Population Architecture Using Genomics and Epidemiology

National Human Genome Research Institute

National Institutes of Health
U.S. Department of Health and Human Services

Population Architecture using Genomics and Epidemiology (PAGE) Consortium

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Genome-wide association studies have identified many genetic variants related to disease and have highlighted the need to further explore initial findings in non-European populations. The Population Architecture using Genomics and Epidemiology (PAGE) Consortium (RFA HG-07-014 and RFA HG-07-015) was formed in July 2008 and was renewed for a second phase (PAGE II) in September, 2013 (RFA HG-12-010 and RFA HG-12-015).

The first phase of PAGE examined putative causal genetic variants across approximately 100,000 African Americans, Asian Americans, American Indians, European Americans, Hispanic Americans, and Native Hawaiians from four groups representing nine large U.S.-based cohorts. Two genotyping approaches were employed - targeted genotyping of selected SNPs identified in genome-wide association studies of common disease, and a large-scale effort focused on the Metabochip array, which facilitated trans-ethnic fine mapping of several diseases of public health importance.  PAGE II will add to these achievements by focusing analysis and genotyping efforts entirely on approximately 50,000 non-European ancestry individuals to better characterize how genetic factors influence susceptibility to disease. In September 2013, the NHGRI announced new awards to four research groups representing six national cohorts. By coordinating genotyping and phenotype harmonization across groups, PAGE is defining the epidemiological architecture of cross-population allele frequencies, relative risks, and distribution of phenotypes associated with particular variants and their environmental modifiers.

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PAGE Investigators

PAGE Investigators shown on U.S. map
Page II Study Investigators

Genetics Epidemiology of Causal Variants Across the Life Course (CALiCo Consortium)

Principal Investigator (PI): Kari North, Ph.D., University of North Carolina at Chapel Hill

Multiethnic Cohort (MEC)
Principal Investigator (PI): Chris Haiman, Ph.D., University of Southern California and Loic Le Marchand, M.D., Ph.D.,  University of Hawaii

Women's Health Initiative (WHI)
Principal Investigators (PIs): Charles Kooperberg, Ph.D. and Ulrike Peters, Ph.D., Fred Hutchinson Cancer Research Center

Mount Sinai Biobank Program (MSSM Institute for Personalized Medicine)
Principal Investigator (PI): Ruth Loos, Ph.D., Mount Sinai School of Medicine
Coordinating Center

Principal Investigator (PI): Tara C. Matise, Ph.D., Department of Genetics, Rutgers University, New Brunswick, N.J.

Genotyping Center

Center for Inherited Disease Research, Johns Hopkins University

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PAGE II Study Organization

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Study Design, Participant and Genotyping Characteristics of PAGE Cohorts

Cohort Focus of Cohort Mean Age Age Range % Female
MSSM Biobank Multiple phenotypes linked
to electronic health records
54 18-98 59
MEC Cancer, diabetes 60 45-78 55
WHI Women's Health 63 50-79 100
CALiCo-ARIC Cardiovascular Disease 54 45-64 55.1
CALiCo-CARDIA Cardiovascular Disease 25 18-30 54.4
CALiCo-SHS Cardiovascular Disease 40 14-91 59.3
CALiCo-HCHS-SOL Cardiovascular Disease 55 18-72 65

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Population Architecture using Genomics and Epidemiology (PAGE) website

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Published Manuscripts

Published Manuscripts related to Population Architecture using Genomics and Epidemiology (PAGE)

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Lucia Hindorff, Ph.D., M.P.H.

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Last Updated: August 7, 2014