From Genome Function to Biomedical Insight: ENCODE and Beyond

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March 10-11, 2015

Natcher Conference Center
Building 45, Room E1/E2
NIH Campus
Bethesda, Md.

On March 10-11, 2015, the National Human Genome Research Institute (NHGRI) sponsored the workshop - From Genome Function to Biomedical Insight: ENCODE and Beyond - at the Natcher Conference Center on the NIH main campus.

The objectives of the workshop were to:

  1. Discuss the scientific questions and opportunities for better understanding genome function and applying that knowledge to basic biological questions and disease studies through large-scale genomics studies.
  2. Consider options for future NHGRI projects that would address these questions and opportunities.
 
Printable Agenda PDF file
Functional Genomics Workshop Report PDF fileNew
View workshop videos and slides from March 10 March 11

Tuesday, March 10, 2015

Time Topic Moderator/Presenter
1:00 p.m. Welcome and Setting the Context
YouTube video Video
Eric Green
1:15 p.m. Purpose of Workshop: Background and Planning Process for Future Initiatives
YouTube video Video | Slides PDF file
Elise Feingold
1:35 p.m. From Genome Function to Biomedical Insights: Defining the Scientific Challenges
YouTube video Video | Slides PDF file
Ewan Birney
2:05 p.m. Discussion
2:30 p.m. Break
3:00 p.m. Genome Function circa 2016: Updates from Related Projects
YouTube video Video | Slides PDF file
Moderator: Daniel Gilchrist
ENCODE
YouTube video Video | Slides PDF file
Michael Snyder
REMC/IHEC/BLUEPRINT
PsychENCODE
Genomics of Gene Regulation (GGR)
4D Nucleome
FunVar
YouTube video Video | Slides PDF file
Michael Pazin
FANTOM
GTEx
LINCS
TCGA/ICGC
KOMP2/IMPC
YouTube video Video | Slides PDF file
Daniel Gilchrist
4:00 p.m. Proposals for Future Directions
ENCODE PIs' Vision for Functional Genomics
YouTube video Video | Slides PDF file
Joseph Ecker
Recommendations related to genome function from NHGRI's
Planning Workshop on the Future Opportunities
for Genome Sequencing and Beyond
YouTube video Video (Gerstein) | Slides PDF file(Gerstein)
YouTube video Video (Myers) | Slides PDF file(Myers)
Mark Gerstein
Richard Myers
5:00 p.m. General Discussion
YouTube video Video
6:00 p.m. Working Dinner
Topic #1: Identifying and Characterizing Functional Elements
Moderator: Carol Bult
7:00 p.m. Introduction
YouTube video Video
Elise Feingold
The regulatory landscape: where are the gaps?
YouTube video Video | Slides PDF file
Ross Hardison
7:30 p.m. ENCODE 2020: improving the syntax for understanding functional elements in the genome
YouTube video Video | Slides PDF file
Laurie Boyer
7:45 p.m. Creating a framework for mechanistic studies
YouTube video Video | Slides PDF file
B. Franklin Pugh
8:00 p.m. Genomics at the "quantum" level: new directions for genomic data generation and functional validation
YouTube video Video | Slides PDF file
William Greenleaf
8:15 p.m. Topic #1 General Discussion
YouTube video Video
9:00 p.m. Adjourn

 

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Wednesday, March 11, 2014

Time Topic Moderator/Presenter
Topic #2: Using Genomic Assay of Function to Interpret the Role of Genetic Variation
Moderator: Eric Boerwinkle
8:00 a.m. Introduction
YouTube video Video
Eric Boerwinkle
Hirschsprung disease consequent to mutations in the RET gene regulatory network
YouTube video Video | Slides PDF file
Aravinda Chakravarti
8:25 a.m. Leveraging whole genome annotation for genotype-phenotype association studies
YouTube video Video
Eric Boerwinkle
8:50 a.m. Genetically predicted endophenotypes: getting to the next level in understanding how genome variation drives disease
YouTube video Video | Slides PDF file
Nancy Cox
9:05 a.m. Identification of regulatory variation important for maternal metabolism during pregnancy
YouTube video Video | Slides PDF file
William Lowe
9:20 a.m. Topic #2 General Discussion
YouTube video Video
10:05 a.m. Break
10:15 a.m. Ewan Birney Announcement
YouTube video Video
Eric Green
Topic #3: Using Genomic Assays of Function to Study Basic Biological Questions
Moderator: Aviv Regev
10:30 a.m. Introduction
YouTube video Video
Aviv Regev
Understanding basic biology using functional genomics: solving the genotype-phenotype problem
YouTube video Video | Slides PDF file
Brenda Andrews
10:50 a.m. Fundamental insights into gene regulation from genomic analyses: past successes and future challenges
YouTube video Video | Slides PDF file
Karen Adelman
11:10 a.m. Analyzing cytosine modifications in genomic DNA
YouTube video Video | Slides PDF file
Anjana Rao
11:30 a.m. Ask not what you can do for ENCODE - ask what ENCODE can do for you
YouTube video Video | Slides PDF file
John O'Shea
11:50 a.m. Topic #3 General Discussion
YouTube video Video
12:30 p.m. Lunch
1:30 p.m. Discussion
YouTube video Video
Moderators: Eric Boerwinkle, Carol Bult, Aviv Regev
2:30 p.m. Final Recommendations, Including Priorities and Balance of Activities
YouTube video Video | Slides PDF file
Jeff Schloss
3:30 p.m. Adjourn

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Last Updated: April 15, 2015