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William Gahl, M.D., Ph.D. defines Cell Membrane (Plasma Membrane)

Cell Membrane (Plasma Membrane)

The cell membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside environment. The cell membrane consists of a lipid bilayer that is semipermeable. The cell membrane regulates the transport of materials entering and exiting the cell.

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Cell Membrane (Plasma Membrane)

The cell membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside environment. The cell membrane consists of a lipid bilayer that is semipermeable. The cell membrane regulates the transport of materials entering and exiting the cell.

Narration Transcription

The plasma membrane, or the cell membrane, provides protection for a cell. It also provides a fixed environment inside the cell, and that membrane has several different functions. One is to transport nutrients into the cell and also to transport toxic substances out of the cell. Another is that the membrane of the cell, which would be the plasma membrane, will have proteins on it which interact with other cells. Those proteins can be glycoproteins, meaning there's a sugar and a protein moiety, or they could be lipid proteins, meaning that there's a fat and a protein. And those proteins which stick outside of the plasma membrane will allow for one cell to interact with another cell. The cell membrane also provides some structural support for a cell. And there are different types of plasma membranes in different types of cells, and the plasma membrane has in it in general a lot of cholesterol as its lipid component. That's different from certain other membranes from within the cell. Now, there are different plants and different microbes, such as bacteria and algae, which have different protective mechanisms. In fact, they have a cell wall outside of them, and that cell wall is much tougher and is structurally more sound than a plasma membrane is.


Doctor Profile

William Gahl, M.D., Ph.D.

William Gahl, M.D., Ph.D.

Occupation
Clinical Director, NHGRI Medical Genetics Branch; Head, Human Biochemical Genetics Section

Biography
Dr. Gahl studies rare inborn errors of metabolism through the observation and treatment of patients in the clinic, and through biochemical, molecular biological and cell biological investigations in the laboratory. His group focuses on a number of disorders, including cystinosis, Hermansky-Pudlak syndrome, alkaptonuria and sialic acid diseases. Dr. Gahl has a long-standing research interest in cystinosis, a lysosomal storage disorder caused by a mutation in the CTNS gene. Over the past two decades, Dr. Gahl's laboratory has elucidated the pathogenesis of this disease and demonstrated the safety and efficacy of cysteamine (²-mercaptoethylamine) therapy, a treatment that depletes cells of cystine.

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