Search Results
Policy Issues
Revisions to the Common Rule modernize, simplify, and enhance oversight for human subjects research in the United States.
… The final version of the Common Rule was published in the Federal Register on January 19, … nature of research since the original publication of the Common Rule in 1991. … Compliance with the new rules will …
The Informed Consent Resource
Explore the basic elements of informed consent that are required by the Common Rule and that are relevant to genomics.
… elements of informed consent that are required by the Common Rule (45 CFR 46, Subpart A) and that are relevant to … families and communities).  Protections from risks: The Common Rule regulations, the Office of Human Research …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… The Centers for Common Disease Genomics (CCDG) are a collaborative … rare risk and protective variants contributing to multiple common disease phenotypes. … The CCDG initiative explores a … the general principles of genomic architecture underlying common, complex inherited diseases. Understand how best to …
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.
… research will focus on understanding the genomic bases of common and rare human diseases. … The National Human Genome … (NHGRI), part of NIH, today launched the Centers for Common Disease Genomics (CCDG), which will use genome sequencing to explore the genomic contributions to common diseases such as heart disease, diabetes, stroke and …
News Release
NHGRI will highlight rare disease research that benefits affected patients and provides insights into more common disorders on Rare Disease Day.
… affected patients and also provides insights into more common disorders.​ … They are underlining this important … connection between the rare Gaucher disease and the more common Parkinson's disease. While patients with Gaucher … disease studies have the potential to shed light on more common diseases in a perspective published February 22, 2017, …
The Genomics Landscape
In the November 2019 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the International Common Disease Alliance's scientific plenary and launch meeting in September, which included an international panel on opportunities emerging outside the U.S., North America, and Europe; discussions about polygenic risk scores; and an overview about data platforms, data sharing, and ethics.
… institute and the field of genomics. …  The International Common Disease Alliance (ICDA) was recently established as a … shares many goals with the ICDA. Accelerating progress in common disease genetics discovery and translation is … NHGRI-funded programs, most prominently the Centers for Common Disease Genomics . NHGRI strongly agrees with ICDA’s …
The Informed Consent Resource
Explore genomics-relevant considerations for informed consent and guidance on how to approach them.
… are not considered to be research subjects under the Common Rule, there are consent-relevant considerations related to … often stored for future research use. It is increasingly common for samples and/or data to be stored in repositories …
News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
Genetic Disorders
Skin cancer is the most common type of cancer in the United States.
… Skin cancer is the most common type of cancer in the United States. An estimated 40 … have skin cancer at least once. … Skin cancer is the most common type of cancer in the United States. An estimated 40 … to age 65 will have skin cancer at least once. The most common skin cancer is basal cell carcinoma, which accounts …
Genetic Disorders
Velocardiofacial syndrome is the most common syndrome associated with a cleft palate.
… Velocardiofacial syndrome is the most common syndrome associated with a cleft palate. … … are found in each child who is born with VCFS. The most common features are palatal differences (~75 percent), heart … Syndrome … Velocardiofacial syndrome is the most common syndrome associated with a cleft palate. … …