Skip Navigation

The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-Space (AnVIL)


The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) is a scalable and interoperable resource for the genomic scientific community, that leverages a cloud-based infrastructure for democratizing genomic data access, sharing and computing across large genomic, and genomic related, data sets. The AnVIL will facilitate integration and computing on and across large datasets generated by NHGRI programs, as well as initiatives funded by the National Institutes of Health (NIH), or by other agencies that support human genomics research.

In addition, the AnVIL will be a component of the emerging NIH Data Commons, and is expected to collaborate and integrate with other genomic data resources through the adoption of the FAIR (Findable, Accessible, Interoperable, Reusable) principles, as their specifications emerge from the scientific community. The AnVIL will provide a collaborative environment where datasets and analysis workflows can be shared within a consortium, and be prepared for public release to the broad scientific community through AnVIL user interfaces. 

Specifically, the AnVIL resource will provide genomic researchers with the following key elements:  
  •  Cloud-based infrastructure and software platform
  •  Shared analysis and computing environment 
  •  Participation in a federated genomic data commons ecosystem 
  •  Cloud services cost control 
  •  Genomic datasets, phenotypes and metadata 
  •  Data access and data security 
  •  User training and outreach 
  •  Incorporation of scientific and technology advance for storing, accessing, sharing and computing on large genomic datasets

This website supplements the information in RFA-HG-17-011. Applicants are encouraged to closely review the information on this page and in the RFA while developing their application. 

AnVIL Related Information

Funding Opportunity Announcement (FOA)

Details regarding the AnVIL FOA can be viewed by clicking the link below:

The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-Space (AnVIL)

Note: Applicants are encouraged to thoroughly review the RFA-HG-17-011 before applying.

Key Dates:

  • Due date for Letters of Intent: October 10th, 2017
  • Final date for application submission: November 9th, 2017


  • An informational webinar related to the AnVIL FOA is being developed. Please check back here for further details.

Frequently Asked Question

Are For Profit entities eligible to submit an application in response to the RFA-HG-17- 011?

Yes, For Profit and Small Business entities are eligible to apply to this RFA. 

Is an applicant eligible for RFA-HG-17-011 if it will be able to achieve one, two, or three, but not all the goals of the AnVIL?

No, the applicant is expected to address all the goals in the RFA-HG-17-011. 

Can applicants submit a budget that is over the amount listed in the RFA-HG-17-011?


Is the intention of the AnVIL resource to host multiple copies of selected datasets?

No, the intention of the AnVIL is not to host multiple copies of selected datasets. Rather, the AnVIL will host some selected datasets as a foundation on which AnVIL users can conduct analyses or add data or develop derived datasets of broad interest to the community. The AnVIL will also provide tools and services to access and compute on datasets that reside on other cloud based platforms.  

Are letters of support mandatory in responding to the RFA-HG-17-011?

Letters of support are not mandatory for this RFA but are encouraged as evidence of the applicants' experience in providing resources to the community and the applicants' expertise in developing and managing cloud-based genomics resources.

Are letters of Intent a requirement in responding to the RFA-HG-17-011?

Letters of intent are not mandatory but are strongly encouraged for this RFA.

Can figures and tables be used in the summary and budget section?

Yes, however applicants must adhere to the page limits as stated in Page Limitation section of the RFA-HG-17-011.

Will the AnVIL resource be responsible for moving datasets to other repositories?

Applicants should anticipate having to move datasets into other repositories.  However, the final decision will be based on guidance from NHGRI staff, and the AnVIL advisory committees identified in the RFA-HG-17-011.

Will only the datasets listed in RFA-HG-17-011 be included for the federated data commons systems?

Applicants are required to propose datasets they believe are appropriate for populating the AnVIL resource. However, final determination of datasets integrated into AnVIL resource will be made by NHGRI staff and the AnVIL advisory committees. 

Should all security certification proposed in response to the RFA-HG-17-011 be in place prior to an award being issued?

Yes, applicants should have all proposed security certification in place prior to an award being issued.

Are awardees expected to work with cloud providers that are not part of their original application package?

Yes, awardees should anticipate having to work with cloud providers that are not part of their original application. The software platform supporting the AnVIL should be cloud provider agnostic, and easily portable across cloud platforms.

As the project is scheduled to start July 2018, is the grantee expected to spend out funds allocated for FY18 by the end of the fiscal year in September 2018?

FY18 funds can used for a 12-month project period ending in FY19.

Does the foreign component prevents any work performed by people affiliated with foreign institutions, or may grantees consider foreign experts to support parts of the development of the AnVIL?

Applicants must ensure effort(s) provided by foreign organizations are not providing significant scientific contribution to the project. Examples of significant scientific contributions, as outlined under the definition of foreign components, can be found at the NIH Grants Policy Statement.  Consultants would generally be allowed unless the involvement of the consultant would be considered as an Other Significant Contributor. Please see Professional Services Costs in the NIH Grants Policy Statement Selected Items of Cost for more information.

Contact Information

For AnVIL related comments or questions please contact NHGRI at:


Posted: August 4, 2017