Search Results
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… of DNA Elements (ENCODE) in September 2003 to carry out a project to identify all functional elements in the human … of non-exonic conservation with respect to the orthologous mouse genomic sequence (see below), for a total of nine … that showed less than 75 percent base alignment with mouse sequence were discarded. For the remaining subwindows, …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… controlling movement. Midbrain neurons from the new mouse model. The green shows the clumped alpha-synuclein. … In the study, the authors used a Parkinson's disease mouse model that carried extra copies of a mutated form of … is different about the cross-bred mice. Ultimately, this mouse model can be used to develop and evaluate new …
About Genomics
The Human Genome Project was an inward voyage of discovery led by an international team of researchers looking to sequence and map all the genes of our species.
… The Human Genome Project (HGP) is one of the greatest scientific feats in history. The project was a voyage of biological discovery led by an … October 1990 and completed in April 2003, the Human Genome Project’s signature accomplishment – generating the first …
Fact Sheet
A fact sheet detailing how the project began and how it shaped the future of research and technology.
… The Big Picture The Human Genome Project was a landmark global scientific effort whose … sequence of the human genome. In 2003, the Human Genome Project produced a genome sequence that accounted for over … bacterium E. coli , baker’s yeast, fruit fly, nematode and mouse. The project’s architects and participants hoped the …
The Genomics Landscape
In the June 2019 edition of The Genomics Landscape, NHGRI Director Eric Green details the legacy of the Human Microbiome Project as it reaches completion.
… catalyzed the launching of the NIH Human Microbiome Project (HMP). In 2007, the NIH Common Fund initiated the HMP … multiple initiatives, including the International HapMap Project , the 1000 Genomes Project , the Genomic Resources Program, the Centers of …
Research Funding
The Genotype-Tissue Expression (GTEx) Project will create a resource that researchers can use to study how inherited changes in genes lead to common diseases
… 2010 (See: NIH launches Genotype-Tissue Expression project ), GTEx will create a resource that researchers can … gift of tissues and medical information to the GTEx project makes possible research that will help improve our … cure these diseases in the future. In addition, the GTEx project includes a study to explore the effectiveness of the …
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
… Jeannine Mjoseth … Databases such as the 1000 Genomes Project and the Exome Aggregation Consortium (ExAC) harbor … The Genomic Ascertainment Cohort (TGAC), a two-year pilot project that will allow them to recall genotyped people and … traits, such as height, eye color or blood type. The project reverses a long-standing research paradigm of …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… is a staff scientist and director of the NHGRI Transgenic Mouse Core at the NIH. In 1984, she received her M.S. at … 1994 and completed her thesis, The Tissue - Specificity of Mouse Ets-1 Regulatory Region in a Transgenic Model. In 1994, … supervisor in the NHGRI Embryonic Stem Cell and Transgenic Mouse Core and became director in 1997. Ms. Garrett oversees …
News Release
Grants are awarded to GTEx project to explore human gene expression and regulation in different tissues, and how genomic variation modulates that expression.
… grants as part of the Genotype-Tissue Expression (GTEx) project to explore how human genes are expressed and … over three years pending the availability of funds. The project is funded by the NIH Common Fund, the National … (NHLBI). "The new studies complement the current GTEx project in assessing genomic variation and gene expression," …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project utilizes a deliberative stakeholder-engagement approach to develop patient educational materials for sickle cell disease gene therapy.
… them make such decisions. … The Democratizing Education Project welcomes your feedback about the sickle cell disease … Education for Sickle Cell Disease Gene Therapy project invited more than 50 stakeholders to participate in a … leaders, government representatives and researchers.  The project group met over four days in both large and small …