A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. A variety of different model organisms are used in this regard, but mice are especially useful because they share mammalian features with humans and suffer from many of the same diseases. A large number of mouse models have been created to target specific human diseases using selective breeding and genetic engineering.
To play the media you will need to either update your browser to a recent version or update your Flash plugin
Scientists have been using animals to help model human diseases for over a hundred years. Mice are particularly useful for this because they have many of the same biological features as humans, as well as having over 80 percent identical genetic components that people have. So therefore, if we have a mouse that models a particular human disease, it becomes very useful for following the progression of the disease from very early after birth to a severe disease state. And it also becomes a model for us to identify what genes are involved in that disease, as well as looking for therapeutic interventions.
William Pavan, Ph.D.
Senior Investigator, Genetic Disease Research Branch; Head, Mouse Embryology Section
Dr. Pavan's laboratory uses genomic tools to study how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a variety of tissues throughout the body. In vertebrate development, neural crest cells form at the top of the neural tube. They then migrate throughout the body to populate the peripheral nervous system and form other tissues. When the genetic machinery that controls neural crest cell development goes awry, it can cause many human diseases, ranging from Waardenburg syndrome to cleft lip and palate.