National Human Genome Research Institute

National Human Genome Research Institute

Director's Report Related Documents: September 2005

Ethics/Conflict of Interest

• Summary of NIH-Specific Amendments to Conflict of Interest Ethics Regulations [nih.gov]
  

Requests for Information (RFI)/Notices (NOT)

• Request for Information: Comments on the Identification of Mendelian Disorders by Genomic Sequencing [grants1.nih.gov]
• Notice of Intent to Publish Four Requests for Applications (RFAs) for Knockout Mouse Project (KOMP) [grants1.nih.gov]

Sequencing Status update

• Current Mechanism Table
• News Release: NHGRI Selects 13 New Targets For Large-Scale Sequencing Program

Large-Scale Sequencing Concept Clearance

• Large-Scale Sequencing Concept Clearance, September 2005 National Advisory Council for Human Genome Research
  September 12-13, 2005

Sequencing Meetings

• Workshop on the Future of the Large-Scale Sequencing Program
  June 13, 2005

Chimp Genome Analysis Published

• News Release: New Genome Comparison Finds Chimps, Humans Very Similar at the DNA Level
  
  
• Initial sequence of the chimpanzee genome and comparison with the human genome
  Nature, September 2005

$1000 and $100,000 Genome Sequencing Technology Grants Awarded

• News Release: NHGRI Expands Effort to Revolutionize Sequencing Technologies

New, Superfast Sequencing Methods

• Genome sequencing in microfabricated high-density picolitre reactors [nature.com]
• Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome [sciencemag.org]
• Cut-Rate Genomes on the Horizon?
• Superfast DNA sequencing [usnews.com]

NCI/NHGRI Collaboration on Cancer Sequencing Meeting

• Tackling the Cancer Genome [sciencemag.org]

Multi-Species Genome Comparisons

• News Release: Multi-Species Genome Comparison Sheds New Light On Evolutionary Processes, Cancer Mutations
• Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps [sciencemag.org]
  

Anti-Cancer Drugs May Hold Promise for Progeria

• News Release: Anti-Cancer Drugs May Hold Promise for Premature Aging Disorder
  
• Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
• Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
• Inhibiting farnesylation of progerin prevents the characteristic characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

Action Items of Interest

• NIH puts cash behind national screening network
• Research Policy Alert

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