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2008 National DNA Day Online Chatroom Transcript

This is just one question from an archive of the National DNA Day Moderated Chat held in April 2008. The NHGRI Director and many genomics experts from across NHGRI took questions from students, teachers and the general public on topics ranging from basic genomic research, to the genetic basis of disease, to ethical questions about genetic privacy.


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What is the purpose for chromatin uncoiling and coiling during prophase?
     Pam Schwartzberg, M.D., Ph.D.: We study mouse models of primary immunodeficiencies (genetic diseases that impair the ability of the immune system to fight infections) and how specific disorders affect responses to infectious diseases. Chromatin needs to uncoil during mitosis in order for DNA to replicate. During prophase, chromosomes re-condense in order for them to start the process of separation which will be mediated by centromeres binding to kinetochores via microtubules.
Abbeville High School in SC (12th grade student)


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