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Genomic Medicine X: Research Directions in Pharmacogenomics Implementation 

Pharmacogenomics On May 2-3, 2017, the National Human Genome Research Institute (NHGRI) sponsored its 10th Genomic Medicine meeting - Genomic Medicine X: Research Directions in Pharmacogenomics Implementation  - at the Sheraton Silver Spring Hotel in Silver Spring, Maryland.

The objectives of the meeting were to:

  • Survey national landscape of research programs in pharmacogenomics implementation
  • Review current advances and clinical applications of pharmacogenomics
  • Discuss limitations and obstacles in pharmacogenomics clinical implementation
  • Identify evidence gaps and studies that are needed to address them
  • Design strategies for large-scale evaluation and implementation of pharmacogenomics in clinical care in the United States.
     

Meeting Summary PDF file

Executive Summary PDF file

Tweets from the meeting: #GenomicMed10 PDF file

GOLDILOKs Study: Patient Booklet PDF file

Tuesday, May 2, 2017

Time Topic Speaker
8:00 a.m. Breakfast  
8:30 a.m. Welcome, Opening Remarks, General Updates Teri Manolio
NIH/NHGRI
8:45 a.m. Announcements, Opening Remarks
VideoSlides
Mary Relling
(Organizing Committee Chair)
St. Jude Children's Research Hospital
Session 1: The PGx Landscape - Overview of Ongoing Projects; Success Stories and Lessons Learned

Moderator: Howard Jacob
HudsonAlpha Institute for Biotechnology
9:00 a.m. Angela's Story - Why Pharmacogenetics Matters
VideoSlides
Guest Speaker: Paul Anderson
9:20 a.m. Exploiting Pharmacogenetic Discovery to Improve Patient Care: Why Aren't We There Yet?
VideoSlides
Keynote Speaker: Dan Roden
Vanderbilt University
9:50 a.m. NIH Supported PGx Research
VideoSlides

Simona Volpi
NIH/NHGRI

10:10 a.m. Discussion on Session 1
Video
10:20 a.m. Break
Session 2: Resources for PGx Implementation

Moderator: Geoff Ginsburg
Duke University
10:40 a.m. CPIC, Clinical Pharmacogenetics Implementation Consortium and PharmGKB
VideoSlides
Mary Relling
St. Jude Children's Research Hospital
11:00 a.m. ClinGen, Clinical Genome Resource and ClinVar, Clinical Variant Resource
VideoSlides
Heidi Rehm
ClinGen-Partners
11:20 a.m. DiGITizE, Displaying and Integrating Genetic Information Through the EHR
VideoSlides
Sandy Aronson
Partners
11:40 a.m. PharmCAT, Pharmacogenomic Clinical Annotation Tool
VideoSlides

Marylyn Ritchie
Geisinger Health System

12:00 p.m. Discussion on Session 2
Video
 
1:00 p.m. Working Lunch
Session 3: Implementation Research Projects

Moderator: Marc Williams
Geisinger Health System
1:30 p.m. Exceptional Responders Study
VideoSlides
Nikhil Wagle
Dana-Farber Cancer Institute
1:50 p.m. INdiana GENomics Implementation: an Opportunity for the UnderServed
VideoSlides
Todd Skaar
Indiana University
2:10 p.m. PGx Implementation Research Programs at Northwestern
VideoSlides
Minoli Perera
Northwestern
2:30 p.m. PGx Implementation at Mission Health System
VideoSlides
Lynn Dressler
Mission Health System
2:50 p.m. PGx Implementation Research Programs at Vanderbilt
VideoSlides
Josh Denny
Vanderbilt University
3:10 p.m. Discussion on Session 3
Video
4:10 p.m. Break
4:30 p.m.

Panel Discussion: Research Gaps to be Addressed

Dick Weinshilboum - Mayo Clinic
Mary Relling - St. Jude Children's Research Hospital
Micheline Piquette-Miller - University of Toronto
Julie Johnson  - University of Florida
Steve Leeder - Children's Mercy
John Wilson - Optum

Video
Moderator: Rex Chisholm
Northwestern University

 
6:00 p.m. Meeting Adjourn

Wednesday, May 3, 2017

Time Topic Speaker
8:00 a.m. Breakfast  
Session 4: Evaluating Outcomes and Cost-effectiveness

Moderator: Patricia Deverka
American Institutes for Research
8:30 a.m. eMERGE-PGx
VideoSlides
Laura Rasmussen-Torvik
Northwestern University
8:50 a.m. Addressing Knowledge Deficits in Pediatric PGx:
The GOLDILOKs Initiative at Children's Mercy Hospital 
VideoSlides
Steve Leeder
Children's Mercy Kansas City
9:10 a.m. Clopidogrel
VideoSlides
Larisa Cavallari
University of Florida
9:30 a.m. Pragmatic Application of Economic and Cost-effectiveness Analysis: Examples from Genomic Medicine Implementation Projects
VideoSlides
Marc Williams
Geisinger Health System
9:50 a.m. Discussion for Session 4
Video
10:50 a.m. Break
Session 5: Multidisciplinary Approaches and Training PGx Practitioners

Moderator: Carol Bult
The Jackson Laboratory
11:10 a.m. Multidisciplinary Approaches and Training PGx Practitioners at the University of Florida
VideoSlides
Kristin Weitzel
University of Florida
11:30 a.m. The Inter-Society Coordinating Committee (ISCC) and Training PGx Practitioners
VideoSlides
Robert Wildin
NIH/NHGRI
11:50 a.m. Multidisciplinary Approaches and Training PGx Practitioners at Moffitt
VideoSlides

Howard McLeod
Moffitt Cancer Center

12:10 p.m. Pick up Lunch & Return to Session
12:30 p.m. Discussion for Session 5
Video
Session 6: Role of NHGRI and the Genomic Medicine Community in PGx Implementation Research

Moderator: Laura Rodriguez
NIH/NHGRI
1:30 p.m. Summary and Synthesis
 
VideoSlides
Teri Manolio
NIH/NHGRI

Mary Relling
St. Jude Children's Research Hospital
2:30 p.m. Next Steps
3:00 p.m. Meeting Adjourn

Last Updated: June 15, 2017