The purpose of this study is to learn more about how microbes on your child's skin (e.g. bacteria, yeast, viruses) interact with each other and with their human host to contribute to health and disease.
We would like to enroll children who have a very common skin condition called Atopic Dermatitis (AD), also known as eczema. Specifically, we are seeking children with moderate to severe AD.
We would also like to compare the microbes on the skin of children with moderate/severe AD to that of healthy volunteers' of the same age, who do not have AD.
Lastly, we wish to study the microbes on the skin of children and adults who have been diagnosed with primary immune disorders known as HIES (hyperimmunoglobulin-E syndrome), WAS (Wiskott-Aldrich syndrome) and DOCK8 immunodeficiency, because they frequently have skin problems similar to AD.
If eligible, we will review your child's medical history and perform a skin examination. We will draw some blood, usually only on the first visit. Children will have their skin swabbed and/or scraped; and their noses swabbed.
We will also ask your child to return periodically to the NIH for additional skin and nasal sampling. We hope that the results of this research will advance the way we prevent, diagnose, and treat AD and similar skin diseases.
Eligible children will be compensated in accordance with NIH policy.
Last Reviewed: April 19, 2012