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News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… signs of damage. Their metabolism and pattern of gene expression were different from those of healthy cells, … The research team reported that the metabolism and gene expression of the crucial TFH cells are still "largely … transcription factor known as Blimp1. TCF1 turns off expression of Blimp1, just as Blimp1 turns off expression of …
News Release
In a new large-scale genetic analysis, National Institutes of Health (NIH) scientists have found set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes.
… the largest sequenced-based analysis of microRNA expression in human pancreatic islets to date,” said Francis … the stage for understanding how microRNAs fine-tune gene expression in pancreatic islets and its implications for … the largest sequenced-based analysis of microRNA expression in human pancreatic islets to date. The results of …
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… disease. All the best, … Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… the cellular receptor for SARS-CoV-2. In the edited mice, expression patterns of ACE2 were similar to those in humans …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… However, they also uncovered many DNA variations and gene expression patterns that are not shared, potentially limiting … researchers found that differences appeared in specific tissue and cell types. "We didn't know before these results … sites (which identify regulatory DNA) in 45 mouse cell and tissue types to those in humans. They reported in Science …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data.
… the RFA, individual projects collect genomic data on gene expression, as well as surrogate markers of regulatory … in different cell fates or cell states. They use the gene expression and functional element data to construct gene … University of Massachusetts Medical School Rules Of Gene Expression Modeled On Human Dendritic Cell Response To …
News Release
NHGRI awards $6.7 million in new research grants to develop DNA sequencing technologies that are more sensitive, faster, cheaper and more accurate.
… lead to imprecise and incomplete read-outs of gene expression and transcript diversity. Additionally, this way … than the genome in certain cases," he said. "Gene expression in a cancer cell is going to be different than in …
File
… Slides_Epigenetic effects and gene expression.pptx …
Research Funding
Expired Funding Opportunity Announcements dating back to 1994, including Requests for Application, Program Announcements and Notices.
… Optional)" RFA-HG-21-026 : Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Project (U24 Clinical Trials Not …