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Talking Glossary of Genetic Terms

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Julie A. Segre, Ph.D. defines Nucleopore

Nucleopore

noo KLEE uh por

The nucleopore is one of a series of small holes found in the nuclear membrane. The nucleopore serves as a channel used for transporting nucleic acids and proteins into and out of the cell nucleus.

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Nucleopore

The nucleopore is one of a series of small holes found in the nuclear membrane. The nucleopore serves as a channel used for transporting nucleic acids and proteins into and out of the cell nucleus.

Narration Transcription

Nucleopore. Within the nuclear membrane of the cell there are small holes, or pores, that allow the very selective transport of nucleic acids and proteins into and out of the cell nucleus. The material found in the cell nucleus is distinct from the material found in the cytoplasm. And these nucleopores, which are of regulated size, allow for the very selective transport of nucleic acids and proteins into and out of the cell nucleus. We used to think that it was a regulated process of how nucleic acids such as mRNAs moved out of the cell nucleus, and recently we've become more aware that there also is a regulated process by which cells transport proteins and nucleic acids into the nucleus, so this is a dynamic process.


Doctor Profile

Julie A. Segre, Ph.D.

Julie A. Segre, Ph.D.

Occupation
Senior Investigator, Genetics and Molecular Biology Branch; Head, Epithelial Biology Section

Biography
Dr. Segre's research focuses on the dynamic process by which the epidermis maintains a proper balance between proliferation and differentiation. Combining classical genetics techniques and modern genomic tools, her laboratory uses mouse models to investigate the function of novel genes important for in utero human epidermal development, normal wound healing and skin regeneration. The epidermis acts as a barrier to infectious agents and protects against the loss of critical bodily fluids. However, in infants born prematurely, immaturity of the skin places them at great risk of disease and early death.

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