National Institutes of Health U.S. Department of Health and Human Services
A listing of news releases from other National Institutes of Health (NIH) institutes and centers, academic and non-profit institutions, and scientists or scientific societies related to NHGRI-funded work.
March 10, 2014: New genetic cause of children's liver disease discovered From Kings College London: The discovery of a 'faulty gene' in children with liver disease could pave the way for new treatments for children with a range of serious and life-threatening liver conditions. The findings - published on March 9th in Nature Genetics - follow two years of research by doctors and scientists at King's College London and King's College Hospital, both part of King's Health Partners AHSC. An NHGRI grant helped fund the research.
March 3, 2014: Media Availability: NIH Team Identifies New Genetic Syndrome From the National Institute of Allergy and Infectious Diseases: Researchers at the National Institutes of Health (NIH) have identified a new genetic syndrome characterized by a constellation of health problems, including severe allergy, immune deficiency, autoimmunity and motor and neurocognitive impairment. The researchers, led by scientists at the NIH's National Institute of Allergy and Infectious Diseases (NIAID), observed that the syndrome's diverse symptoms are the result of mutations in a single gene associated with sugar metabolism. They plan to evaluate certain types of sugars as a potential treatment for people with this rare genetic condition in an upcoming clinical trial. The study, published in the Journal of Allergy and Clinical Immunology, was conducted by scientists from NIAID, the National Human Genome Research Institute and the National Institute of Neurological Disorders and Stroke, all components of NIH, and collaborators.
March 3, 2014: Media Availability:Study of Antibody Evolution Charts Course toward HIV Vaccine From the National Institute of Allergy and Infectious Diseases: In an advance for HIV vaccine research, a scientific team has discovered how the immune system makes a powerful antibody that blocks HIV infection of cells by targeting a site on the virus called V1V2. Many researchers believe that if a vaccine could elicit potent antibodies to a specific conserved site in the V1V2 region, one of a handful of sites that remains constant on the fast-mutating virus, then the vaccine could protect people from HIV infection. Analyses of the results of a clinical trial of the only experimental HIV vaccine to date to have modest success in people suggest that antibodies to sites within V1V2 were protective. The new findings point the way toward a potentially more effective vaccine that would generate V1V2-directed HIV neutralizing antibodies. The research, published in the journal Nature, is from a collaboration of authors, including Jim Mullikin, director of the NIH Intramural Sequencing Center, administered by NHGRI.
March 3, 2014: Study pinpoints protective mutations for type 2 diabetes From the Broad Institute: An international team led by researchers at the Broad Institute and Massachusetts General Hospital (MGH) has identified mutations in a gene that can reduce the risk of developing type 2 diabetes, even in people who have risk factors such as obesity and old age. The results focus the search for developing novel therapeutic strategies for type 2 diabetes; if a drug can be developed that mimics the protective effect of these mutations, it could open up new ways of preventing this devastating disease. NHGRI helped fund the research.
February 28, 2014: First of its kind web portal to bolster research and treatment for rare diseases From Children's Hospital of Eastern Ontario: A new web portal - PhenomeCentral - is being launched today as a resource for clinicians and scientists worldwide to learn about the existence of cases similar to their own and to eventually improve the understanding of disorder symptoms and underlying causes. The NIH Undiagnosed Diseases Program, administered by the National Human Genome Research Institute is a founding partner in the PhenomeCentral consortium.
February 28, 2014: New method IDs working copies of genes in human cells; could help diagnose sick tissues early From Harvard Medical School: In biology, as in real estate, location matters. Working copies of active genes - called messenger RNAs or mRNAs - are positioned strategically throughout living tissues, and their location often helps regulate how cells and tissues grow and develop. Now a team at the Wyss Institute of Biologically Inspired Engineering at Harvard University and Harvard Medical School, in collaboration with the Allen Institute for Brain Science, has developed a new method that allows scientists to pinpoint thousands of mRNAs and other types of RNAs at once in intact cells - all while determining the sequence of letters, or bases, that identify them and reveal what they do. The project was funded by NHGRI's Centers of Excellence in Genomic Science.
February 10, 2014: Shortening guide RNA markedly improves specificity of CRISPR-Cas nucleases From Massachusetts General Hospital: A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe how adjusting the length of the the guide RNA (gRNA) component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases (RGNs) can substantially reduce the occurrence of DNA mutations at sites other than the intended target, a limitation the team had previously described just last year. NHGRI helped fund the study.
January 24, 2014: Study expands the cancer genomics universe From The Broad Institute: A landmark study across many cancer types reveals that the universe of cancer mutations is much bigger than previously thought. By analyzing the genomes of thousands of patients' tumors, a Broad Institute-led research team has discovered many new cancer genes - expanding the list of known genes tied to these cancers by 25 percent. Moreover, the study shows that many key cancer genes still remain to be discovered. The team's work, which lays a critical foundation for future cancer drug development, also shows that creating a comprehensive catalog of cancer genes for scores of cancer types is feasible with as few as 100,000 patient samples. Funding for these studies was provided in part by the National Human Genome Research Institute.
January 22, 2014: New studies show that many rare mutations contribute to schizophrenia risk From The Broad Institute: Researchers from the Broad Institute and several partnering institutions have taken a closer look at the human genome to learn more about the genetic underpinnings of schizophrenia. In two studies published this week in Nature, scientists analyzed the exomes, or protein-coding regions, of people with schizophrenia and their healthy counterparts, pinpointing the sites of mutations and identifying patterns that reveal clues about the biology underlying the disorder. Funding for these studies was provided in part by the National Human Genome Research Institute.
January 22, 2014: NIH and Appistry Partner to Implement Genetic Analysis Pipeline for Undiagnosed Diseases Program From Appistry: Appistry, Inc., a leading provider of high-performance computing and analytics solutions for next-generation medicine, is partnering with the Undiagnosed Diseases Program (UDP) at the National Institutes of Health (NIH) to implement a unique genetic-analysis pipeline for patient diagnosis. Assembled by the NIH and brought into production by Appistry, the pipeline considers family genetics to narrow the search for the genetic changes that underlie many rare and undiagnosed diseases. NHGRI helped establish the Undiagnosed Diseases Program.
January 22, 2014: Study shows 1 in 5 women with ovarian cancer has inherited predisposition From Washington University in St. Louis: A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis. Most women in the study would have been unaware of a genetic predisposition to ovarian cancer because they didn't have strong family histories that suggested it.The research, published Jan. 22 in Nature Communications, is the first large-scale analysis of the combined contributions of inherited and acquired mutations in a major cancer type.NHGRI helped fund the study.
January 19, 2014:Decoded: DNA of blood-sucking worm that infects world's poor From Washington University in St. Louis: Going barefoot in parts of Africa, Asia and South America contributes to hookworm infections, which afflict an estimated 700 million of the world's poor. The parasitic worm lives in the soil and enters the body through the feet. By feeding on victims' blood, the worms cause anemia and, in children, stunted growth and learning problems. Now, researchers at Washington University School of Medicine in St. Louis have decoded the genome of the hookworm, Necator americanus, finding clues to how it infects and survives in humans and to aid in development of new therapies to combat hookworm disease. The research is published Jan. 19 in Nature Genetics. The genome sequencing and annotation work was funded by NHGRI.
January 9, 2014: Elephant shark genome decoded From Washington University in St. Louis: An international team of researchers has sequenced the genome of the elephant shark, a curious-looking fish with a snout that resembles the end of an elephant's trunk. The elephant shark and its cousins the sharks, rays, skates and chimaeras are the world's oldest-living jawed vertebrates. But their skeletons are made of cartilage rather than bone, making this group of vertebrates an oddity on the evolutionary tree.
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