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Division of Genomic Medicine

A Catalog of Published Genome-Wide Association Studies


Update (5/12/15): The NHGRI-EBI GWAS Catalog has moved to the European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) at  http://www.ebi.ac.uk/gwas. Users may now find the new search interface and updated content at this site.  Questions about the GWAS Catalog may be directed to gwas-info@ebi.ac.uk.

Why has the catalog moved to EMBL-EBI?
From September 2010 to the present, delivery and development of the Catalog has been a collaborative project between EMBL-EBI and NHGRI. In March 2015 the Catalog infrastructure moved to EMBL-EBI to enable delivery of an improved user interface, including ontology driven Catalog searching, and new curatorial infrastructure, supporting improved QC processes. Catalog content available through this original GWAS Catalog website was last updated on February 20th 2015 with all previous and updated content available at EMBL-EBI. 


The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog).
Read our recent article from Nucleic Acids Research.

Published Genome-Wide Associations
Credit: Darryl Leja and Teri Manolio, NHGRI; Tony Burdett, Dani Welter, and Helen Parkinson, EBI

 
An archived tab-delimited file of the GWAS Catalog content prior to the EBI transition is available here: Tab Delimited File
 

The genome-wide association study (GWAS) publications in the Catalog include a primary GWAS analysis, defined as array-based genotyping and analysis of 100,000+ pre-QC SNPs selected to tag variation across the genome and without regard to gene content.  GWAS data from published studies which are incorporated into new GWAS analyses are eligible, provided they meet the other criteria.  Studies imputing sequencing data to genotyping arrays are eligible as long as the arrays include sufficient genome-wide coverage so that the post-imputation analysis meets the definition of a GWAS analysis, as described above. The scope of the GWAS Catalog is currently being expanded to include studies of large-scale targeted/non-genome-wide arrays, including the Metabochip, Immunochip and Exome arrays. This is currently in a pilot phase where prioritization of targeted and exome array studies for inclusion in the Catalog is by 1) relevance of the trait analyzed 2) user request.  

How to cite the NHGRI GWAS Catalog:
MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, Junkins H, McMahon A, Milano A, Morales J, Pendlington Z, Welter D, Burdett T, Hindorff L, Flicek P, Cunningham F, and Parkinson H. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Research, 2017, Vol. 45 (Database issue): D896-D901.

For questions or comments about this page, send an e-mail to: gwas_table@mail.nih.gov

 

 

 

 





Notice: The updated Catalog content may now be searched at http://www.ebi.ac.uk/gwas/.

An archived, tab-delimited file of the GWAS Catalog content prior to the EBI transition is available here: Tab Delimited File

Date Added to Catalog (since 11/25/08) First Author/Date/ Journal/Study Disease/Trait Initial
Sample Description
Replication Sample Description Region Reported Gene(s) Mapped Gene(s) Strongest SNP-Risk Allele Context Risk Allele Frequency in Controls P-value
OR or beta-coefficient and [95% CI]
Platform
[SNPs passing QC]
CNV
08/07/13 Wade TD
April 09, 2013
Int J Eat Disord
Genetic variants associated with disordered eating.
Anorexia nervosa 237 European ancestry female cases, 2,287 European ancestry female controls NA 10q23.1 GRID1 GRID1 rs76765968-T intron 0.856 2 x 10-6 .064 [0.037-0.091] unit decrease Illumina
[6,150,213] (Imputed)
N
06/06/13 Wu JH
January 29, 2013
Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Stearic acid (18:0) plasma levels 8,961 European ancestry individuals   10q23.1 GRID1 LOC101929624 rs12098564-A ncRNA NR 4 x 10-7 .435 unit decrease Affymetrix & Illumina
[~2.5 million] (imputed)
N
02/13/13 Wu C
November 24, 2012
Gut
Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Pancreatic cancer 642 European ancestry cases 363 Chinese ancestry cases 10q23.1 GRID1 GRID1 rs10788473-T intron 0.38 3 x 10-6 1.27 [1.15-1.41] Illumina
[2,731,086] (imputed)
N
11/22/12 Divaris K
July 01, 2012
J Dent Res
Genome-wide association study of periodontal pathogen colonization.
Periodontal microbiota 1,020 European ancestry individuals NA 10q23.1 GRID1, MI346, WAPAL GRID1 rs1970525-G intron 0.054 4 x 10-6 (A. actino) 2.89 [1.85-4.52] Affymetrix
[~2.5 million] (imputed)
N
08/07/09 Vasan RS
July 08, 2009
JAMA
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
Cardiac structure and function 12,612 European ancestry individuals 4,094 European ancestry individuals 10q23.1 GRID1 GRID1 rs7910620-G intron 0.01 7 x 10-7 (LV wall thickness) .17 [0.11-0.23] cm increase Affymetrix & Illumina
[~2.5 million] (imputed)
N




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Catalog Data Last Updated: February 20, 2015
Web Page Text Last Updated: September 16, 2015