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Frameshift Mutation

A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.

Date:June 12, 2010
Credit:Darryl Leja, NHGRI
Dimensions:2981 x 1772
File Size:1.2 Mb
Rights:PublicExcept where otherwise noted, this image is in the public domain and may be used, linked or reproduced without permission. If you use an image, please credit the source listed above with a link back to www.genome.gov where possible. Thank you!



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