A pair of studies from investigators with The Cancer Genome Atlas (TCGA) Research Network has provided new insight into the genomic workings of the deadly types of brain and skin cancer. The findings point to new ways of classifying these cancers based on genomics, which should lead to smarter ways to predict disease behavior and better decisions about treatment. The results were reported in the June 18, online edition of Cell. Read more
Stanford University researchers combined genome sequence data from The Cancer Genome Atlas (TCGA) with data from regulatory regions from the Encyclopedia of DNA Elements (ENCODE) to identify mutations affecting gene activity in cancer. The NHGRI-supported research, published in the June 8th issue of Nature Genetics, suggests that mutations in genome regions that control gene activity may play a significant role in cancer. Read more
Ribonucleic acid (RNA) transmits genetic information from DNA to the cell's protein-producing machinery. RNAs adopt specific physical structures to control when genes are turned on and off. Scientists have now devised a way to view RNA structures in living cells. The new approach, developed at Stanford University with NHGRI support, may greatly improve understanding of gene regulation in biology and medicine.
Read the paper: Structural imprints in vivo decode RNA regulatory mechanisms. Nature, March 18, 2015.
Researchers have linked multiple new regions of the human genome to body mass index (BMI) and fat distribution, according to two studies just published in Nature. Population Architecture using Genomics and Epidemiology Consortium scientists supported by the National Human Genome Research Institute contributed to the studies that may lead to more effective therapeutic targets. Read more at nature.com:
Last Updated: June 24, 2015
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