NHGRI AnVIL Webinar Q&A Session
Yes, For Profit and Small Business entities are eligible to apply to this RFA.
No, the applicant is expected to address all the goals in the RFA-HG-17-011.
Applicants must ensure effort(s) provided by foreign organizations are not providing significant scientific contribution to the project. Examples of significant scientific contributions, as outlined under the definition of foreign components, can be found at the NIH Grants Policy Statement. Consultants would generally be allowed unless the involvement of the consultant would be considered as an Other Significant Contributor. Please see Professional Services Costs in the NIH Grants Policy Statement Selected Items of Cost for more information.
No - Please refer to the answer to the question above for more information.
The NHGRI AnVIL aims to facilitate genomic data access by the broad scientific community, integration and computing on and across large datasets generated by NHGRI programs, using a cloud based infrastructure.
The NIH launched the Data Commons Pilot Phase (DCPP) to test ways to store, access and share FAIR biomedical data and associated tools in the cloud (https://commonfund.nih.gov/bd2k/commons). The AnVIL is expected to coordinate with the activities of the DCPP Consortium with respect to data and tools provided to the scientific community.
If computing can be easily ported across cloud service providers then there will be no need to copy or move data from the Data Commons into the AnVIL and vice versa. If there is a significant performance bottleneck, then there may be a need to move or copy data across the systems. Decisions will be made based on the evaluation of the technical challenges and costs.
NHGRI aims to take advantage of the expected decreased costs of cloud services and the competition in the market place of cloud vendors.
NHGRI will not be billing the users of the cloud services of the AnVIL. Applicants should propose how they plan to develop and implement a billing system for the use of the cloud's storage and computing resources of the AnVIL.
Matching or cost sharing with cloud vendors is permissible. The details of the applicant's agreement with the cloud vendor should be described in your proposal. The awardee will be responsible for administering the cost sharing agreement and for alerting NHGRI immediately should the terms of the agreement change over the award period. Matching or cost sharing requirements are subject to the same policies governing allowability of other costs under an approved budget.
The proposed budget for cloud costs should include expected storage, computing and egress costs over the award period. Cloud costs will be a significant cost item for the AnVIL, and NHGRI will monitor these costs over the award period.
Yes, awardees should anticipate having to work with cloud providers that are not part of their original application. The software platform supporting the AnVIL should be cloud provider agnostic, and easily portable across cloud platforms.
There is no expectation for the AnVIL to mostly implement existing software. There will likely be projects and activities where implementation of existing software is appropriate and encouraged. New software should be developed as necessary.
The initial proposal for analytical tools and pipelines should come from the applicant and will depend on their proposed datasets. Over the award period, NHGRI in collaboration with the Data Steering Committee and the External Scientific Committee may adjust priorities and/or request the implementation of specific tools/pipelines that were not in initial proposal.
No, the intention of the AnVIL is not to host multiple copies of selected datasets. Rather, the AnVIL will host some selected datasets as a foundation on which AnVIL users can conduct analyses or add data or develop derived datasets of broad interest to the community. The AnVIL will also provide tools and services to access and compute on datasets that reside on other cloud based platforms.
Applicants should anticipate having to move datasets into other repositories. However, the final decision will be based on guidance from NHGRI staff, and the AnVIL advisory committees identified in the RFA-HG-17-011.
Applicants are required to propose datasets they believe are appropriate for populating the AnVIL resource. However, final determination of datasets integrated into AnVIL resource will be made by NHGRI staff and the AnVIL advisory committees.
It is not the intention of NHGRI to host independent datasets from the NIH data commons. Hosting GTEx data is not a requirement for the AnVIL RFA. Please see previous questions regarding datasets for further clarification.
The 30-page limit refers to the research strategy section only.
Letters of support are not mandatory for this RFA but are encouraged as evidence of the applicants' experience in providing resources to the community and the applicants' expertise in developing and managing cloud-based genomics resources.
Letters of intent are not mandatory but are strongly encouraged for this RFA.
Yes, however applicants must adhere to the page limits as stated in Page Limitation section of the RFA-HG-17-011.
There are no specific data security requirements for AnVIL. However, the NIH security best practices and provisions (https://www.ncbi.nlm.nih.gov/projects/gap/pdf/dbgap_2b_security_procedures.pdf) should be implemented to protect the privacy and confidentiality of research participants, and prevent unauthorized access to data. Refer to the RFA, Section 1 "Data security and access" for additional information (https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-17-011.html#_Section_I._Funding)
Yes, applicants should have all proposed security certification in place prior to an award being issued.
NHGRI will select the members of both the Data Steering Committee and the External Scientific Committee.
Please do not identify individuals who you plan on having serve on your proposed advisory committee, nor contact individuals about your proposed advisory committee. This is so you don't unintentionally limit potential individuals for review of applications. Details on a general structure of the proposed advisory committee are okay to include in your application, just no specific names.
FY18 funds can used for a 12-month project period ending in FY19.
Posted: September 22, 2017