Pamela Schwartzberg, M.D., Ph.D., senior investigator in the Genetic Disease Research Branch of the National Human Genome Research Institute (NHGRI), is a 2008 inductee into the Association of American Physicians (AAP). Her induction into the AAP took place at the organization's annual meeting in Chicago, April 25-27, 2008. She also was the recipient in April 2008 of the AAI-BD Biosciences Investigator Award from the American Association of Immunologists.
Dr. Schwartzberg is a head of the Cell Signaling Section, where she conducts a first-rate research program in the broad field of T-cell signaling. Her investigations utilize genetic and biochemical approaches to dissect signaling pathways in T cells and determine the roles these pathways play in lymphocyte development and function.
Her research group generates mouse models that lack genes affecting a variety of signaling molecules to see how the loss of a particular gene affects the immune system. They have generated mouse models lacking genes involved in or related to several primary human immunodeficiency syndromes. Their studies aim to help explain what is going wrong in human immune diseases, to advance basic scientific understanding of immune system function in general and to identify likely pathways for therapeutic developments.
The AAP was founded in 1885 and is the preeminent organization of U.S. physician scientists. Its distinguished membership includes seven previous NHGRI inductees. The organization is widely regarded as an influential forum for the generation and dissemination of biomedical knowledge, with a membership that includes Nobel laureates and members of the National Academy of Sciences and the Institute of Medicine.
Last Reviewed: February 28, 2012