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The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… genome function, the proteins that bind to DNA, and how RNA molecules interact to regulate gene expression. The …
Fact Sheet
Viruses are bundles of genetic material wrapped in a protein coat that can infect living things.
… molecule in the form of nucleic acids such as DNA or RNA. a protein layer, or coat, that surrounds and protects … can cause disease. Viruses that encode information with RNA rather than DNA tend to have a higher rate of mutations. … an organism's entire nucleic acid material (such as DNA or RNA), which is known as its genome. In 1977, researchers …
Staff
Dr. Mullikin was the former director of the NIH Intramural Sequencing Center (NISC).
… targeted capture methods (Teer et al., Genome Res 2010), RNA sequence analysis, and whole-genome sequence assembly … development, cellular development and cancer progression. RNA sequence analysis is another area of rapid analytical … JC, Biesecker LG. Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. …
Event
We invite scholars to submit ideas to be one of six to seven speakers at our symposium, “Irreducible Subjects: Disability and Genomics in the Past, Present, and Future”, with an additional opportunity to join a collected set of papers on the same theme.
News Release
NIH researchers analyzed the gene activities of immune cells in children with mitochondrial disorders and found that their B cells, which produce antibodies to fight viral infections, are less able to survive cellular stress.
… system. Using a genomic technique called single-cell RNA sequencing, which analyzes gene activity in different … a microRNA called mir4485 . MicroRNAs are small strings of RNA that help control when and where genes are turned on and …
The Genomics Landscape
In the February 2, 2023 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about the new NIH Data Management and Sharing (DMS) Policy and how it emphasizes the importance of good data management practices.
… was released in partnership with NHGRI and focuses on RNA biology. The program aims to support projects that pursue … creative, technologically advanced approaches to study RNA function in complex biological systems and that harness RNA research to advance biotechnology. The goal is to …
News Release
Research points to the effects of nutrients in how DNA mutates in the mitochondria.
… going to make new cells, and you need to create more RNA for those cells to do their job,” said Lawrence Brody, … are linked to creating the building blocks of DNA and RNA, and not having enough of these vitamins can interfere … going to make new cells, and you need to create more RNA for those cells to do their job. That's the raw material …
Media Advisory
NHGRI hosts a Reddit AMA with Jennifer Doudna, Ph.D., and her research group.
… Learn more about Dr. Doudna's research at http://rna.berkeley.edu/ Contact: Sheena Faherty, Ph.D. NHGRI …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in May 2023.
… Report 17 NASEM Study: Toward Sequencing and Mapping RNA Modifications NASEM RNA Study Website NASEM RNA Workshop Recording NASEM RNA Ideation Challenge 18 Human …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… of the ENCODE pilot project. Antibodies that recognize RNA polymerase II and TAFII250, a component of a general … that initiates the preinitiation complex assembly for RNA polymerase II, should be bound to the promoters of all genes actively transcribed by RNA polymerase II. The RNA polymerase II antibody is …