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News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… modifications of DNA, proteins that bind to DNA, and RNA (a sister molecule to DNA) interact to regulate genes. … types, such as long-range DNA interactions and protein-RNA interactions." As a new feature, ENCODE 3 researchers …
Staff
Dr. Shurjo Sen is a program director in NHGRI's Division of Genome Sciences who manages a portfolio of grants focused upon genomic data sciences, and is particularly interested in transitioning genomics from a centralized data repository model to cloud-based collaborative science.
… R, Munson PJ, McVicar DW, Biesecker LG. Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery … Program. Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular … improve run-specific systematic error analysis for DNA and RNA sequencing. PLoS One . 2012;7(7):e41356 [ PubMed ] …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… new body from only its mouth. The researchers sequenced RNA from Hydractinia symbiolongicarpus , a small, tube-shaped … far from the its mouth. Credit: Darryl Leja, NHGRI.   When RNA sequencing pointed to senescence, the researchers scanned …
Staff
Dr. Lanata is a staff clinician in NHGRI's Genomics of Autoimmune Rheumatic Disease Section.
… N, Dahl A, Lanata CM , Matloubian M, et al. Single-cell RNA-seq reveals cell type-specific molecular and genetic … Lanata C , Gate RE, et al. Multiplexed droplet single-cell RNA-sequencing using natural genetic variation . Nat …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in February 2023.
… Awards 24 NASEM Study: Toward Sequencing and Mapping of RNA Modifications NASEM RNA Study Website NASEM RNA Workshop Recording 25 Global Alliance for Genomics and …
Research at NHGRI
The NIH Intramural Sequencing Center is a multi-disciplinary genomics facility that emphasizes the generation and analysis of DNA sequence.
… of sequencing projects include whole exome sequencing, RNA sequencing, custom capture sequencing, CHiP-seq and whole …
Staff
Diana Bianchi is an adjunct investigator in the Medical Genetics Branch at the National Human Genome Research Institute. ​
… gene expression microarray analyses of the cell-free RNA that floats in amniotic fluid, a maternal biofluid that … phenotype variation, we are expanding our knowledge using RNA sequencing. Prenatal Therapy for Down Syndrome Down … fluid transcriptome, we have shown that the cell-free RNA in human mid-trimester amniotic fluid supernatant …
File
… Expression Analysis, Functional Enrichment, and Network Inference_042716.pdf …
Outreach
A list of high quality educational activities to engage students on DNA Day.
… Pages include a double helix, DNA replication and an RNA polymerase. Molecules of Interitance from GSLC This … involved in inheritance, including DNA and Genes, RNA, Proteins and The Central Dogma, which explains the … concepts. Videos include: "Transcription & Translation: RNA Splicing", "DNA Molecule: How DNA is Packaged", "DNA …
Staff
Dr. Lisa Helbling Chadwick is a program director in Division of Extramural Research at the National Human Genome Research Institute. ​
… genomic technologies related to gene expression or RNA regulation. She also oversees NHGRI’s GREGoR Program, …