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Educational Resources
A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
… Mutation … A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to …
Educational Resources
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three.
… is not divisible by three. … Genetic Mutation, Base Pairs, DNA Sequence … A frameshift mutation in a gene refers to the …
Educational Resources
A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.
… amino acid in the resulting protein. … Missense Mutation, DNA Mutation, DNA Sequence … A missense mutation is a DNA change that … position in the resulting protein. Some missense mutations alter the function of the resulting protein. … A …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… The DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in … it can be very difficult to develop a test to detect these mutations, because most large genes have many regions where …
Educational Resources
A point mutation is when a single base pair is altered.
… base pair is added, deleted or changed. While most point mutations are benign, they can also have various functional …
Educational Resources
A nonsense mutation is the substitution of a single base pair that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid.
… Code, Genetic Mutation … A nonsense mutation occurs in DNA when a sequence change gives rise to a stop codon rather …
News Release
Research points to the effects of nutrients in how DNA mutates in the mitochondria.
… Research points to the effects of nutrients in how DNA mutates in the mitochondria. … In a very real sense, you … some vitamins can affect one of these essential molecules, DNA.  “You need to create more DNA if you're going to make … contribute to changes to the DNA sequence, also known as mutations. Imagine fishing tiles out of the bag in a Scrabble …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… researchers and their collaborators have identified mutations in the TAF1 gene. They've also demonstrated that … Darryl Leja, NHGRI.   Dr. Bell and her team isolated DNA from tumor cells and from normal cells from patients with … in the protein-coding regions of the tumor and normal DNA from 16 CCEC patients, and found mutations in 222 genes …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… that these cells are prone to increased numbers of genetic mutations. A new study by scientists at the National Human … of Health, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning. … and the subcloning techniques. They then sequenced the DNA of the skin cells as well as the iPSCs and the subcloned …
Educational Resources
DNA replication is the process by which a molecule of DNA is duplicated.
… DNA Replication … DNA replication is the process by which a molecule of DNA is duplicated. … DNA, Cell Division, Cell Biology … DNA replication is the …