A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest. Physical maps are used to help scientists identify and isolate genes by positional cloning.
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Physical maps of DNA reflect the location of landmarks across a chromosome. Such landmarks can correspond to functional parts of the DNA, such as genes, or just random non-functional sequences. At a minimum, physical maps depict the relative order of landmarks across a chromosome; more refined physical maps actually indicate the exact distances between adjacent landmarks. Nowadays, very precise physical maps can be constructed based on the actual sequence of a chromosome, which provides exact base pair distances between landmarks.
Eric D. Green, M.D., Ph.D.
Dr. Green's research focuses on three major areas: First, sequencing and comparing targeted stretches of DNA from a wide variety of species en route to unraveling the complexities of genome function; second, developing innovative research tools and technologies for performing genome analysis; and third, identifying and characterizing genes associated with human disease. In his multiple roles as scientific director of NHGRI, chief of the Genome Technology Branch, and director of the NIH Intramural Sequencing Center (NISC), he has fundamental interests in mapping, sequencing, and interpreting vertebrate genomes.