Hwang J.-Y., Banerjee S., Majee A., Gupta A., Myung K. Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 101:9039-9044. 2004. [PubMed]

Motegi A., Kunts K., Majeed A., Smith S., Myung K. Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae. Mol. Cell. Biol., 26:1424-1433. 2006. [PubMed]

Motegi A., Sood R., Moinova H., Markowitz S.D., Liu P.P., Myung K. Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. J. Cell Biol., 175:703-708. Epub ahead of print. 2006. [PubMed]

Banerjee S., Myung K. Increased genome instability and telomere length in the elg1-deficient S. cerevisiae mutant are regulated by S-phase checkpoints. Euk. Cell, 6:1557-66. 2004. [PubMed]

Motegi A, Liaw H, Lee K, Roest H, Maas A, Moinova H, Markowitz S, Ding H, Hoeijmakers J, Myung K. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc. Natl. Acad. Sci. USA, 105:12411-12416. 2008. [PubMed]

Sikdar N., Banerjee S., Han Z., Smith S., Myung K. Spt2 defines a new transcription-dependent gross chromosomal rearrangement pathway. PLos Genet, 4(12):e1000290. 2008. [PubMed]

Sikdar N., Banerjee S., Lee K., Wincovitch S., Pak E., Dutra A., and Myung K. DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle, 8:3199-3207. 2009. [PubMed]

Yan Z, Delannoy M, Liang C, Daee D, Osman F, Oostra A, Du H, Lin T, Schuster B, Decaillet C, Stasiak A, Stasiak A, Woodcock C, Stone S, Hoatlin M, Schindler D, Joenje H, Sen R, de Winter J, Whitby M, Myung K, Constantinou A, Wang W. A histone-fold complex and FANCM constitute a DNA remodeling complex to maintain genome stability. Mol. Cell, 37:865-878. 2010. [PubMed]

Lee K-Y, Yang K, Cohn M, Sikdar N, D'Andrea A, Myung K. Human ELG1 regulates the level of ubiquitinated PCNA through its interaction with PCNA and USP1. J. Biol. Chem, 285:10362-103. 2010. [PubMed]

Liaw H, Lee D, and Myung K. DNA-PK dependent RPA2 phosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS One, 6:e21424. 2011. [PubMed]

Bell D, Sikdar N, Lee K-Y, Price J, Chaterjee R, Park H-D, Fox J, Ishiai M, Rugg ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan C, NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J, Sipahimalani P, Godwin AK, Sgroi DC, Merino MJ, Elliott G, Elkahloun A, Vinson C, Takata M, Mullikin JC, Wolfsberg TG, Hieter P, Lim D-S, and Myung K. Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genetics, 7:e1002245. 2011. [PubMed]

Fox J, Lee K-Y, and Myung K. Dynamic regulation of PCNA ubiquitylation/deubiquitylation. FEBS Letter, 585:2780-2785 .2011. [PubMed]

Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, Tice R, Austin C, and Myung K. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci, 109:5423-5428. 2012. [PubMed]

Daee D, Ferrari E, Logerich S, Branzei D, Sung P, and Myung K. Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM homolog Mph1. J. Biol. Chem., 287:26563-26575. 2012. [PubMed]

Fox J. and Myung K. Cell-based high-throughput screens for the discovery of chemotherapeutic agents. Oncotarget, 3:581-585. 2012. [PubMed]

Lee K-Y, Fu, H, Aldjem, M, Myung K. ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin. J. Cell Biol., 200:31-44. 2013. [PubMed]

Smith S, Fox J, Mejia M, Ruangpradit W, Saberi A, Kim S, Choi Y, Oh S, Wang Y, Choi K, Li L, Hendrickson E, Takeda S, Muller M and Myung K. Histone Deacetylase inhibitors synergize with defects in DNA repair to kill cancer cells. PLoS One, 9(1):e87203.  2014. [PubMed]

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Last Updated: July 10, 2014