Talking Glossary of Genetic Terms
A peptide is one or more amino acids linked by chemical bonds. The term also refers to the type of chemical bond that joins the amino acids together. A series of linked amino acids is a polypeptide. The cell's proteins are made from one or more polypeptides.
The term "peptides" refers to a series of amino acids linked together. Amino acids are the basic unit that make proteins, and a short series of those--short chain of amino acids--is called a peptide. Peptides are then organized in more complex structures, which are called proteins. And proteins are the building blocks of a cell.
Name: Fabio Candotti, M.D.
Occupation: Senior Investigator, Genetics and Molecular Biology Branch; Head, Disorders of Immunity Section
Biography: Dr. Candotti's laboratory studies the molecular basis of inherited disorders of the immune system in order to develop better treatments for these conditions. Currently, for many inherited immune deficiency disorders, the only available therapeutic option is hematopoietic stem cell transplantation (HSCT), an intensive procedure that carries a number of risks. Dr. Candotti is seeking treatment alternatives to HSCT, focusing on gene replacement approaches. His laboratory is developing gene therapies for two rare immune deficiency syndromes, adenosine deaminase (ADA) deficiency and Wiskott-Aldrich syndrome (WAS).