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The Genomics Landscape

25th Anniversary of the Launch of the Human Genome Project

NHGRI Director Eric Green, M.D., Ph.D.
Eric Green
By Eric D. Green, M.D., Ph.D.
Director, National Human Genome Research Institute
October 6, 2015

This month brought a historic 'odometer moment' for the field of genomics - October 1, 2015, marked the 25th anniversary of the launch of the Human Genome Project. I, for one, cannot believe a quarter-century has now passed since many of us started working on the project. At the same time, it is truly incredible to think about how far genomics has progressed since that time. I thought the significance of this anniversary warranted making this topic the lead story in this month's The Genomics Landscape; in addition, I reflect on this important anniversary in a recent video interview now available on the NHGRI website.

With this issue, I am also happy to report that The Genomics Landscape turns two years old. Even after 24 issues, the number of noteworthy items has not diminished, as evidenced by the other topics featured here; see various details below, along with other information items that I hope will be of interest to you.

Specifically, October's The Genomics Landscape features stories about:

All the best,


25th Anniversary of the Launch of the Human Genome Project

A quarter-century ago, the NIH teamed up with the U.S. Department of Energy, the Wellcome Trust in the United Kingdom, and scientists from around the world to launch the Human Genome Project (HGP) - a massive, collaborative effort to map and sequence the human genome. October 1, 2015, marked the 25th anniversary of this launch. I find it hard to believe that it has been 25 years since the Project lunged from its starting line! 

In 1990, scientists and program administrators set lofty goals to complete the HGP in 15 years and at a cost of ~$1 per base of the human genome. Since the human genome is ~3 billion bases in size, the total cost of the HGP was, therefore, projected to be $3 billion dollars. While hopes were high that this could be achieved, there were many obstacles to overcome. Genetic and physical maps of the human genome needed to be generated. DNA sequencing technologies and strategies needed to be developed. Coordination and robust management practices needed to be put into place. In the beginning, it was unclear to many of the participants whether the HGP could be completed in the projected time or at the projected cost.

At the time of the HGP's launch, I was a postdoctoral fellow in Dr. Maynard Olson's laboratory at Washington University (see picture below), working on the human genome mapping efforts of the HGP. It was the beginning of a new scientific era, and none of us quite envisioned just how quickly genomics would come into its own as a discipline and become so integral to other areas of basic research, let alone translational and clinical research.  

On left: Maynard Olson and Eric Green, Washington University, 1990.
On right: Cover art from the 2001 publication describing the draft genome sequence in Nature.

To capture the stories and experiences of some HGP participants, NHGRI and the NHGRI History of Genomics Program will be hosting a special seminar series, "A Quarter Century after the Human Genome Project's Launch: Lessons beyond the Base Pairs," on the NIH campus. We will kick off the series in December with a panel discussion chaired by me, and including former NHGRI Director and current NIH Director, Francis Collins, and former NHGRI Deputy Directors, Elke Jordan and Mark Guyer. Other confirmed speakers for the series include: Maynard Olson, Ewan Birney, Bob Cook-Deegan, Marco Marra, and David Bentley. The lectures and discussions will be videorecorded, and the NHGRI History of Genomics Program will conduct oral history interviews with the presenters and add these to the Institute's growing historical archives.

From left to right: HGP graphic from NHGRI, HGP graphic from U.S. DOE, and cover of the 1988 National Academies report "Mapping and Sequencing the Human Genome".

Part of the HGP's legacy was the fashion in which it paved the way for other 'big biology' projects that followed. Reflecting on this anniversary, I recently co-authored a Nature Comment entitled "Twenty-Five Years of Big Biology" with Francis Collins and James Watson, former Directors of NHGRI (or the National Center for Human Genome Research, as we were named at the time Dr. Watson was Director). In that Comment, we describe six key lessons from the HGP beyond the actual genomic data and technologies. These lessons have served to guide many important research projects, including many that are ongoing today. In addition to the written Comment, Nature also recently released a 'podcast' interview with me about the HGP's 25th anniversary.

When the HGP started, there was much uncertainty about whether we could really sequence the human genome, let alone do it in 15 years. Being able to sequence a human genome in a matter of days for close to $1,000 seemed like science fiction. Yet this is the reality we are in today! The technological advances that have occurred to make this happen are truly astounding. I am certain that genomics will prove to be as exciting (and impactful) in the next 25 years as it has been over the last 25.

To access a brief history of the Human Genome Project (HGP), see

More from The Genomics Landscape

NIH & NHGRI News of Interest

Kaufmann Appointed Head of NCATS' Office of Rare Diseases Research

Genome Unlocking Life's Code: Timeline of Ancient DNA

NIH Framework Points the Way Forward for Building National, Large-Scale Research Cohort, a Key Component of the President's Precision Medicine Initiative

NIH Addresses the Science of Diversity

NIH Commits $36M to Train Junior Faculty in Africa

Dr. Eric Green Discusses the Work of NHGRI and His Perspective on Genomics

Grants to Help Identify Variants in the Genome's Regulatory Regions that Affect Disease Risk

Precision Medicine: Much More Than Just Genetics

Undiagnosed Diseases Network Launches Online Application Portal

NHGRI Welcomes 2015 ASHG/NHGRI Education and Public Policy Fellows

NHGRI Researchers to Present Talks, Posters at ASHG Annual Meeting

NIH Common Fund Launches Four Programs Designed to Take Aim at Gaps in Biomedical Research

United States Patent and Trademark Office Report on Confirmatory Genetic Diagnostic Test Activity

Funding News

Notice on NIH Research Involving Introduction of Human Pluripotent Cells into Non-Human Vertebrate Animal Pre-Gastrulation Embryos

Participation of Additional NIH Components in "Emerging Global Leader Award"

Funding Opportunities

A Data Analysis and Coordinating Center for Research Training and Career Development Activities

Novel Nucleic Acid Sequencing Technology Development (R21, R01, and R43/R44)

Genomics Research

Investigating Why Cancer Comes Back

An Ancient Tumor in Dogs Might Teach New Tricks about Cancer in People

Who Should Decide? The Complex Ethics of Pediatric Genome Sequencing

Diet, Exercise, Smoking Habits and Genes Interact to Affect AMD Risk

A New Single-Molecule Tool to Observe Enzymes at Work

New Hope for Undiagnosed, Critically Ill Newborns at Rady Children's

Scientists Create World's Largest Catalog of Human Genomic Variation

Scientists Test New Gene Therapy for Vision Loss from a Mitochondrial Disease

Genome Advance of the Month

Gene-Editing Technology Uncovers Genetic Link to Infertility

Upcoming Webcasts

Human Heredity and Health in Africa Project Presentations - October 13, 2015

Awards & Recognition

Thomas A. Waldmann Award for Excellence in Human Immunology 2015 - Dan Kastner

Sigma Theta Tau Honor Society of Nursing: International Awards for Nursing Excellence Best of Publication 2015 - Jean Jenkins

University of Texas Alumnus Recognized for Leukemia Research - Paul Liu



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Last Updated: October 6, 2015
Posted: August 4, 2008