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NIH

Integrating Genomic Sequencing into Clinical Care: CSER and Beyond

September 28, 2015

DoubleTree by Hilton Hotel Bethesda - Washington D.C.
8120 Wisconsin Ave.
Bethesda, Md. 20814

Doctor with Patient On September 28, 2015, the National Human Genome Research Institute (NHGRI) sponsored the Integrating Genomic Sequencing into Clinical Care: CSER and Beyond meeting at the DoubleTree by Hilton Hotel in Bethesda, Md.

The objectives for the meeting were:

  1. To summarize and evaluate key scientific contributions of the Clinical Sequencing Exploratory Research (CSER) Program.
  2. To identify and prioritize scientific opportunities and questions for the next 5-10 years that would address informed integration of genomic sequencing into clinical care.
  3. To identify optimal organizational features of a potential follow-up program.
Workshop Report PDF file
Tweets from the Meeting: #CSERandBeyond PDF file
Printable Agenda PDF file
CSER Background DocumentPDF file

Schedule of Events

Time Topic Presenters/Moderators
Opening Remarks
8:15 - 8:30 a.m. Call to Order and Introductions
YouTube video Video
Lucia Hindorff
8:30 - 8:50 a.m. Setting the Context
(15-minute presentation, 5-minute Q&A)
YouTube video Video | Slides PDF file
Eric Green
8:50 - 9:05 a.m. NHGRI's Genomic Medicine Portfolio
(10-minute presentation, 5-minute Q&A)
YouTube video Video | Slides PDF file
Teri Manolio
9:05 - 9:15 a.m. Recommendations from NHGRI's 2014 Workshop: Future Opportunities for Genome Sequencing & Beyond
YouTube video Video | Slides PDF file
Carolyn Hutter
9:15 - 9:40 a.m. CSER: Veni, Vidi and Roadmap to Vici
(20-minute presentation, 5-minute Q&A)
YouTube video Video | Slides PDF file
Katrina Goddard
9:40 - 9:50 a.m. NHGRI perspective on CSER and Overview of Meeting Topics
YouTube video Video | Slides PDF file
Lucia Hindorff
Presentations and Discussion
All topics below include consideration of relevant ELSI issues.
9:50 - 10:40 a.m. Facilitating Development of a Shared Evidence Base for Healthcare Systems
YouTube video Video (Rehm) | Slides PDF file(Rehm, Masys and Roden)

YouTube video Video (Masys)

YouTube video Video (Group Discussion)

YouTube video Video (Roden)
Moderators: Dan Roden, Ian Krantz
Challenges/Opportunities: Heidi Rehm (10 minutes)
Reaction: Dan Masys (10 minutes)
Group Discussion (25 minutes)
Summary: Dan Roden (5 minutes)
10:40 - 11:00 a.m. Break
11:00 - 11:50 a.m.

Interpreting Variants / Actionability

YouTube video Video | Slides PDF file (Jarvik)

YouTube video Video | Slides PDF file (Lyon)

YouTube video Video (Group Discussion)

YouTube video Video (Leonard)
Moderators: Debra Leonard, Levi Garraway
Challenges/Opportunities: Gail Jarvik (10 minutes)
Reaction: Elaine Lyon (10 minutes)
Group Discussion (25 minutes )
Summary: Debra Leonard (5 minutes)
11:50 a.m. - 12:40 p.m. Assessing Clinical Utility
YouTube video Video | Slides PDF file (R. Green)

YouTube video Video | Slides PDF file (Ashley)

YouTube video Video (Group Discussion)

YouTube video Video (Relling)
Moderators: Mary Relling, Arul Chinnaiyan
Challenges/Opportunities: Robert Green (10 minutes)
Reaction: Euan Ashley (10 minutes)
Group Discussion (25 minutes)
Summary: Mary Relling (5 minutes)
12:40 - 1:10 p.m. Working Lunch (Pick up Lunches)
1:10 - 2:00 p.m. Patient-centered Research: From Consent to Outcomes
YouTube video Video | Slides PDF file (Joffe)

YouTube video Video | Slides PDF file (Might)

YouTube video Video (Group Discussion)

YouTube video Video (Hughes Halbert)
Moderators: Chanita Hughes Halbert, Ben Wilfond
Challenges/Opportunities: Steve Joffe (10 minutes)
Reaction: Matt Might (10 minutes)
Group Discussion: 25 minutes
Summary: Chanita Hughes Halbert (5 minutes)
2:00 - 2:50 p.m. Increasing Ancestral, Socionomic and Clinical Diversity
YouTube video Video | Slides PDF file (Evans)

YouTube video Video | Slides PDF file(Bustamante)

YouTube video Video (Group Discussion)

YouTube video Video (Ossorio)
Moderators: Pilar Ossorio, Greg Cooper
Challenges/Opportunities: Jim Evans (10 minutes)
Reaction: Carlos Bustamante (10 minutes)
Group Discussion (25 minutes)
Summary: Pilar Ossorio (5 minutes)
2:50 - 3:40 p.m. Healthcare Utilization, Economics and Value
YouTube video Video | Slides PDF file(Veenstra)

YouTube video Video | Slides PDF file(Deverka)

YouTube video Video (Group Discussion)

YouTube video Video (Armstrong)
Moderators: Katrina Armstrong, Sharon Plon
Challenges/Opportunities: Dave Veenstra (10 minutes)
Reaction: Pat Deverka (10 minutes)
Group Discussion (25 minutes)
Summary: Katrina Armstrong (5 minutes)
3:40 - 4:00 p.m. Break
4:00 - 5:30 p.m. Meeting Summary and Prioritizing Future Opportunities in the Next 5-10 Years
(15 minutes for summary slides, 75 minutes for moderated discussion)
YouTube video Video | Slides PDF file (Hindorff and Hutter)

YouTube video Video (Nussbaum/Ohno-Machado)
Summary Slides: Lucia Hindorff and Carolyn Hutter

Moderators: Robert Nussbaum and Lucila Ohno-Machado
5:30 - 5:45 p.m. Closing Comments
YouTube video Video
Eric Green
5:45 p.m. Adjourn

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Last Updated: December 7, 2015