On October 17, 2017, the ENCODE Consortium held a workshop at the American Society of Human Genetics (ASHG) annual meeting.
This advanced workshop began with an overview of the ENCODE project. The contents and underlying methods of the human and mouse ENCODE Registry of candidate Regulatory Elements (cRE) followed. Next was a live demo of Search Candidate Regulatory Elements by ENCODE (SCREEN), an online tool that enables users to explore cREs across hundreds of human and mouse cell and tissue types and filter regions by various facets.
Participants used SCREEN to work through hands-on examples focusing on comparing enhancer-like elements across tissues, predicting enhancer-gene interactions, and annotating genetic variants.
Exercises demonstrated how to access and download supporting data, how to visualize regions of interest using dynamic graphs and external genome browsers, and how to compare gene expression profiles, intersect regions and correlate signals for datasets of interest with the ENCODE Encyclopedia.
Workshop attendees received instruction or hands-on experience on the following resources:
This workshop educated researchers, clinicians and genetic counselors on how to use ENCODE data to further biological investigation.
Note: All slides and handouts are in PDF format.
For questions or more information contact:
Zhiping Weng, Ph.D.
Posted: March 28, 2018