The following are research areas of interest that have been identified by the participating ICs. Program Officer contact information is also included.
The NHGRI is interested in research in the three research domains outlined above that addresses:
This includes basic normative and conceptual research and the generation of data and development of tools that can be applied across many different diseases and conditions. Projects focused on a single disease or disorder may be of lower priority for NHGRI unless generalizability is clearly shown.
Nicole Lockhart (Genetic and Genomic Research)
Dave Kaufman (Genetic and Genomic Healthcare)
Joy Boyer (Broader Societal Issues)
The NCI is interested in research that focuses on the ethical, legal and social issues related to cancer and genomics. In particular, the NCI is interested in the following:
The ultimate goal of this research will be to understand how people make sense of and act upon genetic and genomic information related to cancer; to inform the ethical conduct of cancer research involving genetic and genomic information and data; and overall to improve outcomes related to cancer.
National Cancer Institute (NCI)
The National Institute on Aging (NIA) is interested in research that focuses on the ethical, legal and social issues related to aging and genomics. Examples of topics of particular interest include: research on the anticipated and actual impact of genetic and genomic information; studies on ethical, regulatory and policy challenges in aging research (such as clinical trials, population-based studies) incorporating genetic and genomic technologies; issues raised by the collection, storage and use of biological samples and associated data; studies that incorporate and investigate the perspectives of diverse communities; and studies on models of participant and community engagement or participatory research in aging research. The ultimate goal of this research will be to understand how people make sense of and act upon genetic and genomic information related to aging and diseases of aging; to inform the ethical conduct of aging research involving genetic and genomic information and data; and overall to improve outcomes related to aging and diseases of aging.
National Institute on Aging (NIA)
The NIAID has specific interest in research that addresses a range of social, ethical and legal issues for individuals and communities related to genetic and genomic research involving infectious disease, allergy, autoimmune disorders and transplantation. Examples of topics of particular interest in these areas include issues in research on human genetic determinants of infectious disease transmission, in the US or in international settings, research on stakeholder views (including IRB or ethics committees, community members, and others) or community consultation, and research related to the return of genetic research results in resource limited settings.
National Institute of Allergy and Infectious Diseases (NIAID)
The NIDCD is interested in addressing ethical, legal and social issues, related to normal and disordered processes, that evolve from genomic research in our mission areas of hearing, balance, taste, smell, voice, speech, and language.
National Institute on Deafness and Other Communication Disorders (NIDCD)
The NIEHS is interested in addressing social, ethical, and legal concerns of the public in research endeavors related to gene-environment interactions, environmental health hazards, genetic susceptibility to environmental exposures and ELSI issues related to research involving children, aged populations, tribal communities and other vulnerable populations impacted by specific environmental exposures. In particular, NIEHS has an interest in supporting collaborations between scientists and the public for the development of culturally appropriate translations of the scientific findings of research on complex, environmentally-relevant diseases, as well as assessment of the comprehensibility and effectiveness of educational interventions used (i.e., whether they raise environmental health literacy). NIEHS is additionally interested in research on the bioethical issues related to ownership of biosamples collected in environmental health studies, data sharing requirements when it involves data derived from tribal-based environmental health studies, or stigma associated with identification of genetic conditions that put individuals at greater risk from environmental exposures.
National Institute of Environmental Health Sciences (NIEHS)
The NINDS is particularly interested in applications which address subjects relevant to its core mission, and the subjects and disorders which it serves as a primary lead at the NIH, see http://www.ninds.nih.gov/about_ninds/mission.htm.
National Institute of Neurological Disorders and Stroke (NINDS)
Minority and health disparities populations are underrepresented in genomic research with fewer than 4% of genetic association studies conducted in people of non-European descent. Within genetic research, health disparities populations have been subject to bias, discrimination and racism and experienced group harms from interpretation of genetic findings. Further, minority and health disparities populations often have differences in preferences, values, norms and goals for research, health care, and health. NIMHD is interested in supporting research that seeks to understand or address cultural preferences, values and norms to ensure equitable and ethical uptake of the output of genomic research and genomic medicine.
NIMHD is also interested in supporting research that seeks to understand or address mechanisms and pathways that contribute to health disparities in genomic medicine. Health disparities arise through an interplay of multiple factors such as genetic, cultural, and structural operating at multiple levels e.g., individual, family/household, community, built environment, and healthcare factors.
The research must focus on one or more U.S. minority or health disparity populations (African Americans/Blacks, Hispanics/Latinos, American Indians/Alaska Natives, Asians, Native Hawaiians and Other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minority populations). Research may use available secondary data, health system data and/or collection of primary data.
Advance understanding of self-identified race and ethnicity (SIRE) and ancestry informative markers (AIMs) in genomics and biomedical research to enhance ability to describe research participants' diverse backgrounds and experiences in scientifically and socially meaningful ways.
Nancy L. Jones
National Institute on Minority Health and Health Disparities (NIMHD)
The Fogarty International Center (FIC) is interested in supporting research on ethical issues related to human genome research relevant to low and middle income countries, in particular, studies conducted by investigators in these countries.
Fogarty International Center (FIC)
Posted: June 28, 2017